CN207181358U - A kind of more working electrode glucose sensors - Google Patents
A kind of more working electrode glucose sensors Download PDFInfo
- Publication number
- CN207181358U CN207181358U CN201720655146.9U CN201720655146U CN207181358U CN 207181358 U CN207181358 U CN 207181358U CN 201720655146 U CN201720655146 U CN 201720655146U CN 207181358 U CN207181358 U CN 207181358U
- Authority
- CN
- China
- Prior art keywords
- electrode
- working electrode
- substrate
- tissue fluid
- working
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
It the utility model is related to a kind of more working electrode glucose sensors, including substrate, the front of the substrate is printed with electrod-array, multigroup working electrode, reference electrode are distributed with the electrod-array, electrode is drawn to electrode and tissue fluid, the back side of the substrate is provided with through hole and working electrode, reference electrode, connecting wire and lead leg to electrode and tissue fluid absorption electrode on substrate；With it is existing based on the product of reverses iontophoresis technology compared with, more work electrode sensor structures provided by the utility model, the test scope of concentration of glucose can greatly be improved；More work electrode test comparative analyses, obtain more accurate blood sugar concentration；At the back side of substrate, the complexity for the front lead that setting connecting wire structure substantially reduces, the leg of another aspect back side connecting wire can directly weld with hardware circuit board, can improve the integrated level of equipment, be easy to miniaturization and wearableization.
Description
Technical field
A kind of more working electrode glucose sensors are the utility model is related to, belong to biological information detection field.
Background technology
The blood sugar concentration for being mainly characterized by slowly persistently rising of diabetes, when blood sugar concentration rises to certain height
When, sugar can be then detected in urine higher than renal glucose threshold.Diabetic causes internal generation because blood sugar concentration is abnormal
Thank to disorder, easily cause the severe complications such as Diabetic ketosis, cardio cerebrovascular affection, nephrosis, illness in eye, acromelic gangrene and infection.By
In the method that there is no radical cure diabetes at present, therefore, control blood sugar concentration is to treat the Main Means of diabetes.
At present, the blood glucose meter sold on the market be mostly invasive, it is necessary to finger acupuncture treatment sampling, to patient bring pain and not
Just, blood sugar concentration continuous monitoring while can not also be realized.Therefore noninvasive dynamics monitoring technology turns into the study hotspot in the field.Nothing
Wound blood sugar detecting method have a lot, such as near infrared light method, mid-infrared and far-infrared light method, polarized light approach, ultrasonic sound and light spectroscopy, instead from
Sub- electro-osmosis method, tissue fluid ultrafiltration extraction method etc., wherein Near-Infrared Absorption Method are due to materials such as internal water, protein, fat, hemochrome
Larger to measurement result interference, precision is not received typically by clinic.The system for detecting blood sugar of Medtronic passes through fine acupuncture
Broken epidermis, direct monitoring tissue liquid blood sugar concentration, the degree of accuracy is higher, but belongs to minimal invasive techniques, and consumptive material is extremely expensive.Instead from
Sub- electro-osmosis method in epidermis by applying electric field, and the Na ions in tissue fluid are to movable cathode, and the Cl ions Ghandler motion that faces south moves, skin
It is negatively charged under normal circumstances, ion stream of the Na ions as main carriers, neutral glucose molecule is carried to skin surface,
Realize the purpose of noninvasive extraction.
However, the blood sugar test product based on reverses iontophoresis method, such as glucowatch, are present light during extracting interstitial fluid
Microstimulation skin, and single working electrode measurement blood glucose range are narrow, for various concentrations blood glucose matching degree and the degree of accuracy
The defects of poor.
Utility model content
The technical problems to be solved in the utility model is：To overcome above mentioned problem, there is provided a kind of more working electrode glucose
Sensor.
Technical scheme is used by the utility model solves its technical problem：
A kind of more working electrode glucose sensors, including substrate, the front of the substrate is printed with electrod-array, described
Multigroup working electrode, reference electrode are distributed with electrod-array, electrode is drawn to electrode and tissue fluid, the back side of the substrate is set
It is equipped with by the through hole on substrate and working electrode, reference electrode, the connection that electrode electrically connects is drawn to electrode and tissue fluid leads
Line and lead leg；
Multigroup working electrode can measure multi-group data, and be analyzed with actual value, closest so as to obtain
The data of actual value；
The reference electrode is used for the operating voltage of calibration electrode；
It is described that electrode is used to form loop with working electrode；
The tissue fluid draws electrode and is used to extract liquid to be detected.
Preferably, the electrod-array includes the multiple tissue fluid absorption electrode collar for surrounding circle, and the tissue fluid draws electricity
Multiple workspaces are formed in polar circle, the tissue fluid draws electrode collar adjacent one side and offers corresponding breach, each described
Multigroup working electrode, the reference electrode and the centre that multigroup working electrode is arranged on to electrode are provided with workspace.
Preferably, the working electrode of some groups of different areas is provided with each workspace, different operating electrode
Area ratio scope is 1-100.
Preferably, the region overlay that the substrate back is provided with connecting wire has insulating barrier, reserves drawing for connecting wire
Wire bonding placement of foot, in the working electrode of substrate face, reference electrode, the region overlay that electrode is drawn to electrode and tissue fluid
Layer of gel disk.
Preferably, the gel disk includes PEO, polyvinyl alcohol (PVA), chitosan or agarose；The gel
Composition in disk also includes bovine serum albumin (BSA) and/or buffer solution (PBS) and/or glucose oxidase (GOD) and/or prevented
Rotten agent and/or NMF and/or penetrating agent and/or complexing agent and/or anti-interference agent.
The beneficial effects of the utility model are：With it is existing based on the product of reverses iontophoresis technology compared with, this practicality
More work electrode sensor structures of new offer, the test scope of concentration of glucose can greatly be improved；More working electrodes
Test comparison is analyzed, and obtains more accurate concentration of glucose；The complexity for the front lead that back pin configuration substantially reduces, separately
One side back side lead leg can directly weld with hardware circuit board, can improve the integrated level of equipment, is easy to miniaturization and can wear
Dai Hua.
Brief description of the drawings
The utility model is further illustrated with reference to the accompanying drawings and examples.
Fig. 1 is the substrate schematic diagram containing through hole of the embodiment of the utility model one；
Fig. 2 is the front view of more working electrode glucose sensors described in the utility model；
Fig. 3 is the rearview of more working electrode glucose sensors described in the utility model；
Fig. 4 is the schematic diagram that glucose sensor described in the utility model is used for blood sugar detection apparatus；
The schematic diagram of electrode voltage loading is extracted when Fig. 5 is the blood sugar test of the embodiment of the utility model one；
Fig. 6 is the glucose sensor different operating electrode of the embodiment of the utility model one in various concentrations standard glucose
The matched curve schematic diagram of concentration of glucose is measured in solution.
In figure mark for：1- bandages, 2- base fixtures, 3- hardware circuit boards, the more working electrode glucose sensings of 4-
Device, 41- substrates, 42- through holes, 43- tissue fluid draw electrode, and 44- is to electrode, 45- reference electrodes, 461- working electrodes, 462-
Working electrode, 463- working electrodes, 464- working electrodes, 47- lead pressure points, 48- connecting wires, 49- insulating barriers, 410- leads
Leg, 5- gel disks.
Embodiment
The utility model is described in further detail presently in connection with accompanying drawing.These accompanying drawings are simplified schematic diagram,
Only illustrate basic structure of the present utility model in a schematic way, therefore it only shows the composition relevant with the utility model.
Embodiment 1
A kind of more working electrode glucose sensors, as shown in Figures 2 and 3, including substrate 41, the substrate 41 is specific
Using when can be ceramics, glass, macromolecule or plastic or other material, the front of the substrate 41 is printed with electrod-array, described
Multigroup working electrode (461-464), reference electrode 45 are distributed with electrod-array, electrode 43 is drawn to electrode 44 and tissue fluid,
The back side of the substrate 41 be provided with through hole 42 on substrate 41 with working electrode (461-464), reference electrode 45, to electricity
Connecting wire 48 and the lead leg 410 that electrode 43 electrically connects are drawn in pole 44, tissue fluid；
Multigroup working electrode (461-464) can measure multi-group data, and be analyzed with actual value, so as to
To the data closest to actual value；
The reference electrode 45 is used for the operating voltage of calibration electrode (461-464)；
It is described that electrode 44 is used to form loop with working electrode (461-464)；
The tissue fluid draws electrode 43 and is used to extract liquid to be detected.
With it is existing based on the product of reverses iontophoresis technology compared with, more work electrode sensings provided by the utility model
Device structure, the test scope of concentration of glucose can greatly be improved；More work electrode test comparative analyses, are obtained more accurate
Concentration of glucose；The complexity for the front lead that the setting structure of connecting wire 48 substantially reduces, the opposing party at the back side of substrate 41
The lead leg 410 of face back side connecting wire 48 can directly weld with hardware circuit board 3, can improve the integrated level of equipment, be easy to
Miniaturization and wearableization.
Embodiment 2
On the basis of more working electrode glucose sensors described in embodiment 1, in the present embodiment, the electrod-array
Multiple tissue fluid including surrounding square ring are drawn electrode 43 and enclosed, but the tissue fluid draws electrode 43 and encloses and can also set as needed
The circle of ring, side shape circle or other irregular shapes is set to, the tissue fluid draws electrode 43 and encloses the interior multiple workspaces of formation,
The tissue fluid draws the circle adjacent one side of electrode 43 and offers corresponding breach, and multigroup work is provided with each workspace
Make electrode (461-464), the reference electrode 45 and the centre that multigroup working electrode (461-464) is arranged on to electrode 44.
The working electrode (461-464) of some groups of different areas, different operating electrode are provided with each workspace
The area ratio scope of (461-464) is 1-100.In a preferred embodiment, 4 groups of works are provided with each workspace
Make electrode (461-464), working electrode 462, working electrode 463, the area ratio of working electrode 464 and working electrode 461 are
1:2:3:4,4 groups of working electrodes are divided into two pairs and are arranged on reference electrode 45 and the both sides up and down to electrode 44, upper and lower both sides
Two pairs of working electrode areas be 5:5, and in order to ensure the working electrode 461 and work of symmetry, maximum area and minimum area
Make electrode 462 to design on top, second and the working electrode 463 and working electrode 464 of the third-largest small area design following.
In a preferred embodiment, the connecting wire 48 is drawn and in the leg of one side formation rule at through hole 42
Arrangement, the region overlay that the back side of substrate 41 is provided with connecting wire 48 have insulating barrier 49, only reserve lead leg 410
Put.In the positive working electrode (461-464) of substrate 41, reference electrode 45, electrode 43 is drawn to electrode 44 and tissue fluid
Region overlay layer of gel disk 5.In a preferred embodiment, the gel disk 5 mainly includes PEO, polyethylene
Alcohol (PVA), chitosan or agarose or the compatible hydrogel material of other biological；Composition in the gel disk 5 may also include
Following auxiliary material：Bovine serum albumin (BSA) and/or buffer solution (PBS) and/or glucose oxidase (GOD) and/or preservative
And/or NMF and/or penetrating agent and/or complexing agent and/or anti-interference agent.The preservative is used to keep enzyme in gel disk 5
Never degenerate, the NMF is used to keep gel disk 5 to moisten, and the penetrating agent is used to promote glucose from subcutaneous osmotic to skin
Surface.
Embodiment 3
The manufacture method of the utility model more working electrode glucose sensors described above, as shown in figure 1, including step
S1：Some patterns of through hole 42 are formed on the substrate 41, the substrate 41 can be ceramics, glass, height in specific application
Molecule or plastic or other material；The method for forming the through hole 42 can be mechanical punching or laser boring, or by designing mould,
Directly molding forms the base substrate with through hole 42, and forms required substrate by processing, and the position of through hole 42 is set as needed
Put, limited without specific.
As shown in Fig. 2 step S2：Electrocondution slurry is filled by silk-screen printing technique in front first, tissue fluid is formed and inhales
Power taking pole 43, working electrode (461-464), reference electrode 45 and to electrode 44, and fill the 42 positive back side of through hole and form mutual link
Structure, then Pt or conductive carbon etc. are modified on working electrode (461-464).The electrocondution slurry can be Ag, Ag/AgCl, Pt or C
Deng material, Ag/AgCl is selected in the utility model embodiment, according to other conductive materials, need to be modified on reference electrode 45
Ag/AgCl。
As shown in figure 3, step S3：At the back side of substrate 41 by silk-screen printing technique printed circuit cable, and curing process,
The conductor material can be the materials such as Ag, Ag/AgCl, Pt or C, be used as and led from Ag/AgCl in the utility model embodiment
Wire material；Back up Ag/AgCl can further fill through hole 42, it is ensured that interconnection structure is stable.In a preferred embodiment,
A layer insulating 49 is overleaf brushed, only reserves the part of lead leg 410, is easy to subsequently be connected with hardware circuit board 3, and do not draw
Play short circuit.The insulating barrier 49 can be silica gel, insulating tape or resin etc..It is pointed out that the pattern of front and back
Change in no particular order, i.e., between step S2 and S3 in no particular order, step S3 can also be first carried out, then perform step S2, this practicality is new
Type embodiment is first to do positive patterning, then does rear surface pattern.
In a preferred embodiment, in the step S3, the end shape of the connecting wire 48 at the back side of substrate 41
Into lead leg 410, the lead leg 410 can hardware circuit board 3 directly weld, connecting wire 48 also goes out to form in through hole 42
Lead pressure point 47, make connection more firm.
In a preferred embodiment, in addition to step S4：In the working electrode (461-464), reference electrode 45, right
Electrode 44 and tissue fluid draw the region overlay layer of gel disk 5 of electrode 43.
In a preferred embodiment, in addition to step S31：Silver/chlorine is used to the extraction electrode and reference electrode 45
Change silver to be modified；Electronic media compound is coordinated to modify with electrocondution slurry the working electrode (461-464), or
Glucose oxidase and electronic media compound are modified on the working electrode (461-464)；The electronic media compound is
Prussian blue or osmium polymer.
Embodiment 4
On the basis of above example, there is provided the more working electrode glucose sensors of a utility model specifically should
With example, as shown in figure 4, hardware circuit board 3 is fixed in base fixture 2, the both sides cohesive bandage of base fixture 2
1 or wrist button bandage 1 connect, be attached to arm, the place such as wrist and ankle during convenient use.By the more working electrodes of the utility model
Glucose sensor 4, it is connected by the lead leg 410 of back side connecting wire 48 with hardware circuit board 3, and is fixed on hardware electricity
On road plate 3, the design of whole blood sugar detection apparatus is completed.Gel disk 5 is placed in more working electrode glucose sensors 4 during use
On, and arm is attached to, the place such as wrist and ankle carries out blood sugar test.
As shown in figure 5, during detection, power supply is connected first, and loads the positive voltage of certain time, carries out tissue fluid extracting.
Stop after extracting, on right side, working electrode on-load voltage carries out examination of glucose concentration, obtains one group of interstitial fluid glucose concentration
Data.Then the positive voltage of certain time is loaded, carries out tissue fluid extracting.Stop after extracting, the working electrode loading electricity in left side
Pressure carries out examination of glucose concentration, obtains another group of interstitial fluid glucose concentration data, and so on repeatedly several times.It is described
It can be 0~2V to extract voltage, and the single extracts the time and is generally 0~5min, the single detection time is generally 0~
10min, the iterative cycles number are generally 1~5 time.
Using it is above-mentioned according to desirable embodiment of the present utility model as enlightenment, pass through above-mentioned description, related work people
Member can carry out various changes and amendments in the range of without departing from this item utility model technological thought completely.This item is real
The content being not limited to new technical scope on specification, it is necessary to which its technology is determined according to right
Property scope.
Claims (4)
1. a kind of more working electrode glucose sensors, it is characterised in that including substrate, the front of the substrate is printed with electrode
Array, multigroup working electrode, reference electrode are distributed with the electrod-array, electrode, the lining are drawn to electrode and tissue fluid
The through hole that the back side at bottom is provided with substrate and working electrode, reference electrode, electrode is drawn to electrode and tissue fluid be electrically connected
The connecting wire and lead leg connect.
2. more working electrode glucose sensors as claimed in claim 1, it is characterised in that the electrod-array includes surrounding
Multiple tissue fluid of circle draw electrode collar, and the tissue fluid is drawn and multiple workspaces are formed in electrode collar, and the tissue fluid is drawn
Electrode collar adjacent one side offers corresponding breach, and multigroup working electrode, the reference are provided with each workspace
Electrode and the centre that multigroup working electrode is arranged on to electrode.
3. more working electrode glucose sensors as claimed in claim 2, it is characterised in that set in each workspace
There is the working electrode of some groups of different areas, the area ratio scope of different operating electrode is 1-100.
4. more working electrode glucose sensors as described in claim any one of 1-3, it is characterised in that the substrate back
The region overlay for being provided with connecting wire has insulating barrier, the lead leg position of connecting wire is reserved, described in substrate face
Working electrode, reference electrode, the region overlay layer of gel disk that electrode is drawn to electrode and tissue fluid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720655146.9U CN207181358U (en) | 2017-06-07 | 2017-06-07 | A kind of more working electrode glucose sensors |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720655146.9U CN207181358U (en) | 2017-06-07 | 2017-06-07 | A kind of more working electrode glucose sensors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207181358U true CN207181358U (en) | 2018-04-03 |
Family
ID=61734882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720655146.9U Active CN207181358U (en) | 2017-06-07 | 2017-06-07 | A kind of more working electrode glucose sensors |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207181358U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110687186A (en) * | 2019-11-01 | 2020-01-14 | 苏州禾苏传感器科技有限公司 | Nitrogen oxide sensor chip |
-
2017
- 2017-06-07 CN CN201720655146.9U patent/CN207181358U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110687186A (en) * | 2019-11-01 | 2020-01-14 | 苏州禾苏传感器科技有限公司 | Nitrogen oxide sensor chip |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107064266A (en) | A kind of many working electrode glucose sensors and its manufacture method | |
| US10206604B2 (en) | Arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing | |
| US10166387B2 (en) | Arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing | |
| Lyu et al. | Soft wearable healthcare materials and devices | |
| CN105748065B (en) | A kind of moisturizing micropin matrix array surface biological electricity electrode | |
| CN104224170B (en) | A kind of array-type flexible surface myoelectric electrode and preparation method | |
| Nagamine et al. | An array of porous microneedles for transdermal monitoring of intercellular swelling | |
| Zhang et al. | Current development of materials science and engineering towards epidermal sensors | |
| CN108956737B (en) | Flexible micro- needle sensor and preparation method thereof, 3 D stereo shape electrode and its packaging body | |
| US10473611B2 (en) | Electrochemical sensor and method for producing electrochemical sensor | |
| CN106901753A (en) | Electrode needle, biological information measurement device and liquid supplying apparatus | |
| CN103750819A (en) | Sensor device capable of controlling insertion angle in subcutaneous tissue | |
| CN206714755U (en) | A kind of microneedle electrodes | |
| Faham et al. | Electrochemical-based remote biomarker monitoring: Toward Internet of Wearable Things in telemedicine | |
| CN207181358U (en) | A kind of more working electrode glucose sensors | |
| CN111487300A (en) | Cell electrochemical sensor based on 3D printing technology and application thereof | |
| Zhu et al. | Effect of interstitial fluid pH on transdermal glucose extraction by reverse iontophoresis | |
| Huang et al. | 3D-assembled microneedle ion sensor-based wearable system for the transdermal monitoring of physiological ion fluctuations | |
| Yao et al. | Anisotropic ion conducting particulate composites for bioelectronics | |
| Zhang et al. | Integrated solid-state wearable sweat sensor system for sodium and potassium ion concentration detection | |
| CN205697767U (en) | Biofeedback electrode patch at the bottom of a kind of disposable basin | |
| CN207439948U (en) | A kind of blood sugar test mechanism of electromagnetism interference | |
| CN109998526A (en) | 12 leads transparent electrocardio band preparation method and device based on Graphene electrodes | |
| Sun et al. | Ionic components of wound current at mouse skin incisional wounds | |
| CN206671251U (en) | A kind of biological detecting test piece |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |