CN207123651U - A kind of near-infrared fluorescent inverted microscope system and its application - Google Patents
A kind of near-infrared fluorescent inverted microscope system and its application Download PDFInfo
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- CN207123651U CN207123651U CN201720392386.4U CN201720392386U CN207123651U CN 207123651 U CN207123651 U CN 207123651U CN 201720392386 U CN201720392386 U CN 201720392386U CN 207123651 U CN207123651 U CN 207123651U
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Abstract
The utility model discloses a kind of near-infrared fluorescent inverted microscope system, including inverted fluorescence microscope and near infrared device, the near infrared device is arranged in the inverted fluorescence microscope base, the near infrared device includes near-infrared fluorescent detector, focusing objective len and near infrared filter, and near-infrared fluorescent detector, focusing objective len and the near infrared filter have and can realize the area's fluorescence of near-infrared two with optical axis near-infrared fluorescent inverted microscope systems of the present utility model altogether（NIR‑II 1000‑1700 nm）The imaging of wave band, at the same have the characteristics that time space high resolution, biological tissue absorb and scatter it is extremely low, particularly suitable for biomedical imaging field apply.
Description
Technical field
A kind of microscopic system is the utility model is related to, more particularly to a kind of imaging wavelength range is in the area's wave band of near-infrared two
Near-infrared fluorescent inverted microscope system and its application.
Background technology
The work spectral range of fluorescence imaging is predominantly located at visible ray (400-650nm) and the area (NIR- of near-infrared one at present
I 650-900nm).Compared to the visible and area's fluorescence imaging of near-infrared one, area's fluorescence (the NIR-II 1000- of near-infrared two
Absorption and scattering of the biological tissue to photon 1700nm) are greatly reduced, is almost disturbed without archebiosis fluorescence, thus it is near red
Outer 2nd area fluorescence imaging has the spatial resolution of more preferable tissue penetration depths and Geng Gao, is considered as the most potential next generation
Fluoroscopic image technology.However, the area's fluorescence imaging device of near-infrared two of practical use is at home and abroad there is no at present.
The content of the invention
Main purpose of the present utility model is to provide a kind of near-infrared fluorescent inverted microscope system, near-infrared inversion
Microscope covers the area's 1000-1700nm wave bands of near-infrared two, to overcome deficiency of the prior art.
To realize foregoing purpose of utility model, the technical solution adopted in the utility model includes：
The utility model embodiment provides a kind of near-infrared fluorescent inverted microscope system, and it includes being inverted fluorescence microscopy
Mirror and near infrared device, the near infrared device are arranged in the inverted fluorescence microscope base, the near infrared device bag
Include near-infrared fluorescent detector, focusing objective len and near infrared filter, the near-infrared fluorescent detector, focusing objective len and near red
Outer optical filter has same optical axis altogether.
Further, the wavelength for the fluorescence signal that the near-infrared fluorescent detector is gathered is 900-1700nm.
Further, the wavelength of excitation source is 254-1350nm in the inverted fluorescence microscope.
Compared with prior art,
Near-infrared fluorescent inverted microscope system of the present utility model can realize the area fluorescence (NIR-II of near-infrared two
1000-1700nm) the imaging of wave band, at the same have the characteristics that time space high resolution, biological tissue absorb and scatter it is extremely low, especially
It is suitable to apply in biomedical imaging field.
Brief description of the drawings
Fig. 1 is a kind of structural representation of near-infrared fluorescent inverted microscope system in the exemplary embodiments of the utility model one
Figure.
Fig. 2 is near infrared device in a kind of near-infrared fluorescent inverted microscope system in the exemplary embodiments of the utility model one
Structural representation.
Description of reference numerals：Near-infrared fluorescent detector 1, conglomeration 2, and near infrared filter 3.
Embodiment
For the purpose of this utility model, technical scheme and advantage is more clearly understood, below in conjunction with specific embodiment, and
Referring to the drawings, the utility model is further described.
Refer to Fig. 1 and show a kind of near-infrared fluorescent inverted microscope system in the exemplary embodiments of the utility model one
System, it includes inverted fluorescence microscope and near-infrared fluorescent device, and it is glimmering that the near-infrared fluorescent installation drawing 2 is arranged on the inversion
The base of light microscope.
Wherein, described near infrared device Fig. 2 includes near-infrared fluorescent detector 1, the focusing objective len set with optical axis
2 and near infrared filter 3.
Wherein, the focusing objective len 2 can be used for focusing in imaging, make images relatively sharp.
Wherein, the near infrared filter 3 is for filtering interference fluorescence, and optical filter can be selected arbitrarily as needed
Select, including the band logical of different wavelength of fluorescence, length are logical and short logical.
Wherein, the fluorescent signals wavelengths that the near-infrared fluorescent detector 1 gathers are 900-1700nm.
Wherein, the wavelength of the excitation source of the inverted fluorescence microscope is 254-1350nm, further, can be with root
According to the excitation source of the needs for treating different excitation wavelengths, within this range unrestricted choice suitable wavelength.Compared to prior art,
The utility model sets near-infrared fluorescent detector by the base in inverted fluorescence microscope, with more preferable time space
Resolution ratio, imaging effect is improved, also provides powerful support for the area's living imaging of near-infrared two.
The various embodiments described above are merely to illustrate the utility model, wherein the structure of each part, connected mode and method are implemented
Process etc. can all be varied from, every equivalents carried out on the basis of technical solutions of the utility model and change
Enter, should not exclude outside the scope of protection of the utility model.
Claims (3)
- A kind of 1. near-infrared fluorescent inverted microscope system, it is characterised in that including inverted fluorescence microscope and near infrared device, The near infrared device is arranged in the inverted fluorescence microscope base,The near infrared device includes near-infrared fluorescent detector, focusing objective len and near infrared filter, the near-infrared fluorescent Detector, focusing objective len and near infrared filter have same optical axis altogether.
- A kind of 2. near-infrared fluorescent inverted microscope system according to claim 1, it is characterised in that：The near-infrared is glimmering The wavelength for the fluorescence signal that photo-detector is gathered is 900-1700nm.
- A kind of 3. near-infrared fluorescent inverted microscope system according to claim 1, it is characterised in that：The inversion fluorescence The wavelength of excitation source is 254-1350nm in microscope.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201720392386.4U CN207123651U (en) | 2017-04-14 | 2017-04-14 | A kind of near-infrared fluorescent inverted microscope system and its application |
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| CN201720392386.4U CN207123651U (en) | 2017-04-14 | 2017-04-14 | A kind of near-infrared fluorescent inverted microscope system and its application |
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| CN207123651U true CN207123651U (en) | 2018-03-20 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106950686A (en) * | 2017-04-14 | 2017-07-14 | 苏州影睿光学科技有限公司 | A kind of near-infrared fluorescent inverted microscope system and its application |
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2017
- 2017-04-14 CN CN201720392386.4U patent/CN207123651U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106950686A (en) * | 2017-04-14 | 2017-07-14 | 苏州影睿光学科技有限公司 | A kind of near-infrared fluorescent inverted microscope system and its application |
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