CN207114375U - Detect the device containing loop structure of medicine disintegration degree - Google Patents
Detect the device containing loop structure of medicine disintegration degree Download PDFInfo
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- CN207114375U CN207114375U CN201720985131.9U CN201720985131U CN207114375U CN 207114375 U CN207114375 U CN 207114375U CN 201720985131 U CN201720985131 U CN 201720985131U CN 207114375 U CN207114375 U CN 207114375U
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- disintegration
- elastic construction
- capsule
- gas passage
- outlet
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Abstract
It the utility model is related to medicine detection instrument field, disclose a kind of device containing loop structure for detecting medicine disintegration degree, including disintegration case (1), disintegration capsule (2), circulating liquid entrance (9) and circulating liquid outlet (10) are provided with the disintegration case (1), contain gas passage (3) in the disintegration capsule (2), at least two elastic constructions (4) are provided between the both ends of the gas passage (3)；Entrance (5) and outlet (6) are provided with the disintegration capsule (2), the both ends of the gas passage (3) are each passed through entrance (5) and the outlet (6) of the disintegration capsule (2)；The entrance (5) is used to introduce liquid medium and medicine into the disintegration capsule (2)；The outlet is flexibly connected with the outer wall of the gas passage (3) run through.Device of the present utility model can simulate stomach and wriggle to drive the actual disintegration environment that medicine moves.
Description
Technical field
Medicine detection instrument field is the utility model is related to, in particular it relates to which a kind of containing for detection medicine disintegration degree is followed
The device of ring structure.
Background technology
Disintegration tester is basis《Pharmacopoeia of People's Republic of China》Ground about the regulation that the disintegration time limiteds such as tablet, pill are detected
The medicine inspection instrument of system, sets multiple beakers, holding medicine in beaker, is moved up and down beaker by elevating mechanism, observes medicine
Disintegration situation to detect the disintegration time limited of medicine.
Because medicine is typically in disintegration in the stomach, and prior art provides is only through the moving up and down to drive of beaker
The movement of medicine can not simulate stomach wriggling to drive the environment of the actual disintegration of medicine movement come the disintegration tester tested, from
And cause using the disintegration tester of prior art offer come testing drug disintegration when the result that obtains do not have too many reality
Meaning.
Utility model content
The purpose of this utility model is the defects of overcoming prior art, there is provided one kind can simulate stomach and wriggle to drive medicine
The device containing loop structure of the testing drug disintegration of the actual disintegration environment of thing movement.
In order to solve the above-mentioned technical problem, the utility model provides a kind of medicine disintegration degree of detecting and contains loop structure
Device, the device include disintegration case, it is described disintegration case in be provided with disintegration capsule, circulating liquid entrance and circulating liquid outlet,
Contain gas passage in the disintegration capsule, at least two elastic constructions are provided between the both ends of the gas passage；The disintegration
Entrance and exit is provided with capsule, the both ends of the gas passage are each passed through the entrance and exit of the disintegration capsule；It is described enter
Mouth is used to introduce liquid medium and medicine into the disintegration capsule；The outer wall activity of gas passage of the outlet with running through connects
Connect.
In the disintegration of testing drug, the liquid medium of the disintegration for testing drug is contained in the disintegration capsule,
In order to prevent the liquid medium from being flowed out by the outlet, the outlet is set to off closed state.That is, the outlet is enclosed
It is closed around the gas passage.
The circulating liquid entrance is used into the disintegration case introduce circulating liquid, and the circulating liquid of introducing can be tool
The liquid of required temperature when having test, and the box portion of preferably described disintegration case is made up of insulation construction.The circulation fluid
The circulating liquid that body exports for that will be disintegrated in case is drawn.When the temperature of the circulating liquid in the disintegration case starts to reduce,
Or when the heating-up temperature for the circulating liquid for setting having heaters and heater to cause in the disintegration case to be disintegrated in case is too high
When, the high-temp liquid drawn in disintegration case is preferably exported by circulating liquid, and from the circulating liquid entrance to the disintegration
Cryogenic liquid is introduced in case, to cause the fluid temperature in disintegration case suitable, can so realize fast cooling.Also, with
The passage of testing time, certain flow is set so that circulating liquid continues through the circulating liquid entrance and introduces and pass through
Circulating liquid outlet is drawn, and when keeping the circulating liquid total amount that is disintegrated in case constant, the circulating liquid being disintegrated in case
On Fluctuations balance be advantageous to provide for disintegration capsule and simulate stomach in the truth for example in human body, so as to be advantageous to test result
It is closer to the truth.
After being completed, the outlet of the disintegration capsule can be opened, is drawn the liquid medium with facilitating.
According to the first preferred embodiment, the first elastic construction and the second elasticity are contained in the elastic construction
Structure, and the scalability of first elastic construction and the second elastic construction is different.
It is described on the basis of the first preferred embodiment according to second of preferred embodiment
In elastic construction also containing the 3rd elastic construction or and the 4th elastic construction, and the scalability of two neighboring elastic construction
It is different.
The elastic construction of the present utility model can also set more than 4.Under preferable case, each elastic construction
1.2~20 times of length of inelastic structural component of the length between two neighboring elastic construction.
It is preferred that the inelastic structural component of the gas passage does not have retractility.
Under preferable case, the close arrival end of the gas passage is connected with the source of the gas with pressure so that is come from
The gas with pressure of the source of the gas enters the gas passage, and sequentially passes through at least two elastic construction.It is excellent
In the case of choosing, the air pressure into the gas with pressure in the gas passage is over time and different.People in the art
Member can set the air pressure of (regulation) gas according to the wriggling situation of stomach, so that the elastic construction is at different moments
Flexible situation is different.Also, the utility model discontinuous by the way of the peristole cycle is simulated introduces the gas.
The utility model has no particular limits to the material of the elastic construction, if can realize elastic construction with
The introducing of pressed gas and carry out flexible.
The gas that the utility model carries pressure by being introduced into enters in the gas passage with elastic construction so that gas
Irregularly stretching occurs in elastic construction in passage, so as to correspondingly cause the motion for being disintegrated intracapsular liquid medium, this fortune
The dynamic actual environment that can be substantially more nearly stomach.
Preferably, the disintegration capsule is spheroid shape, and the close arrival end of the disintegration capsule is in the disintegration case
Height than close to the port of export height it is high.
Preferably, visual windows are provided with the disintegration capsule, and the disintegration capsule in addition to visual windows part in
Portion is provided with irregular raised structures.The disintegration situation of the medicine in the disintegration capsule can be observed by the visual windows.
The raised structures are preferably transparence, and the raised structures can simulate stomach interior wall construction.
Under preferable case, the utricule part of the disintegration capsule is made up of transparent material.It is preferred that the utricule portion of the disintegration capsule
The elasticity divided is significantly less than the elasticity of the elastic construction of the gas passage.Or the disintegration capsule can not have elasticity.
Using it is provided by the utility model detection medicine disintegration degree device when, preferred embodiment is：Close disintegration
The outlet of capsule, from it is described disintegration capsule entrance introduce liquid medium (liquid medium for simulation stomach inner case liquid) and
Medicine, the gas with pressure is introduced from the nearly arrival end of the gas passage with certain cycle (simulation peristole cycle),
The gas of introducing passes sequentially through each elastic construction；Also, because the scalability of each elastic construction is different so that gas leads to
Disintegration capsule is caused to produce " wriggling " of different amplitudes when crossing elastic construction.
Device of the present utility model causes medicine disintegration environment closer to the actual environment wriggled in stomach, so as to improve disintegration
The measure accuracy of degree, this has great importance for medicament and Pharmaceutical Analysis field.
Brief description of the drawings
Fig. 1 is a kind of structural representation of the disintegration tester of preferred embodiment of the present utility model；
Fig. 2 is a kind of structural representation of the disintegration capsule of preferred embodiment of the present utility model.
Description of reference numerals
1st, it is disintegrated case 2, disintegration capsule
3rd, gas passage 4, elastic construction
41st, the first elastic construction 42, the second elastic construction
43rd, the 3rd elastic construction
5th, entrance 6, outlet
7th, visual windows 8, raised structures
9th, circulating liquid entrance 10, circulating liquid outlet
Embodiment
The end points of disclosed scope and any value are not limited to the accurate scope or value herein, these scopes or
Value should be understood to comprising the value close to these scopes or value.For number range, between the endpoint value of each scope, respectively
It can be combined with each other between the endpoint value of individual scope and single point value, and individually between point value and obtain one or more
New number range, these number ranges should be considered as specific open herein.
The device containing loop structure of testing drug disintegration of the present utility model is carried out below in conjunction with accompanying drawing detailed
Description.
As shown in figure 1, the device containing loop structure of testing drug disintegration of the present utility model includes：The device bag
Disintegration case 1 is included, disintegration capsule 2, circulating liquid entrance 9 and circulating liquid outlet 10, the disintegration capsule 2 are provided with the disintegration case 1
In contain gas passage 3, be provided with least two elastic constructions 4 between the both ends of the gas passage 3；In the disintegration capsule 2
Entrance 5 and outlet 6 are provided with, the both ends of the gas passage 3 are each passed through entrance 5 and the outlet 6 of the disintegration capsule 2；It is described
Entrance 5 is used to introduce liquid medium and medicine into the disintegration capsule 2；The outer wall of gas passage 3 of the outlet with running through is lived
Dynamic connection.
In the disintegration of testing drug, the liquid medium of the disintegration for testing drug is contained in the disintegration capsule 2,
In order to prevent the liquid medium that by the outflow of outlet 6, the outlet 6 is set to off into closed state.That is, the outlet
6 is closed around the gas passage 3.
The circulating liquid entrance 9 is used to introduce circulating liquid into the disintegration case 1, and the circulating liquid of introducing can be
The liquid of required temperature during with test, and the box portion of preferably described disintegration case 1 is made up of insulation construction.The circulation
The circulating liquid that liquid outlet 10 is used to be disintegrated in case 1 is drawn.When the temperature of the circulating liquid in the disintegration case 1 starts to drop
When low, or, when the heating temperature for the circulating liquid for setting having heaters and heater to cause in the disintegration case 1 to be disintegrated in case 1
When spending high, the high-temp liquid in disintegration casees 1 is preferably drawn by circulating liquid outlet 10, and from the circulating liquid entrance 9
Cryogenic liquid is introduced into the disintegration case, to cause the fluid temperature in disintegration case 1 suitable, can so realize fast prompt drop
Temperature.Also, with the passage of testing time, certain flow is set so that circulating liquid continues through the circulating liquid entrance
9 introduce and by the circulating liquid outlet 10 draw, and keep be disintegrated case 1 in circulating liquid total amount it is constant when, collapse
The On Fluctuations balance of circulating liquid in solution case 1 is advantageous to provide simulation stomach in the truth for example in human body for disintegration capsule 2,
It is closer to the truth so as to be advantageous to test result.
After being completed, the outlet of the disintegration capsule 2 can be opened, is drawn the liquid medium with facilitating.
According to the first preferred embodiment, the first elastic construction 41 and second is contained in the elastic construction 4
Elastic construction 42, and first elastic construction 41 is different with the scalability of the second elastic construction 42.
It is described on the basis of the first preferred embodiment according to second of preferred embodiment
In elastic construction also containing the 3rd elastic construction 43 or and the 4th elastic construction, and two elastic constructions of arbitrary neighborhood can
Retractility is different.
The elastic construction of the present utility model can also set more than 4.Under preferable case, each elastic construction
1.2~20 times of the length of inelastic structural component of 4 length between two neighboring elastic construction.Thus, it is possible to more stick on
" wriggling " situation is cut in simulation stomach.
It is preferred that the inelastic structural component of the gas passage 3 does not have retractility.
Under preferable case, the close arrival end of the gas passage 3 is connected with the source of the gas with pressure so that is come from
The gas with pressure of the source of the gas enters the gas passage 3, and sequentially passes through at least two elastic construction 4.
Under preferable case, the air pressure into the gas with pressure in the gas passage 3 is over time and different.Art technology
Personnel can set the air pressure of (regulation) gas according to the wriggling situation of stomach, so that the elastic construction 4 is when different
The flexible situation carved is different.Also, the utility model discontinuous by the way of the peristole cycle is simulated introduces the gas.
The utility model has no particular limits to the material of the elastic construction 4, if can realize elastic construction 4 with
The introducing of pressed gas and carry out flexible.
The gas that the utility model carries pressure by being introduced into enters in the gas passage 3 with elastic construction 4 so that gas
Irregularly stretching occurs in elastic construction 4 in body passage 3, so as to correspondingly cause the motion of the liquid medium in disintegration capsule 2, this
Kind motion can substantially be more nearly the actual environment of stomach.
Preferably, the disintegration capsule 2 is spheroid shape, and the close arrival end of the disintegration capsule 2 is in the disintegration case 1
In height than close to the port of export height it is high.
Preferably, visual windows 7 are provided with the disintegration capsule 2, and the disintegration capsule 2 is in addition to the part of visual windows 7
Be internally provided with irregular raised structures 8 (as shown in Fig. 2 of the present utility model).It can be seen by the visual windows 7
Examine the disintegration situation of the medicine in the disintegration capsule 2.The raised structures 8 preferably transparence, and the energy of the raised structures 8
Enough simulate stomach interior wall construction.
Under preferable case, the utricule part of the disintegration capsule 2 is made up of transparent material.It is preferred that the utricule of the disintegration capsule 2
Partial elasticity is significantly less than the elasticity of the elastic construction 4 of the gas passage 3.Or the disintegration capsule 2 can not have bullet
Property.
Using it is provided by the utility model detection medicine disintegration degree device when, preferred embodiment is：Close disintegration
The outlet 6 of capsule 2, the liquid medium (liquid of inner case of the liquid medium for simulation stomach is introduced from the entrance 5 of the disintegration capsule 2
Body) and medicine, introduced with certain cycle (simulation peristole cycle) from the nearly arrival end of the gas passage 3 with pressure
Gas, the gas of introducing pass sequentially through each elastic construction 4；Also, because the scalability of each elastic construction 4 is different, make
Obtain " wriggling " for causing disintegration capsule 2 to produce different amplitudes when gas passes through elastic construction.
Preferred embodiment of the present utility model described in detail above, still, the utility model is not limited to this.At this
In the range of the technology design of utility model, a variety of simple variants can be carried out to the technical solution of the utility model, including it is each
Technical characteristic is combined with any other suitable method, and these simple variants and combination should equally be considered as the utility model
Disclosure of that, belong to the scope of protection of the utility model.
Claims (7)
- A kind of 1. device containing loop structure for detecting medicine disintegration degree, it is characterised in that：The device includes disintegration case (1), Disintegration capsule (2), circulating liquid entrance (9) and circulating liquid outlet (10), the disintegration capsule (2) are provided with the disintegration case (1) In contain gas passage (3), be provided with least two elastic constructions (4) between the both ends of the gas passage (3)；The disintegration Entrance (5) and outlet (6) are provided with capsule (2), the both ends of the gas passage (3) are each passed through entering for disintegration capsule (2) Mouth (5) and outlet (6)；The entrance (5) is used to introduce liquid medium and medicine into the disintegration capsule (2)；It is described outlet with The outer wall of the gas passage (3) run through is flexibly connected.
- 2. device according to claim 1, it is characterised in that：Contain the first elastic construction in the elastic construction (4) (41) and the second elastic construction (42), and the scalability of first elastic construction (41) and the second elastic construction (42) is not Together.
- 3. device according to claim 1, it is characterised in that：Also contain the 3rd elastic construction in the elastic construction (4) (43) or and the 4th elastic construction, and the scalability of two neighboring elastic construction is different.
- 4. according to the device described in any one in claim 1-3, it is characterised in that：The close institute of the gas passage (3) State entrance (5) end to be connected with the source of the gas with pressure so that the gas with pressure from the source of the gas enters the gas Passage (3), and sequentially pass through at least two elastic construction (4).
- 5. device according to claim 4, it is characterised in that：The disintegration capsule (2) is spheroid shape, and the disintegration capsule (2) height ratio height close to outlet (6) end of close entrance (5) end in the disintegration case (1) is high.
- 6. device according to claim 4, it is characterised in that：Visual windows (7) are provided with the disintegration capsule (2), and The disintegration capsule (2) is internally provided with irregular raised structures (8) in addition to visual windows (7) part.
- 7. device according to claim 4, it is characterised in that：The length of each elastic construction (4) is two neighboring 1.2~20 times of the length of inelastic structural component between elastic construction (4).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720985131.9U CN207114375U (en) | 2017-08-08 | 2017-08-08 | Detect the device containing loop structure of medicine disintegration degree |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720985131.9U CN207114375U (en) | 2017-08-08 | 2017-08-08 | Detect the device containing loop structure of medicine disintegration degree |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207114375U true CN207114375U (en) | 2018-03-16 |
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ID=61571127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720985131.9U Active CN207114375U (en) | 2017-08-08 | 2017-08-08 | Detect the device containing loop structure of medicine disintegration degree |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207114375U (en) |
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2017
- 2017-08-08 CN CN201720985131.9U patent/CN207114375U/en active Active
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