CN206950171U - One kind is used for melanoma early stage unmarked clinical real-time detection apparatus - Google Patents
One kind is used for melanoma early stage unmarked clinical real-time detection apparatus Download PDFInfo
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- CN206950171U CN206950171U CN201621441444.XU CN201621441444U CN206950171U CN 206950171 U CN206950171 U CN 206950171U CN 201621441444 U CN201621441444 U CN 201621441444U CN 206950171 U CN206950171 U CN 206950171U
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Abstract
It the utility model is related to one kind and be used for melanoma early stage unmarked clinical real-time detection apparatus, including：Photoacoustic signal excitation component：Coupled lens including laser and for coupled laser beam；Laser transmission assembly：Including the Transmission Fibers for transmitting the light beam sent from photoacoustic signal excitation component；Blood vessel positioning component：Laser line generator including adapting to detection position blood vessel for shaping light beam, the laser trimmer of laser facula size on laser line generator and for adjusting output, and for fixed laser line generator in the detection fixing band in detection position；Photoacoustic signal probe assembly：Including the photoacoustic signal collecting unit in detection fixing band, and the photoacoustic signal processing unit being connected with photoacoustic signal collecting unit.Compared with prior art, the utility model can realize clinical detection, Non-invasive detection, without drawing blood, without mark, provide new approach etc. for the early detection of clinical tumor cell.
Description
Technical field
A kind of detection means of melanoma is the utility model is related to, is used for melanoma early stage nothing more particularly, to one kind
Mark clinical real-time detection apparatus.
Background technology
At present, cancer is one of serious threat human life and the disease killer of health.Cancer patient if early stage and
Shi Faxian is simultaneously treated, and can improve the survival rate of patient, and this has very big benefit for patient.So for cancer
Early diagnose, early detection and treat in time.
Melanoma is a kind of pernicious cancer, is one of cutaneum carcinoma of most serious in world wide.In all doctors
Control among invalid cutaneum carcinoma patient, the death rate is up to more than 80% as caused by cutaneum carcinoma.In the world, all can every year
There are the melanoma new cases of 160,000.Every year in the world, melanoma can cause about 48, the death of 000
Quantity.The cases of cancer of this type is widely distributed in Caucasus region, particularly in sun-drenched weather.In recent years,
On North America, Europe, South Africa and Latin America and other places, the tumor incidence of the type also ramps.
If not yet full-grown cancer cell can be moved completely in the presence of morbidity early detection this type cancer
Remove, the chance for the treatment of will be substantially increased.For many years, oncologist think part medical intervention (such as palpation, biopsy,
Surgery excision etc.) it may promote to shift, cause tumour cell to be discharged into blood, considerably increase the risk of transfer.How
Morning of the detection as melanoma cells can be carried out to the tumour cell in human body not drawing blood, not contacting tumor tissues position
Phase diagnoses urgent problem to be solved.Clinical test shows：It is closely related to circulate the transfer of melanoma cells and melanoma, because
If this can detect the number of melanoma cells in circulation, an important index can be provided for the diagnosis of melanoma.
Utility model content
The purpose of this utility model is exactly to be used for black to provide one kind the defects of overcoming above-mentioned prior art to exist
Unmarked clinical real-time detection apparatus of plain knurl early stage.
The purpose of this utility model can be achieved through the following technical solutions：
One kind is used for melanoma early stage unmarked clinical real-time detection apparatus, including：
Photoacoustic signal excitation component：Including laser and it is connected at laser emission port and for the coupling of coupled laser beam
Lens；
Laser transmission assembly：Including the Transmission Fibers for transmitting the light beam sent from photoacoustic signal excitation component, the biography
Lose fine one end connection coupled lens, other end connection laser line generator；
Blood vessel positioning component：Laser line generator including adapting to detection position blood vessel for shaping light beam, installation
The laser trimmer of laser facula size on laser line generator and for adjusting output, and for fixed laser line
Property generator is in the detection fixing band in detection position；
Photoacoustic signal probe assembly：Including the photoacoustic signal collecting unit in detection fixing band, and and optoacoustic
The photoacoustic signal processing unit of signal gathering unit connection.
Preferably, described laser is ytterbium-doping optical fiber laser, and its pulse frequency is 0.5MHz, wavelength 1064nm,
Pulse temporal width is 10ns, pulse energy 100uJ.
Preferably, the dispersion angle of described laser line generator is 60 degree, a diameter of 10mm of its crystal, but unlimited
Can be 30 degree, 45 degree, any angles such as 60 degree in 60 degree, diameter is not limited to 10mm, and diameter can be 1-100mm.
Preferably, detection position is wrist, and corresponding detection fixing band is bracelet wrist strap, is also reserved with bracelet wrist strap
For installing the aperture of the photoacoustic signal collecting unit.
It is furthermore preferred that described wrist annulus is the scalable wrist using the non-toxic polyethylene material of 3D printing technique printing
Band.
Preferably, described photoacoustic signal collecting unit is 10MHz immersion type ultrasonic probe.
Melanoma cells in blood circulation show than normal cell rich in more melanin, experiment：Melanin exists
Signal can be produced under blood background, melanin has strong the characteristics of absorbing to specific wavelength.Based on both the above characteristic, this practicality
A kind of diagnostic device detected in real time for melanoma early stage unmarked clinic of new design, its specific detection process are：
Low-power, high-frequency laser, which are sent, from laser enters the defeated component of laser, laser after (coupled lens) light beam coupling
Beam Propagation to blood vessel positioning component, and is carried out spot shaping by defeated component, makes the circular light spot that laser transmission assembly transmits
Laser shaping is in strip hot spot, so as to cover the blood vessel at the positions such as human body wrist；Laser is irradiated to endovascular melanin
After oncocyte, the luminous energy that melanoma cells absorb is converted into heat energy by molecular vibration and thermal-elastic expansion, causes local first
The increase of beginning pressure, forms wave source, is finally detected by the photoacoustic signal collecting unit of skin surface, and photoacoustic signal collecting unit is visited
The melanoma cells number for obtaining passing through in the unit interval after photoacoustic signal processing unit processes after photoacoustic signal is measured to supply
Researcher and doctor's reference.
Photoacoustic signal processing unit of the present utility model does denoising to the photoacoustic signal measured first, and method includes small
Ripple denoising and average denoising.Wavelet Denoising Method can effective filter out the various noises in signal, make signal definitely；Averagely go
The signal to noise ratio of signal can be effectively improved by making an uproar.Processing to signal is divided into Time Domain Processing and frequency domain processing.Time Domain Processing includes
The statistics of threshold decision and relevant parameter.The setting of threshold value has used equation, and the parameter of statistics mainly includes the half of signal peak
High overall with (FWHM) and peak valley gap value.
Compared with prior art, the utility model has advantages below：
1st, this method can effectively detect the target cell (such as melanoma cells) in circulation, obtain the optoacoustic letter of cell
Number.By the analyzing and processing to target cell photoacoustic signal, the feature of tumour cell photoacoustic signal can be obtained, is realized to tumour
Early detection.
2nd, clinical detection, Non-invasive detection can be accomplished, without drawing blood, without mark, be clinical tumor cell early detection
Provide new approach.The signal obtained by using the algorithm to detection is processed and analyzed, can be in carly fruit drop live body
Whether there is the presence of target cell in the circulatory system, and then an important clinical index is provided for clinical judgment melanoma.This is right
There is great meaning in the early prevention of tumour patient and treatment.
3rd, the arrangement achieves the flexible transfer of laser, it is possible to achieve the isolation of equipment and patient, effectively prevent patient
To the feared state of mind of large-scale diagnostic device.
4th, the bracelet wrist strap design of the device has adjustable function, can Long term noninvasive suitable for different detection crowds
Detection.
5th, the equipment can expand to the neck such as other cancer cells and red blood cell, stem cell based on melanoma cells
Domain, it is widely used.
Brief description of the drawings
Fig. 1 is structural representation of the present utility model；
In figure, 1- photoacoustic signal excitation components, 11- lasers, 12- coupled lens, 2- laser transmission assemblies, 3- blood vessels determine
Hyte part, 31- laser line generators, 32- laser trimmers, 33- bracelet wrist straps, 4- photoacoustic signal probe assemblies, 41- optoacoustics
Signal gathering unit, 42- photoacoustic signal processing units.
Embodiment
The utility model is described in detail with specific embodiment below in conjunction with the accompanying drawings.
Embodiment 1
One kind is used for melanoma early stage unmarked clinical real-time detection apparatus, its structure as shown in figure 1, including：
Photoacoustic signal excitation component 1：Including laser 11 and it is connected at the emission port of laser 11 and is used for coupled laser beam
Coupled lens 12, wherein, laser 11 is ytterbium-doping optical fiber laser 11, and its pulse frequency is 0.5MHz, wavelength 1064nm,
Pulse temporal width is 10ns, pulse energy 100uJ.
Laser transmission assembly 2：, should including the Transmission Fibers for transmitting the light beam sent from photoacoustic signal excitation component 1
Transmission Fibers one end connects coupled lens 12, other end connection laser line generator 31；Transmission Fibers are that core diameter is 1000um
Single-mode fiber.
Blood vessel positioning component 3：Laser line generator 31 including adapting to wrist blood vessel for shaping light beam, is arranged on
The laser trimmer 32 of laser facula size on laser line generator 31 and for adjustment output, and for fixed laser
Line generator 31 is in the bracelet wrist strap 33 in wrist.Laser line generator 31 uses dispersion angle as 60 degree, its crystal
A diameter of 10mm, but 60 degree are not limited to, can be 30 degree, 45 degree, any angles such as 60 degree.
Wrist annulus is the scalable wrist strap using the non-toxic polyethylene material of 3D printing technique printing.In bracelet wrist strap 33
On be also reserved with aperture for installing photoacoustic signal collecting unit 41.
Photoacoustic signal probe assembly 4：Including the photoacoustic signal collecting unit 41 in bracelet wrist strap 33, and with light
The photoacoustic signal processing unit 42 that acoustical signal collecting unit 41 connects.Photoacoustic signal collecting unit 41 is that 10MHz immersion type surpasses
Sonic probe.
The specific detection process of the present embodiment is：From laser 11 sends low-power, high-frequency laser passes through (coupled lens
12) the defeated component 2 of laser is entered after light beam coupling, laser transmission assembly 2 to blood vessel positioning component 3, and carries out beam Propagation
Spot shaping, the laser shaping of the circular light spot of the transmission of laser transmission assembly 2 is set to be in strip hot spot, so as to cover human body wrist
The blood vessel at the positions such as portion；After laser is irradiated to endovascular melanoma cells, the luminous energy that melanoma cells absorb is by dividing
Son vibration and thermal-elastic expansion are converted into heat energy, cause the increase of local and initial pressure, wave source are formed, finally by the light of skin surface
Acoustical signal collecting unit 41 is detected, and photoacoustic signal collecting unit 41 is detected after photoacoustic signal through photoacoustic signal processing unit 42
The melanoma cells number for obtaining passing through in the unit interval after processing refers to for researcher and doctor.
Photoacoustic signal processing unit 42 does denoising to the photoacoustic signal measured first, and method includes Wavelet Denoising Method peace
Equal denoising.Wavelet Denoising Method can effective filter out the various noises in signal, make signal definitely；Average denoising can be effective
Improve the signal to noise ratio of signal in ground.Processing to signal is divided into Time Domain Processing and frequency domain processing.Time Domain Processing include threshold decision and
The statistics of relevant parameter.The setting of threshold value has used equation, and the parameter of statistics mainly includes the full width at half maximum of signal peak
And peak valley gap value (FWHM).
The above-mentioned description to embodiment is understood that for ease of those skilled in the art and using practicality
It is new.Person skilled in the art obviously can easily make various modifications to these embodiments, and illustrating herein
General Principle be applied in other embodiment without by performing creative labour.Therefore, the utility model is not limited to above-mentioned
Embodiment, those skilled in the art according to announcement of the present utility model, do not depart from improvement that the utility model category made and
Modification all should be within the scope of protection of the utility model.
Claims (7)
1. one kind is used for melanoma early stage unmarked clinical real-time detection apparatus, it is characterised in that including：
Photoacoustic signal excitation component (1)：Including laser (11) and it is connected at laser (11) emission port and is used for coupled laser
The coupled lens (12) of beam；
Laser transmission assembly (2)：, should including the Transmission Fibers for transmitting the light beam sent from photoacoustic signal excitation component (1)
Transmission Fibers one end connection coupled lens (12), other end connection laser line generator (31)；
Blood vessel positioning component (3)：Laser line generator (31) including adapting to detection position blood vessel for shaping light beam, peace
The laser trimmer (32) of laser facula size on laser line generator (31) and for adjusting output, and be used for
Fixed laser line generator (31) is in the detection fixing band in detection position；
Photoacoustic signal probe assembly (4)：Including installed in detection fixing band on photoacoustic signal collecting unit (41), and with light
The photoacoustic signal processing unit (42) of acoustical signal collecting unit (41) connection.
2. one kind according to claim 1 is used for melanoma early stage unmarked clinical real-time detection apparatus, its feature exists
It is ytterbium-doping optical fiber laser in, described laser (11), its pulse frequency is 0.5MHz, wavelength 1064nm, the burst length
Width is 10ns, pulse energy 100uJ.
3. one kind according to claim 1 is used for melanoma early stage unmarked clinical real-time detection apparatus, its feature exists
In the angle of divergence of described laser line generator (31) is 30 °, 45 ° or 60 °, a diameter of 1-100mm of its crystal.
4. one kind according to claim 3 is used for melanoma early stage unmarked clinical real-time detection apparatus, its feature exists
In the angle of divergence of described laser line generator (31) is 60 °, a diameter of 10mm of its crystal.
5. one kind according to claim 1 is used for melanoma early stage unmarked clinical real-time detection apparatus, its feature exists
In detection position is wrist, and corresponding detection fixing band is bracelet wrist strap (33), is also reserved with and is used in bracelet wrist strap (33)
The aperture of the photoacoustic signal collecting unit (41) is installed.
6. one kind according to claim 5 is used for melanoma early stage unmarked clinical real-time detection apparatus, its feature exists
In described wrist annulus is the scalable wrist strap using the non-toxic polyethylene material of 3D printing technique printing.
7. one kind according to claim 1 is used for melanoma early stage unmarked clinical real-time detection apparatus, its feature exists
In described photoacoustic signal collecting unit (41) is 10MHz immersion type ultrasonic probe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621441444.XU CN206950171U (en) | 2016-12-27 | 2016-12-27 | One kind is used for melanoma early stage unmarked clinical real-time detection apparatus |
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|---|---|---|---|
| CN201621441444.XU CN206950171U (en) | 2016-12-27 | 2016-12-27 | One kind is used for melanoma early stage unmarked clinical real-time detection apparatus |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106510727A (en) * | 2016-12-27 | 2017-03-22 | 上海交通大学 | Early-stage mark-free clinic real-time detection device for melanoma |
-
2016
- 2016-12-27 CN CN201621441444.XU patent/CN206950171U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106510727A (en) * | 2016-12-27 | 2017-03-22 | 上海交通大学 | Early-stage mark-free clinic real-time detection device for melanoma |
| CN106510727B (en) * | 2016-12-27 | 2024-04-02 | 上海交通大学 | Be used for early no mark clinical real-time detection device of melanoma |
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| Date | Code | Title | Description |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20230509 Address after: J, Building 6, No. 1288 Yecheng Road, Jiading District, Shanghai, 201815 Patentee after: Yuanyu Biomedical Technology (Shanghai) Co.,Ltd. Address before: 200240 No. 800, Dongchuan Road, Shanghai, Minhang District Patentee before: SHANGHAI JIAO TONG University |
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| TR01 | Transfer of patent right |