CN106923827A - The coils special of the HIFU Treatment animal tumor guided by MRI - Google Patents
The coils special of the HIFU Treatment animal tumor guided by MRI Download PDFInfo
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- CN106923827A CN106923827A CN201511030471.8A CN201511030471A CN106923827A CN 106923827 A CN106923827 A CN 106923827A CN 201511030471 A CN201511030471 A CN 201511030471A CN 106923827 A CN106923827 A CN 106923827A
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- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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Abstract
A kind of coils special of the HIFU Treatment animal tumor guided by MRI, including：One supporting table；One arch support, is set up in the supporting table upper bottom surface, upper bottom surface one arcuate space of formation with the supporting table, and the outer surface of the supporting table bottom surface and arch support is uniformly sticked for the multi-channel coil for gathering MRI image；One guidance panel, is slideably positioned in the supporting table upper bottom surface, and through the arcuate space, animal fixture, anaesthetic mask and anaesthesia pipeline is provided with the guidance panel in the arcuate space；And a via, bottom surface and guidance panel to the arcuate space are formed and focus on ultrasonic passage in the supporting table.Using multi-passage design, function admirable is capable of achieving to accelerate collection image real-time monitoring good；Suitable animal stationary fixture and gas anesthesia pipeline are designed, can continue Animal Anesthesia long-acting, fixation postures are comfortably stablized, mobile facility is easy to operate.
Description
Technical field
The present invention relates to surgical instruments field, more particularly to a kind of HIFU Treatment animal guided by MRI
The coils special of tumour.
Background technology
In terms of the metabolism of real-time monitoring medicine, MRI (Magnetic Resonance Imaging, magnetic resonance
Imaging) there is the ability of three-dimensional high definition imaging and multi-parameter scanning, therefore MRI molecular images turn into disease
Early diagnosis, the important means of drug metabolism tracking.High intensity focused ultrasound technology (High Intensity
Focused Ultrasound, HIFU) it is the penetration into tissue and energy deposition having using ultrasonic wave, will
Ectogenetic focusing ultrasonic wave is imitated to pathological tissues in organism (therapy target) by the machinery of ultrasound
Answer, fuel factor and cavitation effect reach the purpose for treating tumour.
High-strength focusing ultrasonic therapy is a kind of new method of the good malignant entity tumor of emerging Noninvasive therapy,
Its mechanism is by focusing on ultrasound to be brought up into more than 60 ° tumor tissues temperature moment in a short time, is caused
Tumour cell produces irreversible necrosis, tissue coagulation necrosis and protein denaturation.The pass of focused ultrasound therapy
Key is that ultrasonic energy focused on deep target tissue and coagulation necrosis is formed, and the logical Dao Shangzhen of surrounding harmony
Unaffected or acceptable influence is often organized, i.e., ensures the security and high efficiency of focused ultrasound therapy simultaneously.
Imaging for Monitoring is the basic guarantee for realizing safe treatment, is also that the efficient, fine of image guiding is controlled with personalization
The basis for the treatment of.
The characteristic of base MRI high-resolution and non-invasive real-time monitoring, under development MRI guiding in real time and monitoring
HIFU Treatment technology and equipment turned into an important development direction of HIFU Treatment.At present both at home and abroad
Research team all actively develop guide of magnetic resonant image and monitoring under HIFU Treatment rat tumor experiment grind
Study carefully.By be primarily present in the high-strength focusing ultrasonic therapy rat tumor experimental study of guided by magnetic resonance it is following not
Foot：(1) penetration depth of coil and image resolution ratio are not enough, and the close-up generation to tumor tissues is unfavorable
Influence.(2) treatment target cannot be stablized, and not only increasing the complexity of experimental implementation can also influence focusing super
The efficiency of sound targeted therapy.(3) treatment target anesthesia duration is short, it is high to breathe unstable, fatal rate.
The content of the invention
Present invention aim at a kind of coils special of the HIFU Treatment animal tumor guided by MRI of offer,
Aim to solve the problem that the not enough problem of the penetration depth and image resolution ratio of coil.
The invention provides a kind of coils special of the HIFU Treatment animal tumor guided by MRI, including：
One supporting table；
One arch support, is set up in the supporting table upper bottom surface, and forming one with the upper bottom surface of the supporting table encircles
The outer surface of shape space, the supporting table bottom surface and arch support is uniformly sticked for gathering MRI
The multi-channel coil of image；
One guidance panel, is slideably positioned in the supporting table upper bottom surface, and through the arcuate space, it is described
Animal fixture, anaesthetic mask and anaesthesia pipeline are provided with guidance panel in the arcuate space；
One via, bottom surface and guidance panel to the arcuate space are formed to focus on and surpassed in the supporting table
Sound passage.
The coil of the coils special of the above-mentioned HIFU Treatment animal tumor guided by MRI is set using multichannel
Meter, function admirable is capable of achieving to accelerate collection image real-time monitoring good；Both comprising fixed mouse in the program
Grip device comprising gas anesthesia pipeline device design, designs suitable animal stationary fixture and gas anesthesia again
Pipeline, can continue Animal Anesthesia long-acting, and fixation postures are comfortably stablized, and mobile facility is easy to operate；Again
The also compatible high intensity focused ultrasound of person's program implements the spy of target administration or ablation to knub position
Point.
Brief description of the drawings
Fig. 1 be present pre-ferred embodiments in by MRI guide HIFU Treatment animal tumor coils special
Structural representation；
Fig. 2 is arch branch in the coils special of the HIFU Treatment animal tumor guided by MRI shown in Fig. 1
The outer surface of frame and the deployed configuration schematic diagram of the bottom surface of supporting table；
Fig. 3 is operating surface in the coils special of the HIFU Treatment animal tumor guided by MRI shown in Fig. 1
The overlooking the structure diagram of plate.
Specific embodiment
In order that the technical problem to be solved in the present invention, technical scheme and beneficial effect become more apparent, with
Lower combination drawings and Examples, the present invention will be described in further detail.It should be appreciated that described herein
Specific embodiment be only used to explain the present invention, be not intended to limit the present invention.
Fig. 1, Fig. 2 and Fig. 3 are referred to, is understood for convenience and is illustrated, Fig. 1 employs perspective structure figure.
The coils special of the HIFU Treatment animal tumor guided by MRI in present pre-ferred embodiments includes supporting table
1st, arch support 2, multi-channel coil 3, via 4 and guidance panel 5.
Arch support 2 is semicircular arc, is set up in the upper bottom surface of supporting table 1, the upper bottom surface shape with supporting table 1
Animal 100 can be housed in interior arcuate space 12, the bottom surface of supporting table 1 and arch support 2 into one
Outer surface be uniformly sticked for gathering MRI image, high s/n ratio multi-channel coil 3.With reference to figure
2.In the present embodiment, the coil channel 31 of multi-channel coil 3 is four, and four coil channels 31 are mutual
Handing-over.In other embodiments, the coil channel 31 of multi-channel coil 3 can for 3,5,6
It is individual etc..
Wherein, be located at for via 4 by a coil channel 31 in the bottom surface of supporting table 1 of multi-channel coil 3
In the opening of the bottom surface of supporting table 1 is enclosed in, the via 4 is cylinder, and via 4 runs through the supporting table 1
Upper bottom surface and guidance panel 5 to arcuate space 12 are formed and focus on ultrasonic passage, it is ensured that focus on ultrasonic wave energy
Amount efficiently can smoothly reach the tumor region of animal 100.
In the present embodiment, with animal 100 (such as mouse) coils special 3, tumor region is carried out quickly,
High-resolution imaging, tumour ablation treating is implemented with high intensity focused ultrasound, realizes magnetic resonance truly
Guiding focused ultrasound therapy animal tumor technology.The advantage of magnetic resonance imaging is to differentiate energy with high tissue
Power, can relatively easily distinguish normal structure and tumor tissues therefore be well suited for for carrying out high intensity focused ultrasound
Monitoring in treatment.The design of coil 3 is that the special receiving coil 3 of magnetic resonance imaging mouse swells with ultrasound is focused on
Knurl ablation technology is mutually compatible.
Refer to Fig. 1 and Fig. 3, guidance panel 5 is slideably positioned in the upper bottom surface of supporting table 1, and through arch
Space 12.Guidance panel 5 is embedded in supporting table 1, is connected with supporting table 1 using track, before and after realizing
Move freely.Guidance panel 5 is used to carry and fixation animal 100 to be tested, and animal 100 is pushed to
Arcuate space 12 under arch support 2.
Further, animal fixture 51, anaesthetic mask is provided with the arcuate space 12 on guidance panel 5
52 and anaesthesia pipeline 53.In the present embodiment, animal fixture 51 and anaesthetic mask 52 are arranged at guidance panel
5 around via 4.
The port of export of anaesthesia pipeline 53 sets one is used to catch on the buckle 531 of animal teeth.Specifically, animal
100 fixtures 51 are used for fixing animal foot, it is ensured that stablize motionless, animal fixture 51 can be bandage, press from both sides
Son etc..Anaesthesia pipeline 53 uses double glazing pipe, the anesthetic gases of mixture of oxygen is passed through.Front end
A buckle 531 is designed for catching on animal teeth, its head is remained stationary as.
Anaesthetic mask 52 is fixed on the port of export of anaesthesia pipeline 53.Animal 100 is fixed when using, mask
Cover on animal 100 (mouse) nose.
The fixed support 54 for fixing anaesthesia pipeline 53, fixed support 54 are additionally provided with guidance panel 5
It is arranged at outside arcuate space 12.Fixed support 54 uses tight after anaesthesia pipeline 53 is clamped on guidance panel 5
Gu screw 55 is fixed, the perforate that has of wherein fixed support 54 can pass through anaesthesia pipeline 53.
Motion artifacts can have a negative impact to MRI, it is necessary to the comfortable placement animal described above of design
100 guidance panel 5 and stationary fixture device.The anesthesia of long-acting stabilization makes mouse steadily breathe, to carrying
High magnetic resonance picture quality has extremely important influence.In addition, in order that focusing on ultrasonic wave energy reaches tumour
Region, it is necessary to can be connect well in the via 4 of the suitable bore of 3 lower surface design of supporting table one, and peripheral sealing
Touch water.
All structures that fill of the HIFU Treatment animal tumor guided by MRI can be using 3D printing, cost
It is cheap.Design is succinct, easy to operate.It is capable of achieving guided by magnetic resonance high intensity focused ultrasound and implements experiment on mice
(tumour heating ablation, Opening Blood Brain Barrier, target administration etc.) is studied.
In the above-mentioned technical solutions, with advantages below：
(1) can accelerate to gather image, and high resolution using the coil 3 of multi-passage design, signal to noise ratio is good
(2) the compatible ultrasound that focuses on implements the experiment such as tumour heating ablation, Opening Blood Brain Barrier, target administration
Research
(3) guidance panel 5 with track is designed, animal fixture 51, anaesthetic mask 52 and anaesthesia pipeline
53 devices are designed, and experimental subjects anesthesia is lasting long-acting, and fixation postures are comfortably stablized, mobile facility, operation letter
Just.
Presently preferred embodiments of the present invention is the foregoing is only, is not intended to limit the invention, it is all in this hair
Any modification, equivalent and improvement made within bright spirit and principle etc., should be included in the present invention
Protection domain within.
Claims (9)
1. it is a kind of by MRI guide HIFU Treatment animal tumor coils special, it is characterised in that including：
One supporting table；
One arch support, is set up in the supporting table upper bottom surface, and forming one with the upper bottom surface of the supporting table encircles
The outer surface of shape space, the supporting table bottom surface and arch support is uniformly sticked for gathering MRI
The multi-channel coil of image；
One guidance panel, is slideably positioned in the supporting table upper bottom surface, and through the arcuate space, it is described
Animal fixture, anaesthetic mask and anaesthesia pipeline are provided with guidance panel in the arcuate space；
One via, bottom surface and guidance panel to the arcuate space are formed to focus on and surpassed in the supporting table
Sound passage.
2. the coils special of the HIFU Treatment animal tumor for being guided by MRI as claimed in claim 1, its
It is characterised by, be located at the via under the supporting table by one of coil channel of the multi-channel coil
In the opening of bottom surface is enclosed in.
3. the coils special of the HIFU Treatment animal tumor for being guided by MRI as claimed in claim 1, its
It is characterised by, the animal fixture and anaesthetic mask are arranged at the guidance panel around the via.
4. the coils special of the HIFU Treatment animal tumor for being guided by MRI as claimed in claim 1, its
It is characterised by, the via is cylinder.
5. the coils special of the HIFU Treatment animal tumor for being guided by MRI as claimed in claim 1, its
It is characterised by, the port of export of the anaesthesia pipeline sets one is used to catch on the buckle of animal teeth.
6. as described in claim 1 or 5 by MRI guide HIFU Treatment animal tumor coils special,
Characterized in that, the anaesthetic mask is fixed on the port of export of the anaesthesia pipeline.
7. the coils special of the HIFU Treatment animal tumor for being guided by MRI as claimed in claim 1, its
It is characterised by, the arch support is semicircular arc.
8. the coils special of the HIFU Treatment animal tumor for being guided by MRI as claimed in claim 1, its
It is characterised by, the coil channel of the multi-channel coil is four, and four coil channels mutually join.
9. the coils special of the HIFU Treatment animal tumor for being guided by MRI as claimed in claim 1, its
It is characterised by, the fixed support for fixing the anaesthesia pipeline is additionally provided with the guidance panel, it is described
Fixed support is arranged at outside the arcuate space.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201511030471.8A CN106923827A (en) | 2015-12-31 | 2015-12-31 | The coils special of the HIFU Treatment animal tumor guided by MRI |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511030471.8A CN106923827A (en) | 2015-12-31 | 2015-12-31 | The coils special of the HIFU Treatment animal tumor guided by MRI |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107907845A (en) * | 2017-12-15 | 2018-04-13 | 国家纳米科学中心 | A kind of measuring device for toy NMR imaging |
| CN108144185A (en) * | 2018-01-22 | 2018-06-12 | 崔梓华 | A kind of loop construction, the magnet therapeutic apparatus and magnetotherapy method with loop construction |
| CN110507917A (en) * | 2019-07-30 | 2019-11-29 | 哈尔滨医科大学 | A kind of low-strength focusing ultrasonic blasting system of super high field guided by magnetic resonance |
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| CN101808577A (en) * | 2007-05-24 | 2010-08-18 | 皇家飞利浦电子股份有限公司 | Small animal imaging capsule and bed system |
| CN102458578A (en) * | 2009-06-12 | 2012-05-16 | 皇家飞利浦电子股份有限公司 | Mr imaging guided ultrasound therapy |
| CN103003712A (en) * | 2010-01-05 | 2013-03-27 | 财团法人卫生研究院 | Receiving surface coils used during thermal ablation procedure |
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| CN1786730A (en) * | 2004-12-08 | 2006-06-14 | 上海辰光医疗科技有限公司 | Apparatus of animal radio-frequency coil for magnetic resonance imaging system |
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| CN103003712A (en) * | 2010-01-05 | 2013-03-27 | 财团法人卫生研究院 | Receiving surface coils used during thermal ablation procedure |
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| CN107907845A (en) * | 2017-12-15 | 2018-04-13 | 国家纳米科学中心 | A kind of measuring device for toy NMR imaging |
| CN108144185A (en) * | 2018-01-22 | 2018-06-12 | 崔梓华 | A kind of loop construction, the magnet therapeutic apparatus and magnetotherapy method with loop construction |
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| CN110507917A (en) * | 2019-07-30 | 2019-11-29 | 哈尔滨医科大学 | A kind of low-strength focusing ultrasonic blasting system of super high field guided by magnetic resonance |
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