CN206910912U - A kind of filter for activated thioester of cefixime side chain - Google Patents
A kind of filter for activated thioester of cefixime side chain Download PDFInfo
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- CN206910912U CN206910912U CN201720711284.4U CN201720711284U CN206910912U CN 206910912 U CN206910912 U CN 206910912U CN 201720711284 U CN201720711284 U CN 201720711284U CN 206910912 U CN206910912 U CN 206910912U
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- kettle
- filter
- filtrate
- vacuum extractor
- condensation
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Abstract
The utility model discloses a kind of filter for activated thioester of cefixime side chain, be connected including the filter with filtering medium layer, with filter for the vacuum extractor collecting the filtrate kettle of filtrate and connected with filtrate kettle, condensation kettle is provided between described vacuum extractor and filtrate kettle, described condensation kettle is provided with the air inlet pipe for stretching into its bottom, and the entrance of described air inlet pipe is connected with filtrate kettle.The filter between vacuum extractor and filtrate kettle by setting condensation kettle, when the boiling point of filtrate solvent is relatively low, can be condensed out in kettle is condensed, without into vacuum extractor, the harmful effect brought to vacuum extractor is avoided, meanwhile, decrease the loss of solvent.
Description
Technical field
The utility model belongs to field of chemical equipment, and in particular to a kind of filtering for activated thioester of cefixime side chain fills
Put.
Background technology
Filtering is one of most common operation in Chemical Manufacture and pharmaceutical synthesis, is in motive force or the effect of other external force
Penetration by liquid medium in low suspension liquid, solid particle and other materials are retained by filter medium, so that solid and liquid point
From operation.Filtering is sometimes to obtain solid matter, is sometimes in order to obtain liquid substance, according to purpose not
Together, concrete structure is also different.
Filtering separates the difference of driving force according to it, is divided into natural filtration, is filtered under diminished pressure and pressure filtration, wherein, normal pressure
Filtering typically by the use of be gravity as driving force, the comparison applied in the lab is more, applied in actual industrial production compared with
It is few.In actual industrial production, relatively common operation is pressure filtration and is filtered under diminished pressure, wherein, it is filtered under diminished pressure and (also known as takes out
Filter) so that the rate of filtration is fast, filter process safety simple to operate, application is the most extensive.
Existing pumping and filtering device generally comprises：(can be filter frame, funnel or filter disc etc., according to institute provided with filter medium
Depending on the difference of the amount for the material for needing to filter) filter, be used to below the filter collecting the collection device of filtrate, with
The vacuum extractor that space between filter and collection device is connected.
In the building-up process of activated thioester of cefixime side chain, post processing needs, which are used, is filtered under diminished pressure operation.In the decompression
, it is necessary to which low boiling point solvent (such as dichloromethane) is separated with product in filtering, and due to filter and collection device it
Between be connected with vacuum extractor, inevitably lead to low boiling point solvent into vacuum extractor, one side solvent can be true to taking out
Empty device causes to corrode, and brings deleterious effect, on the other hand also results in solvent and wastes, and causes dirt to environment
Dye.
Utility model content
The utility model provides a kind of filter for activated thioester of cefixime side chain, and the filter can have
Effect reduces the loss of solvent, meanwhile, avoid adversely affecting vacuum extractor.
A kind of filter for activated thioester of cefixime side chain, including filter and mistake with filtering medium layer
Filter be connected for the vacuum extractor collecting the filtrate kettle of filtrate and connected with filtrate kettle, described vacuum means
Put and condensation kettle is provided between filtrate kettle；
Described condensation kettle is provided with the air inlet pipe for stretching into its bottom, and the entrance of described air inlet pipe is connected with filtrate kettle；
The side wall upper part of described condensation kettle is provided with gas outlet, and described gas outlet is connected with vacuum extractor.
The utility model, can be by vacuum means by setting extra condensation kettle between filtrate kettle and vacuum extractor
The gaseous solvent for putting sucking-off condenses out, and prevents these gaseous solvents from entering in vacuum extractor, on the one hand can avoid these
Solvent damages vacuum extractor, on the other hand, decreases solvent loss.
Preferably, the bottom of described condensation kettle offers the liquid outlet with closing valve.The valve filter into
Be closed during row, when condense the quantity of solvent condensed out in kettle it is more when, can by the valve open to condensation
Liquid cleared up.
Top as further preferred, described filter is provided with washing mouth, and described liquid outlet is washed with described
Wash mouth and be connected by washing pipeline, described washing pipeline is provided with transfer tube.After suction filtration terminates, the driving can be opened
Pump, the condensate liquid in condenser is squeezed into filter filter cake is washed.Now, because the temperature of wash solution is relatively low,
Clean result ratio is even more ideal with other solvents.
In order to uniformly be washed to filter cake, clean result is improved, as further preferred, described washing mouth
Provided with liquid distribution device.
In order to improve the condensation effect of condensation kettle, described condensation kettle be arranged to it is elongated columnar structured, wherein, cylinder
Length-to-diameter be more than 5：1.
When condense the amount of liquid condensed in kettle it is more when, can be by the lower submerged of air inlet pipe, now, if turned off vacuumizing
Device, it may result in the suck-back of liquid.Preferably, described air inlet pipe be provided with can with the Buffer valve of air communication,
Now, before vacuum extractor is closed, Buffer valve is first opened, can effectively prevent the suck-back of liquid.
Preferably, the bottom of described filtrate kettle is provided with leakage fluid dram.Entirely mistake can not taken apart using the leakage fluid dram
Under conditions of filtering device, filtrate is released, operation is more convenient.
Compared with the existing technology, the beneficial effects of the utility model are embodied in：
(1) the utility model between vacuum extractor and filtrate kettle by setting condensation kettle, when the boiling point of filtrate solvent
When relatively low, can be condensed out in kettle is condensed, without into vacuum extractor, avoid vacuum extractor is brought it is bad
Influence, meanwhile, decrease the loss of solvent.
(2) connected by the way that the top for condensing kettle and filter is washed into mouth, can using the solvent condensed out as
Cleaning solution uses, more preferable than the clean result of usual vehicle because the temperature of the condensate liquid is lower, can effectively prevent product
Loss.
Brief description of the drawings
Fig. 1 is the structural representation of the filter of the present utility model for activated thioester of cefixime side chain；In figure, 1：
Filter；2：Filtrate kettle；3：Vacuum extractor；4：Condense kettle；5：Air inlet pipe；6：Gas outlet；7：Wash pipeline；8：Transfer tube；
9：Liquid distribution device；10：Buffer valve.
Embodiment
Filter of the present utility model is further described below in conjunction with the accompanying drawings.
The structural representation of the filter for activated thioester of cefixime side chain as shown in Figure 1 understands that the filtering fills
The left side put is the filter 1 and filtrate kettle 2 connected up and down, is provided with charging aperture in the side wall upper part of filter 1, the charging aperture is used
In addition material to be filtered；Filter medium (such as filter cloth) is carried in the bottom of filter 1, for separating solid particle and liquid
Body；Filtrate kettle 2 is used to collect the filtrate after filtering.Leakage fluid dram is being provided with using the bottom of filtrate kettle 2, the leakage fluid dram can be not
Under conditions of taking whole filter apart, filtrate is released, operation is more convenient.
It is connected in the side wall upper part of filtrate kettle 2 by an air inlet pipe 5 with condensation kettle 4, the air inlet pipe 5 is passed directly into condensation
Near the bottom of kettle 4, gas outlet 6 is provided with the side wall upper part of condensation kettle 4, the gas outlet 6 and vacuum extractor 3 (such as vacuum
Pump) it is connected.When carrying out vacuum pumping to filter 1, the relatively low solvent of boiling point, which has, to be partly into condenser
Row condensation, the bottom of condensation kettle 4 is condensed upon, because the position of gas outlet 6 is higher, the liquid suction in the condenser will not be taken out
Vacuum plant 3.
In order to reach preferable condensation effect, condensation kettle 4 needs to be positioned in low temperature environment, according to filtrate solvent not
Together, different temperature-reducing mediums can be selected, for the low-down solvent of some boiling points, liquid nitrogen or dry ice can be used.
A Buffer valve 10 is provided with the air inlet pipe 5 that filtrate kettle 2 and condensation kettle 4 connect, the Buffer valve 10 is filtering
It is closed under state, at the end of suction filtration process, first opens the valve, is then being closed vacuum extractor 3, can keep away
Exempt to condense the liquid in kettle 4 into suction filtrate kettle 2.
A liquid outlet is provided with the bottom of condensation kettle 4, the liquid outlet is communicated to the top of filter 1 by washing pipeline 7
Portion, and a liquid distribution device 9 is provided with exit, it is provided with transfer tube 8 and closing valve on washing pipeline 7.Normal
Suction filtration state under, the valve is closed, when separation of solid and liquid terminate or condense liquid is more in kettle 4 when, can beat
Closing valve and transfer tube 8 are opened, condensate liquid is squeezed into the liquid distribution device 9 at the top of filter 1, liquid equably falls on filter
On cake, filter cake is washed.Simultaneously as the temperature of the condensate liquid is relatively low, the dissolving of product can be efficiently reduced, is reached
More preferable clean result.
The technical solution of the utility model and beneficial effect are described in detail above-described embodiment,
It should be understood that the foregoing is only most preferred embodiment of the present utility model, the utility model is not limited to, it is all at this
Any modification, supplement and equivalent substitution made in the spirit of utility model etc., should be included in guarantor of the present utility model
Within the scope of shield.
Claims (6)
1. a kind of filter for activated thioester of cefixime side chain, including filter (1) and mistake with filtering medium layer
Filter (1) be connected for the vacuum extractor (3) collecting the filtrate kettle (2) of filtrate and connected with filtrate kettle (2), its
It is characterised by, condensation kettle (4) is provided between described vacuum extractor (3) and filtrate kettle (2)；
Described condensation kettle (4) is provided with the air inlet pipe (5) for stretching into its bottom, entrance and the filtrate kettle (2) of described air inlet pipe (5)
It is connected；
The side wall upper part of described condensation kettle (4) is provided with gas outlet (6), and described gas outlet (6) are connected with vacuum extractor (3)
It is logical.
2. filter according to claim 1, it is characterised in that the bottom of described condensation kettle (4), which offers, to be carried
The liquid outlet of closing valve.
3. filter according to claim 2, it is characterised in that the top of described filter (1) is provided with washing mouth,
Described liquid outlet is connected with described washing mouth by washing pipeline (7), and described washing pipeline (7) is provided with transfer tube
(8)。
4. filter according to claim 3, it is characterised in that described washing mouth is provided with liquid distribution device (9).
5. filter according to claim 1, it is characterised in that described air inlet pipe (5), which is provided with, to be connected with air
Logical Buffer valve (10).
6. filter according to claim 1, it is characterised in that the bottom of described filtrate kettle (2) is provided with leakage fluid dram.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720711284.4U CN206910912U (en) | 2017-06-19 | 2017-06-19 | A kind of filter for activated thioester of cefixime side chain |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720711284.4U CN206910912U (en) | 2017-06-19 | 2017-06-19 | A kind of filter for activated thioester of cefixime side chain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206910912U true CN206910912U (en) | 2018-01-23 |
Family
ID=61321894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720711284.4U Active CN206910912U (en) | 2017-06-19 | 2017-06-19 | A kind of filter for activated thioester of cefixime side chain |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206910912U (en) |
-
2017
- 2017-06-19 CN CN201720711284.4U patent/CN206910912U/en active Active
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