CN206868248U - A kind of micro-fluid chip using the reversible encapsulation of magnet - Google Patents
A kind of micro-fluid chip using the reversible encapsulation of magnet Download PDFInfo
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- CN206868248U CN206868248U CN201720582995.6U CN201720582995U CN206868248U CN 206868248 U CN206868248 U CN 206868248U CN 201720582995 U CN201720582995 U CN 201720582995U CN 206868248 U CN206868248 U CN 206868248U
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Abstract
The utility model discloses a kind of micro-fluid chip using the reversible encapsulation of magnet, including cover plate and bottom plate, cover plate is located above bottom plate, cover plate is flexibly connected with bottom plate, cover plate is provided with fluid intake, the first microchannel and fluid issuing, fluid intake connects with the first microchannel, fluid enters the first microchannel by fluid intake, bottom plate includes the second microchannel connected with the first microchannel, first microchannel forms Disengagement zone with the second microchannel connectivity part, second microchannel connects with fluid issuing, and fluid enters fluid issuing after entering the second microchannel.The utility model cover plate is flexibly connected the reversible seal for realizing micro-fluid chip with bottom plate, and not only encapsulation is simple, easily contraposition, and cleans convenient disassembly, and filter membrane replacing is simple.In addition, fluid intake and the first microchannel, fluid issuing and the second microchannel are connected using female Luer, easy installation and removal.Also, this micro-fluid chip makes simply, and compact-sized, cost is low, and can be mass-produced.
Description
Technical field
It the utility model is related to a kind of micro-fluid chip, and in particular to a kind of micro-fluid chip of reversible encapsulation, the miniflow
Body chip carries out accuracy controlling to the fluid in filter process, and the separation for carrying out sample is realized by filter membrane.
Background technology
Micro-fluid chip forms microchannel net based on micro electro mechanical processing technology on the chip of a block number square centimeter
Network structure and other functional units, accurate control of fluid, the sample preparation involved by the fields such as biochemistry, biochemical reaction, separation
It is integrated in basic operation units such as analysis detections on chip, reduces the consumption of biological sample and reagent, improves analysis speed
Degree, alleviates analysis cost, makes high flux, and on a large scale, automation, in real time detection is possibly realized, biomedical in environmental science
Had a wide range of applications with clinical diagnosis.
Filter membrane is the significant element for the process that is separated by filtration.Complete the purpose that is separated by filtration, it is necessary to develop filter membrane and
Corresponding fluid is by the condition of film, such as the operating condition such as flow velocity, streamline, and the condition of fluid can pass through micro-fluid chip
It is designed and regulates and controls.But at present, micro-fluid chip forms the micro- ditch of permanent closure using the bonding technology of si-glass mostly
Road, its advantage is will not leakage；Shortcoming is that permanent micro- raceway groove can not be dismantled repeatedly, and filter membrane can not conveniently take out.Gu etc. carries
A kind of micro-fluidic chip clamp of sandwich structure is gone out, has been fixed by screw and nut, and liquid entrance uses spiral shell
Pit, the installation of its fixture and fluid inlet and outlet and dismounting trouble, cost is high, and is difficult to largely produce.
Utility model content
In order to solve micro-fluid chip installation in the prior art and dismounting trouble, cost is high, and is difficult to a large amount of productions etc. and asks
Topic, the utility model provide a kind of micro-fluid chip using the reversible encapsulation of magnet.
The purpose of this utility model will be achieved through the following technical solutions：A kind of microfluid core using the reversible encapsulation of magnet
Piece, including cover plate and bottom plate, cover plate are located above bottom plate, and cover plate is flexibly connected with bottom plate, and cover plate is provided with fluid intake, first
Microchannel and fluid issuing, fluid intake connect with the first microchannel, and fluid enters the first microchannel by fluid intake,
Bottom plate includes the second microchannel connected with the first microchannel, and the first microchannel forms Disengagement zone with the second microchannel connectivity part,
Second microchannel connects with fluid issuing, and fluid enters fluid issuing after entering the second microchannel.
Preferably, described a kind of micro-fluid chip using the reversible encapsulation of magnet, it is female that the fluid intake is provided with first
Female Luer, one end of the first microchannel are provided with the first public female Luer, and fluid intake passes through the first female Luer connector and first
First public female Luer connection of microchannel, the fluid issuing are provided with the second female Luer connector, and one end of the second microchannel is set
There is the second public female Luer, fluid issuing is connected by the second female Luer connector with the second public female Luer of the second microchannel.
Preferably, described a kind of micro-fluid chip using the reversible encapsulation of magnet, filter membrane is provided with the Disengagement zone, point
The cell in fluid, the soft material of organelle are intercepted on filter membrane from area.
Preferably, described a kind of micro-fluid chip using the reversible encapsulation of magnet, the filter membrane at least two, filter membrane
Disengagement zone is disposed in parallel in up and down, and fluid is flowed into the second microchannel after being filtered successively from filter membrane, realizes the multistage of fluid
It is separated by filtration.
Preferably, described a kind of micro-fluid chip using the reversible encapsulation of magnet, the cover plate pass through magnet with bottom plate
Be flexibly connected, the first magnet be provided with cover plate, be provided with second magnet opposite with the magnet polarities of cover plate first in bottom plate, cover plate and
Bottom plate is attracted each other by the effect of opposed polarity magnet.
Preferably, described a kind of micro-fluid chip using the reversible encapsulation of magnet, the first magnet more than one, the
One magnet is evenly distributed in cover plate, and the second magnet more than one, the second magnet is uniformly distributed in the soleplate.
Preferably, described a kind of micro-fluid chip using the reversible encapsulation of magnet, in addition to intermediate plate, intermediate plate are located at
Between cover plate and bottom plate, intermediate plate is flexibly connected with cover plate and bottom plate respectively, and the first microchannel is micro- logical through intermediate plate and second
Road connects, and the second microchannel connects through intermediate plate with fluid issuing, and fluid flows through intermediate plate from the first microchannel and enters the
Two microchannels enter fluid issuing by intermediate plate again.
Preferably, described a kind of micro-fluid chip using the reversible encapsulation of magnet, the top of the intermediate plate are provided with the
Three magnet, intermediate plate are flexibly connected by the 3rd magnet with cover plate, and the lower section of intermediate plate is provided with the 4th magnet, and intermediate plate passes through
Four magnet are flexibly connected with bottom plate.
Preferably, described a kind of micro-fluid chip using the reversible encapsulation of magnet, the cover plate is by upper cover plate and lower cover
Plate forms, and upper cover plate is located above lower cover, and upper cover plate is hard material, and lower cover is elastomeric material.
Preferably, described a kind of micro-fluid chip using the reversible encapsulation of magnet, the bottom plate is by upper plate and bottom
Plate forms, and upper plate is located above lower shoe, and upper plate is elastomeric material, and lower shoe is hard material.
Preferably, described a kind of micro-fluid chip using the reversible encapsulation of magnet, the fluid intake more than one, stream
Body entrance is consistent with the number of fluid issuing, and fluid intake is connected with the first microchannel respectively, the second microchannel respectively with fluid
Outlet.
Compared with prior art, the utility model has the advantages that：Cover plate of the present invention is flexibly connected real with bottom plate
The reversible seal of micro-fluid chip is showed, not only encapsulation is simple, easily contraposition, and cleans convenient disassembly, and filter membrane replacing is simple.
In addition, fluid intake and the first microchannel, fluid issuing and the second microchannel are connected using female Luer, installing/dismounting side
Just.Also, this micro-fluid chip makes simply, and compact-sized, cost is low, and can be mass-produced.
Brief description of the drawings
, below will be to embodiment in order to illustrate more clearly of the utility model embodiment or technical scheme of the prior art
Or the required accompanying drawing used is briefly described in description of the prior art, it should be apparent that, drawings in the following description are only
It is one embodiment of the present utility model, for those of ordinary skill in the art, before creative labor is not paid
Put, other accompanying drawings can also be obtained according to these accompanying drawings.
Fig. 1 is the top view of micro-fluid chip in the embodiment 1；
Fig. 2 is the explosive view of the A-A views of micro-fluid chip in the embodiment 1；
Fig. 3 is the explosive view of micro-fluid chip in the embodiment 2；
Fig. 4 is the top view of micro-fluid chip in the embodiment 3.
In figure：1 cover plate, 11 fluid intakes, 12 first microchannels, 13 fluid issuings, 14 upper cover plates, 15 lower covers；2 bottoms
Plate, 21 second microchannels, 22 upper plates, 23 lower shoes；3 Disengagement zone, 31 filter membranes；4 magnet；5 intermediate plates, 51 upper stratas；Among 52
Layer；53 bottoms.
Embodiment
Below in conjunction with the accompanying drawing in the utility model embodiment, the technical scheme in the embodiment of the utility model is carried out
Clearly and completely describing, it is clear that described embodiment is only the utility model part of the embodiment, rather than whole
Embodiment.Based on the embodiment in the utility model, those of ordinary skill in the art are not under the premise of creative work is made
The every other embodiment obtained, belong to the scope of the utility model protection.
As shown in Fig. 1 to Fig. 2, a kind of micro-fluid chip using the reversible encapsulation of magnet, including cover plate 1 and bottom plate 2, cover plate
1 is flexibly connected positioned at the top of bottom plate 2, cover plate 1 with bottom plate 2, and cover plate 1 is provided with fluid intake 11, the first microchannel 12 and fluid
Outlet 13, fluid intake 11 connects with the first microchannel 12, and fluid enters the first microchannel 12, bottom plate by fluid intake 11
2 the second microchannels 21 including being connected with the first microchannel 12, the first microchannel 11 and the connectivity part of the second microchannel 21, which are formed, divides
From area 3, the second microchannel 21 connects with fluid issuing 13, and fluid enters fluid issuing 13 after entering the second microchannel 21.
The fluid intake 11 is provided with the first female Luer connector, and one end of the first microchannel 12 connects provided with first public Rule
Head, fluid intake 11 are connected by the first female Luer connector with the first public female Luer of the first microchannel 12, and the fluid goes out
Mouthfuls 13 are provided with the second female Luer connector, and one end of the second microchannel 21 is provided with the second public female Luer, and fluid issuing 13 passes through the
Two female Luer connectors connect with the second public female Luer of the second microchannel 21.
Filter membrane 31 is provided with the Disengagement zone 3, Disengagement zone 3 intercepts the cell in fluid, the soft material of organelle in filter membrane
On 31.The filter membrane 31 at least two, filter membrane is disposed in parallel in Disengagement zone 3 about 31, fluid filters from filter membrane 31 successively
After be flowed into the second microchannel 21, realize fluid multistage filtering separation.
The cover plate 1 is flexibly connected with bottom plate 2 by magnet 4, and the first magnet is provided with cover plate 1, is provided with and lid in bottom plate 2
The second opposite magnet of the magnet polarities of plate 1 first, cover plate 1 are attracted each other with bottom plate 2 by the effect of opposed polarity magnet.It is described
First magnet more than one, the first magnet are evenly distributed in cover plate 1, and the second magnet more than one, the second magnet is uniformly distributed
In bottom plate 2.
The cover plate 1 is made up of upper cover plate 14 and lower cover 15, and upper cover plate 14 is located at the top of lower cover 15, and upper cover plate 14 is
Hard material, such as polyethylene (PE), polyvinyl chloride (PVC), polystyrene (PS), polypropylene (PP), ABS resin, poly- methyl-prop
E pioic acid methyl ester (PMMA), makrolon (PC), or other solid materials, such as quartz, glass, silicon chip.Lower cover 15 is
Elastomeric material, such as silica gel or rubber.Fluid intake 11 and fluid issuing 13 are arranged on upper cover plate 14.First magnet is located at
In upper cover plate 14.
The bottom plate 2 is made up of upper plate 22 and lower shoe 23, and upper plate 22 is located at the top of lower shoe 23, and upper plate 22 is
Elastomeric material, such as quartz, glass, silicon chip.Lower shoe 23 is hard material, such as polyethylene (PE), polyvinyl chloride (PVC), is gathered
Styrene (PS), polypropylene (PP), ABS resin, polymethyl methacrylate (PMMA), makrolon (PC), or it is other
Solid material, such as quartz, glass, silicon chip.Second magnet is located in lower shoe 23.
Embodiment 2
On the basis of embodiment 1, as shown in figure 3, the micro-fluid chip also includes intermediate plate 5, intermediate plate 5 is located at cover plate
Between 1 and bottom plate 2, intermediate plate 5 is flexibly connected with cover plate 1 and bottom plate 2 respectively, and the first microchannel 12 passes through intermediate plate 5 and second
Microchannel 21 connects, and the second microchannel 21 connects through intermediate plate 5 with fluid issuing 13, during fluid flows through from the first microchannel 12
Between plate 5 enter the second microchannel 21 and enter fluid issuing 13 by intermediate plate 5 again.The top of the intermediate plate 5 is provided with the
Three magnet, the 3rd magnet with the first magnet polarities on the contrary, intermediate plate 5 is flexibly connected by the 3rd magnet with cover plate 1, intermediate plate 5
Lower section be provided with the 4th magnet, the 4th magnet and the second magnet polarities on the contrary, intermediate plate 5 passes through the activity of the 4th magnet and bottom plate 2
Connection.The intermediate plate 5 is made up of upper strata 51, intermediate layer 52 and bottom 53, and the 3rd magnet is located at the top of intermediate layer 52, the 4th magnetic
Iron is located at the lower section of intermediate layer 52, and upper strata 51 and bottom 53 use elastomeric material, to ensure intermediate plate 5 and cover plate 1, intermediate plate 5
The sealing being connected with bottom plate 2.
Embodiment 3
On the basis of embodiment 1, as shown in figure 4, the more than one of the fluid intake 11, fluid intake 11 go out with fluid
Mouthfuls 13 number is consistent, and fluid intake 11 is connected with the first microchannel 12 respectively, the first microchannel 12 and the second microchannel 21
Connectivity part forms Disengagement zone 3, and the second microchannel 21 connects with fluid issuing 13 respectively.
Preferred embodiment of the present utility model is the foregoing is only, it is all at this not to limit the utility model
Within the spirit and principle of utility model, any modification, equivalent substitution and improvements made etc., the utility model should be included in
Protection domain within.
Claims (10)
- A kind of 1. micro-fluid chip using the reversible encapsulation of magnet, it is characterised in that：Including cover plate and bottom plate, cover plate is located at bottom plate Top, cover plate are flexibly connected with bottom plate, and cover plate is provided with fluid intake, the first microchannel and fluid issuing, fluid intake and One microchannel connects, and fluid enters the first microchannel by fluid intake, and bottom plate includes second connected with the first microchannel Microchannel, the first microchannel form Disengagement zone with the second microchannel connectivity part, and the second microchannel connects with fluid issuing, and fluid enters Fluid issuing is entered after entering to the second microchannel.
- A kind of 2. micro-fluid chip using the reversible encapsulation of magnet according to claim 1, it is characterised in that：The fluid Entrance is provided with the first female Luer connector, and one end of the first microchannel is provided with the first public female Luer, and fluid intake is female by first Female Luer connects with the first public female Luer of the first microchannel, and the fluid issuing is provided with the second female Luer connector, and second One end of microchannel is provided with the second public female Luer, and fluid issuing passes through the second female Luer connector and the second public affairs of the second microchannel Female Luer connects.
- A kind of 3. micro-fluid chip using the reversible encapsulation of magnet according to claim 1, it is characterised in that：The separation Filter membrane is provided with area, Disengagement zone intercepts the cell in fluid, the soft material of organelle on filter membrane.
- A kind of 4. micro-fluid chip using the reversible encapsulation of magnet according to claim 3, it is characterised in that：The filter membrane At least two, filter membrane is disposed in parallel in Disengagement zone up and down, and fluid is flowed into the second microchannel after being filtered successively from filter membrane, real The multistage filtering separation of fluid is showed.
- A kind of 5. micro-fluid chip using the reversible encapsulation of magnet according to claim 1, it is characterised in that：The cover plate It is flexibly connected with bottom plate by magnet, the first magnet is provided with cover plate, is provided with bottom plate opposite with the magnet polarities of cover plate first Second magnet, cover plate are attracted each other with bottom plate by the effect of opposed polarity magnet.
- A kind of 6. micro-fluid chip using the reversible encapsulation of magnet according to claim 5, it is characterised in that：Described first Magnet more than one, the first magnet are evenly distributed in cover plate, and the second magnet more than one, the second magnet is evenly distributed on bottom plate In.
- A kind of 7. micro-fluid chip using the reversible encapsulation of magnet according to claim 1, it is characterised in that：In also including Between plate, between cover plate and bottom plate, intermediate plate is flexibly connected intermediate plate with cover plate and bottom plate respectively, during the first microchannel passes through Between plate connected with the second microchannel, the second microchannel connects through intermediate plate with fluid issuing, and fluid flows through from the first microchannel Intermediate plate enters the second microchannel and enters fluid issuing by intermediate plate again.
- A kind of 8. micro-fluid chip using the reversible encapsulation of magnet according to claim 7, it is characterised in that：The centre The top of plate is provided with the 3rd magnet, and intermediate plate is flexibly connected by the 3rd magnet with cover plate, and the lower section of intermediate plate is provided with the 4th magnetic Iron, intermediate plate are flexibly connected by the 4th magnet with bottom plate.
- A kind of 9. micro-fluid chip using the reversible encapsulation of magnet according to claim 1, it is characterised in that：The cover plate It is made up of upper cover plate and lower cover, upper cover plate is located above lower cover, and upper cover plate is hard material, and lower cover is elastomeric material； The bottom plate is made up of upper plate and lower shoe, and upper plate is located above lower shoe, and upper plate is elastomeric material, and lower shoe is hard Material.
- A kind of 10. micro-fluid chip using the reversible encapsulation of magnet according to claim 1, it is characterised in that：The stream Body entrance more than one, fluid intake is consistent with the number of fluid issuing, and fluid intake is connected with the first microchannel respectively, and second Microchannel connects with fluid issuing respectively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720582995.6U CN206868248U (en) | 2017-05-24 | 2017-05-24 | A kind of micro-fluid chip using the reversible encapsulation of magnet |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201720582995.6U CN206868248U (en) | 2017-05-24 | 2017-05-24 | A kind of micro-fluid chip using the reversible encapsulation of magnet |
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| CN206868248U true CN206868248U (en) | 2018-01-12 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108499619A (en) * | 2018-03-09 | 2018-09-07 | 复旦大学 | A kind of integrated micro-fluidic filtrating chip of film and its preparation method and application |
| CN109735430A (en) * | 2019-01-28 | 2019-05-10 | 武汉纺织大学 | A kind of micro-fluidic chip of three-dimensional magnetophoresis separation |
| CN112795478A (en) * | 2021-01-27 | 2021-05-14 | 广州安方生物科技有限公司 | Cell separation device, cell separation method and application |
-
2017
- 2017-05-24 CN CN201720582995.6U patent/CN206868248U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108499619A (en) * | 2018-03-09 | 2018-09-07 | 复旦大学 | A kind of integrated micro-fluidic filtrating chip of film and its preparation method and application |
| CN108499619B (en) * | 2018-03-09 | 2020-09-29 | 复旦大学 | Membrane integrated type micro-fluidic filter chip and preparation method and application thereof |
| CN109735430A (en) * | 2019-01-28 | 2019-05-10 | 武汉纺织大学 | A kind of micro-fluidic chip of three-dimensional magnetophoresis separation |
| CN112795478A (en) * | 2021-01-27 | 2021-05-14 | 广州安方生物科技有限公司 | Cell separation device, cell separation method and application |
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