CN206560851U - Integral dual milk particle generating means and its processing mold - Google Patents
Integral dual milk particle generating means and its processing mold Download PDFInfo
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- CN206560851U CN206560851U CN201621398303.4U CN201621398303U CN206560851U CN 206560851 U CN206560851 U CN 206560851U CN 201621398303 U CN201621398303 U CN 201621398303U CN 206560851 U CN206560851 U CN 206560851U
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Abstract
The utility model discloses a kind of Integral dual milk particle generating means and its processing mold, the device includes perfusion mould and generator body, first processes assembly jig, and PDMS solution is irrigated in a mold, the coaxial generator body in three holes is formed after solidification, the demoulding.Go out sample pipeline by the use of the hole of generator body as interphase, be inserted into that interior phase goes out sample pipeline and foreign minister goes out sample pipeline formation coaxial device, solution system is injected in a device and produces dual milk particle.Integral dual milk particle generating means of the present utility model uses coaxial shear mode, can prepare internal diameter~2000 μm, the dual milk particle of the monodispersed W/O/W in wall thickness~250 μm.The perfusion mould of Integral dual milk particle generating means of the present utility model can be reused, reproducible；The generator body obtained by perfusion mould is simple to operate applied widely, easy cleaning, and control accuracy is high, can effectively solve current emulsion micropackaging hair and prepare the uncontrollable problem of diameter, wall thickness in grade polymer microballoon.
Description
Technical field
The utility model is related to a kind of dual milk particle generating means, and in particular to a kind of Integral dual milk particle generating means
And its processing mold.
Background technology
In ICF researchs, frequently with polymer microballoon as pellet fuel container, the diameter of polymer microballoon is micro- from hundreds of
Rice arrives several millimeters.Polymer microballoon is generally prepared using emulsion method, i.e., first generates W/O/W double emulsion, then removes having for O phases
Machine solvent, the polymer spherical shell solidified, polymer microballoon diameter is general at hundreds of microns to several millimeters.Conventional preparation is double
The method of gravity emulsion has mechanical mixing method and microfluidic control method.Mechanical mixing method prepare double emulsion Size Distribution it is wide, examination
Agent usage amount is big, is not suitable for accurate control.Micro-fluidic technologies are a kind of sides for preparing multiple emulsion of the development nineties in last century
Method, the mode for producing drop according to micro-fluidic technologies, which can be divided into T-shaped shearing, parallel shearing and converge shearing microfluid, to be filled
Put.Chun-Xia Zhao and Minseok Seo etc. have studied T-shaped shearing in two-phase fluid, parallel shearing, convergence shearing, film breast
The mechanism of action of the modes such as change, analyzes the influence of phase parameter, has obtained the mono- breasts of the monodispersed W/O of small size of various forms
Liquid；Rhutesh K.Shah etc. utilize coaxial shear mode, are prepared for substance, dual, multiple emulsion.But common microfluid
Emulsion size prepared by technology is smaller, in micro/nano level, is mainly used in the fields such as biology, medicine, chemical industry, oil, at present, needs badly
It is a kind of to prepare the generating means of the monodispersed dual milk particle of grade.And the dual milk particle used in the prior art occurs
Device be knockdown structure, such as patent document CN 105771825A disclose one kind can quantity-produced milk particle generator, its
Assembling process is complicated, and sealing is poor, and its liquid pipe needs extra addition pipeline, in-convenience in use.
Utility model content
A purpose of the present utility model is to solve at least the above and/or defect, and offer at least will be described later
Advantage.
Sent out to realize according to these purposes of the present utility model and further advantage there is provided a kind of Integral dual milk particle
Generating apparatus, including：
Generator body, it includes：Integrally formed supporter；
The interior phase sample channel for internal phase emulsions sample introduction positioned at supporter upper end；
It is used for the interphase sample channel of middle phase emulsion sample introduction positioned at supporter side, its one end connection interphase goes out
Sample pipeline；The interphase goes out sample pipeline and connects and be coaxially disposed with interior phase sample channel；
Positioned at foreign minister's sample channel for outer phase emulsion sample introduction of supporter opposite side, its one end connection foreign minister goes out sample pipe
Road；The foreign minister goes out sample pipeline and goes out sample pipeline communication with interphase and be coaxially disposed；
Steam vent, it goes out sample pipeline through foreign minister and stretched into supporter；
Wherein, by the sample introduction of interior phase sample channel, interphase sample channel and the different emulsions of foreign minister's sample channel progress,
And sample pipeline is gone out by interphase and foreign minister goes out sample pipeline and forms dual milk particle.
Preferably, the integrally formed supporter is formed in one dimethyl silicone polymer or modified polydimethyl
Siloxanes supporter.
The utility model also provides a kind of perfusion mould for processing above-mentioned Integral dual milk particle generating means, including：
Fixed outer framework, it is hollow structure, phase sample introduction occupy-place cylinder in the top surface perforate insertion of the fixed outer framework；
Holes insertion interphase sample introduction occupy-place cylinder and steam vent occupy-place cylinder above and below being opened respectively in the side of hollow fixation outer framework；
Foreign minister's sample introduction occupy-place cylinder is inserted in another STH of hollow fixation outer framework；Opened in the lower end of hollow fixation outer framework
Hole insertion foreign minister goes out sample occupy-place cylinder；Conical bore and cylindrical hole are opened in the top that the foreign minister goes out sample occupy-place cylinder from top to bottom,
Insertion interphase goes out sample occupy-place cylinder in the cylindrical hole；The bottom of the interior phase sample introduction occupy-place cylinder and interphase go out sample occupy-place
The tip contact of cylinder；The top side that one end of the interphase sample introduction occupy-place cylinder and interphase go out sample occupy-place cylinder connects
Touch；One end of foreign minister's sample introduction occupy-place cylinder and foreign minister go out the top contacts side surfaces of sample occupy-place cylinder；The steam vent occupy-place
Cylinder goes out sample occupy-place cylinder through foreign minister and stretched into bellmouth；The interior phase sample introduction occupy-place cylinder, interphase go out sample occupy-place circle
Post and foreign minister go out sample occupy-place cylinder and are coaxially disposed；
Wherein, hydrophobic transparent dimethyl silicone polymer solution is poured into after perfusion mould is completed, after solidification, successively
Phase sample introduction occupy-place cylinder, interphase sample introduction occupy-place cylinder, foreign minister's sample introduction occupy-place cylinder, steam vent occupy-place cylinder, foreign minister in removing
Go out sample occupy-place cylinder and interphase goes out sample occupy-place cylinder, form generator body.
Preferably, the interior phase sample introduction occupy-place cylinder, interphase sample introduction occupy-place cylinder, foreign minister's sample introduction occupy-place cylinder, row
Stomata occupy-place cylinder, foreign minister go out sample occupy-place cylinder and interphase to go out sample occupy-place cylinder be metal bar.
Preferably, the metal bar is any one in copper rod, iron staff, stainless steel bar, aluminium bar.
Preferably, the hollow fixation outer framework is that polytetrafluoroethylene (PTFE) fixes outer framework.
Preferably, one end of the interphase sample introduction occupy-place cylinder is provided with the top for going out sample occupy-place cylinder with interphase
The deep-slotted chip breaker that side cambered surface matches；One end of foreign minister's sample introduction occupy-place cylinder is provided with the top for going out sample occupy-place cylinder with foreign minister
The deep-slotted chip breaker that end side surface cambered surface matches.
The utility model at least includes following beneficial effect：
(1) the perfusion mould of Integral dual milk particle generating means of the present utility model can be reused, reproducible；By
The generator body that perfusion mould is obtained is simple to operate applied widely, and easy cleaning, control accuracy is high, can effectively solve current breast
Liquid micropackaging hair prepares the uncontrollable problem of diameter, wall thickness in grade polymer microballoon.
(2) relative to knockdown dual milk particle generating means in the prior art, dual milk particle of the present utility model occurs
Device is integrally formed, and it has easy to use, good sealing effect, simple operation and other advantages.
(2) Integral dual milk particle generating means of the present utility model can produce the dual milk particle of single dispersing major diameter, should
Device uses coaxial shear mode, can prepare internal diameter~2000 μm, monodispersed water/PAMS (the poly- Alpha-Methyls in wall thickness~250 μm
Styrene)-FB (fluorobenzene)/PVA (polyvinyl alcohol), water/PS (polystyrene)-FB/PVA, water/DPS (N, N '-diphenyl fourth two
Acid amides)-FB/PVA W/O/W dual milk particle.
Further advantage of the present utility model, target and feature embody part by following explanation, and part will also pass through
Research of the present utility model and practice are understood by the person skilled in the art.
Brief description of the drawings：
Fig. 1 is the structural representation of Integral dual milk particle generating means of the present utility model；
Fig. 2 is the perfusion mould structure schematic diagram of the present utility model for processing Integral dual milk particle generating means.
Embodiment：
The utility model is described in further detail below in conjunction with the accompanying drawings, to make those skilled in the art with reference to explanation
Book word can be implemented according to this.
It should be appreciated that such as " having ", "comprising" and " comprising " term used herein do not allot one or many
The presence or addition of individual other elements or its combination.
Fig. 1 shows a kind of Integral dual milk particle generating means of the present utility model, including：Generator body, it is wrapped
Include：Integrally formed supporter 14；
The interior phase sample channel 8 for internal phase emulsions sample introduction positioned at the upper end of supporter 14；
Positioned at being used in the middle of the interphase sample channel 9 of middle phase emulsion sample introduction, its one end connection for the side of supporter 14
Mutually go out sample pipeline 10；The interphase goes out sample pipeline 10 and connects and be coaxially disposed with interior phase sample channel 9；
Positioned at foreign minister's sample channel 11 for outer phase emulsion sample introduction of the opposite side of supporter 14, its one end connection foreign minister goes out
Sample pipeline 12；The foreign minister, which goes out sample pipeline 12 and interphase and goes out sample pipeline 10, to be connected and is coaxially disposed；
Steam vent 13, it goes out sample pipeline 12 through foreign minister and stretched into supporter 14；
Wherein, by the sample introduction of interior phase sample channel, interphase sample channel and the different emulsions of foreign minister's sample channel progress,
And sample pipeline is gone out by interphase and foreign minister goes out sample pipeline and forms dual milk particle；
In the above-mentioned technical solutions, the dimethyl silicone polymer that the integrally formed supporter 14 is formed in one
Or modified dimethyl polysiloxane supporter (PDMS)；PDMS is viscoelastic solid, it is easy to insert three-phase pipeline；While PDMS
Material is transparent, it is easy to observe the production of milk particle；PDMS materials are hydrophobic property in itself, and its passage formed is not required to carry out
Hydrophobic treatment can be used as middle oil phase pipeline and use.
The preparation of dual milk particle is carried out using above-mentioned Integral dual milk particle generating means, its operating process is as follows：a.
No. 5 stainless pins are inserted interior phase sample channel 8, it is concordant that bottom goes out the bottom of sample pipeline 10 with interphase by tubulature road；By two 12
Number stainless pin inserts interphase sample channel 9 and foreign minister's sample channel 11 respectively；Using plastic conduit by 3 stainless pins with
Syringe connection equipped with three-phase solution；The glass tube Jing Guo hydrophilic treated is gone out into sample pipeline 12 from lower end insertion foreign minister again；b.
Emulsion is produced, and opens syringe pump, sets three-phase flow velocity, and syringe pump is run successively by foreign minister, interphase, the order of interior phase, and c. is received
Collect milk particle；After syringe pump is stable, internal diameter~2000 μm, the monodispersed water-in-oil-in-water compositions in wall thickness~250 μm can be obtained,
By injecting different solution in foreign minister, interphase, interior phase, can with obtain as：Water/PAMS-FB/PVA, water/PS-FB/
PVA, water/DPS-FB/PVA W/O/W dual milk particle.
The utility model also provides a kind of perfusion mould for processing above-mentioned Integral dual milk particle generating means, including：
As shown in Fig. 2
Fixed outer framework 1, it is hollow structure, phase sample introduction occupy-place circle in the top surface perforate insertion of the fixed outer framework 1
Post 2；Holes insertion interphase sample introduction occupy-place cylinder 3 and steam vent are accounted for above and below being opened respectively in the side of hollow fixation outer framework 1
Circle of position post 7；In another STH insertion foreign minister's sample introduction occupy-place cylinder 4 of hollow fixation outer framework 1；In hollow fixation housing
The lower end perforate insertion foreign minister of frame 1 goes out sample occupy-place cylinder 6；Circular cone is opened from top to bottom in the top that the foreign minister goes out sample occupy-place cylinder 6
Hole and cylindrical hole, insertion interphase goes out sample occupy-place cylinder 5 in the cylindrical hole；The bottom of the interior phase sample introduction occupy-place cylinder 2
Go out the tip contact of sample occupy-place cylinder 5 with interphase；One end of the interphase sample introduction occupy-place cylinder 3 and interphase go out sample occupy-place
The top contacts side surfaces of cylinder 5；One end of foreign minister's sample introduction occupy-place cylinder 4 and foreign minister go out the top side of sample occupy-place cylinder 6
Contact；The steam vent occupy-place cylinder 7 goes out sample occupy-place cylinder 6 through foreign minister and stretched into bellmouth；The interior phase sample introduction occupy-place
Cylinder 2, interphase go out sample occupy-place cylinder 5 and foreign minister goes out sample occupy-place cylinder 6 and is coaxially disposed；
Wherein, perfusion mould pours into hydrophobic transparent dimethyl silicone polymer solution after being completed, and after solidification, takes off successively
Except interior phase sample introduction occupy-place cylinder 2, interphase sample introduction occupy-place cylinder 3, foreign minister's sample introduction occupy-place cylinder 4, steam vent occupy-place cylinder 7, in addition to
Mutually go out sample occupy-place cylinder 6 and interphase goes out sample occupy-place cylinder 5, form integrally formed generator body.
In the above-mentioned technical solutions, the interior phase sample introduction occupy-place cylinder 2, interphase sample introduction occupy-place cylinder 3, foreign minister's sample introduction are accounted for
Circle of position post 4, steam vent occupy-place cylinder 7, foreign minister go out sample occupy-place cylinder 6 and interphase to go out sample occupy-place cylinder 5 be metal bar, use
Metal bar can easily be removed after polymer solution solidification, will not be together with the polymer bonding after solidification.
In the above-mentioned technical solutions, the metal bar is any one in copper rod, iron staff, stainless steel bar, aluminium bar, is used
This technical scheme, easily can remove metal bar, will not be together with the polymer bonding after solidification.
In the above-mentioned technical solutions, the hollow fixation outer framework 1 is that polytetrafluoroethylene (PTFE) fixes outer framework.
In the above-mentioned technical solutions, one end of the interphase sample introduction occupy-place cylinder 3 is provided with goes out sample occupy-place with interphase
The deep-slotted chip breaker that the top side cambered surface of cylinder 5 matches；One end of foreign minister's sample introduction occupy-place cylinder 4 is provided with goes out sample with foreign minister
The deep-slotted chip breaker that the top side cambered surface of occupy-place cylinder 6 matches, using this technical scheme, the He of interphase sample introduction occupy-place cylinder 3
Interphase goes out sample occupy-place cylinder 5, foreign minister's sample introduction occupy-place cylinder 4 and foreign minister and goes out sample occupy-place cylinder 6 and can closely contact, Neng Gou
It forms unimpeded sample intake passage after removing.
Number of devices and treatment scale described herein are for simplifying explanation of the present utility model.To the utility model
Integral dual milk particle generating means and its application of processing mold, modifications and variations be to one skilled in the art
Obviously.
Although embodiment of the present utility model is disclosed as above, it is not restricted in specification and embodiment
Listed to use, it can be applied to various suitable fields of the present utility model completely, for those skilled in the art,
Other modification is easily achieved, therefore under the universal limited without departing substantially from claim and equivalency range, this reality
Specific details is not limited to new and shown here as the legend with description.
Claims (7)
1. a kind of Integral dual milk particle generating means, it is characterised in that including：
Generator body, it includes：Integrally formed supporter；
The interior phase sample channel for internal phase emulsions sample introduction positioned at supporter upper end；
It is used for the interphase sample channel of middle phase emulsion sample introduction positioned at supporter side, its one end connection interphase goes out sample pipe
Road；The interphase goes out sample pipeline and connects and be coaxially disposed with interior phase sample channel；
Positioned at foreign minister's sample channel for outer phase emulsion sample introduction of supporter opposite side, its one end connection foreign minister goes out sample pipeline；
The foreign minister goes out sample pipeline and goes out sample pipeline communication with interphase and be coaxially disposed；
Steam vent, it goes out sample pipeline through foreign minister and stretched into supporter；
Wherein, by the sample introduction of interior phase sample channel, interphase sample channel and the different emulsions of foreign minister's sample channel progress, and lead to
Cross that interphase goes out sample pipeline and foreign minister goes out sample pipeline and forms dual milk particle.
2. Integral dual milk particle generating means as claimed in claim 1, it is characterised in that the integrally formed supporter
The dimethyl silicone polymer or modified dimethyl polysiloxane supporter being formed in one.
3. a kind of processing mold of Integral dual milk particle generating means as claimed in claim 1, it is characterised in that including：
Fixed outer framework, it is hollow structure, phase sample introduction occupy-place cylinder in the top surface perforate insertion of the fixed outer framework；In
The side of empty fixation outer framework open respectively above and below holes insertion interphase sample introduction occupy-place cylinder and steam vent occupy-place cylinder；In
Another STH insertion foreign minister's sample introduction occupy-place cylinder of empty fixation outer framework；Inserted in the lower end perforate of hollow fixation outer framework
Enter foreign minister and go out sample occupy-place cylinder；Conical bore and cylindrical hole are opened in the top that the foreign minister goes out sample occupy-place cylinder from top to bottom, described
Insertion interphase goes out sample occupy-place cylinder in cylindrical hole；The bottom of the interior phase sample introduction occupy-place cylinder and interphase go out sample occupy-place cylinder
Tip contact；One end of the interphase sample introduction occupy-place cylinder and interphase go out the top contacts side surfaces of sample occupy-place cylinder；Institute
One end and foreign minister for stating foreign minister's sample introduction occupy-place cylinder go out the top contacts side surfaces of sample occupy-place cylinder；The steam vent occupy-place cylinder is worn
Foreign minister is crossed to go out sample occupy-place cylinder and stretch into bellmouth；The interior phase sample introduction occupy-place cylinder, interphase go out sample occupy-place cylinder and outer
Mutually go out sample occupy-place cylinder to be coaxially disposed；
Wherein, hydrophobic transparent dimethyl silicone polymer solution is poured into after perfusion mould is completed, after solidification, removed successively
Interior phase sample introduction occupy-place cylinder, interphase sample introduction occupy-place cylinder, foreign minister's sample introduction occupy-place cylinder, steam vent occupy-place cylinder, foreign minister go out sample
Occupy-place cylinder and interphase go out sample occupy-place cylinder, form generator body.
4. the processing mold of Integral dual milk particle generating means as claimed in claim 3, it is characterised in that the interior phase is entered
Sample occupy-place cylinder, interphase sample introduction occupy-place cylinder, foreign minister's sample introduction occupy-place cylinder, steam vent occupy-place cylinder, foreign minister go out sample occupy-place circle
It is metal bar that post and interphase, which go out sample occupy-place cylinder,.
5. the processing mold of Integral dual milk particle generating means as claimed in claim 4, it is characterised in that the metal bar
For any one in copper rod, iron staff, stainless steel bar, aluminium bar.
6. the processing mold of Integral dual milk particle generating means as claimed in claim 3, it is characterised in that described hollow
Fixed outer framework is that polytetrafluoroethylene (PTFE) fixes outer framework.
7. the processing mold of Integral dual milk particle generating means as claimed in claim 3, it is characterised in that the interphase
One end of sample introduction occupy-place cylinder is provided with the deep-slotted chip breaker that the top side cambered surface for going out sample occupy-place cylinder with interphase matches；It is described
One end of foreign minister's sample introduction occupy-place cylinder is provided with the deep-slotted chip breaker that the top side cambered surface for going out sample occupy-place cylinder with foreign minister matches.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201621398303.4U CN206560851U (en) | 2016-12-20 | 2016-12-20 | Integral dual milk particle generating means and its processing mold |
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| CN201621398303.4U CN206560851U (en) | 2016-12-20 | 2016-12-20 | Integral dual milk particle generating means and its processing mold |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106492716A (en) * | 2016-12-20 | 2017-03-15 | 中国工程物理研究院激光聚变研究中心 | Integral dual milk particle generating meanss and its processing method |
-
2016
- 2016-12-20 CN CN201621398303.4U patent/CN206560851U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106492716A (en) * | 2016-12-20 | 2017-03-15 | 中国工程物理研究院激光聚变研究中心 | Integral dual milk particle generating meanss and its processing method |
| CN106492716B (en) * | 2016-12-20 | 2024-01-30 | 中国工程物理研究院激光聚变研究中心 | Integrated double-emulsion particle generating device and processing method thereof |
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