CN206504926U - One kind is electrically isolated device - Google Patents
One kind is electrically isolated device Download PDFInfo
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- CN206504926U CN206504926U CN201720188927.1U CN201720188927U CN206504926U CN 206504926 U CN206504926 U CN 206504926U CN 201720188927 U CN201720188927 U CN 201720188927U CN 206504926 U CN206504926 U CN 206504926U
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- capillary
- solution cavity
- support
- corrosion
- electric isolution
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Abstract
Device is electrically isolated the utility model discloses one kind, including support, interior solution cavity, the capillary for setting cushioning liquid, support is provided with capillary slot, solution cavity is on support, solution cavity one end open, other end closing, electrode is provided with opening, blind end is additionally provided with perforation, and capillary one end is inserted from capillary slot and passed through by perforating from solution cavity, and by setting sealing ring sealed penetration.Using electric isolution device of the present utility model, the electrically separated instrument such as Capillary Electrophoresis, electrochromatography can be successfully used in, with special power-up purposes；By using the method for corrosion, capillary surface is prepared into cavernous structure, easily electricity is incorporated into capillary separation channels, it is to avoid the deficiency such as cumbersome and short life of conventional fabrication method, method is easy, stably, long lifespan；The potential Analyze ＆ separate applied to more complicated sample.
Description
Technical field
The utility model belongs to electrophoresis and chromatography field, and in particular to one kind is electrically isolated device.
Background technology
The electrically separated technology of capillary (including electrophoresis, electrochromatography etc.) it is a kind of efficient, quick differential emerging in recent years
From technology.Compared with other Analytical Separations such as efficient liquid phase, the electrically separated technology of capillary has a Gao Zhuxiao, high separation,
Fast etc. the advantage of high sensitivity and analyze speed, may apply to biological medicine, food security, the every field such as environmental protection.
However, a kind of simple to operate, reliable and stable, the longer electric isolution device of service life and its manufacturing technology urgently go out
It is existing.
Utility model content
Technical problem to be solved in the utility model is to provide a kind of electric isolution device, can be used successfully to capillary electricity
The electrically separated instrument such as swimming, electrochromatography, with special power-up purposes.
In order to solve the above-mentioned technical problem, the utility model is adopted the following technical scheme that：
On the one hand, a kind of be electrically isolated on device, including support, interior solution cavity, the capillary for setting cushioning liquid, support sets
There is capillary slot, solution cavity is on support, solution cavity one end open, the other end is closed, electrode, envelope are provided with opening
Closed end is additionally provided with perforation, and capillary one end is inserted from capillary slot and passed through by perforating from solution cavity, and by setting
Sealing ring sealed penetration.
The cushioning liquid is borax buffer solution.
The support is plate shaped, one kind in circular or column structure.
The capacity of the solution cavity is 0.1ml~100ml.
The capillary is vitreous silica capillary, peek capillaries or stainless steel capillary.
Using electric isolution device of the present utility model, the electrically separated instrument such as Capillary Electrophoresis, electrochromatography can be successfully used in
Device, with special power-up purposes；By using the method for corrosion, a bit of tube wall surface on capillary is prepared porous
Electricity, is easily incorporated into capillary separation channels by the structure of shape, it is to avoid cumbersome and life-span of conventional fabrication method
It is short to wait not enough, method is easy, stably, long lifespan；The potential Analyze ＆ separate applied to more complicated sample.
Brief description of the drawings
Fig. 1 is the top perspective schematic diagram of electric isolution device of the present utility model.
Fig. 2 is the sectional view of the line A-A along along Fig. 1.
Fig. 3 is the rear perspective schematic diagram of electric isolution device of the present utility model.
Fig. 4 is the face upwarding stereogram of electric isolution device of the present utility model.
Fig. 5 is the A portions enlarged diagram in Fig. 2.
Fig. 6 is the exploded perspective view of corrosion device of the present utility model.
Fig. 7 is that the electric isolution device as obtained by the utility model embodiment 1 is applied to adenine, cytimidine, urinates phonetic
Pyridine, the separating resulting curve map of 4 kinds of nucleosides of uridine.
Embodiment
A kind of device that is electrically isolated of the present utility model is as shown in Fig. 1~Fig. 5, including support 1, the interior solution for setting cushioning liquid
Cavity 2, capillary 3, support 1 are provided with capillary slot 5, and solution cavity 2 is on support 1, the one end open of solution cavity 2,
The other end is closed, and electrode 4 is provided with opening, and blind end is additionally provided with perforation, and the one end of capillary 3 is inserted and led to from capillary slot 5
Cross perforation to pass through from solution cavity 2, and by setting the sealed penetration of sealing ring 6, the corrosion part of capillary 3 is fixed on just
Inside solution cavity 2.
As one embodiment, the cushioning liquid is the cushioning liquid such as borax or phosphate.
As one embodiment, the support 1 can use plate shaped, one kind in the structure such as circle, column.
As one embodiment, the capacity of the solution cavity 2 is 0.1ml~100ml.
As one embodiment, the capillary 3 can use vitreous silica capillary, peek capillaries, Stainless Steel Capillary
Pipe or other capillaries, internal diameter are 5 μm -300 μm, and length is by 10cm to 300cm.
Electric isolution device of the present utility model is adopted to be made with the following method：
A. pretreated capillary 3 is installed in corrosion device, the corrosion device is as shown in fig. 6, it is by acidproof
Device 7, the cavity 8 that can load acid solution and capillary are fixed passage 9 and constituted；
B. corrosion liquid and closed corrosion device are poured into and carries out corrosion capillary 3, the corrosion liquid be hydrochloric acid, sulfuric acid,
One or several kinds of mixed liquors in hydrofluoric acid etc., the concentration of the corrosion liquid is between 1%~10%, and corrosion temperature is 25 °
~65 °, the time is 2~48h；
C. corrosion device is opened, with 30~60min of deionized water rinsing capillary rusty surface；
D. after being dried with 50~70 DEG C of temperature of vacuum drying chamber to capillary 3, capillary 3 is installed on support by slot
On 1 and through solution cavity 2, cushioning liquid is poured into solution cavity 2, the cushioning liquid can use borax buffer solution,
It is standby using as mobile phase.
As one embodiment, the pretreatment comprises the following steps：
A1. 5~30min of deionized water rinsing capillary is used；
A2. 3~5h of the scouring of wool tubule is rushed with NaOH solution；
A3. 5~30min of capillary described in deionized water rinsing is used.
As needed, the pretreatment may also include：
A0. before a1 steps rinses 10~50min of capillary tube inner wall with methanol；
A4. after a3 steps rinses 10~30min of capillary with HCl solution；A5. with deionized water rinsing 5~
30min。
Furthermore it is also possible to which repeat step a and step c, so that described corrosion permeability reaches to a certain degree, that is, causes
Capillary surface is in cavernous structure.
Below, preparation method of the present utility model is further illustrated with specific embodiment：
Embodiment 1, this method comprises the following steps：
First, pretreatment：
In order to activate the silicone hydroxyl in capillary, first with deionized water rinsing capillary 30min, then with 1M NaOH
Solution rinses capillary 3h, finally with capillary 30min described in deionized water rinsing.
2nd, it is installed on corrosion device：
The pretreated 75 μm of internal diameter capillary tubes of 50cm length are taken, is installed on and is electrically isolated in the corrosion device of device.
Three：Tarnishing processes
(1) 2ml, 1% hydrochloric acid are poured into；
(2) closed corrosion device, it is to avoid acid solution is volatilized and absorbed water；
(3) room temperature corrosion 6h；
(4) corrosion device is opened, with deionized water rinsing capillary rusty surface 30min；
(5) 50 degree of vacuum drying chambers are dried.
Four：Installation process
The good capillary of corrosion is passed through into solution cavity and is installed on support, borax buffer solution is poured into stand-by.
As shown in fig. 7, to be electrically isolated device application HPCE by the way that embodiment 1 is obtained, realizing fast to gland
The separation of 4 kinds of nucleosides such as purine, cytimidine, uracil, uridine.50 μm of internal diameters, overall length 65cm (effective column length 40cm) electric isolution
Device, using borax buffer solution as mobile phase, separation voltage be -15kV under conditions of, under 254nm wavelength, realize to gland
Purine, cytimidine, uracil, the separation of four kinds of nucleosides of uridine, it is shown that good separating capacity.
Embodiment 2
This method comprises the following steps：
First, pretreatment：
In order to activate the silicone hydroxyl in capillary, methanol is spent first and rinses capillary tube inner wall 20min, ionized water rinses hair
Tubule 10min, then rinses capillary 3h, finally with capillary 30min described in deionized water rinsing with 1M NaOH solution.
2nd, it is installed on corrosion device：
The pretreated 75 μm of internal diameter capillary tubes of 50cm length are taken, is installed on and is electrically isolated in the corrosion device of device.
Three：Tarnishing processes
(1) 2ml, 5% sulfuric acid are poured into；
(2) closed corrosion device, it is to avoid acid solution is volatilized and absorbed water；
(3) room temperature corrosion 3h；
(4) corrosion device is opened, with deionized water rinsing capillary rusty surface 30mi n；
(5) 50 degree of vacuum drying chambers are dried.
Four：Installation process
The good capillary of corrosion is passed through into solution cavity and is installed on support, borax buffer solution is poured into stand-by.
Embodiment 3
This method comprises the following steps：
First, pretreatment：
In order to activate the silicone hydroxyl in capillary, capillary tube inner wall 40min, deionized water rinsing are rinsed with methanol successively
20min, 1M NaOH solution rinse capillary 3h, deionized water rinsing 20min, 1M HCl 20min, and deionization is finally used again
Water rinses the capillary 30min.
2nd, it is installed on corrosion device：
The pretreated 75 μm of internal diameter capillary tubes of 60cm length are taken, are installed in electric isolution device corrosion device；
Three：Tarnishing processes
(1) 2ml, 3% hydrofluoric acid are poured into；
(2) closed corrosion device, it is to avoid acid solution is volatilized and absorbed water；
(3) 30 DEG C of corrosion 3.5h；
(4) isolating device device is opened, with deionized water rinsing capillary rusty surface 50min；
(5) 70 degree of vacuum drying chambers are dried.
Four：Installation process
The good capillary of corrosion is installed on support, cushioning liquid is poured into stand-by.
Embodiment 4
The present embodiment is related to a kind of preparation method for being electrically isolated device, comprises the following steps：
First, pretreatment：
In order to activate the silicone hydroxyl in capillary, capillary 30min, deionized water rinsing 10min are rinsed with methanol successively,
1M NaOH solution rinses capillary 2h, and deionized water rinsing 10min, 1M HCl rinse 10min, deionized water finally used again
Rinse the capillary 30min.
2nd, it is installed on corrosion device：
The pretreated 75 μm of internal diameter capillary tubes of 60cm length are taken, are installed in electric isolution device corrosion device；
Three：Tarnishing processes
(1) 2ml, 8% hydrochloric acid are poured into；
(2) closed electric isolution device device, it is to avoid acid solution is volatilized and absorbed water；
(3) 40 DEG C of corrosion 2h；
(4) isolating device device is opened, with deionized water rinsing capillary rusty surface 30min；
After (5) 50 degree of vacuum drying chambers are dried.
Four：Installation process
The good capillary of corrosion is installed on support, cushioning liquid is poured into stand-by.
The obtained device that is electrically isolated of embodiment 2,3,4 is equally detected according to the method for embodiment 1, equally measured point
From better performances.
But, those of ordinary skill in the art is it should be appreciated that the embodiment of the above is intended merely to explanation originally
Utility model, and be not used as it is of the present utility model limit, if in spirit of the present utility model, to
Change, the modification of the upper embodiment will all fall in Claims scope of the present utility model.
Claims (5)
1. one kind is electrically isolated device, it is characterised in that：Including support, interior solution cavity, the capillary for setting cushioning liquid, on support
Provided with capillary slot, solution cavity is on support, solution cavity one end open, other end closing, and electrode is provided with opening,
Blind end is additionally provided with perforation, and capillary one end is inserted from capillary slot and passed through by perforating from solution cavity, and by setting
Put sealing ring sealed penetration.
2. electric isolution device according to claim 1, it is characterised in that：The cushioning liquid is borax buffer solution.
3. electric isolution device according to claim 1, it is characterised in that：The support is plate shaped, circular or column knot
One kind in structure.
4. electric isolution device according to claim 1, it is characterised in that：The capacity of the solution cavity be 0.1ml~
100ml。
5. electric isolution device according to claim 4, it is characterised in that：The capillary be vitreous silica capillary,
Peek capillaries or stainless steel capillary.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720188927.1U CN206504926U (en) | 2017-03-01 | 2017-03-01 | One kind is electrically isolated device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720188927.1U CN206504926U (en) | 2017-03-01 | 2017-03-01 | One kind is electrically isolated device |
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| Publication Number | Publication Date |
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| CN206504926U true CN206504926U (en) | 2017-09-19 |
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| CN201720188927.1U Active CN206504926U (en) | 2017-03-01 | 2017-03-01 | One kind is electrically isolated device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106840825A (en) * | 2017-03-01 | 2017-06-13 | 上海通微分析技术有限公司 | One kind electric isolution device and preparation method thereof |
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2017
- 2017-03-01 CN CN201720188927.1U patent/CN206504926U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106840825A (en) * | 2017-03-01 | 2017-06-13 | 上海通微分析技术有限公司 | One kind electric isolution device and preparation method thereof |
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