CN206473863U - A kind of resin chromatography splitter - Google Patents
A kind of resin chromatography splitter Download PDFInfo
- Publication number
- CN206473863U CN206473863U CN201720083320.7U CN201720083320U CN206473863U CN 206473863 U CN206473863 U CN 206473863U CN 201720083320 U CN201720083320 U CN 201720083320U CN 206473863 U CN206473863 U CN 206473863U
- Authority
- CN
- China
- Prior art keywords
- chuck
- resin
- feed pipe
- cylinder
- rinse tank
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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- 239000011347 resin Substances 0.000 title claims abstract description 60
- 229920005989 resin Polymers 0.000 title claims abstract description 60
- 238000004587 chromatography analysis Methods 0.000 title claims abstract description 23
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000006004 Quartz sand Substances 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 238000007599 discharging Methods 0.000 claims abstract description 6
- 239000004744 fabric Substances 0.000 claims abstract description 6
- 230000035699 permeability Effects 0.000 claims abstract description 5
- 239000002245 particle Substances 0.000 claims description 5
- 239000012780 transparent material Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 238000009413 insulation Methods 0.000 abstract description 3
- 238000010438 heat treatment Methods 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 description 14
- PYMYPHUHKUWMLA-LMVFSUKVSA-N aldehydo-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 10
- 238000007445 Chromatographic isolation Methods 0.000 description 6
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 5
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000011010 flushing procedure Methods 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 230000003321 amplification Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 238000004382 potting Methods 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Landscapes
- Devices And Processes Conducted In The Presence Of Fluids And Solid Particles (AREA)
Abstract
The utility model proposes a kind of resin chromatography splitter, including the feed pipe set above cylinder, upper capping, feed pipe side is provided with the discharging opening set in charging aperture, lower capping, one end that feed pipe is stretched into capping is connected with distributor, it is connected above feed pipe with rinse tank, it is provided with rinse tank above screen cloth, rinse tank and is provided with overfall, upper capping is provided with manhole and loophole；Lower section, which is provided with below quartz sand layer, quartz sand layer, in cylinder is provided with arch-shaped clapboard, and arch-shaped clapboard is provided with permeability hole；Cylinder outer wall is provided with chuck, and chuck bottom is provided with water inlet, and chuck top is provided with delivery port；Resin outlet is provided with below chuck.Resin column center section outer wall is provided with chuck, and chuck bottom is provided with hot water inlet, and top is provided with hot water outlet, can carry out insulation operation to chromatography column by chuck heating, it is ensured that production is normally carried out.
Description
Technical field
The utility model belongs to chemical field, and in particular to resin chromatography splitter is used in a kind of D-ribose production.
Background technology
Purification workshop section in D-ribose production process is needed to use chromatography column, and chromatography column at present is only included
Resin column, resin column housing is individual layer, and D-ribose feed liquid can only be divided under normal temperature condition by chromatography column
From purification, and chromatography column needs periodically to carry out recoil rinsing in use, prevents resin to be compacted, and removes miscellaneous in resin
Matter, is primarily present following shortcoming in actual production process：Due to D-ribose, viscosity is larger under cryogenic, and chromatogram point
It can only be operated from post under normal temperature condition, when temperature is relatively low, chromatography column flows decrease, separating effect is deteriorated, chromatogram point
From post treatment effeciency degradation, larger is influenceed on manufacturing schedule.
Chromatography column needs periodically progress recoil rinsing to prevent resin to be compacted in use, removes miscellaneous in resin
Matter, because resin column fills up chromatographic isolation resin, upper space is smaller and chromatographic isolation resin density is smaller, in recoil rinsing
During the situation that chromatographic isolation resin is overflowed by overfall can often occur, cause chromatographic isolation resin waste, increase life
Produce cost.
Resin is installed after post, it is possible to carry out liquid separating-purifying.But when liquid flows into resin separating column, it can rush
The resin particle on surface, makes resin separating column surface form spill, and liquid produces bias current and vortex when passing through resin column, influence is most
Whole separating resulting.
Utility model content
The utility model can not be incubated to solve existing chromatography column, chromatogram can often occur in recoil rinse cycle
There is provided a kind of chromatography column by technical problem that overfall overflows for separation resin.
Realizing the technical solution of the utility model is：Set above a kind of resin chromatography splitter, including cylinder, upper capping
Feed pipe, the discharging opening that feed pipe side is set provided with charging aperture, in lower capping, one end that feed pipe is stretched into capping connects
It is connected to above distributor, feed pipe and is connected with rinse tank, is provided with rinse tank above screen cloth, rinse tank and is provided with overfall, upper envelope
Cover provided with manhole and loophole；Lower section, which is provided with below quartz sand layer, quartz sand layer, in cylinder is provided with arch-shaped clapboard, arch-shaped clapboard
It is provided with permeability hole；Cylinder outer wall is provided with chuck, and chuck bottom is provided with water inlet, and chuck top is provided with delivery port；Below chuck
Provided with resin outlet.
Pipeline between rinse tank and charging aperture is provided with valve.
Quartz sand layer is set to layer 2-4, and quartz sand particle mesh number reduces from top to bottom.
Manhole is provided with explosion-proof with the lid being respectively provided with above loophole above the lid being made up of transparent material, loophole
Lamp.
Distributor body is into circle, and distributor lower section, which is connected with to be connected with below house steward, house steward, to be in charge of, and is in charge of lower section uniform
Provided with nozzle.
Set one to enclose along inboard wall of cylinder below cylinder and circular plate be provided with below U-lag, arch-shaped clapboard, circular plate with
U-lag is engaged.
The beneficial effects of the utility model are：1. resin column center section outer wall is provided with chuck, chuck bottom is provided with heat
Water inlet, top is provided with hot water outlet, can carry out insulation operation to chromatography column by chuck heating, it is ensured that production is normally entered
OK；2. being connected at the top of resin column by pipeline with rinse tank, connecting pipe is provided with valve, and rinse tank top is provided with overfall,
Increase after rinse tank, be effectively reduced chromatographic isolation resin in recoil rinse cycle and overflowed by overfall；3. use this practicality
It is new to carry out insulation operation to chromatography column, influence of the low temperature to production is efficiently solved, increase rinse tank is solved instead
The problem of chromatographic isolation resin is overflowed by overfall during rinsing, reduces equipment operation cost, improves product competition
Power；4. setting distributor above resin separating column, liquid is evenly spread to liquid on resin by distributor into resin,
The too fast resin particle for having rushed surface of flow rate of liquid is prevented, resin separating column surface is formed spill, bias current and vortex shadow is produced
Ring and be finally recovered effect.
Brief description of the drawings
Fig. 1 is structural representation of the present utility model；
Fig. 2 is the amplification plan view of distributor.
Embodiment
As shown in Figure 1-2, the feed pipe set above a kind of resin chromatography splitter, including cylinder, upper capping, feed pipe
Side is provided with the discharging opening 17 set in charging aperture 7, lower capping, and one end that feed pipe is stretched into capping is connected with distributor,
It is connected above feed pipe with rinse tank 8, screen cloth 9 is provided with rinse tank 8, the top of rinse tank 8 is provided with overfall 10, upper capping and set
There are manhole 11 and loophole 5；Lower section is provided with quartz sand layer 13 in cylinder, and the lower section of quartz sand layer 13 is provided with arch-shaped clapboard 14, arch
Dividing plate 14 is provided with permeability hole 16；Cylinder outer wall is provided with chuck 2, and the bottom of chuck 2 is provided with water inlet 1, and the top of chuck 2 is provided with water outlet
Mouth 12；The lower section of chuck 2 is provided with resin outlet 15.
During work, resin outlet 15 is closed, several layers of quartz sands are laid below cylinder, the mesh number from top to bottom of quartz sand layer 13
Once reduce, the lower section of quartz sand layer 13 is arch-shaped clapboard 14, afterwards from manhole 11 into cylinder potting resin, treating that resin reaches needs
During the amount wanted, capping, lower capping, manhole 11, loophole 5, valve 8-1 in closing open hot and cold water, allow hot and cold water to flow through folder
Set, flowed into from water inlet 1, is flowed out afterwards from delivery port 12, it is ensured that moderate temperature in resin separation process middle column body, if summer
Temperature is too high, can be passed through cold water, and winter temperature is too low, is passed through hot water, prevents the viscosity and then shadow of the too low influence liquid of temperature
Separating effect is rung, D-ribose feed liquid is entered in distributor from charging aperture 7 afterwards, distributor body is into circle, below distributor
House steward 4 is connected with, the lower section of house steward 4, which is connected with, is in charge of 3, is in charge of 3 lower sections and is uniformly provided with nozzle, liquid is flowed into from house steward 4 is in charge of 3
It is interior, then from being in charge of in the nozzle inflow resin column that lower section is set, prevent liquid from flowing directly into resin column using distributor, cause
Groove is formed above resin column, bias current is produced and is finally recovered effect with vortes interference.Liquid is through resin and quartz sand layer 13, afterwards
Flow down, flowed out from discharging opening 17 through the permeability hole 16 on arch-shaped clapboard 14, the purpose for setting arch-shaped clapboard 14 is that arcuate surface can
Effectively relax the pressure that resin bed is brought.
It is preferred that, the pipeline between rinse tank 8 and charging aperture 7 is provided with valve 8-1.When resin uses a period of time
Afterwards, it is necessary to recoil to resin and rinsed, now need to open valve 8-1, backwash liquid slowly rises from resin bottom, resin
Recoil is got up, and counter-flushing liquid is flowed into rinse tank 8 from pipeline, and rinse tank 8 is provided with screen cloth 9, and screen cloth 9 can be prevented effectively on resin
Floating, and the partially liq for rinsing resin can flow out from overfall 10, remaining flushing liquor is treated after resin sedimentation from discharging opening 17
Outflow, further, quartz sand layer 13 is set to layer 2-4, and quartz sand particle mesh number reduces from top to bottom.
Further, manhole 11 is respectively provided with the lid being made up of transparent material, the top of loophole 5 with the top of loophole 5
Lid be provided with explosion-proof lamp 6, need often to observe resin situation in cylinder in the course of work, can now open explosion-proof lamp 6,
Because the lid above loophole 5 is set to transparent, the light of explosion-proof lamp 6 enters in cylinder through lid, and staff can
With from the progress of manhole 11.
Claims (6)
1. the charging that the feed pipe set above a kind of resin chromatography splitter, including cylinder, upper capping, feed pipe side are set
Mouthful（7）, the discharging opening that sets in lower capping（17）, it is characterised in that：Feed pipe stretches into the connection of one end in capping and is distributed
Device, feed pipe top and rinse tank（8）It is connected, rinse tank（8）It is interior to be provided with screen cloth（9）, rinse tank（8）Top is provided with overfall
（10）, upper capping is provided with manhole（11）With loophole（5）；Lower section is provided with quartz sand layer in cylinder（13）, quartz sand layer（13）
Lower section is provided with arch-shaped clapboard（14）, arch-shaped clapboard（14）It is provided with permeability hole（16）；Cylinder outer wall is provided with chuck（2）, chuck（2）
Bottom is provided with water inlet（1）, chuck（2）Top is provided with delivery port（12）；Chuck（2）Lower section is provided with resin outlet（15）.
2. resin chromatography splitter according to claim 1, it is characterised in that：Rinse tank（8）With charging aperture（7）Between
Pipeline is provided with valve（8-1）.
3. resin chromatography splitter according to claim 1, it is characterised in that：Quartz sand layer（13）Layer 2-4 is set to, from
Top to bottm quartz sand particle mesh number reduces.
4. resin chromatography splitter according to claim 1, it is characterised in that：Manhole（11）With loophole（5）Top is equal
The lid being made up of transparent material, loophole are set（5）The lid of top is provided with explosion-proof lamp（6）.
5. resin chromatography splitter according to claim 1, it is characterised in that：Distributor body is into circle, under distributor
Side is connected with house steward（4）, house steward（4）Lower section, which is connected with, to be in charge of（3）, it is in charge of（3）Lower section is uniformly provided with nozzle.
6. resin chromatography splitter according to claim 1, it is characterised in that：One is set to enclose along inboard wall of cylinder below cylinder
U-lag, arch-shaped clapboard（14）Lower section is provided with circular plate, and circular plate is engaged with U-lag.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720083320.7U CN206473863U (en) | 2017-01-23 | 2017-01-23 | A kind of resin chromatography splitter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720083320.7U CN206473863U (en) | 2017-01-23 | 2017-01-23 | A kind of resin chromatography splitter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206473863U true CN206473863U (en) | 2017-09-08 |
Family
ID=59753953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720083320.7U Active CN206473863U (en) | 2017-01-23 | 2017-01-23 | A kind of resin chromatography splitter |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206473863U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109569025A (en) * | 2018-12-29 | 2019-04-05 | 中国原子能科学研究院 | A kind of extraction separation device, methods and applications |
-
2017
- 2017-01-23 CN CN201720083320.7U patent/CN206473863U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109569025A (en) * | 2018-12-29 | 2019-04-05 | 中国原子能科学研究院 | A kind of extraction separation device, methods and applications |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20231011 Address after: 458000 No.9 Muping Road, Shancheng District, Hebi City, Henan Province Patentee after: Xintuoyang Bioengineering Co.,Ltd. Address before: No. 30 Huahua Road, High tech Zone, Zhengzhou City, Henan Province, 450066 Patentee before: Zhengzhou Tuoyang Biological Engineering Co.,Ltd. |
|
| TR01 | Transfer of patent right |