CN206445218U - A kind of continuous reaction unit for preparing collaurum - Google Patents
A kind of continuous reaction unit for preparing collaurum Download PDFInfo
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- CN206445218U CN206445218U CN201720080688.8U CN201720080688U CN206445218U CN 206445218 U CN206445218 U CN 206445218U CN 201720080688 U CN201720080688 U CN 201720080688U CN 206445218 U CN206445218 U CN 206445218U
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- collaurum
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Abstract
The utility model discloses the reaction unit for continuously preparing collaurum, including raw material stainless steel, reaction vessel and the heater for heating response container；Raw material stainless steel is provided with feed(raw material)inlet, mixture export and agitating device；The arrival end of reaction vessel is connected with mixture export, and the port of export of reaction vessel is provided with collaurum collection vessel；The liquid formation mixed liquor that agitating device is used to stir in raw material stainless steel；The duration that mixed liquor is flowed into from reaction vessel arrival end and flowed out from the port of export matches with setting duration.Charging, mixing, reaction and the continous way production that is collected as of collaurum of whole reaction unit are designed, but its is simple in construction, no complicated pipe spray apparatus, production is time-consuming short, collaurum can not only be produced in enormous quantities, also can small-scale production collaurum, pass through open and close valve and can adjust collaurum preparation amount.
Description
Technical field
The utility model is related to a kind of reaction unit for preparing collaurum, more particularly to a kind of continuously prepares the anti-of collaurum
Answer device.
Background technology
Collaurum is that gold chloride is reduced into the stabilization formed after golden simple substance, uniformly, in single dispersity is suspended in liquid
Gold grain suspension in body, collaurum can be used for immunohistochemistry, immunity percolation, immunochromatography technique as label
Deng colloid gold label has developed into an important immunolabelling technique during the nearly last ten years.Colloid gold immune is analyzed in medicine
The research in many fields such as detection, biomedicine has been developed, and is increasingly paid attention to by Related Research Domain.
Traditional collaurum production process is difficult to control nucleation and formation speed in reduction process well, so makes
Standby colloidal gold particle particle heterogeneity, size and shape (such as ellipse, triangle, rectangle, rhombus) can not also be controlled
System；Such particle will be unable to uniformly be coated with the cohesive process with albumen, can not be uniformly distributed in the solution, finally
Color, sensitiveness, specificity and the stability of product will be influenceed.The production method of existing collaurum includes batch and produces and connect
Continuous formula production；Batch production is applied to limited production, and it is referred to as batch reactor using container, in batch reactor, because
The concentration of reactant and product be with time consecutive variations, can be by the reduction or the increasing of production concentration of observing response thing concentration
Greatly, reaction is tracked according to concentration and the functional relation of time；But batch production yields is small, production that can only be in batches,
Can not continuously it be produced, time-consuming for production, batch produces the colloid gold particle difference in size between uncontrollable different batches,
Uncontrollable directly result in of differences between batches is difficult to prepare a large amount of homogeneous, stable colloidal gold solutions.And continous way production is suitable
For mass producing, reactant is continuously added into reactor during production, and product is constantly formed and continuously removed, meanwhile, continous way
Production needs to be equipped with complicated pipe spray apparatus for the cleaning to equipment, and batch production is small due to its yield, then without complicated
Pipe spray apparatus；Existing collaurum production equipment lacks a kind of company for being not only suitable for small-scale production again suitable for large-scale production
Continuous formula collaurum production equipment, and without being equipped with complicated pipe spray apparatus.
Utility model content
The purpose of this utility model seeks to overcome existing collaurum production equipment to carry out small-scale continous way life
Production or traditional continous way production, the colloidal gold particle particle of preparation are uneven, and there is provided a kind of continuous for the problem of device structure is complicated
The reaction unit of collaurum is prepared, it has simple in construction, it is adaptable to the continuous production of large and small scale, production is time-consuming short, prepares
Colloidal gold particle particle it is homogeneous, the characteristics of granular size and controlled shape.
To achieve the above object, the continuous reaction unit for preparing collaurum designed by the utility model, including raw material are mixed
Close container, reaction vessel and the heater for heating the reaction vessel；The raw material stainless steel enters provided with raw material
Mouth, mixture export and agitating device；The arrival end of the reaction vessel is connected with the mixture export, the reaction vessel
The port of export be provided with collaurum collection vessel；The liquid that the agitating device is used to stir in the raw material stainless steel forms mixed
Close liquid；The duration that the mixed liquor is flowed into from the reaction vessel arrival end and flowed out from the port of export matches with setting duration.
Further, the reaction vessel is the body for spiraling or bending, or is flat box body.
The beneficial effect of above-mentioned further scheme is：Pass through the body that reaction vessel is set to spiral or bent so that
The path that mixed liquor in reaction vessel flows in certain displacement range is longer, reduces the volume of reaction unit；And due to
Body is to spiral or bend so that further mixing occurs in flow process for mixed liquor so that reaction is more fully, uniformly；It is logical
Cross and reaction vessel is set to flat box body, the reaction vessel made is easily manufactured, installs and cleaned.
Further, the reaction vessel is obliquely installed, and its arrival end is higher than the port of export.
The beneficial effect of above-mentioned further scheme is：By the way that reaction vessel is obliquely installed so that internal mix liquid is in weight
Moved under power effect to the port of export, reduce the setting of pump so that reaction unit structure is simpler；It can be tilted simultaneously by changing it
The angular adjustment reaction time.
Further, the heater is constant water bath box；The reaction vessel is placed in the constant water bath box.
The beneficial effect of above-mentioned further scheme is：Heated at constant temperature is carried out to reaction vessel by constant water bath box, improved
Reaction efficiency.
Preferably, the raw material stainless steel, reaction vessel and collaurum collection vessel are all glass material.
The beneficial effect of above-mentioned preferred scheme is：By using glass material, prevent that the pollution effect colloid of container is golden
Amount and stability.
Preferably, the agitating device in the raw material stainless steel magnetic stir bar and with stirring that it coordinates
Mix device.
Further, the feed(raw material)inlet has multiple.
Preferably, the feed(raw material)inlet, which connects to set, is communicated with raw material cabin.
Further, it is additionally provided with waste liquid outlet in the raw material stainless steel；The port of export of the reaction vessel and described
Feed(raw material)inlet, mixture export and the waste liquid outlet of raw material stainless steel are respectively equipped with open and close valve.
The beneficial effect of above-mentioned further scheme is：It is easy to clean raw material stainless steel by waste liquid outlet；Pass through opening and closing
The effect of valve, is easy to control and adjusts collaurum preparation amount.
Preferably, the arrival end of the reaction vessel and the removable connection of mixture export of the raw material stainless steel.
The beneficial effect of above-mentioned preferred scheme is：Pass through reaction vessel and the removable connection of raw material stainless steel so that anti-
Answer device cleaning replacement convenient.
The beneficial effects of the utility model are：By the way that raw material stainless steel is connected with reaction vessel, and limit mixed liquor
The duration for flowing into and being flowed out from the port of export from reaction vessel arrival end matches with setting duration so that mixed liquor enters reaction and held
Start reaction after device immediately, until being right up to reaction duration needed for reaction when being flowed out from the port of export, finally flow out to collaurum
Collection vessel；Charging, mixing, reaction and the continous way production that is collected as of collaurum of whole reaction unit are designed, but its structure
Simply, no complicated pipe spray apparatus, production is time-consuming short, can not only produce collaurum in enormous quantities, also can small-scale production colloid
Gold, collaurum preparation amount is can adjust by open and close valve.Due to different material storehouse can independent control, and can arbitrarily adjust raw material addition
Amount so that different material can be added with arbitrary proportion, so as to prepare the collaurum of variable grain size according to demand
Solution.
Brief description of the drawings
Fig. 1 is a kind of structural representation of the continuous reaction unit for preparing collaurum of the utility model.
In figure, 1. raw material stainless steels；1.1. feed(raw material)inlet；1.2. mixture export；1.3. waste liquid outlet；2. reaction is held
Device；2.1. arrival end；2.2. the port of export；3. heater；4. agitating device；5. collaurum collection vessel；6. open and close valve；7. it is former
Feed bin.
Embodiment
The utility model is described in further detail below in conjunction with the drawings and specific embodiments.
The continuous reaction unit for preparing collaurum as shown in Figure 1, including raw material stainless steel 1, reaction vessel 2 and be used for
The heater 3 of heating response container 2；Raw material stainless steel 1 is provided with feed(raw material)inlet 1.1, mixture export 1.2 and stirring dress
Put 4；The arrival end 2.1 of reaction vessel 2 is connected with mixture export 1.2, and the port of export 2.2 of reaction vessel 2 is received provided with collaurum
Collect container 5；The liquid formation mixed liquor that agitating device 4 is used to stir in raw material stainless steel 1；Mixed liquor enters from reaction vessel 2
The duration that mouth end 2.1 flows into and flowed out from the port of export 2.2 matches with setting duration.
Wherein, preferably, mixed liquor flowed into from the arrival end 2.1 of reaction vessel 2 and from the port of export 2.2 flow out when it is a length of
10 minutes, that is, a length of 10 minutes during the setting reacted, but it is not excluded for other setting durations；The heated temperature of reaction vessel 2 is high
In 90 DEG C, preferably 95 DEG C.
Reaction vessel 2 is the body for spiraling or bending, or is flat box body.By the way that reaction vessel 2 is set to spiral
Or the body of bending so that the path that the mixed liquor in reaction vessel 2 flows in certain displacement range is longer, reduces reaction
The volume of device；And because body is to spiral or bend so that further mixing occurs in flow process for mixed liquor so that anti-
Should more fully, uniformly；By the way that reaction vessel 2 to be set to flat box body, the reaction vessel 2 made is easily manufactured, install and
Cleaning.
Reaction vessel 2 is obliquely installed, and its arrival end 2.1 is higher than the port of export 2.2.By the way that reaction vessel 2 is obliquely installed, make
Obtain internal mix liquid to move to the port of export 2.2 under gravity, reduce the setting of pump so that reaction unit structure is simpler；
Simultaneously can be by changing its angle of inclination adjusting reaction time.
Heater 3 is constant water bath box；Reaction vessel 2 is placed in constant water bath box.By constant water bath box to reaction
Container 2 carries out heated at constant temperature, improves reaction efficiency.
Raw material stainless steel 1, reaction vessel 2 and collaurum collection vessel 5 are all glass material.By using glass material
Matter, prevents the pollution effect collaurum quality and stability of container.
Agitating device 4 is the magnetic stir bar in raw material stainless steel 1 and the agitator coordinated with it.
Feed(raw material)inlet 1.1 has multiple.
Feed(raw material)inlet 1.1, which connects to set, is communicated with raw material cabin 7.
Waste liquid outlet 1.3 is additionally provided with raw material stainless steel 1；The port of export 2.2 and raw material stainless steel 1 of reaction vessel 2
Feed(raw material)inlet 1.1, mixture export 1.2 and waste liquid outlet 1.3 be respectively equipped with open and close valve 6.It is easy to clearly by waste liquid outlet 1.3
Wash raw material stainless steel 1；By the effect of open and close valve 6, it is easy to control and adjusts collaurum preparation amount.
The arrival end 2.1 of reaction vessel 2 and the removable connection of the mixture export 1.2 of raw material stainless steel 1.Pass through reaction
Container 2 and the removable connection of raw material stainless steel 1 so that reaction unit cleaning replacement is convenient.
By opening the open and close valve 6 at feed(raw material)inlet 1.1 so that corresponding raw material enters raw material stainless steel 1, in stirring dress
Mixed in the presence of putting 4, mixed mixed liquor flows into reaction vessel 2 by the arrival end 2.1 of reaction vessel 2, because reaction is held
Device 2 is heated to more than 90 DEG C, thus mixed liquor once into reaction vessel 2 i.e. start reaction, until reaction 10 minutes after from
The port of export 2.2 flows out；The collaurum of preparation is flowed out in collaurum collection vessel 5；Therefore, can not in collaurum collection vessel 5
It is disconnected to there is freshly prepd collaurum to enter；If the collaurum discharge of 2 port of export of reaction vessel 2.2 is former with entering at feed(raw material)inlet 1.1
Expect that the material quantity in stainless steel 1 is identical, then reaction unit can continuously produce collaurum, when if desired stopping reaction, close former
Material entrance 1.1 at or mixture export 1.2 at open and close valve 6 can stopped reaction, it is necessary to continue prepare when, be then turned on accordingly opening
Valve closing 6.
Claims (10)
1. a kind of continuous reaction unit for preparing collaurum, it is characterised in that：Including raw material stainless steel (1), reaction vessel (2)
And for heating the heater (3) of the reaction vessel (2)；The raw material stainless steel (1) is provided with feed(raw material)inlet
(1.1), mixture export (1.2) and agitating device (4)；The arrival end (2.1) of the reaction vessel (2) goes out with the mixed liquor
Mouth (1.2) connection, the port of export (2.2) of the reaction vessel (2) is provided with collaurum collection vessel (5)；The agitating device (4)
For stirring the formation mixed liquor of the liquid in the raw material stainless steel (1)；The mixed liquor is from the reaction vessel (2) entrance
The duration that end (2.1) flows into and flowed out from the port of export (2.2) matches with setting duration.
2. a kind of continuous reaction unit for preparing collaurum according to claim 1, it is characterised in that：The reaction vessel
(2) it is the body for spiraling or bending, or is flat box body.
3. a kind of continuous reaction unit for preparing collaurum according to claim 1, it is characterised in that：The reaction vessel
(2) it is obliquely installed, its arrival end (2.1) is higher than the port of export (2.2).
4. a kind of continuous reaction unit for preparing collaurum according to claim 1, it is characterised in that：The heater
(3) it is constant water bath box；The reaction vessel (2) is placed in the constant water bath box.
5. a kind of continuous reaction unit for preparing collaurum according to any one of Claims 1-4, it is characterised in that：Institute
It is all glass material to state raw material stainless steel (1), reaction vessel (2) and collaurum collection vessel (5).
6. a kind of continuous reaction unit for preparing collaurum according to claim 5, it is characterised in that：The agitating device
(4) it is the magnetic stir bar in the raw material stainless steel (1) and the agitator coordinated with it.
7. a kind of continuous reaction unit for preparing collaurum according to claim 5, it is characterised in that：The feed(raw material)inlet
(1.1) have multiple.
8. a kind of continuous reaction unit for preparing collaurum according to claim 5, it is characterised in that：The feed(raw material)inlet
(1.1) connect to set and be communicated with raw material cabin (7).
9. a kind of continuous reaction unit for preparing collaurum according to claim 5, it is characterised in that：The raw material mixing
Waste liquid outlet (1.3) is additionally provided with container (1)；The port of export (2.2) and the raw material stainless steel of the reaction vessel (2)
(1) feed(raw material)inlet (1.1), mixture export (1.2) and waste liquid outlet (1.3) is respectively equipped with open and close valve (6).
10. a kind of continuous reaction unit for preparing collaurum according to claim 5, it is characterised in that：The reaction is held
The arrival end (2.1) of device (2) and the removable connection of mixture export (1.2) of the raw material stainless steel (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720080688.8U CN206445218U (en) | 2017-01-22 | 2017-01-22 | A kind of continuous reaction unit for preparing collaurum |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720080688.8U CN206445218U (en) | 2017-01-22 | 2017-01-22 | A kind of continuous reaction unit for preparing collaurum |
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| Publication Number | Publication Date |
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| CN206445218U true CN206445218U (en) | 2017-08-29 |
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| CN201720080688.8U Active CN206445218U (en) | 2017-01-22 | 2017-01-22 | A kind of continuous reaction unit for preparing collaurum |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106735306A (en) * | 2017-01-22 | 2017-05-31 | 武汉璟泓万方堂医药科技股份有限公司 | A kind of continuous reaction unit for preparing collaurum |
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2017
- 2017-01-22 CN CN201720080688.8U patent/CN206445218U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106735306A (en) * | 2017-01-22 | 2017-05-31 | 武汉璟泓万方堂医药科技股份有限公司 | A kind of continuous reaction unit for preparing collaurum |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: 430000 No.18, East biopark Road, Donghu New Technology Development Zone, Wuhan City, Hubei Province Patentee after: Wuhan Jinghong Technology Co., Ltd Address before: 430075, No. 858, high-tech Avenue, Jiangxia District, Hubei, Wuhan, Optics Valley biological pharmaceutical base, two stage, A86-2 Patentee before: Wuhan Jinghong Wanfangtang Medical Technology Co., Ltd. |
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| CP03 | Change of name, title or address |