CN206396103U - A kind of extraction element of cross-linking sodium hyaluronate gel - Google Patents
A kind of extraction element of cross-linking sodium hyaluronate gel Download PDFInfo
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- CN206396103U CN206396103U CN201720034607.0U CN201720034607U CN206396103U CN 206396103 U CN206396103 U CN 206396103U CN 201720034607 U CN201720034607 U CN 201720034607U CN 206396103 U CN206396103 U CN 206396103U
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- pipeline
- centrifuge
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- tank
- sodium hyaluronate
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Abstract
A kind of extraction element of cross-linking sodium hyaluronate gel, it is characterized in that：Including insulated and stirred tank, filtering centrifuge, second agitator tank, chromatographic column, secondary centrifuging component and collecting tank are sequentially connected, the arrival end of the insulated and stirred tank is provided with zymotic fluid entrance and water inlet, top includes three additive entrances, top layer of the bottom side provided with pipeline and filtering centrifuge is connected, the filtering centrifuge from top to bottom includes filter layer successively, centrifuge layer and washing layer, the washing layer both sides are respectively equipped with the waterpipe of one-in-and-one-out, bottom is connected provided with pipeline with the second agitator tank, the second agitator tank bottom side is provided with pipeline with being connected at the top of chromatographic column, the chromatography column bottom is connected provided with pipeline with secondary centrifuging component.The utility model is designed for the extraction process of cross-linking sodium hyaluronate gel, and structure is novel, and technological process is carried out into modularization, improves quantity-produced operability.
Description
Technical field
The utility model is related to the production equipment of hyaluronic acid sodium gel, particularly a kind of cross-linking sodium hyaluronate gel
Extraction element.
Background technology
Sodium hyaluronate (Sodium Hyaluronate) is a kind of macromolecule polysaccharide body being present in cockscomb and animal connective tissue,
Its extracting and refining from animal connective tissue is obtained, Hyaluronic Acid or sodium hyaluronate with good water-retaining property and lubricity
(Sodium Hyaluronate).The primary raw material of cosmetics and the viscoelastic agent of ophthalmologic operation, the profit of Bones and joints chamber have been widely used as it at present
Anti-blocking agent in lubrication prescription, and gynaecology, surgical operation.
At present, the method for production hyaluronic acid is mostly fermentation extraction method at present.After ferment tank terminates, zymotic fluid warp
Cross the techniques such as precipitation, filtering, secondary precipitation, dehydration, drying.This method is discontinuous, especially in fermentation liquid precipitate mistake
, it is necessary to which 8-10 hours staticly settle, causes production discontinuous, extraction efficiency, yield are low in journey, output increased is difficult.With
The demand increase of hyaluronic acid, an urgent demand improves its production yields.
Utility model content
In order to overcome the disadvantages mentioned above of prior art, the purpose of this utility model be to provide by extraction process modularization, can
With a kind of extraction element for the cross-linking sodium hyaluronate gel being carried out continuously.
The utility model solves the technical scheme that its technical problem used：A kind of cross-linking sodium hyaluronate gel is carried
Device is taken, wherein：Including insulated and stirred tank, filtering centrifuge, the second agitator tank, chromatographic column, secondary centrifuging component and collecting tank
It is sequentially connected, the arrival end of the insulated and stirred tank is provided with zymotic fluid entrance and water inlet, and top includes three additives and entered
Mouthful, top layer of the bottom side provided with pipeline and filtering centrifuge is connected, and the filtering centrifuge from top to bottom includes filtering successively
Layer, centrifugation layer and washing layer, the washing layer both sides are respectively equipped with the waterpipe of one-in-and-one-out, and bottom is stirred provided with pipeline with second
Tank connection is mixed, the second agitator tank bottom side at the top of chromatographic column provided with pipeline with being connected, and the chromatography column bottom is provided with pipe
Road is connected with secondary centrifuging component, and the secondary centrifuging component includes the first centrifuge and the second centrifuge, first centrifugation
Motor spindle is connected provided with the first collection conduit with collecting tank, and the first centrifuge is stretched into provided with pipeline at the top of second centrifuge
Interior, bottom is connected provided with the second collection conduit with collecting tank.
It is used as further improvement of the utility model：Control magnetic valve is equipped with the pipeline.
Compared with prior art, the beneficial effects of the utility model are：
The utility model is designed for the extraction process of cross-linking sodium hyaluronate gel, and structure is novel, by technique stream
Cheng Jinhang modularizations, improve quantity-produced operability.
Brief description of the drawings
Fig. 1 is structural representation of the present utility model.
Embodiment
The utility model is further illustrated with embodiment in conjunction with brief description of the drawings：
With reference to Fig. 1, a kind of extraction element of cross-linking sodium hyaluronate gel, wherein：Including insulated and stirred tank 1, filter from
Scheming 2, the second agitator tank 3, chromatographic column 4, secondary centrifuging component 5 and collecting tank 6 are sequentially connected, the entrance of the insulated and stirred tank
End is provided with zymotic fluid entrance 11 and water inlet 12, and top includes three additive entrances 13, and bottom side is provided with pipeline and mistake
The top layer connection of centrifuge is filtered, the filtering centrifuge from top to bottom includes filter layer 21, centrifugation layer 22 and washing layer 23 successively,
The washing layer both sides are respectively equipped with the waterpipe of one-in-and-one-out, and bottom is connected provided with pipeline with the second agitator tank 3, and described second
The bottom side of agitator tank 3 is connected provided with pipeline with the top of chromatographic column 4, and the bottom of chromatographic column 4 is provided with pipeline and secondary centrifuging group
Part 5 is connected, and the secondary centrifuging component includes the first centrifuge and the second centrifuge, and the first centrifugation motor spindle is provided with first
Collection conduit is connected with collecting tank 6, is stretched at the top of second centrifuge provided with pipeline in the first centrifuge, and bottom is provided with second
Collection conduit is connected with collecting tank.
Insulated and stirred tank is injected by zymotic fluid and water to be diluted, and is added from additive entrance to the zymotic fluid after dilution
Plus diatomite and activated carbon, by pipeline flow-direction filtering centrifuge after insulated and stirred, by filter layer filtered after enter centrifugation
Layer, the side of the centrifugation layer is provided with cetyl ammonium bromide solution entrance 24, is entered by adding cetyl ammonium bromide solution
Row stirring centrifugation, obtains solid precipitation, into washing layer, is washed by the one-in-and-one-out waterpipe of both sides, institute after washing
Obtain solid precipitation by pipeline to enter at the top of the second agitator tank, second agitator tank provided with sodium chloride solution entrance 31, pass through
Sodium chloride solution is added, stirring to solid precipitation is completely dissolved, and resulting solution after dissolving is flowed through into chromatographic column with certain speed,
Solution after chromatographic column enters secondary centrifuging component.
Solution by adding centrifugation after ethanol, is obtained sediment by the first centrifuge in the secondary centrifuging component
And supernatant, sediment is collected in collecting tank by the first mobile phone, supernatant is extracted by the second centrifuge, in the second centrifuge
Absolute ethyl alcohol is added, sediment is collected in collecting tank by the second collection conduit after centrifugation.
Control magnetic valve is equipped with the pipeline.By controlling magnetic valve to be interrupted each process or module
Block, the preparation and work of next group can be proceeded by completing to operate in a certain interruption, it is ensured that extract continuous production, effectively
Improve efficiency.
In summary, one of ordinary skill in the art is read after the utility model file, according to skill of the present utility model
Art scheme and technical concept make other various corresponding conversion schemes without creative mental labour, belong to this practicality new
The scope that type is protected.
Claims (2)
1. a kind of extraction element of cross-linking sodium hyaluronate gel, it is characterized in that：Including insulated and stirred tank, filtering centrifuge,
Two agitator tanks, chromatographic column, secondary centrifuging component and collecting tank are sequentially connected, and the arrival end of the insulated and stirred tank is provided with zymotic fluid
Entrance and water inlet, top include three additive entrances, and top layer of the bottom side provided with pipeline and filtering centrifuge is connected,
The filtering centrifuge from top to bottom includes filter layer, centrifugation layer and washing layer successively, and the washing layer both sides are respectively equipped with one
Enter a waterpipe out, bottom is connected provided with pipeline with the second agitator tank, the second agitator tank bottom side provided with pipeline with
Connected at the top of chromatographic column, the chromatography column bottom is connected provided with pipeline with secondary centrifuging component, and the secondary centrifuging component includes
First centrifuge and the second centrifuge, the first centrifugation motor spindle are connected provided with the first collection conduit with collecting tank, and described the
Stretched at the top of two centrifuges provided with pipeline in the first centrifuge, bottom is connected provided with the second collection conduit with collecting tank.
2. a kind of extraction element of cross-linking sodium hyaluronate gel according to claim 1, it is characterized in that：In the pipeline
It is equipped with control magnetic valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720034607.0U CN206396103U (en) | 2017-01-12 | 2017-01-12 | A kind of extraction element of cross-linking sodium hyaluronate gel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720034607.0U CN206396103U (en) | 2017-01-12 | 2017-01-12 | A kind of extraction element of cross-linking sodium hyaluronate gel |
Publications (1)
| Publication Number | Publication Date |
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| CN206396103U true CN206396103U (en) | 2017-08-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201720034607.0U Active CN206396103U (en) | 2017-01-12 | 2017-01-12 | A kind of extraction element of cross-linking sodium hyaluronate gel |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110669150A (en) * | 2019-10-23 | 2020-01-10 | 李晓晖 | Equipment and process for extracting active substances of dendrobium huoshanense |
| CN113336871A (en) * | 2021-06-28 | 2021-09-03 | 浙江美华鼎昌医药科技有限公司 | In-vitro dissolution method of cross-linked sodium hyaluronate gel |
-
2017
- 2017-01-12 CN CN201720034607.0U patent/CN206396103U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110669150A (en) * | 2019-10-23 | 2020-01-10 | 李晓晖 | Equipment and process for extracting active substances of dendrobium huoshanense |
| CN110669150B (en) * | 2019-10-23 | 2022-05-06 | 杭州茗宝生物科技有限公司 | Equipment and process for extracting active substances of dendrobium huoshanense |
| CN113336871A (en) * | 2021-06-28 | 2021-09-03 | 浙江美华鼎昌医药科技有限公司 | In-vitro dissolution method of cross-linked sodium hyaluronate gel |
| CN113336871B (en) * | 2021-06-28 | 2022-05-06 | 浙江美华鼎昌医药科技有限公司 | In-vitro dissolution method of cross-linked sodium hyaluronate gel |
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