CN206387781U - A kind of six column chromatography separators - Google Patents
A kind of six column chromatography separators Download PDFInfo
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- CN206387781U CN206387781U CN201720071798.8U CN201720071798U CN206387781U CN 206387781 U CN206387781 U CN 206387781U CN 201720071798 U CN201720071798 U CN 201720071798U CN 206387781 U CN206387781 U CN 206387781U
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Abstract
The utility model is related to a kind of six column chromatographies separator, including liquor inlet, eluent import, balancing tank, piece-rate system, analyze detecting system and liquid outlet, liquor inlet and eluent import are provided with inlet valve, liquor inlet and eluent import are connected by inlet valve with pump M, pump M is connected by pipeline with balancing tank, balancing tank is provided with the exhaust outlet with air outlet valve, the other end of balancing tank is connected by pipeline with the import of piece-rate system, the outlet of piece-rate system is provided with pump N, pump N first outlet is connected by pipeline with analysis detecting system, provided with switch A between pump N and analysis detecting system, pump N second outlet is connected by pipeline with liquid outlet, provided with switch B between pump N and liquid outlet.The utility model can remove liquid into the bubble in liquid before piece-rate system, be conducive to avoiding the filler in infringement piece-rate system pillar, can directly obtain the material of corresponding purity.
Description
Technical field
The utility model is related to a kind of six column chromatographies separator, belongs to technical field of chromatography separation.
Background technology
In chromatography, will insert an actionless phase (solid or liquid) in glass tube or stainless steel tube turns into fixation
Phase；The phase (being usually gas or liquid) moved from top to bottom turns into mobile phase；Pipe equipped with stationary phase turns into chromatographic column.
When sample mixture passes through stationary phase in mobile phase, it will be had an effect with stationary phase, because each component is in property and structure
On difference, the mutual type, strong and weak also variant with stationary phase, therefore in the presence of same motive force, different component exists
Stationary phase holdup time length is different, so as to be flowed out by successively different order from stationary phase.
In the prior art, six column chromatography separators often have bubble in sample introduction and enter piece-rate system, to separation
Result produce influence, and cause existing six column chromatography system continuously to run, production capacity reduction occur, quality is unstable
Situation.
Utility model content
The utility model aims to solve the problem that above mentioned problem there is provided a kind of six column chromatographies separator, and the utility model can
To remove liquid into the bubble in liquid before piece-rate system, be conducive to avoiding the filler in infringement piece-rate system pillar,
And separation is more accurate, efficient, the later stage adds analysis detecting system, can directly obtain the material of corresponding purity, mobile
End can be timely to obtain the process of separation.The technical solution of the utility model is as follows：
A kind of six column chromatography separators, including liquor inlet, eluent import, balancing tank, piece-rate system, analysis
Detecting system and liquid outlet, liquor inlet and eluent import are provided with inlet valve, and liquor inlet and eluent import are by entering
Material valve is connected with pump M, and pump M is connected by pipeline with balancing tank, and balancing tank is provided with the exhaust outlet with air outlet valve, balance
The other end of storage tank is connected by pipeline with the import of piece-rate system, and the outlet of piece-rate system is provided with pump N, pump N first outlet
It is connected by pipeline with analysis detecting system, provided with switch A between pump N and analysis detecting system, pump N second outlet passes through pipe
Road is connected with liquid outlet, provided with switch B between pump N and liquid outlet.
On the basis of above-mentioned technical proposal, the piece-rate system includes resin column C1, pump A, resin column C2, pump B, resin
6 posts are connected in series in post C3, pump C, resin column C4, pump D, resin column C5, pump E, resin column C6, pump F, piece-rate system, resin column
C1 imports are connected with pump F outlets, and resin column C1 lower part outlet is connected by pump A with the import on resin column C2 tops, resin column
C2 lower part outlet is connected by pump B with the import on resin column C3 tops, and resin column C3 lower part outlet passes through pump C and resin column
The import on C4 tops is connected, and resin column C4 lower part outlet is connected by pump D with the import on resin column C5 tops, resin column C5's
Lower part outlet is connected by pump E with the import on resin column C6 tops, and resin column C6 outlets connect by pump F with resin column C1 entrances
Connect, form closed cycle；
The import of 6 resin columns is provided with inlet valve and water intaking valve, and the front end of inlet valve and water intaking valve is provided with pipe rupture valve,
Outlet is provided with outlet valve and residual-gas valve, and the pipeline of piece-rate system is provided with pressure detecting system, flow quantity detecting system and density inspection
Examining system.
When certain resin column goes out product, conveyed by the resin column respective pump before material to next resin column pipe rupture valve
The product discharge valve at end, the valve is simultaneously open, and product is discharged collection.The optional position of pipe-line system is provided with flow detection
Meter, for characterization processes flow and cumulative volume, flowmeter and wherein one pump are mutually chain, are adjusted by the variable frequency adjustment of pump motor
The output flow of whole pump, reaches the flow of technological requirement.Density sensing system is used for detecting the change in concentration situation of material.Work as completion
After the separation once fed, system enters closed cycle separation phase, and after separation is completed again, charging/discharging valve is switched to down
One post carries out similar operations.
On the basis of above-mentioned technical proposal, described analysis detecting system includes analyzer, data processing equipment and hand
Machine, analyzer is connected with data processing equipment, and data processing equipment sends analysis result to mobile phone by after data processing, this
One structure can cause user timely to understand separating resulting.
On the basis of above-mentioned technical proposal, the data processing equipment passes through wireless transmission signal；It is preferred that, at data
Reason device transmits signal by WiFi network.
The utility model has the following advantages that：
The utility model can remove liquid into the bubble in liquid before piece-rate system, improve Quality Down in separation
Situation.And the situation of understanding separation that can be immediately using the utility model, it is time saving and energy saving.
Brief description of the drawings
Fig. 1 is the utility model structural representation；
Fig. 2 is piece-rate system structural representation in the utility model；
The structural representation that Fig. 3 is resin column C1 to resin column C2 in the utility model；
Fig. 4 is analysis detecting system structural representation in the utility model.
Symbol description
1. liquor inlet, 2. eluent imports, 3. balancing tanks, 4. piece-rate systems, 5. analysis detecting systems, 6. go out liquid
Mouth, 7. air outlet valves, 8. inlet valves, 9. pump M, 10. exhaust outlets, 11. pump N, 12. switch A, 13. switch B, 14. analyzers, 15. numbers
According to processing unit, 16. mobile phones；C1-C6 is respectively resin column C1, resin column C2, resin column C3, resin column C4, resin column C5, tree
Fat post C6；P201-P206 is respectively pump A, pump B, pump C, pump D, pump E, pump F.
Embodiment
The utility model is described in further detail with example below in conjunction with the accompanying drawings：
Embodiment 1
A kind of six column chromatography separators, as Figure 1-3, chromatographic separation device include liquor inlet 1, eluent and entered
Mouthfuls 2, balancing tank 3, piece-rate system 4, analysis detecting system 5 and liquid outlet 6, liquor inlet 1 and eluent import 2 be provided with into
Expect valve 8, liquor inlet 1 and eluent import 2 are connected by inlet valve 8 with pump M 9, and pump M 9 passes through pipeline and balancing tank 3
It is connected, balancing tank 3 is provided with the exhaust outlet 10 with air outlet valve 7, the other end of balancing tank 3 passes through pipeline and piece-rate system 4
Import be connected, the outlet of piece-rate system 4 is provided with pump N 11, and pump N 11 first outlet passes through pipeline and analysis detecting system 5
It is connected, provided with switch A 12 between pump N 11 and analysis detecting system 5, pump N 11 second outlet passes through pipeline and liquid outlet 6
It is connected, provided with switch B 13 between pump N 11 and liquid outlet 6；
The piece-rate system 4 include resin column C1, pump A, resin column C2, pump B, resin column C3, pump C, resin column C4, pump D,
6 posts are connected in series in resin column C5, pump E, resin column C6, pump F, piece-rate system, and resin column C1 imports are connected with pump F outlets, are set
Fat post C1 lower part outlet is connected by pump A with the import on resin column C2 tops, and resin column C2 lower part outlet is by pump B and tree
The import on fat post C3 tops is connected, and resin column C3 lower part outlet is connected by pump C with the import on resin column C4 tops, resin column
C4 lower part outlet is connected by pump D with the import on resin column C5 tops, and resin column C5 lower part outlet passes through pump E and resin column
The import on C6 tops is connected, and resin column C6 outlets are connected by pump F with resin column C1 entrances, form closed cycle；
The import of 6 resin columns is provided with inlet valve and water intaking valve, and the front end of inlet valve and water intaking valve is provided with pipe rupture valve,
Outlet is provided with outlet valve and residual-gas valve, and the pipeline of piece-rate system is provided with pressure detecting system, flow quantity detecting system and density inspection
Examining system.
Embodiment 2
On the basis of embodiment 1, as Figure 1-4, described analysis detecting system 5 includes analyzer 14, at data
Device 15 and mobile phone 16 are managed, analyzer 14 is connected with data processing equipment 15, and data processing equipment 15 passes through after data processing
WiFi sends analysis result to mobile phone 16, and this structure can cause user timely to understand separating resulting.
The utility model is illustrated by way of example above, but the utility model is not limited to above-mentioned specific implementation
Example, all any change done based on the utility model or modification belong to the claimed scope of the utility model.
Claims (6)
1. a kind of six column chromatographies separator, it is characterised in that chromatographic separation device include liquor inlet, eluent import,
Balancing tank, piece-rate system, analysis detecting system and liquid outlet, liquor inlet and eluent import are provided with inlet valve, feed liquid
Import and eluent import are connected by inlet valve with pump M, and pump M is connected by pipeline with balancing tank, is set on balancing tank
There is the exhaust outlet with air outlet valve, the other end of balancing tank is connected by pipeline with the import of piece-rate system, piece-rate system goes out
Mouth is provided with pump N, and pump N first outlet is connected with analysis detecting system by pipeline, is provided with and opens between pump N and analysis detecting system
A is closed, pump N second outlet is connected by pipeline with liquid outlet, provided with switch B between pump N and liquid outlet.
2. a kind of six column chromatographies separator according to claim 1, it is characterised in that the piece-rate system includes tree
Fat post C1, pump A, resin column C2, pump B, resin column C3, pump C, resin column C4, pump D, resin column C5, pump E, resin column C6, pump F,
6 posts are connected in series in piece-rate system, and resin column C1 imports are connected with pump F outlets, and resin column C1 lower part outlet is by pump A and tree
The import on fat post C2 tops is connected, and resin column C2 lower part outlet is connected by pump B with the import on resin column C3 tops, resin column
C3 lower part outlet is connected by pump C with the import on resin column C4 tops, and resin column C4 lower part outlet passes through pump D and resin column
The import on C5 tops is connected, and resin column C5 lower part outlet is connected by pump E with the import on resin column C6 tops, and resin column C6 goes out
Mouth is connected by pump F with resin column C1 entrances, forms closed cycle.
3. a kind of six column chromatographies separator according to claim 2, it is characterised in that the import of 6 resin columns is set
There are an inlet valve and water intaking valve, the front end of inlet valve and water intaking valve is provided with pipe rupture valve, and outlet is provided with outlet valve and residual-gas valve, point
Pipeline from system is provided with pressure detecting system, flow quantity detecting system and density sensing system.
4. a kind of six column chromatographies separator according to claim 1, it is characterised in that described analysis detecting system
Including analyzer, data processing equipment and mobile phone, analyzer is connected with data processing equipment, and data processing equipment is by data processing
Afterwards, analysis result is sent to mobile phone.
5. a kind of six column chromatographies separator according to claim 4, it is characterised in that the data processing equipment leads to
Cross wireless transmission signal.
6. a kind of six column chromatographies separator according to claim 5, it is characterised in that the data processing equipment leads to
Cross WiFi network transmission signal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720071798.8U CN206387781U (en) | 2017-01-20 | 2017-01-20 | A kind of six column chromatography separators |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720071798.8U CN206387781U (en) | 2017-01-20 | 2017-01-20 | A kind of six column chromatography separators |
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| Publication Number | Publication Date |
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| CN206387781U true CN206387781U (en) | 2017-08-08 |
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| CN201720071798.8U Active CN206387781U (en) | 2017-01-20 | 2017-01-20 | A kind of six column chromatography separators |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113493429A (en) * | 2021-05-22 | 2021-10-12 | 山东兆光色谱分离技术有限公司 | Industrialized gulonic acid three-component separation system and separation method thereof |
-
2017
- 2017-01-20 CN CN201720071798.8U patent/CN206387781U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113493429A (en) * | 2021-05-22 | 2021-10-12 | 山东兆光色谱分离技术有限公司 | Industrialized gulonic acid three-component separation system and separation method thereof |
| CN113493429B (en) * | 2021-05-22 | 2022-10-21 | 山东兆光色谱分离技术有限公司 | Industrialized gulonic acid three-component separation device and separation method thereof |
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