CN206278387U - A kind of pharmacokinetics plasma sample freezing storing box - Google Patents
A kind of pharmacokinetics plasma sample freezing storing box Download PDFInfo
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- CN206278387U CN206278387U CN201621287362.4U CN201621287362U CN206278387U CN 206278387 U CN206278387 U CN 206278387U CN 201621287362 U CN201621287362 U CN 201621287362U CN 206278387 U CN206278387 U CN 206278387U
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Abstract
The utility model is related to a kind of pharmacokinetics plasma sample freezing storing box, the freezing storing box includes outside main box and inner cartridge, the main box front side in outside is provided with opening and is communicated with the inner chamber of outside main box, the upper end of the inner cartridge is provided with opening and is communicated with the inner chamber of inner cartridge, the inner cartridge is hidden by the front openings of outside main box and is located in outside main box, outside main box and inner cartridge are arranged in a drawer-type structure, sample fixed block is additionally provided with the inner chamber of the inner cartridge, the sample fixed block is the sample fixed block of sponge material, uniformly sample well is offered on the sample fixed block, the diameter of the sample well is slightly less than the diameter of sample.The utility model switch is convenient, practical, easy to operate, and can prevent inner cartridge from skidding off naturally, while can also effectively prevent sample from skidding off, effectively increases the efficiency that sample is checked.
Description
Technical field
The utility model is related to a kind of freezing storing box, more particularly to a kind of pharmacokinetics plasma sample freezing storing box.
Background technology
Pharmacokinetics mainly studies a science of medicine disposal rule in vivo.By principle of dynamics binding number
Learn absorption, metabolism, distribution and the discharge process of medicine after model quantitative study is taken medicine.Its achievement in research can be used to instruct new drug to set
Meter, Optimized Regimen, improvement formulation, raising drug effect, reduction toxic and side effect.
The concentration of medicine is the key data for calculating pharmacokinetic parameter in different time points blood plasma after being taken medicine.Medicine
The dynamic object for learning research is divided into human body and animal.By taking Pharmacokinetic research as an example, its key step is as follows：First, clinical doctor
Institute gives the medicine of subject's doses according to dosage regimen is designed；(for example it is administered with after different time points after administration
0.5,1,2,3,4,6,8,10,24 hours afterwards), gather subject's venous blood；It is placed in after centrifugal separation plasma and posts label in advance
Test tube in (usually 1.5,2.0 or 4.0mL polypropylen tubes), be placed in being preserved in low temperature refrigerator；Cold chain company is by refrigerator
Middle sample is transported to assay laboratory's detection blood plasma drug concentration and carries out statistical analysis.
Transhipment of the plasma sample between clinical hospitals and assay laboratory is an important flow.In order to prevent sample
Lose, clinical hospitals and assay laboratory need verification to check sample.Detection and statistical analysis for convenience, assay laboratory exists
Also need to sequentially in time arrange the sample of every subject when checking sample.Because the sample size of pharmacokinetics experiment is big,
The particularly usual sample size of human trial more than 1000, sample to check work time-consuming more long.Therefore, if cured in clinic
The work that sample is checked and sorted can be mitigated using suitable accommodation method during institute's sample collection.
The accommodation method that current clinical hospitals are used mainly has following two.First, use valve bag：By every subject
Plasma sample pipe is respectively placed in suitable valve bag, and all small valve bags are placed in a big valve bag afterwards.Separately
A kind of method is that plasma sample pipe is placed in sample freezing storing box in chronological order.
Present clinical hospitals are to use valve bag or blood plasma receiver for the two methods that plasma sample is received.
Valve bag is the chain type valve bag used in daily life.Material is polyethylene.Can be by pressing sealing part
Clip chain reach the purpose of encapsulation.When clinical hospitals receive sample using valve bag, by all time point samples of subject
QC is placed in small size valve bag.On valve bag clinical test and subject information are marked with marking pen.Whole clinical test
Plasma sample is all gathered after finishing.All small size valve bags are placed in large size valve bag, and are remembered in being used on large size valve bag
Number pen mark clinical trial information.
Sample freezing storing box is also the conventional sample storage containers of clinical hospitals and sample analysis laboratory.Conventional capacity is 9*
9 or 10*10, can accommodate 81 and 100 1.5 or 2mL cryopreservation tubes respectively.Freezing storing box material is polypropylene plastics or treated
Hardboard.Box is generally made up of sample cell and lid two parts.Sample cell uses square _type layout.
Valve bag is opened and closing process is cumbersome, if each time point needs to repeat in the case that subject's number is larger
Open a large amount of valve bags.The mark solution of other valve bag surface markers is smeared in operation.Blood plasma is gathered in addition
It is directly placed in valve bag after sample, sample tube is in level rather than erectility under gravity.In sample tube
Blood plasma be also laid in the test tube of lodging under gravity, at this moment plasma sample connects with the lid and lid and test tube of test tube
Oral area position is in contact, and easily causes the situation of seepage or pollution.In addition, the sampfe order in valve bag is rambling, this
Increase the workload that plasma sample checks sequence.
The blood plasma freezing storing box that clinical hospitals are used is polypropylene material, and box surface is very smooth, after being placed in Refrigerator store
Easy frosting during taking-up.Box is more smooth after frosting, is easily slipped when hand-held and overturned, and the sample arranged in order can also become mixed
Random or loss.Other polypropylene material employs tongue and groove design such as to ensure closely to be interacted between box and lid
Shown in figure below.Because box volume itself is larger, the original such as crimp of expanding with heat and contract with cold of this design Chang Yinwei boxes or lid
Because causing to be mismatched between lid and box, and do not close or stubborn situation.
The conventional freezing storing box of another kind is cardboard material, in order to protection against the tide covers waterproof and dampproof film on the surface of hardboard.This
Plant freezing storing box mechanical strength poor, be easily deformed.The design of tongue and groove can not be made additionally, due to hardboard material, is covered
Frequently with the design of paper box between son and sample cell.This design focuses between paper box the mutually height of covering part
Degree.The height of freezing storing box than relatively low (5cm or so), if using the design of all standing, box good leak tightness, but due to not having
Hand point, it is difficult to open.Poorer than seal if shallower if cover height, lid is weak in the interphase interaction of sample cell, too easily
Open.The durability of other this box is not strong, after Reusability after the abrasion of box waterproof overlay film, hygroscopic deformation.This box
Son is made up of hardboard, it is necessary to the complex steps cut and assemble, the later stage will also do surface coating treatment, therefore cost compares
It is high.
In view of above-mentioned defect, the design people is actively subject to research and innovation, to found a kind of medicine of new structure
Dynamics plasma sample freezing storing box, makes it have more the value in industry.
Utility model content
In order to solve the above technical problems, the purpose of this utility model is to provide a kind of pharmacokinetics plasma sample with freezing
Box.
To achieve the above object, the utility model is adopted the following technical scheme that：
A kind of pharmacokinetics plasma sample freezing storing box, the freezing storing box includes outside main box and inner cartridge, described outer
The main box front side in portion is provided with opening and is communicated with the inner chamber of outside main box, and the upper end of the inner cartridge is provided with the inner chamber of opening and inner cartridge
Communicate, the inner cartridge is hidden by the front openings of outside main box and is located in outside main box, be in one by outside main box and inner cartridge
Drawer-type structure arranges that sample fixed block is additionally provided with the inner chamber of the inner cartridge, and the sample fixed block is sponge material
Sample fixed block, uniformly offer sample well on the sample fixed block, the diameter of the sample well is slightly less than sample
Diameter.
Further, described pharmacokinetics plasma sample freezing storing box, wherein, the main box in outside and inner cartridge
Material is polypropylene, and is compressed to cube structure arrangement by mould.
Further, described pharmacokinetics plasma sample freezing storing box, wherein, the rear side of the main box in outside
Magnetic force block is provided with inside, the magnetic attracted with magnetic force block is provided with the side of the inner cartridge mutually touched with magnetic force block
Iron block.
Further, described pharmacokinetics plasma sample freezing storing box, wherein, relative with magnet piece is described interior
It is provided with handle on the side of portion's box, the handle and inner cartridge are formed in one arrangement.
Again further, described pharmacokinetics plasma sample freezing storing box, wherein, the upper end of the main box in outside
Anti-slip veins bar, the anti-slip veins bar standard of upper surface and the anti-slip veins different cloth of bar standard of lower surface are provided with face and lower surface
Put.
Again further, described pharmacokinetics plasma sample freezing storing box, wherein, including the sample fixed block
The depth of portion's box is less than or equal to inner cartridge mid-height.
By such scheme, the utility model at least has advantages below：
1st, drawer type freezing storing box switch convenience, practicality, durability are strong；
2nd, the push-and-pull of drawer type freezing storing box is simple, and sample is deposited taking-up process becomes simple, easy to operate；
Even if the 3rd, using magnetic force design make inner cartridge in closed state inner cartridge be inverted will not also skid off naturally；
4th, outside main box upper surface and lower surface devise anti-slip veins bar, operator is difficult to slip, overturned freezing storing box；
5th, the sample fixed block of the sponge material with sample well is employed in inner cartridge, the sample using sponge material is consolidated
Determine the order that the frictional force between block and sample fixes sample, even if the sample fixed block of sponge material is inverted, sample also will not
Skidded off from sample well, after pharmacokinetics plasma sample is fixed in order, sample will not be at random, substantially increases what sample was checked
Efficiency.
Described above is only the general introduction of technical solutions of the utility model, in order to better understand skill of the present utility model
Art means, and being practiced according to the content of specification, with preferred embodiment of the present utility model and coordinate accompanying drawing detailed below
Describe in detail bright as after.
Brief description of the drawings
In order to illustrate more clearly of the technical scheme of the utility model embodiment, below will be to be used needed for embodiment
Accompanying drawing be briefly described, it will be appreciated that the following drawings illustrate only some embodiments of the present utility model, therefore should not be by
Regard the restriction to scope as, for those of ordinary skill in the art, on the premise of not paying creative work, may be used also
Other related accompanying drawings are obtained with according to these accompanying drawings.
Fig. 1 is structural representation of the present utility model；
Fig. 2 is sponge structure schematic diagram of the present utility model；
Fig. 3 is sectional view of the present utility model.
Specific embodiment
With reference to the accompanying drawings and examples, specific embodiment of the present utility model is described in further detail.Below
Embodiment is used to illustrate the utility model, but is not limited to scope of the present utility model.
In order that those skilled in the art more fully understand the utility model scheme, below in conjunction with the utility model reality
Accompanying drawing in example is applied, the technical scheme in the utility model embodiment is clearly and completely described, it is clear that described reality
Example only a part of embodiment of the utility model is applied, rather than whole embodiments.Described in accompanying drawing and show generally herein
The component of the utility model embodiment for going out can be arranged and designed with a variety of configurations.Therefore, below in accompanying drawing
The detailed description of the embodiment of the present utility model of middle offer is not intended to limit claimed scope of the present utility model, and
It is to be merely representative of selected embodiment of the present utility model.Based on embodiment of the present utility model, those skilled in the art are not having
The every other embodiment obtained on the premise of making creative work, belongs to the scope of the utility model protection.
Embodiment
As shown in Figure 1, Figure 2, Figure 3 shows, a kind of pharmacokinetics plasma sample freezing storing box, the freezing storing box includes outside main
Box 1 and inner cartridge 2, the main front side of box 1 in outside are provided with opening and are communicated with the inner chamber of outside main box, the upper end of the inner cartridge 2
It is provided with opening to be communicated with the inner chamber of inner cartridge, the inner cartridge 2 is hidden by the front openings of outside main box and is located at outside main box 1
It is interior, outside main box 1 and inner cartridge 2 are arranged in a drawer-type structure, it is additionally provided with sample in the inner chamber of the inner cartridge 2 and fixes
Block 3, the sample fixed block 3 is the sample fixed block of sponge material, and uniformly sample well is offered on the sample fixed block 3
31, the diameter of the sample well 31 is slightly less than the diameter of sample.Can realize that switch is convenient, real by the freezing storing box of drawer-type structure
With property, and storage taking-up process becomes landing simple, easy to operate and that sample can be prevented by sample fixed block, it is ensured that sample
Stability.
The material of outside main box 1 and inner cartridge 2 is polypropylene described in the utility model, and is compressed to by mould
Cube structure arrangement, improves the service life of the main box 1 in the outside and inner cartridge 2.
Magnetic force block 12 is provided with the inside of the rear side of outside main box 1 described in the utility model, is collided with magnetic force block 12
The magnet piece 21 attracted with magnetic force block is provided with the side of the tactile inner cartridge 2, can be really by magnetic force block and magnet piece
Protecting inner cartridge and be inverted will not also skid off naturally, while magnetic force block 12 is arranged composition vertically using three blocks of magnetites, it is to avoid magnetite magnetite
Come off the situation for causing to close, and magnetic force block 12 and magnet piece 21 are fixed by glue.
Handle 22, the He of the handle 22 are provided with the utility model on the side of the inner cartridge relative with magnet piece
Inner cartridge is formed in one arrangement, facilitates the operation of operating personnel.
Anti-slip veins bar 11, upper surface are provided with the upper surface and lower surface of outside main box 1 described in the utility model
Anti-slip veins bar standard and lower surface the anti-slip veins different arrangement of bar standard, its direction can be made to hang down by different textures
Directly, the frictional force between operator's hand and box body can largely be increased.
Sample fixed block described in the utility model internally box depth be less than or equal to inner cartridge mid-height, one
Sample can be fixed, it is ensured that its stability, secondly the materials to sample fixed block can be reduced, reach the mesh for reducing its cost
's.
Operation principle of the present utility model is as follows：
Drawer type is obtained and operated when freezing storing box sample is stored in taking-up similar with the daily middle drawer for using, and handle is passed through during taking-up
, sliding into during insertion, operation is simpler compared with valve bag and traditional freezing storing box, and slightly strength freezes 2mL
In pipe insertion sample well, sample is the sample fixed block for being securable to sponge material, sequentially will not be chaotic, the sample when device is inverted
Product are still within stationary state, and the fixation of order makes sample check operating efficiency to greatly improve.
By such scheme, the utility model at least has advantages below：
1st, drawer type freezing storing box switch convenience, practicality, durability are strong；
2nd, the push-and-pull of drawer type freezing storing box is simple, and sample is deposited taking-up process becomes simple, easy to operate；
Even if the 3rd, using magnetic force design make inner cartridge in closed state inner cartridge be inverted will not also skid off naturally；
4th, outside main box upper surface and lower surface devise anti-slip veins bar, operator is difficult to slip, overturned freezing storing box；
5th, the sample fixed block of the sponge material with sample well is employed in inner cartridge, the sample using sponge material is consolidated
Determine the order that the frictional force between block and sample fixes sample, even if the sample fixed block of sponge material is inverted, sample also will not
Skidded off from sample well, after pharmacokinetics plasma sample is fixed in order, sample will not be at random, substantially increases what sample was checked
Efficiency.
The above is only preferred embodiment of the present utility model, is not limited to the utility model, it is noted that
For those skilled in the art, on the premise of the utility model know-why is not departed from, can also do
Go out some improvement and modification, these are improved and modification also should be regarded as protection domain of the present utility model.
Claims (6)
1. a kind of pharmacokinetics plasma sample freezing storing box, it is characterised in that：The freezing storing box includes outside main box and inside
Box, the main box front side in the outside is provided with opening and is communicated with the inner chamber of outside main box, the upper end of the inner cartridge be provided with opening with it is interior
The inner chamber of portion's box communicates, and the inner cartridge is hidden by the front openings of outside main box and is located in outside main box, by outside main box and
Inner cartridge is additionally provided with sample fixed block, the sample fixed block in drawer-type structure arrangement in the inner chamber of the inner cartridge
It is the sample fixed block of sponge material, uniform on the sample fixed block to offer sample well, the diameter of the sample well is omited
Less than the diameter of sample.
2. pharmacokinetics plasma sample freezing storing box according to claim 1, it is characterised in that：The main box in outside and
The material of inner cartridge is polypropylene, and is compressed to cube structure arrangement by mould.
3. pharmacokinetics plasma sample freezing storing box according to claim 1 and 2, it is characterised in that：It is described outside main
Magnetic force block is provided with the inside of the rear side of box, is provided with the side of the inner cartridge mutually touched with magnetic force block and magnetic force block
Attracted magnet piece.
4. pharmacokinetics plasma sample freezing storing box according to claim 3, it is characterised in that：It is relative with magnet piece
It is provided with handle on the side of the inner cartridge, the handle and inner cartridge are formed in one arrangement.
5. pharmacokinetics plasma sample freezing storing box according to claim 1 and 2, it is characterised in that：It is described outside main
Anti-slip veins bar, the anti-slip veins bar standard of upper surface and the anti-slip veins bar system of lower surface are provided with the upper surface and lower surface of box
The different arrangement of formula.
6. pharmacokinetics plasma sample freezing storing box according to claim 1, it is characterised in that：The sample fixed block
Internally the depth of box is less than or equal to inner cartridge mid-height.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621287362.4U CN206278387U (en) | 2016-11-28 | 2016-11-28 | A kind of pharmacokinetics plasma sample freezing storing box |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621287362.4U CN206278387U (en) | 2016-11-28 | 2016-11-28 | A kind of pharmacokinetics plasma sample freezing storing box |
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| CN206278387U true CN206278387U (en) | 2017-06-27 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107364696A (en) * | 2017-09-18 | 2017-11-21 | 贵州大山农业科技有限公司 | A kind of blue or green crisp Lee in orchard transports storage device |
| CN111252334A (en) * | 2020-03-26 | 2020-06-09 | 孙琳 | Chemical reagent storage device |
-
2016
- 2016-11-28 CN CN201621287362.4U patent/CN206278387U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107364696A (en) * | 2017-09-18 | 2017-11-21 | 贵州大山农业科技有限公司 | A kind of blue or green crisp Lee in orchard transports storage device |
| CN111252334A (en) * | 2020-03-26 | 2020-06-09 | 孙琳 | Chemical reagent storage device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information |
Inventor after: Yang Yong Inventor after: Zhong Kan Inventor after: Liu Xuling Inventor after: Chen Tao Inventor after: Zuo Zhenglong Inventor after: Chen Yunhui Inventor after: Tan Wenjuan Inventor before: Yang Yong |
|
| CB03 | Change of inventor or designer information |