CN206239435U - The device of the multi-parameter quantitative determination ovulation based on saliva property - Google Patents
The device of the multi-parameter quantitative determination ovulation based on saliva property Download PDFInfo
- Publication number
- CN206239435U CN206239435U CN201620861681.5U CN201620861681U CN206239435U CN 206239435 U CN206239435 U CN 206239435U CN 201620861681 U CN201620861681 U CN 201620861681U CN 206239435 U CN206239435 U CN 206239435U
- Authority
- CN
- China
- Prior art keywords
- saliva
- module
- ovulation
- electrode
- quantitative determination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The utility model discloses a kind of multi-parameter quantitative determination ovulation device based on saliva property, including saliva collecting device, electrochemical data acquisition module, data transmission module and power module, the saliva collecting device is used to gather saliva, including micro fluidic device；The electrochemical data acquisition module is used to gather electric current, current potential and the impedance signal of saliva electrochemistry, including acquisition electrode and signal processing circuit；The data transmission module is used to carry out the data transfer that electrochemical data acquisition module is gathered to external equipment APP modules the treatment and statistical analysis of data；The power module is used to be powered to electrochemical data acquisition module and data transmission module.The present apparatus can accurately extrapolate device for testing ovulation date, and can be as accurate as 23 hours.
Description
Technical field
The utility model is related to medical apparatus detection field, more particularly to a kind of multi-parameter quantitative determination ovulation device.
Background technology
From the point of view of in current prior art, the detailed mechanism and details of human ovulation are also not very clear.But around ovulation, body
Interior FSH (FSH), lutropin (LH), estrogen and the gonadotropin-releasing hormone (GRH) secreted by hypothalamus
Deng the feedback regulation reaction formed between hormone, cause preovulatory hormonal readiness regular and the change of fierceness, be that ovulation is completed
And the inducement that corpus luteum is formed after ovulation.Have been observed that three hormone peak values play an important role to the generation ovulated：First
Estrogen peak value occurs, and induction GnRH releases increase, thus trigger LH, FSH and almost synchronously reach secretion peak value.Induced ovulation
During generation, FSH and LH must act synergistically, and only a certain proportion of FSH and LH is cooperateed with mutually could the effective row of induction
Ovum, when LH induction ovulations are used alone, whole ruptures are used a certain proportion of FSH and LH by the ovarian follicle that ovary has been raised
When coordinating induction ovulation, only ripe ovarian follicle just ruptures ovulation.
Scientific research finds that now the physical chemistry of saliva can be influenceed and change by estrogen, salt content
With some enzyme materials also in change.The product that saliva detects device for testing ovulation date, the knot based on saliva have been based in the market
Crystalline form state is very much like with the crystal habit of its cervical mucus, shows the figure of a kind of similar fern or plant leaf blade channels and collaterals
Case, this fernlike crystal image typically started appearance at preovulatory 2-3 days, the most clear to ovulation period.After ovulation gradually
Broken, dissolving, until being changed into mottled pattern, by observation crystallize to oneself saliva, visually judge the onset of ovulation and non-ovulation
Phase, but visually observed by observer oneself, without any quantitative target, so by subjective eyesight and microscopical resolution ratio
Influence, and the interference of the factors such as the optics of environment cannot be excluded, results contrast is obscured, and only can probably extrapolate by
The substantially ovulation situation of survey person, extrapolates and be would be possible within couple of days ovulation, but cannot determine that measured's ovulation is specific
Time, this has little significance for the women for practising contraception and becoming pregnant.
Therefore, continue a kind of easy to detect, degree of accuracy monitoring ovulation device again higher.
Utility model content
To solve the above problems, the utility model provides a kind of portable, efficient, accuracy detection means higher,
Device for testing ovulation date can be accurately extrapolated, and be can be as accurate as 2-3 hours.
The purpose of this utility model is achieved through the following technical solutions：
Multi-parameter quantitative determination ovulation device based on saliva property, including saliva collecting device, electrochemical data acquisition
Module, data transmission module and power module, the saliva collecting device are used to gather saliva, including micro fluidic device；It is described
Electrochemical data acquisition module is used to gather electric current, current potential and the impedance signal of saliva electrochemistry, including acquisition electrode and signal
Process circuit；The data transmission module is used for the data transfer of electrochemical data acquisition module collection to external equipment APP
Module carries out the treatment and statistical analysis of data；The power module is used for electrochemical data acquisition module and data transfer
Module for power supply.
Further, above-mentioned micro fluidic device includes injection port, microchannel and chamber.
Further, one end of above-mentioned acquisition electrode is located in saliva collecting device, the other end and signal processing circuit phase
Connection, the acquisition electrode includes reference electrode, a working electrode and an auxiliary electrode, the reference electrode, work
Make one end that electrode and auxiliary electrode be located in saliva collecting device in the arc-shaped and be arranged in order from inside to outside.
Further, above-mentioned reference electrode is silver/silver chloride electrode, and the working electrode and auxiliary electrode are nm of gold electricity
Pole or nano silver electrode.
Further, above-mentioned signal processing circuit includes that amplifying circuit, frequency demodulation circuit, potentiostatic circuit and frequency are adjusted
Circuit processed.
Further, above-mentioned data transmission module is connected by earphone interface with external equipment APP modules.
Further, above-mentioned data transmission module includes bluetooth module, with external equipment APP module wireless connections.
Further, above-mentioned multi-parameter quantitative determination ovulation device also includes temperature collect module, the temperature acquisition mould
Block includes temperature sensor, and the temperature data of the temperature collect module collection is transmitted to external equipment by data transmission module
APP modules.
The beneficial effects of the utility model are：Based on saliva, the total ion of saliva is dense within human ovulation phase and the non-onset of ovulation
Spend with FSH the concentration of LH be proportionate, processed by the electric current to collecting, current potential and impedance signal and statistical
Analysis obtains electron stream collection of illustrative plates and impedance spectrum collection of illustrative plates, can be according to the ovulation period of the personal data accurate detection tester of tester；
Collection in addition combined with tester's temperature data simultaneously sets up algorithm model and standard curve, further increases the row of tester
The ovum time.
Brief description of the drawings
Fig. 1 the utility model embodiments multi-parameter detection ovulation apparatus structure schematic diagram；
Fig. 2 the utility model embodiments multi-parameter detection ovulation device schematic flow sheet；
Fig. 3 the utility model embodiment signal processing module electrical block diagrams；
The multigroup curve maps of Fig. 4；I. temperature curve schematic diagram；II.LH and FSH hormone concentration curve synoptic diagrams；III. it is pregnant to swash
Element and estrogen curve concentration schematic diagram；IV. saliva total ion concentration curve synoptic diagram；
Wherein, 1- saliva collecting devices；2- housings；3- signal processing modules；4- earphone contact pins.
Specific embodiment
Design of the present utility model and principle are described further with reference to the accompanying drawings and detailed description：
As depicted in figs. 1 and 2, a kind of device of the multi-parameter quantitative determination ovulation based on saliva property, including housing 2,
Saliva collecting device 1, electrochemical data acquisition module, temperature collect module, data transmission module and power supply mould are provided with housing 2
Block；
The power module is used to be powered to figure acquisition module, temperature collect module and data transmission module, can be used
Battery as the present apparatus power module, battery case is button cell, it is also possible to reserve charging port, configuration charging bottom in end
Seat completes charge function.
The saliva collecting device 1 includes micro fluidic device, including injection port, microchannel and chamber, the saliva of collection
Can be by injection port with into microchannel, arrival chamber, the microfluidic devices can also use other structures, can such as adopt
With Samsung Electronics Co., Ltd on November 17th, 2010, the utility model patent of application to Publication No. CN102071242A
Structure described in microfluidic device in " microfluidic device, light irradiation device, micro-fluidic system and the method for driving the system ".This practicality is new
The saliva collecting device of type, due to the detection for same tester, can soak the device clear water 1-2 minutes, dry
After reuse, and can reuse about 3000 times, greatly reduce cost.
The electrochemical data acquisition module includes acquisition electrode and signal processing circuit, and acquisition electrode is three electrode bodies
System, i.e. reference electrode, working electrode and auxiliary electrode, reference electrode, working electrode and auxiliary electrode and the chamber of saliva collecting device 1
One end of indoor saliva contacts is concentric circles arc, and reference electrode, working electrode and auxiliary electrode be arranged in order from inside to outside,
The other end of above three electrode is plugged in signal processing circuit, so as to form two loops.Reference electrode and working electrode
Between form loop, for the electrochemical reaction process of test job electrode；Loop is formed between working electrode and auxiliary electrode,
Play transmission and electronically form loop.Reference electrode is for silver/silver chloride electrode, working electrode and auxiliary electrode in the present apparatus
Nanogold electrode.Working electrode and auxiliary electrode can also use nano silver electrode.
Signal processing circuit as shown in figure 3, the electric current of the electrochemical data for collecting, current potential and impedance signal it is amplified,
Data transmission module is transmitted through after frequency demodulation, filtering, frequency modulation process to be connected with external equipment APP modules, it is described outer
Portion's equipment includes the intelligent terminal such as mobile phone, computer.The data transmission module is by earphone contact pin 4 and external equipment
Earphone interface and external equipment APP module wired connections, it is also possible to realize the nothing with external equipment APP modules using bluetooth module
Line is connected.
By taking mobile phone as an example, earphone contact pin is inserted into mobile telephone microphone jack, the increase of frequency from 5300 hertz to
7600 hertz, the reduction of frequency is from 7600 hertz to limitation (its of the frequency of the sine wave input and output signal of certain amplitude
Have to be larger than 20 hertz), 5300 hertz are produced from handset audio jack.5300 hertz correspond to 0V, and 7600 hertz of correspondences-
The frequency demodulation module of 1.5V is added to circuit, and voltage detecting is swept by voltage of conversion frequency.This frequency demodulation mechanism
Circuit is set not limited by different types of smart mobile phone, without considering that different speaker volumes are set.Then ring-type is swept
Retouch voltage and be added to reference electrode with being connected to, working electrode and reference electrode change from 0V to -1.5V and return 0V.Sweep limits
Can be input voltage potential and working electrode -1.6V to+1.5V, positive potential avoids the oxidization condition of silver working electrode.Due to
The frequency of this output voltage is the inspection of low (its detectable limit less than mobile telephone microphone) and amplitude ratio microphone input
The survey limit is higher, and frequency modulation(PFM) (FM) module is added to the frequency model that the remotely-sensed data of circuit conversion is allowed with microphone jack
Enclose interior signal.Because the initial data recorded by cell phone platform is to be from the one of FM integrated circuits (CD4046) different frequency
Row square wave, obtains an average value for the frequency data of window, to obtain initial data.The present apparatus takes full advantage of CD4046's
The characteristics of FM performances first.
The temperature collect module includes the temperature sensor being arranged in the chamber of saliva collecting device 1, the saliva of collection
Temperature signal exported to external equipment APP modules by data transmission module and carry out the treatment and statistical analysis of data.
The use of the present apparatus needs the bimestrial learning process of early stage, that is, user to need continuously to measure bimestrial
Time, daily detection 1-3 times records testing result at that time, and carries out statistical analysis to the data for gathering by software systems, sets up
Personalized model and algorithm, according to data, model and algorithm is obtained, comprehensively for the specific data of each tester, with depth
Degree learning art, sets up corresponding basic standard curve, and the ovulation situation of tester is precisely detected and judged.
As shown in figure 4, the temperature curve of human body, the lutropin of the total ion concentration of saliva and women, rush ovarian follicle life
The change of Cheng Su is strict corresponding relation during ovulating, so that the utility model passes through the electrochemical data for collecting
With FSH the concentration of LH be proportionate.So from temperature, the electrochemical properties of saliva ion, such as electron stream, electrical impedance spectrum
Parameter is it can be inferred that the concentration of FSH LH, and then to judge the precise time of ovulation, can be accurate to 2-3h.Temperature is used as auxiliary
Index, combined with electrochemical parameter judges ovulation period.
In addition, it is to be understood that for those of ordinary skills, can according to the technical solution of the utility model and its
Inventive concept is subject to equivalent or change, and the right that all these changes or replacement should all belong to appended by the utility model will
The protection domain asked.
Claims (11)
1. the multi-parameter quantitative determination ovulation device of saliva property, including saliva collecting device, electrochemical data acquisition mould are based on
Block, data transmission module and power module, it is characterised in that the saliva collecting device is used to gather saliva, including micro-fluidic
Device；The electrochemical data acquisition module is used to gather electrochemical source of current, current potential and the impedance signal of saliva, including collection electricity
Pole and signal processing circuit；The data transmission module is used for the data transfer of electrochemical data acquisition module collection to outside
Device A PP modules carry out the treatment and statistical analysis of data；The power module be used for electrochemical data acquisition module and
Data transmission module is powered.
2. it is according to claim 1 based on saliva property multi-parameter quantitative determination ovulation device, it is characterised in that it is described
Micro fluidic device includes injection port, microchannel and chamber.
3. it is according to claim 1 and 2 based on saliva property multi-parameter quantitative determination ovulation device, it is characterised in that
One end of the acquisition electrode is located in saliva collecting device, and the other end is connected with signal processing circuit, the acquisition electrode
Including a reference electrode, a working electrode and an auxiliary electrode, the reference electrode, working electrode and auxiliary electrode position
In the one end in saliva collecting device is for concentric circles arc and is arranged in order from inside to outside.
4. it is according to claim 3 based on saliva property multi-parameter quantitative determination ovulation device, it is characterised in that it is described
Reference electrode is silver/silver chloride electrode, and the working electrode and auxiliary electrode are nanogold electrode or nano silver electrode.
5. it is according to claim 1 based on saliva property multi-parameter quantitative determination ovulation device, it is characterised in that it is described
Signal processing circuit includes amplifying circuit, frequency demodulation circuit, potentiostatic circuit and frequency modulation circuit.
6. the ovulation of the multi-parameter quantitative determination based on saliva property according to claim 1-2,4-5 any claim is filled
Put, it is characterised in that the data transmission module is connected by earphone interface with external equipment APP modules.
7. the ovulation of the multi-parameter quantitative determination based on saliva property according to claim 1-2,4-5 any claim is filled
Put, it is characterised in that the data transmission module includes bluetooth module, with external equipment APP module wireless connections.
8. it is according to claim 6 based on saliva property multi-parameter quantitative determination ovulation device, it is characterised in that it is described
Data transmission module includes bluetooth module, with external equipment APP module wireless connections.
9. it is according to claim 1 based on saliva property multi-parameter quantitative determination ovulation device, it is characterised in that also wrap
Temperature collect module is included, the temperature collect module includes temperature sensor, the temperature data of the temperature collect module collection
Transmitted to external equipment APP modules by data transmission module.
10. it is according to claim 3 based on saliva property multi-parameter quantitative determination ovulation device, it is characterised in that institute
Stating data transmission module includes bluetooth module, with external equipment APP module wireless connections.
The 11. multi-parameter quantitative determination ovulation devices based on saliva property according to claim 10, it is characterised in that also
Including temperature collect module, the temperature collect module includes temperature sensor, the temperature number of the temperature collect module collection
Transmitted to external equipment APP modules according to by data transmission module.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620861681.5U CN206239435U (en) | 2016-08-10 | 2016-08-10 | The device of the multi-parameter quantitative determination ovulation based on saliva property |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620861681.5U CN206239435U (en) | 2016-08-10 | 2016-08-10 | The device of the multi-parameter quantitative determination ovulation based on saliva property |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206239435U true CN206239435U (en) | 2017-06-13 |
Family
ID=58997909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620861681.5U Active CN206239435U (en) | 2016-08-10 | 2016-08-10 | The device of the multi-parameter quantitative determination ovulation based on saliva property |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206239435U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108185632A (en) * | 2018-03-13 | 2018-06-22 | 京东方科技集团股份有限公司 | A kind of saliva detects toothbrush |
-
2016
- 2016-08-10 CN CN201620861681.5U patent/CN206239435U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108185632A (en) * | 2018-03-13 | 2018-06-22 | 京东方科技集团股份有限公司 | A kind of saliva detects toothbrush |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103622693A (en) | Portable bio-electrical impedance measurement device | |
| CN107714095A (en) | A kind of multi-parameter quantitatively detects the device and detection method of ovulation | |
| CN104622514B (en) | A kind of ovulation test system and method based on dual sensor | |
| CN102613962A (en) | Device for monitoring basal body temperature | |
| CN105738438B (en) | A kind of bipolar electrode method realizes bicarbonate radical and carbonate rapid detection apparatus and its method in water | |
| CN105676141B (en) | A kind of battery capacity on-line measurement system and its measuring method based on damped oscillation | |
| CN206239435U (en) | The device of the multi-parameter quantitative determination ovulation based on saliva property | |
| CN206540901U (en) | Remote soil intelligent monitoring system | |
| CN107714096A (en) | A kind of quantitative detection ovulation device and detection method | |
| CN204542209U (en) | A kind of ovulation of the multisensor based on body fluid conductivity sensor test macro | |
| CN108205000A (en) | Ovulation detecting device | |
| CN207850973U (en) | Ovulation detecting device | |
| CN208621552U (en) | A kind of shell type intelligence POCT instrument | |
| CN206252516U (en) | Quantitative determination ovulation device | |
| CN208110294U (en) | Air-pump type rate pressure detects smartwatch | |
| CN207053238U (en) | A kind of portable type solar energy lithium battery intelligent charger | |
| CN108760842A (en) | A kind of shell type intelligence POCT instrument | |
| CN207575173U (en) | A kind of processor voltage signal for being used to measure saliva impedance | |
| CN206102627U (en) | Children's bluetooth thermometer | |
| CN206102624U (en) | Bluetooth thermometer | |
| CN202002905U (en) | Electrogenerated chemiluminescence transient state analyzer | |
| CN211066609U (en) | Human surface electromyographic signal monitoring device | |
| CN110664092A (en) | Bluetooth mask device and method for using same as mask | |
| CN104280698B (en) | Magnetic field measuring device | |
| CN204169830U (en) | A kind of smart electronics clinical thermometer with wireless charging function |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |