CN206198762U - The micro magnetic bead fixing device of test tube type - Google Patents
The micro magnetic bead fixing device of test tube type Download PDFInfo
- Publication number
- CN206198762U CN206198762U CN201621051287.1U CN201621051287U CN206198762U CN 206198762 U CN206198762 U CN 206198762U CN 201621051287 U CN201621051287 U CN 201621051287U CN 206198762 U CN206198762 U CN 206198762U
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- seat
- honour
- test tube
- center pillar
- magnetic bead
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Abstract
A kind of micro magnetic bead fixing device of test tube type, including the seat of honour, center pillar, ring, ring magnet and lower seat, the wherein seat of honour and lower seat is individually fixed in center pillar upper and lower end, center pillar outside is arranged annular magnet, a ring is gripped between the seat of honour and center pillar, it is lower that another ring is gripped between seat and center pillar.The present apparatus is used to assist to perform repeatedly fixed and release magnetic particle in biomolecular experiments, and the present apparatus can be rapidly completed and attract and fixed action, need to separate molecule and the reduction consumption for leaving in complete reservation reaction, it is effectively increased conventional efficient, and the device space is saved, operation biomolecular experiments is reached stability and simplicity.
Description
Technical field
The utility model is related to a kind of micro magnetic bead fixing device of the test tube type for carrying out Magneto separate Experiment of Principle.
Background technology
Beads enrichment technology has been widely used in immunoassay（immunoassays）On, especially protein,
DNA（DNA）And ribonucleic acid（RNA）In analysis Deng corpse or other object for laboratory examination and chemical testing extract.Wherein, the operating technology of Beads enrichment
It is general to have two ways, respectively manual operation and use mechanical automation instrument.
In terms of manual operation flow, with reference to United States Patent (USP) US6187270B1, it goes out corpse or other object for laboratory examination and chemical testing extract using Beads enrichment
Operating process in, combined with corpse or other object for laboratory examination and chemical testing extract in magnetic bead, by multiple reaction reagent it is quantitative, draw and the complicated step such as filling
Suddenly, then isolation magnetic bead takes out the process of wanted corpse or other object for laboratory examination and chemical testing extract solution all with manual operation.Consequently, it is possible to not only expend
Manpower, and the operating time for spending is also relatively more, and economic benefit and cost are not met really.And another reference United States Patent (USP)
US648810B1, it utilizes spring-compressed strength so that magnet holds in suction pipe bottom and linked cell（Such as corpse or other object for laboratory examination and chemical testing extract）
Magnetic bead.Meanwhile, branched test tube can be purified and cleaning procedure in corresponding test tube.Finally, spring is unclamped so that
Magnet leaves the bottom of suction pipe and Beads enrichment, to carry out precipitation program.But it equally has operating process complicated, and during operation
Between tediously long situation.
And in terms of mechanical automation instrument, its all processes all operable automatically, replace completely artificial operating process with
Manpower demand and the cost of time are reduced, and a various corpse or other object for laboratory examination and chemical testing can be operated simultaneously.Although the yield of corpse or other object for laboratory examination and chemical testing extract is larger, but
The price of self-reacting device is generally all costly and bulky, does not also meet economic benefit.Therefore, typically user cannot accord with
User is needed for when actually used for conjunction.
Utility model content
The utility model main purpose be the above mentioned problem that overcomes known skill to be met with and one kind is provided can be quickly complete
Into simultaneously fixed magnetic particle action is attracted, need to separate the molecule for leaving in complete reservation reaction, and reduce consumption, be effectively increased behaviour
Make efficiency, the micro magnetic bead fixing device of test tube type of save space.
To achieve these objectives, a kind of micro magnetic bead fixing device of test tube type of the utility model includes：
One seat of honour, in a plate-like, is provided with several fixing holes through the seat of honour, for an examination of planting respectively around its outer shroud
Pipe, and the seat of honour bottom surface is provided with a seat of honour groove；
A time seat, in a plate-like, is provided with several fixing grooves corresponding with the fixing hole, for planting respectively around its outer shroud
Test tube afterwards is against and the lower seat top surface is provided with a lower seat groove corresponding with the seat of honour groove；
One center pillar, is arranged between the seat of honour and the lower seat, is born against with lower surface with the center pillar upper surface
In the seat of honour groove with the lower seat groove；
One ring magnet, is sheathed on the center pillar；And
Two rings, are sheathed on the center pillar and are located at respectively between the seat of honour and the ring magnet and described
Between lower seat and the ring magnet.
The seat of honour groove is at the axle center of the seat of honour bottom surface, and the lower seat groove is located at the lower seat top surface axle center
Place.
It is formed with several upper bore in the seat of honour groove of the seat of honour bottom surface, and shape in the lower seat groove of the lower seat top surface
Into there is several lower base holes, and the center pillar upper surface and lower surface are respectively formed with several spiral shells corresponding with the upper and lower bore
Hole.
The seat of honour, center pillar and lower seat are fixed with screw, middle to fix two ring with method of clamping.
The ring magnet is N35 grade strong magnets.
Several fixing grooves are cylindrical, and its diameter is without consistent, but with each self-corresponding fixing hole one
Cause.
The ring magnet is shaped as cylinder, corner cylinder or hexagonal cylinder.
The utility model by being arranged annular magnetic circle on the outside of center pillar, in Magneto separate Experiment of Principle, using annular magnetosphere
Can be rapidly completed attraction and fixed magnetic particle, and can completely retain and need to separate the molecule that leaves in reaction and reduce consumption, reach
To the efficiency for being effectively increased operation biomolecular experiments, and miscellaneous equipment space is saved, operation biomolecular experiments is reached surely
Qualitative and simplicity.
Brief description of the drawings
Fig. 1, is the schematic perspective view of the micro magnetic bead fixing device of the utility model test tube type.
Fig. 2, is the decomposing schematic representation of the micro magnetic bead fixing device of the utility model test tube type.
Fig. 3, is the micro magnetic bead fixing device of the utility model test tube type and test tube installing schematic diagram.
Reference numerals are compareed：
The seat of honour 1；
Fixing hole 11；
Seat of honour groove 12；
Upper bore 13；
Lower seat 2；
Fixing groove 21；
Lower seat groove 22；
Lower base hole 23；
Center pillar 3；
Screw 31；
Screw 32；
Ring magnet 4；
Ring 5；
Test tube 6.
Specific embodiment
Refer to shown in Fig. 1~Fig. 3, the three-dimensional signal of the micro magnetic bead fixing device of test tube type respectively of the present utility model
Figure, the decomposing schematic representation of the micro magnetic bead fixing device of test tube type of the present utility model and the micro magnetic bead of test tube type of the present utility model
Fixing device and test tube installing schematic diagram.As shown in the figure：The utility model system one kind can be in the outer fixing internal reaction magnetic bead of test tube
The micro magnetic bead fixing device of test tube type, it includes a seat of honour 1, seat 2, a center pillar 3, a ring magnet 4 and the institute of two ring 5
Composition.
Above-mentioned the carried seat of honour 1 is in a plate-like, and several fixing holes 11 through the seat of honour 1 are provided with around its outer shroud, is available for
Plant respectively a test tube 6, and a seat of honour groove 12 is provided with the bottom surface axle center of the seat of honour 1, number is formed with the seat of honour groove 12
Individual upper bore 13.
The lower seat 2 is in a plate-like, and several fixing grooves 21 corresponding with these fixing holes 11 are provided with around its outer shroud, is available for point
Not Cha Zhi after test tube 6 against, and a lower seat groove 22 corresponding with the seat of honour groove 12 is provided with the top surface axle center of lower seat 2,
Several lower base holes 23 are formed with the lower seat groove 22.Wherein several fixing grooves 21 are cylindrical, and its diameter
Need not be consistent, can be identical or different, but it is consistent with each self-corresponding fixing hole 11.
The center pillar 3 is arranged between the seat of honour 1 and the lower seat 2, is born against at this with the upper surface of center pillar 3 and lower surface
In seat of honour groove 12 and the lower seat groove 22, and the upper surface of center pillar 3 is respectively formed with the several and upper and lower bore with lower surface
13rd, 23 corresponding screw 31.
The ring magnet 4 is sheathed on the center pillar 3, and its bodies can be any for cylinder, corner cylinder or hexagonal cylinder
Kind.
Two ring 5 is sheathed on the center pillar 3 and is located between the seat of honour 1 and the ring magnet 4 respectively, and the lower seat
Between 2 and the ring magnet 4.In this way, a brand-new micro magnetic bead fixing device of test tube type is constituted by the device of above-mentioned exposure.
Upon assembly, the lower surface of center pillar 3 is resisted against in the lower seat groove 22 of the top surface of lower seat 2, then sequentially by one
Ring 5, the ring magnet 4 and another ring 5 are inserted on the center pillar 3, are finally resisted against the seat of honour groove 12 of the bottom surface of the seat of honour 1
The upper surface of center pillar 3, through upper and lower bore 13,23, is available for screw 32 to penetrate locking in screw 31, reaches solid with screw 32
Determine the seat of honour 1, center pillar 3 and lower seat 2, it is middle then two rings 5 and ring magnet 4 are fixed with method of clamping.Thereby, the utility model institute
Put forward the micro magnetic bead fixing device of test tube type and can be used for the operation of Magneto separate principle related experiment, for example, operate biomolecule reaction to carry
Platform and microscope carrier fixing device, the first step when reagent set is used：Magnetic bead use is fixed in " using Beads enrichment RNA " experiment.
Such experiment often needs repeatedly to fix and release magnetic particle during application is carried out；And closing must be maintained in test tube
Free of contamination environment.There is the present apparatus appropriate design can fix test tube 6, and be attracted simultaneously outside test tube 6 with a ring magnet 4
Magnetic particle in fixed test tube 6, and the annular magnet 4 is N35 grade strong magnets, can be rapidly completed and attract and fixed dynamic
Make, need to separate molecule and the reduction consumption for leaving in complete reservation reaction, be effectively increased the efficiency of operation biomolecular experiments, and
Miscellaneous equipment space is saved, operation biomolecular experiments is reached stability and simplicity.
In sum, the micro magnetic bead fixing device of a kind of test tube type of the utility model system, can be effectively improved is a variety of
Shortcoming, carries the magnetic devices that can carry out Magneto separate Experiment of Principle, may be used to assist the device of operation biomolecular experiments, can be by
The magnetic particle that course of reaction need to be fixed is fixed, and needs to separate molecule and the reduction consumption for leaving in complete reservation reaction, and reaching has
Effect increases the efficiency of operation biomolecular experiments, and saves miscellaneous equipment space, operation biomolecular experiments is reached stability
With simplicity, and then enable that generation of the present utility model is more progressive, more practical, more meet user institute palpus.
Claims (7)
1. the micro magnetic bead fixing device of a kind of test tube type, it is characterised in that including：
One seat of honour, in a plate-like, is provided with several fixing holes through the seat of honour around its outer shroud, for a test tube of planting respectively,
And the seat of honour bottom surface is provided with a seat of honour groove；
A time seat, in a plate-like, is provided with several fixing grooves corresponding with the fixing hole, after planting respectively around its outer shroud
Test tube is against and the lower seat top surface is provided with a lower seat groove corresponding with the seat of honour groove；
One center pillar, is arranged between the seat of honour and the lower seat, is born against in institute with the center pillar upper surface and lower surface
In stating seat of honour groove and the lower seat groove；
One ring magnet, is sheathed on the center pillar；And
Two rings, are sheathed on the center pillar and are located between the seat of honour and the ring magnet respectively, and the lower seat
Between the ring magnet.
2. the micro magnetic bead fixing device of test tube type according to claim 1, it is characterised in that the seat of honour groove is located at institute
State at the axle center of seat of honour bottom surface, and the lower seat groove is at the lower seat top surface axle center.
3. the micro magnetic bead fixing device of test tube type according to claim 1, it is characterised in that the seat of honour of the seat of honour bottom surface
Several upper bore are formed with groove, and several lower base holes are formed with the lower seat groove of the lower seat top surface, and the center pillar
Upper surface and lower surface are respectively formed with several screws corresponding with the upper and lower bore.
4. the micro magnetic bead fixing device of test tube type according to claim 1 or 3, it is characterised in that the seat of honour, center pillar and
Lower seat is fixed with screw, middle to fix two ring with method of clamping.
5. the micro magnetic bead fixing device of test tube type according to claim 1, it is characterised in that the ring magnet is N35
Grade strong magnets.
6. the micro magnetic bead fixing device of test tube type according to claim 1, it is characterised in that several fixing grooves are in circle
Column, and its diameter is without consistent but consistent with each self-corresponding fixing hole.
7. the micro magnetic bead fixing device of test tube type according to claim 1, it is characterised in that the shape of the ring magnet
It is cylinder, corner cylinder or hexagonal cylinder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621051287.1U CN206198762U (en) | 2016-09-13 | 2016-09-13 | The micro magnetic bead fixing device of test tube type |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621051287.1U CN206198762U (en) | 2016-09-13 | 2016-09-13 | The micro magnetic bead fixing device of test tube type |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206198762U true CN206198762U (en) | 2017-05-31 |
Family
ID=58760026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621051287.1U Active CN206198762U (en) | 2016-09-13 | 2016-09-13 | The micro magnetic bead fixing device of test tube type |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206198762U (en) |
-
2016
- 2016-09-13 CN CN201621051287.1U patent/CN206198762U/en active Active
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