CN206192879U - Blood oxygen saturability detection device based on dual -wavelength laser - Google Patents
Blood oxygen saturability detection device based on dual -wavelength laser Download PDFInfo
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- CN206192879U CN206192879U CN201621282502.9U CN201621282502U CN206192879U CN 206192879 U CN206192879 U CN 206192879U CN 201621282502 U CN201621282502 U CN 201621282502U CN 206192879 U CN206192879 U CN 206192879U
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Abstract
The utility model relates to a blood oxygen saturability detection device based on dual -wavelength laser, the device is including triggering formula dual -wavelength laser light source, optical fiber head, beam expanding lens, speculum, objective table, image device and computer, inlay on the objective table and establish a mao glass, triggering formula dual -wavelength laser light source and launching in turn the laser of two kinds of wavelength, laser is through optical fiber head directive beam expanding lens, and the laser that comes out from the beam expanding lens is placed being surveyed the sample and passing through on mao glass in through speculum reflection directive and is surveyed the sample and get into image device, and image device gathers two kinds of wavelength laser transmission in turn and crosses the scattered spot signal of being surveyed the sample and regard as image data to transmit to the computer it, and the computer is handled in order to obtain the oxyhemoglobin saturation who is surveyed the sample the image data who receives. The utility model discloses can not carry out whole audience scanning to being surveyed sample not damaged ground, gather different wavelength in turn and shine scattered spot signal down and can effectively restrain the oxyhemoglobin saturation precision height of being surveyed the influence that the sample position changes and the blood oxygen content change brings, detection.
Description
Technical field
The utility model is related to technical field of medical instruments, more particularly, to a kind of blood oxygen based on dual-wavelength laser
Saturation degree detection means.
Background technology
Noninvasive blood oxygen saturation detection is based on change of the hemoglobin to different wave length absorbing amount, so as to measure oxygen
Hemoglobin (HbO) is closed to account for the percentage of whole hemoglobins and realize.In the detection of perspective formula blood oxygen saturation, if ignored
Due to the decay that the factors such as scattering, reflection are caused, can be in the hope of blood according to Bill-Lambert law (Beer-Lambert Law)
Oxygen saturation.
The luminous intensity measurement of the value to draw accurate blood oxygen saturation, incident light and transmitted light should be reported as precisely as possible, but
Be universal measurement apparatus now precision it is unsatisfactory and speed is not fast enough, it is main reason is that what detector was collected
The spatial resolution of signal is not high, be not the optical scanner of the whole audience and the flow velocity of blood can produce considerable influence to measurement.Institute
So that the device of existing detection blood oxygen saturation has that accuracy of detection is not high, it is necessary to improve.
Utility model content
The purpose of this utility model is to overcome the deficiencies in the prior art, there is provided a kind of blood oxygen based on dual-wavelength laser is satisfied
With degree detection means, the device can carry out whole audience scanning to sample, to sample not damaged, and the blood oxygen saturation for detecting
Degree high precision.
In order to solve the above technical problems, the technical solution adopted in the utility model is：
A kind of blood oxygen saturation detection means based on dual-wavelength laser of offer, including trigger-type dual-wavelength laser light source,
Optical fiber head, beam expanding lens, speculum, objective table, imaging device and computer；Through hole is offered on objective table, is embedded in the through hole
There is frosted glass；Trigger-type dual-wavelength laser light source alternate emission goes out two kinds of laser of wavelength, and laser is expanded by optical fiber head directive
Mirror, from the sample that beam expanding lens laser out is placed on frosted glass by directive after the reflection of speculum, laser transmitted through
Sample enters imaging device, speckle signals and general of the two kinds of wavelength lasers of imaging device interleaved acquisition transmitted through sample
It is transmitted to computer as view data, and the view data that computer docking is received is processed to obtain the blood oxygen saturation of sample
Degree.
In such scheme, by setting trigger-type dual-wavelength laser light source and trigger-type dual-wavelength laser light source is alternately sent out
Two kinds of laser of wavelength are projected, with two kinds of wavelength lasers of imaging device interleaved acquisition are transmitted through the speckle signals of sample and incite somebody to action
It is transmitted to computer as view data, and the view data that computer docking is received is processed to obtain the blood oxygen saturation of sample
Degree.A kind of blood oxygen saturation detection means based on dual-wavelength laser of the utility model, can carry out whole audience scanning to sample,
To sample not damaged, two kinds of wavelength lasers of imaging device interleaved acquisition can effectively press down transmitted through the speckle signals of sample
Sample position processed changes and the oxygen content of blood changes the influence for bringing, the blood oxygen saturation high precision of detection.
Preferably, the speculum and the angle of horizontal plane are 45 °, trigger-type dual-wavelength laser light source, optical fiber head and expansion
Shu Jing is centrally located in same horizontal line, and center and the laser of frosted glass are erected by the reflected light after speculum reflection same
On straight line.The light intensity of the incident light and transmitted light that can guarantee that laser is so set, is conducive to improving the blood oxygen saturation of detection
Precision.
Preferably, the imaging device is COMS cameras.So setting can not only obtain the image of more high spatial resolution
Data, and can be cost-effective.
Preferably, trigger-type dual-wavelength laser light source alternate emission goes out the two kinds of wavelength of laser respectively 650nm and
940nm.Hemoglobin is larger to the absorption coefficient difference of the laser of both wavelength, and the error produced during calculating is small, is conducive to
Improve the precision of the blood oxygen saturation of detection.
Compared with prior art, the beneficial effects of the utility model are：
A kind of blood oxygen saturation detection means based on dual-wavelength laser of the utility model, by setting trigger-type dual wavelength
LASER Light Source simultaneously makes trigger-type dual-wavelength laser light source alternate emission go out two kinds of laser of wavelength, with imaging device interleaved acquisition two
Plant wavelength laser and the figure received to computer, computer docking is transmitted transmitted through the speckle signals of sample and as view data
Processed as data to obtain the blood oxygen saturation of sample, the device can carry out whole audience scanning to sample, to quilt
Test sample product not damaged, two kinds of wavelength lasers of imaging device interleaved acquisition can effectively suppress quilt transmitted through the speckle signals of sample
Survey the influence that sample position changes and oxygen content of blood change brings, the blood oxygen saturation high precision of detection；By the way that trigger-type is double
The two kinds of wavelength of laser respectively 650nm and 940nm that wavelength laser source alternate emission goes out, hemoglobin is to both wavelength
Laser absorption coefficient difference it is larger so that the error produced during calculating is small, is conducive to improving the blood oxygen saturation for detecting
Precision.
Brief description of the drawings
Fig. 1 is a kind of structural representation of the blood oxygen saturation detection means based on dual-wavelength laser of the present embodiment.
Fig. 2 is imaging device collection signal and trigger-type dual-wavelength laser light source trigger signal schematic diagram in Fig. 1.
Fig. 3 is a kind of use flow chart of the blood oxygen saturation detection means based on dual-wavelength laser of the present embodiment.
Specific embodiment
The utility model is further described with reference to specific embodiment.Wherein, being for illustration only property of accompanying drawing
Illustrate, expression is only schematic diagram, rather than pictorial diagram, it is impossible to be interpreted as the limitation to this patent；In order to this reality is better described
With new embodiment, accompanying drawing some parts have omission, zoom in or out, and do not represent the size of actual product；To ability
For field technique personnel, some known features and its explanation may be omitted and will be understood by accompanying drawing.
The same or analogous part of same or analogous label correspondence in the accompanying drawing of the utility model embodiment；In this practicality
In new description, it is to be understood that if having term " on ", D score, the orientation of the instruction such as "left", "right" or position relationship be
Based on orientation shown in the drawings or position relationship, it is for only for ease of description the utility model and simplifies description, rather than instruction
Or imply that the device or element of meaning must be with specific orientation, to be retouched in specific azimuth configuration and operation, therefore accompanying drawing
Term the being for illustration only property explanation of position relationship is stated, it is impossible to be interpreted as the limitation to this patent, for the common skill of this area
For art personnel, the concrete meaning of above-mentioned term can be as the case may be understood.
Embodiment
A kind of structural representation of the blood oxygen saturation detection means based on dual-wavelength laser of the present embodiment as shown in figure 1,
Including trigger-type dual-wavelength laser light source 1, optical fiber head 2, beam expanding lens 3, speculum 4, objective table 7, imaging device 6 and computer 5；Carry
Through hole is offered on thing platform 7, frosted glass 8 is embedded with the through hole；The alternate emission of trigger-type dual-wavelength laser light source 1 goes out two kinds
The laser of wavelength, laser by the directive beam expanding lens 3 of optical fiber head 2, from the laser out of beam expanding lens 3 by after the reflection of speculum 4
The sample that directive is placed on frosted glass 8, laser enters imaging device 6, imaging device interleaved acquisition transmitted through sample
Two kinds of wavelength lasers transmitted through sample speckle signals and transmit to computer 5 as view data, computer docking is received
View data processed to obtain the blood oxygen saturation of sample.
In the present embodiment, the two kinds of wavelength of laser respectively 650nm that the alternate emission of trigger-type dual-wavelength laser light source 1 goes out
And 940nm, hemoglobin is larger to the absorption coefficient of the laser of both wavelength difference, and the error produced during calculating is small, favorably
In the precision of the blood oxygen saturation for improving detection.The first launch wavelength of trigger-type dual-wavelength laser light source 1 is the laser of 650nm, into
As device 6 gathers 650nm laser transmitted through the speckle signals of sample, then, trigger-type dual-wavelength laser light source 1 is first launched
Wavelength is the laser of 940nm, and imaging device 6 gathers 940nm laser transmitted through the speckle signals of sample, so repeatedly, directly
The frame number of the view data gathered to imaging device 6 stops when reaching arranges value.
When detecting the blood oxygen saturation of sample using the device, sample is placed on the hair glass on objective table 7
On glass 8, and replace the laser that the alternate emission wavelength of trigger-type dual-wavelength laser light source 1 is 650nm and 940nm, imaging device 6
Both wavelength lasers are gathered to be transmitted to computer 5, computer 5 transmitted through the speckle signals of sample and as view data
View data to receiving is processed to obtain the blood oxygen saturation of sample.The utility model is a kind of to be swashed based on dual wavelength
The blood oxygen saturation detection means of light, can carry out whole audience scanning to sample, and to sample not damaged, imaging device 6 is handed over
Can effectively suppress the change of sample position transmitted through the speckle signals of sample for two kinds of wavelength lasers of collection to contain with blood oxygen
Amount changes the influence for bringing, the blood oxygen saturation high precision of detection.
Wherein, the angle of the speculum 4 and horizontal plane is 45 °, trigger-type dual-wavelength laser light source 1, optical fiber head 2 and is expanded
Beam mirror 3 is centrally located in same horizontal line, and the center of frosted glass 8 is with laser by the reflected light after the reflection of speculum 4 same
On one vertical curve.The light intensity of the incident light and transmitted light that can guarantee that laser is so set, is conducive to improving the blood oxygen saturation for detecting
The precision of degree.
In addition, the imaging device 6 is COMS cameras.So setting can not only obtain the picture number of more high spatial resolution
According to, and can be cost-effective.
During using above-mentioned blood oxygen saturation detection means based on dual-wavelength laser, comprise the following steps, the step such as Fig. 3
It is shown：
S1. on the frosted glass 8 sample being placed on objective table 7；Picking rate, the exposure of imaging device 6 are set
The laser speckle signal of time and collection as view data frame number, while set trigger-type dual-wavelength laser light source 1 launching
The trigger signal and imaging device 6 of two kinds of wavelength lasers gather the collection signal of laser speckle signal；Specifically, imaging device 6
Collection signal for frequency 2f square-wave signal, trailing edge triggering imaging device 6 expose, start collection, different wave length laser
Trigger signal frequency is f, two wavelength laser trigger signal time delay half periods, and the collection signal of imaging device 6 and trigger-type are double
The trigger signal schematic diagram of wavelength laser source 1 is as shown in Figure 2；
S2. after setting completed, trigger signal, trigger-type dual-wavelength laser light are sent to trigger-type dual-wavelength laser light source 1
The launch wavelength of source 1 is λ1Laser, while sending collection signal to imaging device 6, imaging device 6 starts collection laser speckle letter
Number, trigger signal is sent to trigger-type dual-wavelength laser light source 1 again after the completion of collection, trigger-type dual-wavelength laser light source 1 stops
Only launch wavelength is λ1Laser；Trigger signal, trigger-type dual-wavelength laser light source are sent to trigger-type dual-wavelength laser light source 1
1 launch wavelength is λ2Laser, while sending collection signal to imaging device 6, imaging device 6 starts collection laser speckle letter
Number, trigger signal is sent to trigger-type dual-wavelength laser light source 1 again after the completion of collection, trigger-type dual-wavelength laser light source 1 stops
Only launch wavelength is λ2Laser；And so on, until the frame number of the view data of the collection of imaging device 6 stops when reaching arranges value
Only；Wherein, λ1=650nm, λ2=940nm；
S3. two kinds of speckle signals of wavelength laser of the interleaved acquisition of imaging device 6 are transmitted to computer as view data
5, the view data of 5 pairs of receptions of computer is processed to obtain the blood oxygen saturation of sample, is comprised the following steps：
S31. the view data according to collection putting in order wavelength X1And wavelength X2The picture number of the lower collection of laser irradiation
According to separating, the view data of odd number is wavelength X1The view data of the lower collection of laser irradiation, the image of even number
Data are wavelength X2The view data of the lower collection of laser irradiation；
S32. the wavelength X to isolating1And wavelength X2View data in each pixel temporally enter respectively in t directions
Row Fast Fourier Transform (FFT), to obtain the frequency domain distribution of view data；
The signal strength expression of any pixel is (1) formula in the view data of the collection of imaging device 6；
Ip(t)=I0+In(t)+IRBC (1)
Wherein, I0It is background light intensity, InT () is system noise, IRBCIt is absorption intensity of the red blood cell to light；
Fast Fourier Transform (FFT) is carried out by formula (2) to (1) formula, to obtain the frequency domain distribution of view data；
FFTt→u[Ip(t)]=i0[u]+in[u]+iRBC[u±fi] (2)
Wherein, i0[u] is frequency domain stationary singnal, in[u] is the spectrum signal of system noise, iRBC[u±fi] it is that frequency domain is moved
State signal；
S33. the frequency-region signal FFT to being obtained after Fast Fourier Transform (FFT)t→u[Ip(t)] low frequency filtering is carried out, to obtain frequency
Domain Dynamic Signal iRBC[u±fi]；
S34. inverse Fourier transform is carried out by (3) formula to obtaining Domain Dynamic signal, light intensity is absorbed to obtain erythrocyte
Signal IRBC[t]；
iFFTu→t[iRBC(u±fi)]=IRBC[t] (3)
S35. erythrocyte is calculated to wavelength X by (4) formula1And wavelength X2The variable quantity of the absorption intensity of laser；
S36. according to Beer-Lambert laws, oxyhemoglobin Δ C is calculated by (5) formulaHbO(t)And deoxyhemoglobin
ΔCHbR(t)Change in concentration amount；
Wherein, the absorption coefficient of light of the oxyhemoglobin under the irradiation of 650nm and 940nm wavelength lasersFor
368 and 1214, the absorption coefficient of light of the deoxyhemoglobin under the irradiation of 650nm and 940nm wavelength lasersFor
3750.12 and 693.44；
S37. the blood oxygen saturation of sample is calculated according to (6) formula；
Wherein, Δ SO2The as blood oxygen saturation of sample.
Obviously, above-described embodiment of the present utility model is only intended to clearly illustrate the utility model example, and
It is not the restriction to implementation method of the present utility model.For those of ordinary skill in the field, in described above
On the basis of can also make other changes in different forms.There is no need and unable to give all of implementation method
It is exhaustive.All any modification, equivalent and improvement made within spirit of the present utility model and principle etc., should be included in
Within the utility model scope of the claims.
Claims (4)
1. a kind of blood oxygen saturation detection means based on dual-wavelength laser, it is characterised in that including trigger-type dual-wavelength laser
Light source (1), optical fiber head (2), beam expanding lens (3), speculum (4), objective table (7), imaging device (6) and computer (5)；Objective table
(7) through hole is offered on, frosted glass (8) is embedded with the through hole；Trigger-type dual-wavelength laser light source (1) alternate emission goes out two
The laser of wavelength is planted, laser passes through speculum by optical fiber head (2) directive beam expanding lens (3) from beam expanding lens (3) laser out
(4) sample that directive is placed on frosted glass (8) after reflection, laser enters imaging device (6) transmitted through sample, into
As two kinds of wavelength lasers of device interleaved acquisition are transmitted to electricity transmitted through the speckle signals of sample and as view data
Brain (5), the view data that computer docking is received is processed to obtain the blood oxygen saturation of sample.
2. a kind of blood oxygen saturation detection means based on dual-wavelength laser according to claim 1, it is characterised in that institute
The angle that speculum (4) is stated with horizontal plane is 45 °, trigger-type dual-wavelength laser light source (1), optical fiber head (2) and beam expanding lens (3)
It is centrally located in same horizontal line, center and the laser of frosted glass (8) are erected by the reflected light after speculum (4) reflection same
On straight line.
3. a kind of blood oxygen saturation detection means based on dual-wavelength laser according to claim 1, it is characterised in that institute
It is COMS cameras to state imaging device (6).
4. a kind of blood oxygen saturation detection means based on dual-wavelength laser according to any one of claims 1 to 3, it is special
Levy and be, the two kinds of wavelength of laser respectively 650nm and 940nm that trigger-type dual-wavelength laser light source (1) alternate emission goes out.
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| CN201621282502.9U CN206192879U (en) | 2016-11-25 | 2016-11-25 | Blood oxygen saturability detection device based on dual -wavelength laser |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106442406A (en) * | 2016-11-25 | 2017-02-22 | 佛山科学技术学院 | Device and method for detecting blood oxygen saturation based on dual-wavelength lasers |
| CN109596552A (en) * | 2018-12-24 | 2019-04-09 | 中北大学 | Using list apart from source-detector to the method for measurement tissue oxygenation saturation degree |
| CN111870230A (en) * | 2020-07-16 | 2020-11-03 | 武汉大学 | Multi-parameter tumor blood vessel normalization detection system and detection method |
| CN114376572A (en) * | 2021-12-29 | 2022-04-22 | 华南理工大学 | Detection device and detection method for blood oxygen saturation |
-
2016
- 2016-11-25 CN CN201621282502.9U patent/CN206192879U/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106442406A (en) * | 2016-11-25 | 2017-02-22 | 佛山科学技术学院 | Device and method for detecting blood oxygen saturation based on dual-wavelength lasers |
| CN109596552A (en) * | 2018-12-24 | 2019-04-09 | 中北大学 | Using list apart from source-detector to the method for measurement tissue oxygenation saturation degree |
| CN109596552B (en) * | 2018-12-24 | 2021-07-16 | 中北大学 | Method for measuring tissue blood oxygen saturation using single range light source-detector pair |
| CN111870230A (en) * | 2020-07-16 | 2020-11-03 | 武汉大学 | Multi-parameter tumor blood vessel normalization detection system and detection method |
| CN114376572A (en) * | 2021-12-29 | 2022-04-22 | 华南理工大学 | Detection device and detection method for blood oxygen saturation |
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Granted publication date: 20170524 Termination date: 20171125 |