CN206127040U - A remove heat source system for among pharmaceutical industry - Google Patents
A remove heat source system for among pharmaceutical industry Download PDFInfo
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- CN206127040U CN206127040U CN201621150513.1U CN201621150513U CN206127040U CN 206127040 U CN206127040 U CN 206127040U CN 201621150513 U CN201621150513 U CN 201621150513U CN 206127040 U CN206127040 U CN 206127040U
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Abstract
The utility model provides a remove heat source system for among pharmaceutical industry. Including the feed liquor pipeline, hollow fiber ultrafiltration membrane group spare, heating device, drain line, the backward flow part, ultrafiltrate collecting part and condensate collecting part, the front end of feed liquor pipeline sets up to passing through tube coupling heating device, hollow fiber ultrafiltration membrane group spare sets up to including the stoste entry end, concentrate exit end and ultrafiltrate exit end, the stoste entry end sets up the end into intercommunication feed liquor pipeline, the concentrate exit end sets up to intercommunication drain line, the ultrafiltrate exit end sets up to last exit end and lower exit end, the feed liquor pipeline, hollow fiber ultrafiltration membrane group spare, heating device and backward flow part all set up to passing through tube coupling condensate collecting part. The utility model discloses a heat source in the subunit influenza vaccine manufacturing technology can effectively be got rid of by this system, avoids the heat source exceed the standard value that other foeign elements led to the fact to improve the qualification rate of bacterin preparation.
Description
Technical field
The utility model is related to pharmaceutical chemical industry technical field, more particularly to it is a kind of for pharmaceuticals industry in except thermal source system
System.
Background technology
Thermal source, also known as endotoxin, during pharmaceutical manufacturing, it is the important foundation for ensureing drug quality to remove thermal source.It is existing
What some pharmaceutical technologies considered mostly is the removal of water for pharmaceutical purposes link thermal source, and processing procedure is until injection from the pretreatment of water
With the point of use of water, the technology for being adopted generally includes activated carbon filtration, organic matter removal device, counter-infiltration, hyperfiltration and steaming
Evaporate, to be prevented effectively from water for pharmaceutical purposes in thermal source impact, fundamentally improve medicine overall performance.Due to water for pharmaceutical purposes
Efficient process have been carried out, therefore most pharmacy producers do not take notice of what other foeign elements were likely to result in the configuration process of liquid
Thermal source excessive problem, often directly will be used for production process with the liquid for postponing, so as to easily cause the decline of medicine qualification rate,
Cause the increase of production cost.But, for the thermal source that goes of configuration liquid is processed, using prior art, there are the following problems：
1st, the way of distillation：Water consumption is big, and energy consumption is higher, and because thermal source coolant-temperature gage is also higher, easily causes effectively
The destruction of composition.
2nd, active carbon adsorption：The pin primary activity charcoal of 0.1～0.5% (liquor capacity) is added when with liquid, is boiled
Boil and stir 15 minutes, can just remove most of thermal source, and activated carbon also has decolouring, drainage, deodorant effect, but it is active
Charcoal also can absorbed portion liquid, when using must Excess quantities, small dose drug should not adopt, and in addition the method is less efficient and inhales
Attached dose is difficult to regenerate.
3rd, ion-exchange：Thermal source is negatively charged in aqueous, can be exchanged by resin, but the easy saturation of resin, needs Jing normal
Regeneration.
The content of the invention
Main purpose of the present utility model is to solve problems of the prior art, there is provided one kind can be removed effectively
Thermal source in subunit influenza vaccine production technology, it is to avoid the thermal source that other foeign elements are caused is above standard value, to improve epidemic disease
Seedling prepare qualification rate for pharmaceuticals industry in except heat source system.
To solve above-mentioned technical problem, the technical solution adopted in the utility model is：It is a kind of for pharmaceuticals industry in remove
Heat source system, wherein it is described for pharmaceuticals industry in except heat source system include water influent pipeline, polysulfone hollow fiber ultrafiltration membrane system, plus
Thermal, drain line, refluxing portion, ultrafiltrate collect part and collecting condensation part, and the front end of the water influent pipeline sets
It is set to and the heater is connected by pipeline, the polysulfone hollow fiber ultrafiltration membrane system is set to include stoste arrival end, concentration
The liquid port of export and the ultrafiltrate port of export, the stoste arrival end is set to connect the end of the water influent pipeline, the concentrate
The port of export is set to connect the drain line, and the ultrafiltrate port of export is set to upper outlet end and lower outlet end, it is described on
The port of export is set to connect the refluxing portion, and ultrafiltrate enters the refluxing portion, returns institute by the upper outlet end
State polysulfone hollow fiber ultrafiltration membrane system to be filtered, multi-reflow ultrafiltration improves the production of medicine to ensure the thorough removing of thermal source
Quality, the lower outlet end is set to connect the ultrafiltrate collection part, when ultrafiltrate is after multi-reflow ultrafiltration, control
Regulating valve on the pipeline of the lower outlet end, realizes the collection of liquid, the water influent pipeline, the hollow fiber ultrafiltration membrane group
Part, the heater and the refluxing portion are disposed as connecting the collecting condensation part by pipeline, it is described enter
Diaphragm valve is also set up on liquid pipeline and the refluxing portion.
Further, the polysulfone hollow fiber ultrafiltration membrane system is set to by the first hollow-fibre membrane post and the second doughnut
Film post is constituted, and while a film post is produced, another root film post can be sterilized online and on-line cleaning, to save
Batch time, improves the overall service efficiency of equipment.
Further, the heater is set to include supply channel, steam pipework, boiler and heat-exchanger pump, described
Supply channel is arranged at the upper end of the boiler, and for constantly for the heater providing water source, the steam pipework sets
Be set to and its inner chamber entered by the side wall of the boiler, to realize the boiler in water heating, the heat-exchanger pump is set to
The bottom of the boiler is connected by pipeline, the water in boiler is pumped in the water influent pipeline by the heat-exchanger pump.
Further, the boiler is set to also include phegma import, exhaust outlet and condensation-water drain, the backflow
Liquid import may be contained within the upper end of the boiler with the exhaust outlet, and the phegma import is set to connect institute by pipeline
Refluxing portion is stated, the condensation-water drain is arranged on the side wall of the boiler, and the condensation-water drain is set to by pipe
Road connects the collecting condensation part, so as to realize the process that steam is condensed, it is ensured that vapour system is to water in the boiler
Heating.
Further, the front end of the water influent pipeline also sets up a solution feed pump, is entered by the solution feed pump process auxiliary drive liquid
Enter the polysulfone hollow fiber ultrafiltration membrane system to complete hyperfiltration treatment.
Further, it is respectively provided with a pressure gauge, and the water influent pipeline on the water influent pipeline and the refluxing portion
Pressure gauge carry two point pressure switch, when operating pressure reaches the pressure value of setting, high pressure, low pressure alarming signal can be provided
And make the solution feed pump quit work.
Further, it is respectively provided with the water influent pipeline, the lower outlet end and the pipeline of the condensation-water drain hydrophobic
Valve and temperature sensor, are as early as possible discharged condensed water, air and carbon dioxide by the drain valve, while at utmost
Prevent the leakage of steam, and by the temperature of condensate in the temperature sensor real-time monitoring pipeline, it is ensured that system it is good
Work.
The utility model has the advantages and positive effects that：
(1) by the cooperation of polysulfone hollow fiber ultrafiltration membrane system, heater and refluxing portion so that ultrafiltrate is by upper outlet
End enters refluxing portion, returns polysulfone hollow fiber ultrafiltration membrane system and is filtered, and multi-reflow ultrafiltration ensure that the thorough of thermal source
Remove, so as to provide apyrogenic liquid for subunit influenza vaccine preparation work, improve the quality of production of medicine.
(2) by the pressure gauge arranged in water influent pipeline and refluxing portion, when operating pressure reaches the pressure value of setting,
High pressure, low pressure alarming signal can be given and make solution feed pump quit work, it is ensured that the trouble free service of whole system.
(3) by the drain valve and temperature sensor on the pipeline of water influent pipeline, lower outlet end and condensation-water drain, will be cold
Solidifying water, air and carbon dioxide are discharged as early as possible, while the leakage of steam is farthest prevented, and by temperature sensor reality
When monitor the temperature of condensate in pipeline, it is good to guarantee the work of water influent pipeline, polysulfone hollow fiber ultrafiltration membrane system and heater.
Description of the drawings
Fig. 1 is structural representation of the present utility model.
In figure：10- water influent pipelines, 101- diaphragm valves, 102- solution feed pumps, 103- pressure gauges, 104- drain valves, 105- temperature
Sensor, 20- polysulfone hollow fiber ultrafiltration membrane systems, 201- stoste arrival ends, 202- concentrated solution outlets end, 203- upper outlets end,
204- lower outlet ends, 205- the first hollow-fibre membrane posts, 206- the second hollow-fibre membrane posts, 30- heaters, 301- feed pipes
Road, 302- steam pipeworks, 303- boilers, 304- heat-exchanger pumps, 305- phegma imports, 306- exhaust outlets, 307- condensed waters go out
Mouthful, 40- drain lines, 50- refluxing portions, 60- ultrafiltrates collect part, 70- collecting condensations part.
Specific embodiment
In order to be better understood from the utility model, with reference to specific embodiments and the drawings traveling one is entered to the utility model
The description of step.
As shown in figure 1, it is a kind of for pharmaceuticals industry in except heat source system, including water influent pipeline 10, Hollow Fiber Ultrafiltration
Membrane module 20, heater 30, drain line 40, refluxing portion 50, ultrafiltrate collect part 60 and collecting condensation part 70,
The front end of water influent pipeline 10 is set to connect heater 30 by pipeline, and polysulfone hollow fiber ultrafiltration membrane system 20 is set to include original
Liquid arrival end 201, concentrated solution outlet end 202 and the ultrafiltrate port of export, stoste arrival end 201 is set to connect water influent pipeline 10
End, concentrated solution outlet end 202 is set to connect drain line 40, and the ultrafiltrate port of export is set to upper outlet end 203 and goes out with
Mouth end 204, upper outlet end 203 is set to connect refluxing portion 50, and ultrafiltrate enters refluxing portion 50 by upper outlet end 203,
Return polysulfone hollow fiber ultrafiltration membrane system 20 to be filtered, multi-reflow ultrafiltration improves medicine to ensure the thorough removing of thermal source
The quality of production, lower outlet end 204 be set to connect ultrafiltrate collect part 60, when ultrafiltrate is after multi-reflow ultrafiltration,
Regulating valve on the pipeline of control lower outlet end 204, realizes the collection of liquid, water influent pipeline 10, polysulfone hollow fiber ultrafiltration membrane system
20th, heater 30 and refluxing portion 50 are disposed as connecting collecting condensation part 70 by pipeline, water influent pipeline 10 with
Diaphragm valve 101 is also set up on refluxing portion 50.
Polysulfone hollow fiber ultrafiltration membrane system 20 is set to by the first hollow-fibre membrane post 205 and the second hollow-fibre membrane post 206
Composition, while a film post is produced, another film post can be sterilized online and on-line cleaning, to save during batch
Between, improve the overall service efficiency of equipment.
Heater 30 is set to include supply channel 301, steam pipework 302, boiler 303 and heat-exchanger pump 304, supplies water
Pipeline 301 is arranged at the upper end of boiler 303, for constantly for heater 30 providing water source, steam pipework 302 be set to by
The side wall of boiler 303 enter its inner chamber, to realize boiler 303 in water heating, heat-exchanger pump 304 be set to by pipeline connect
The bottom of boiler 303 is connect, the water in boiler 303 is pumped in water influent pipeline 10 by heat-exchanger pump 304.
Boiler 303 is set to also include phegma import 305, exhaust outlet 306 and condensation-water drain 307 that phegma enters
Mouth 305 may be contained within the upper end of boiler 303 with exhaust outlet 306, and exhaust outlet 306 is used for the discharge of aseptic gas, and phegma enters
Mouth 305 is set to connect refluxing portion 50 by pipeline, and condensation-water drain 307 is arranged on the side wall of boiler 303, and this is cold
Solidifying water out 307 is set to connect collecting condensation part 70 by pipeline, so as to realize the process that steam is condensed, it is ensured that steam
Heating of the system to water in boiler 303.
The front end of water influent pipeline 10 also sets up a solution feed pump 102, and by the process auxiliary drive liquid of solution feed pump 102 doughnut is entered
Hyperfiltration membrane assembly 20 is completing hyperfiltration treatment.
A pressure gauge 103, and the band of pressure gauge 103 in water influent pipeline 10 are respectively provided with water influent pipeline 10 and refluxing portion 50
There is two point pressure switch, when operating pressure reaches the pressure value of setting, high pressure, low pressure alarming signal can be given and solution feed pump is made
102 quit work.
Drain valve 104 and temperature biography are respectively provided with water influent pipeline 10, lower outlet end 204 and the pipeline of condensation-water drain 307
Sensor 105, is as early as possible discharged condensed water, air and carbon dioxide by drain valve 104, while farthest preventing from steaming
The leakage of vapour, and by the temperature of condensate in the real-time monitoring pipeline of temperature sensor 105, it is ensured that the works fine of system.
Using the utility model provide for pharmaceuticals industry in except heat source system, can effectively remove subunit's influenza
Thermal source in production of vaccine technique, it is to avoid the thermal source that other foeign elements are caused is above standard value, to improve the conjunction of vaccine preparation
Lattice rate.When the system works, water source is injected boiler 303 by supply channel 301, and blasts steam pair by steam pipework 302
Water in boiler 303 is heated, and hot water is pumped in water influent pipeline 10 by heat-exchanger pump 304 after heating, while solution feed pump 102
Liquid is pumped into by water influent pipeline 10 so that the mixed liquor of hot water and liquid is entered in polysulfone hollow fiber ultrafiltration membrane system 20, selected
A film post therein is produced, while another film post is sterilized online and on-line cleaning, to save batch time, is carried
The overall service efficiency of high equipment, Jing after hyperfiltration treatment, concentrate is discharged from concentrated solution outlet end 202 by drain line 40, and
Ultrafiltrate enters refluxing portion 50 by upper outlet end 203, is then return to polysulfone hollow fiber ultrafiltration membrane system 20 and is filtered again,
Multi-reflow ultrafiltration improves the quality of production of medicine, when ultrafiltrate is through multi-reflow ultrafiltration to ensure the thorough removing of thermal source
Afterwards, the regulating valve on the pipeline of lower outlet end 204 is controlled, is made ultrafiltrate enter ultrafiltrate by lower outlet end 204 and is collected part 60,
The collection of liquid is realized, and will by the drain valve 104 on the pipeline of water influent pipeline 10, lower outlet end 204 with condensation-water drain 307
Condensed water, air and carbon dioxide are discharged as early as possible, farthest prevent the leakage of steam, and temperature sensor 105 is then
The temperature of condensate in real-time monitoring pipeline, it is ensured that the works fine of system, and coordinate pressure gauge 103 to guarantee each several part in system
Trouble free service.
Embodiment of the present utility model has been described in detail above, but the content is only of the present utility model preferable
Embodiment, it is impossible to be considered as limiting practical range of the present utility model.All impartial changes made according to the utility model scope
Change and improve etc., all should still belong within this patent covering scope.
Claims (7)
1. it is a kind of for pharmaceuticals industry in except heat source system, it is characterised in that：It is described for pharmaceuticals industry in except thermal source system
System include water influent pipeline, polysulfone hollow fiber ultrafiltration membrane system, heater, drain line, refluxing portion, ultrafiltrate collect partly and
Collecting condensation part, the front end of the water influent pipeline is set to connect the heater, the doughnut by pipeline
Hyperfiltration membrane assembly is set to include stoste arrival end, concentrated solution outlet end and the ultrafiltrate port of export that the stoste arrival end is arranged
To connect the end of the water influent pipeline, the concentrated solution outlet end is set to connect the drain line, and the ultrafiltrate goes out
Mouth end is set to upper outlet end and lower outlet end, and the upper outlet end is set to connect the refluxing portion, the lower outlet end
It is set to connect the ultrafiltrate collection part, the water influent pipeline, the polysulfone hollow fiber ultrafiltration membrane system, the heater
And the refluxing portion is disposed as connecting the collecting condensation part, the water influent pipeline and the backflow by pipeline
Diaphragm valve is also set up on part.
2. it is according to claim 1 for pharmaceuticals industry in except heat source system, it is characterised in that：The doughnut surpasses
Filter membrane component is set to be made up of the first hollow-fibre membrane post and the second hollow-fibre membrane post.
3. it is according to claim 1 for pharmaceuticals industry in except heat source system, it is characterised in that：The heater sets
It is set to including supply channel, steam pipework, boiler and heat-exchanger pump, the supply channel is arranged at the upper end of the boiler,
The steam pipework is set to enter its inner chamber by the side wall of the boiler, and the heat-exchanger pump is set to connect institute by pipeline
State the bottom of boiler.
4. it is according to claim 3 for pharmaceuticals industry in except heat source system, it is characterised in that：The boiler is arranged
Also to include phegma import, exhaust outlet and condensation-water drain, the phegma import may be contained within described with the exhaust outlet
The upper end of boiler, the phegma import is set to connect the refluxing portion by pipeline, and the condensation-water drain is arranged
On the side wall of the boiler, and the condensation-water drain is set to connect the collecting condensation part by pipeline.
5. it is according to claim 1 for pharmaceuticals industry in except heat source system, it is characterised in that：The water influent pipeline
Front end also sets up a solution feed pump.
6. it is according to claim 1 for pharmaceuticals industry in except heat source system, it is characterised in that：The water influent pipeline with
A pressure gauge is respectively provided with the refluxing portion.
7. according to claim 1 or 4 for pharmaceuticals industry in except heat source system, it is characterised in that：The feed tube
Drain valve and temperature sensor are respectively provided with road, the lower outlet end and the pipeline of the condensation-water drain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621150513.1U CN206127040U (en) | 2016-10-24 | 2016-10-24 | A remove heat source system for among pharmaceutical industry |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621150513.1U CN206127040U (en) | 2016-10-24 | 2016-10-24 | A remove heat source system for among pharmaceutical industry |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206127040U true CN206127040U (en) | 2017-04-26 |
Family
ID=58575096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621150513.1U Active CN206127040U (en) | 2016-10-24 | 2016-10-24 | A remove heat source system for among pharmaceutical industry |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206127040U (en) |
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2016
- 2016-10-24 CN CN201621150513.1U patent/CN206127040U/en active Active
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