CN205941377U - Heavy metal ion detects chip - Google Patents
Heavy metal ion detects chip Download PDFInfo
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- CN205941377U CN205941377U CN201620775507.9U CN201620775507U CN205941377U CN 205941377 U CN205941377 U CN 205941377U CN 201620775507 U CN201620775507 U CN 201620775507U CN 205941377 U CN205941377 U CN 205941377U
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- metal ion
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- hydrophobic layer
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Abstract
The application discloses heavy metal ion detects chip, including the hydrophilicity substrate, this substrate surface covers there is the one deck hydrophobic layer, and this hydrophobic layer blocks that heavy metal ion gets into the substrate and can allow organic solvent to see through, the hydrophobic layer surface adsorption has the colouring agent that can take place color development reaction with at least a heavy metal ion. The utility model discloses among the heavy metal ion's of the micro -fluidic scraps of paper the detection method, multiple heavy metal ion turns over with specific material and gives birth to color development reaction, handles making heavy metal ion's detectivity obtain very big promotion through surperficial hydrophobization. The micro -fluidic refill piece heavy metal ion detection method of this kind can overcome traditional heavy metal ion detecting instrument complicacy, shortcomings such as the sample demand is big, the application is narrow, test cost height, can determine the nature on line and quantitative determination heavy metal ion.
Description
Technical field
The application is related to a kind of micro-fluidic paper chip detection technique, more particularly to a kind of heavy metal ion detection chip.
Background technology
China about 50% earth surface water source is contaminated, and hundreds of organic compound, heavy metal ion enter water source, simultaneously
Lower water source is also exceeded in fluorine, arsenic, iron, manganese etc..Water containing heavy metal ion (cadmium, chromium, copper, mercury, nickel etc.) is drunk by the mankind, meeting
The mankind are caused to suffer from various diseases, have even can be carcinogenic.Water heavy metal ion pollution is water environment to be caused heavy metal ion dirty
The occurring source of dye., as a kind of natural water wetted material, aqueous testing sample dropping can be in capillary in paper chip for cellulose
The lower automatic flowing of effect, without external driver device, is a kind of extraordinary micro-fluidic material.Micro-fluidic paper chip has very
It is widely applied, in quick diagnosis, food security, the aspect such as environment measuring plays a very important role.Through last decade
Development, micro-fluidic paper chip has many processing methods, such as cut paper method, wax printing method, impact system etc..Current detection means side
There are colorimetric detection method, Electrochemical Detection, chemiluminescence detection etc. in face.Using the water-wet behavior of paper chip, by hydrophobic material, photoetching
Glue, AKD, wax, PDMS, OTS, hydrogel patterning is imprinted on its surface, by constructing hydrophobic channel, Ke Yi in paper chip
Micro-fluidic paper chip is designed and produced in two dimensional surface.By by the paper chip stacked in multi-layers of two, or by the method for paper folding
Paper chip is rolled at one piece, and corresponding hydrophilic region is directed at UNICOM, the paper chip on three directions can be made.Due to many
The method that number makes paper chip for mass constructs the microchannel majority not organic solvent-resistant of paper chip, therefore limits refill
The application in detection for the piece.
Micro-fluidic paper chip is a kind of emerging microfluidic analysis technology platform, have low cost, processing simple, using and
The advantages of easy to carry, have great application prospect in applications such as clinical diagnosis, food quality control and environmental monitorings.
But the most frequently used determination method of traditional micro-fluidic paper chip is colorimetric method, but to there is detection sensitivity low for colorimetric method
Shortcoming.
Utility model content
The purpose of this utility model is to provide a kind of heavy metal ion detection chip, with overcome of the prior art not
Foot.
For achieving the above object, the utility model provides following technical scheme：
The embodiment of the present application discloses a kind of heavy metal ion detection chip, and including hydrophilic base, this substrate surface covers
It is stamped one layer of hydrophobic layer, this hydrophobic layer stops that heavy metal ion enters base material and organic solvent can be allowed to pass through, described hydrophobic layer
Adsorption has the developer that chromogenic reaction can occur with least one heavy metal ion.
Preferably, in above-mentioned heavy metal ion detection chip, described base material is selected from filter paper, cellulose membrane, glass fibers
Dimension, writing paper or brown paper.
Preferably, in above-mentioned heavy metal ion detection chip, described hydrophobic layer material be selected from photoresist, AKD, wax,
PDMS or OTS.
Preferably, in above-mentioned heavy metal ion detection chip, the preparation method of described hydrophobic layer includes：By hydrophobic material
Material is dripped on the surface of micro-fluidic paper chip with the mixed solution of diluent, treat hydrophobic material be uniformly dispersed in substrate surface or
After coating uniformly, base material is heated so that hydrophobic material forms hydrophobic layer on surface..
Preferably, in above-mentioned heavy metal ion detection chip, described diluent is selected from a carbon to the alcohol of four carbon
Class, acetone, dichloromethane, hexane, heptane or petroleum ether.
Preferably, in above-mentioned heavy metal ion detection chip, described developer and metal ion Cr6+、Cu2+、Al3+、
Pb2+In at least one chromogenic reaction can occur.
Compared with prior art, the utility model has the advantage of：The heavy metal ion of the micro-fluidic scraps of paper of the utility model
Detection method in, contents of many kinds of heavy metal ion and predetermined substance instead give birth to chromogenic reaction, make a huge sum of money by surface-hydrophobicized process
The detection sensitivity belonging to ion has obtained great lifting.This micro-fluidic paper chip detection of heavy metal ion method can overcome biography
The shortcomings of system detection of heavy metal ion instrument is complicated, sample requirements are big, application is narrow, testing cost is high, can determine online
Property with quantitative determination heavy metal ion.
Brief description
In order to be illustrated more clearly that the embodiment of the present application or technical scheme of the prior art, below will be to embodiment or existing
Have technology description in required use accompanying drawing be briefly described it should be apparent that, drawings in the following description be only this
Some embodiments described in application, for those of ordinary skill in the art, on the premise of not paying creative work,
Other accompanying drawings can also be obtained according to these accompanying drawings.
Fig. 1 show the top view of heavy metal ion detection chip in the utility model specific embodiment；
Fig. 2 show the side view of heavy metal ion detection chip in the utility model specific embodiment；
Specific embodiment
Below in conjunction with the accompanying drawing in the utility model embodiment, the technical scheme in the utility model embodiment is carried out
Detailed description is it is clear that described embodiment is only a part of embodiment of the utility model, rather than whole enforcement
Example.Based on the embodiment in the utility model, those of ordinary skill in the art institute on the premise of not making creative work
The every other embodiment obtaining, broadly falls into the scope of the utility model protection.
In conjunction with shown in Fig. 1 and Fig. 2, heavy metal ion detection chip, including base material, this base material is formed with the interior of hydrophiling
Portion's base material 1, the surface 2 of hydrophobization, adsorption has developer 3, and definition on the surface 2 of hydrophobization has chromogenic reaction generation area
4.
In this technical scheme, hydrophiling inner substrate stores developer, and hydrophobizing surface adsorbs a certain amount of developer, and
Stop heavy metal ion to be measured deeply so that chromogenic reaction occurs in micro-fluidic paper chip surface, chromogenic reaction toward inside base material
The region that generation area is reacted with developer as heavy metal ion solution to be measured.
In above-mentioned heavy metal ion detection chip, the base material that can select has filter paper, cellulose membrane, glass fibre, book
Write with paper, brown paper.
In above-mentioned heavy metal ion detection chip, the material of the described silicic acid anhydride of micro-fluidic paper chip can be
Photoresist, AKD, wax, PDMS, OTS etc., wherein various hydrophobic materials can select a series of concentration proportioning with diluent
(0.01%-10%).
In above-mentioned heavy metal ion detection chip, by the mixed solution 1 of the hydrophobic material of appropriate volume and diluent
～2 μ l drip on the surface of micro-fluidic paper chip.Conventional diluent has the alcohols to four carbon for the carbon, acetone, dichloromethane
Alkane, hexane, heptane, petroleum ether etc..
Heavy metal ion solution to be measured can be enriched in surface by the hydrophobic material on micro-fluidic surface.
In above-mentioned heavy metal ion detection chip, solid block, powder, the above-mentioned hydrophobic material of film-form can be selected
Material coats one layer on micro-fluidic paper chip surface.
Uniformly or after coating uniformly, micro-fluidic paper chip is put in micro-fluidic paper chip Dispersion on surface after hydrophobic material
In baking oven or on hot plate carry out heating 100～150 DEG C, heat time 2～3min is so that hydrophobic material is formed on surface
Hydrophobic interfaces layer.
Detection method using above-mentioned detection chip includes：Developer dissolves in organic solvent, and developer dropping is existed
The surface of micro-fluidic paper chip, is adsorbed chromogenic reagent solution in the surface of base material and inside by capillarity.Treat that solvent volatilizees
Afterwards, band check weighing metal ion solution dropping is reacted in chromogenic reaction generation area 4, the heavy metal ion that can be detected
There is Cr6+、Cu2+、Al3+、Pb2+One or more of.
Developer is soluble in multiple organic solvents as the alcohols of carbon to four carbon, acetone, dichloromethane, oneself
Alkane, heptane, petroleum ether etc..
Heavy metal ion is reacted with developer, and the color product that reaction generates is gathered in the print that heavy metal ion solution stays
At note.
In one embodiment, 0.1% AKD- n-heptane solution 15 μ l is added in micro-fluidic paper chip hydrophobization
Surface 2, under capillary action solution diffuse to entirely micro-fluidic refill panel region 1,2 and 4, after normal heptane volatilization after, by miniflow
Control paper chip puts into insulation 2～3min at 100 DEG C.The micro-fluidic paper chip made is taken out, in chromogenic reaction generation area 4
Drip the DPC that 0.5 μ l concentration is 3.5%, DDTC, dithizone, chrome azurol S acetone soln.After carrying liqs volatilization, check weighing will be treated
Metal ion solution drips in chromogenic reaction generation area 4, and the metal ion that can be detected has Cr6+、Cu2+、Al3+、Pb2+It
One or more, corresponding Monitoring lower-cut is respectively 0.05mg/L, 0.1mg/L, 0.01mg/L, 0.005mg/L, respectively lower than country
Related request in standard.
Here, also, it should be noted in order to avoid having obscured the utility model because of unnecessary details, in the accompanying drawings
Illustrate only and the structure closely related according to scheme of the present utility model and/or process step, and eliminate and this practicality
The little other details of new relationship.
Finally in addition it is also necessary to explanation, term " inclusion ", "comprising" or its any other variant are intended to non-exclusive
Property comprise so that including a series of process of key elements, method, article or equipment not only include those key elements, and
Also include other key elements being not expressly set out, or also include intrinsic for this process, method, article or equipment
Key element.
Claims (4)
1. it is characterised in that including hydrophilic base, this substrate surface is coated with one layer and dredges a kind of heavy metal ion detection chip
Water layer, this hydrophobic layer stops that heavy metal ion enters base material and organic solvent can be allowed to pass through, and described hydrophobic layer adsorption has
The developer of chromogenic reaction can occur with least one heavy metal ion.
2. heavy metal ion detection chip according to claim 1 it is characterised in that：Described base material is selected from filter paper, fiber
Plain film, glass fibre, writing paper or brown paper.
3. heavy metal ion detection chip according to claim 1 it is characterised in that：Described hydrophobic layer material is selected from photoetching
Glue, AKD, wax, PDMS or OTS.
4. heavy metal ion detection chip according to claim 1 it is characterised in that：Described developer and metal ion Cr6 +、Cu2+、Al3+、Pb2+In at least one chromogenic reaction can occur.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620775507.9U CN205941377U (en) | 2016-07-22 | 2016-07-22 | Heavy metal ion detects chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620775507.9U CN205941377U (en) | 2016-07-22 | 2016-07-22 | Heavy metal ion detects chip |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205941377U true CN205941377U (en) | 2017-02-08 |
Family
ID=57925806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620775507.9U Active CN205941377U (en) | 2016-07-22 | 2016-07-22 | Heavy metal ion detects chip |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN205941377U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106093027A (en) * | 2016-07-22 | 2016-11-09 | 苏州汶颢芯片科技有限公司 | Heavy metal ion detection chip |
| CN106872458A (en) * | 2017-02-24 | 2017-06-20 | 通标标准技术服务（天津）有限公司 | The detection method of heavy metal in food |
| CN109061190A (en) * | 2018-08-22 | 2018-12-21 | 江苏集萃微纳自动化系统与装备技术研究所有限公司 | The preparation of multichannel biosensor array and immune detection application based on paper chip |
-
2016
- 2016-07-22 CN CN201620775507.9U patent/CN205941377U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106093027A (en) * | 2016-07-22 | 2016-11-09 | 苏州汶颢芯片科技有限公司 | Heavy metal ion detection chip |
| CN106872458A (en) * | 2017-02-24 | 2017-06-20 | 通标标准技术服务（天津）有限公司 | The detection method of heavy metal in food |
| CN109061190A (en) * | 2018-08-22 | 2018-12-21 | 江苏集萃微纳自动化系统与装备技术研究所有限公司 | The preparation of multichannel biosensor array and immune detection application based on paper chip |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP03 | "change of name, title or address" | ||
| CP03 | "change of name, title or address" |
Address after: 215000 No. 128, Fang Zhou road, Suzhou Industrial Park, Jiangsu, China Patentee after: SUZHOU WENHAO MICROFLUIDIC TECHNOLOGY Co.,Ltd. Address before: 215808 No. 128, Fang Zhou road, Suzhou Industrial Park, Jiangsu, China Patentee before: SUZHOU WENHAO CHIP TECHNOLOGY Co.,Ltd. |