CN205824328U - A kind of micro-fluidic chip and be applied to the micro-valve of magnetic cock body of micro-fluidic chip - Google Patents
A kind of micro-fluidic chip and be applied to the micro-valve of magnetic cock body of micro-fluidic chip Download PDFInfo
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- CN205824328U CN205824328U CN201620683658.1U CN201620683658U CN205824328U CN 205824328 U CN205824328 U CN 205824328U CN 201620683658 U CN201620683658 U CN 201620683658U CN 205824328 U CN205824328 U CN 205824328U
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- 239000004205 dimethyl polysiloxane Substances 0.000 claims abstract description 13
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims abstract description 13
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims abstract 2
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims abstract 2
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims abstract 2
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- 238000002360 preparation method Methods 0.000 description 4
- 238000011161 development Methods 0.000 description 3
- -1 Polydimethylsiloxane Polymers 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
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- 239000000243 solution Substances 0.000 description 2
- 238000012742 biochemical analysis Methods 0.000 description 1
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Landscapes
- Magnetically Actuated Valves (AREA)
- Electrically Driven Valve-Operating Means (AREA)
Abstract
This utility model relates to a kind of micro-valve of magnetic cock body for micro-fluidic chip, and in one embodiment, the micro-valve of magnetic cock body at least includes: the first electric magnet, the second electric magnet and magnetic cock body；Wherein, the first electric magnet, the top of the cover plate being positioned in chip；Second electric magnet, the lower section of the substrate being positioned in chip；Magnetic cock body, in the fluid channel between substrate and cover plate；First electric magnet and the second electric magnet, by controlling magnetic cock body position in fluid channel, control the opening and closing of the micro-valve of magnetic cock body.This utility model also designs a kind of micro-fluidic chip with the above-mentioned micro-valve of magnetic cock body simultaneously.This utility model uses magnetic force as the driving force of magnetic cock body valve, and energy consumption is low, fast response time；Magnet plug volume surrounding uses PDMS material cladding, pollution-free to microfluid, and has good sealing, prevents the generation of the phenomenon of leakage；Meanwhile, valve processing technology is simple, and low cost can be applicable in nearly all micro-fluidic chip.
Description
Technical Field
The utility model relates to a micro-fluidic field especially relates to a micro-fluidic chip and use and micro-fluidic chip's magnetism cock body micro-valve.
Background
The micro-fluidic chip is formed by micro-processing technology and other processing methods to shrink a biological or chemical laboratory onto a thin plate with a size of only a few square centimeters, and a network is formed by micro-channels, and controllable fluid penetrates through the whole system to realize various functions of the conventional chemical or biological laboratory. In various micro-fluidic chips for biochemical analysis and detection of microorganisms, processes of transportation, mixing, reaction and the like of samples and reagents in the micro-fluidic chips need to be accurately and effectively controlled. This is ensured by the implementation of a large number of micro-valves, which must be efficient and reliable, easily integrated in microfluidic chips, etc.
From the current development level, the microfluidic chip has broken through the major difficulties in the processing technology and the basic fluidic technology in the early development stage, but there are several disadvantages that limit the development, such as the inability to effectively open and close the micro-channel, the accurate control of the flow, the convenient three-dimensional focusing of the micro-fluid, and the main aspects of the control of the micro-fluid.
At present, a micro valve applied to a micro-fluidic chip mainly comprises a heat-sensitive deformation driving valve, an air pressure driving single-layer film valve and a phase change valve.
The thermosensitive material with temperature control deformation characteristic is used as the moving part of the micro valve, when the low-temperature micro fluid flows through, the moving part deforms due to the temperature reduction and leaves the base, and the micro channel is opened; otherwise, the moving part returns to the base and closes the micro-channel. The method has the advantages of no energy consumption, no pollution and the like, but has the advantages of long response time, difficult control, large dead angle area, complex manufacturing process and high cost.
The air pressure driven single-layer film valve is characterized in that the elastic film is deformed to block a micro-channel or partially block the micro-channel by applying air pressure so as to control the on-off and the flow of the micro-fluid.
The main working principle of the phase change valve is to control the on-off of the microfluid by the solid-state and liquid-state transition of part of the microfluid. When the micro valve needs to be closed, micro fluid can be actively refrigerated, so that part of micro fluid is rapidly frozen in a very short time to block a micro channel; when the micro valve needs to be opened, the frozen micro fluid is heated and melted, and the flow state of the micro fluid can be recovered. Because the microfluid needs to be cooled and heated, the manufacturing process is complex and the application range is small.
Disclosure of Invention
An object of the utility model is to provide a be applied to micro-fluidic chip's magnetism cock body microvalve to prior art's not enough, specifically be a design magnetism cock body valve and magnetism cock body, utilize Polydimethylsiloxane (PDMS) to adopt the magnetic plug body that the mode preparation of casting contains magnetic substance, place the magnetism cock body in the miniflow channel of chip, the during operation is through the position of outside magnet control magnetism cock body in the miniflow channel, with the break-make that realizes the miniflow channel, and then the flow direction of control miniflow in the miniflow channel.
To achieve the above object, in a first aspect, the present invention provides a magnetic plug micro-valve for a microfluidic chip, which in one embodiment comprises at least: the electromagnetic valve comprises a first electromagnet, a second electromagnet and a magnetic plug body; wherein,
the first electromagnet is positioned above the cover plate in the chip;
the second electromagnet is positioned below the substrate in the chip;
the magnetic plug body is positioned in the micro-channel between the substrate and the cover plate;
the first electromagnet and the second electromagnet control the opening and closing of the magnetic plug body micro valve by controlling the position of the magnetic plug body in the micro flow channel.
Preferably, each of the first electromagnet and the second electromagnet corresponds to each of the magnetic plugs one to one.
Preferably, the first electromagnet, the second electromagnet and the magnetic plug body are distributed on a vertical straight line.
Preferably, the magnetic plug is located in a micro flow channel between the substrate and the chip, and specifically comprises: the micro-channel is internally provided with a groove structure, and the magnetic plug body is positioned in the groove structure.
Further preferably, the magnetic plug body and the groove structure are the same in size.
Preferably, the first electromagnet and the second electromagnet control the opening and closing of the magnetic plug micro valve by controlling the position of the magnetic plug in the micro flow channel, specifically:
when the first electromagnet is in a power-off state and the second electromagnet is in a power-on state, the magnetic plug body moves towards the direction of the second electromagnet, and at the moment, the magnetic plug body is opened;
and the number of the first and second groups,
when the first electromagnet is in a power-on state and the second electromagnet is in a power-off state, the magnetic plug body moves towards the first electromagnet, and at the moment, the magnetic plug body valve is closed.
Preferably, the magnetic plug body is prepared by coating polydimethylsiloxane PDMS on the outside of a magnetic material.
In a second aspect, the present invention provides a microfluidic chip comprising at least one magnetic plug microvalve according to the first aspect.
The utility model provides a be applied to micro-fluidic chip's magnetism cock body micro-valve, owing to constitute the outside cladding PDMS of magnetism cock body micro-valve, consequently, the magnetism cock body is pollution-free to microfluid, and has good leakproofness. Meanwhile, the micro valve with the magnetic plug body has the advantages of low energy consumption, high speed, wide application range, simple manufacturing process, low cost, mass production and the like.
Drawings
Embodiments of the present invention are described in detail below with reference to the attached drawing figures, wherein:
FIG. 1(a) is the structure of the magnetic plug when the micro-valve is opened;
FIG. 1(b) is the structure of the magnetic plug when the micro-valve is opened;
FIG. 2(a) is a schematic diagram of a cross-shaped microfluidic chip with a magnetic plug microvalve;
FIG. 2(b) is a cross-sectional view of a microfluidic chip with the microvalve opened;
fig. 2(c) is a cross-sectional view of the microfluidic chip with the microvalve closed.
Detailed Description
The invention will be further described with reference to the accompanying drawings and specific examples, which should be understood as being given solely for the purpose of illustration and not as a limitation of the invention in any way, i.e., not as being intended to limit the scope of the invention.
Example one
Fig. 1(a) and fig. 1(b) show respectively the utility model provides a magnetism cock body microvalve is at the schematic diagram of different operating condition, and fig. 1(a) is the structural condition when magnetism cock body microvalve is opened, and fig. 1(b) is the structural condition when magnetism cock body microvalve is opened, is shown by fig. 1 and fig. 2, the utility model provides a magnetism cock body microvalve includes first electro-magnet 4, second electro-magnet 5 and magnetism cock body 7 at least. Specifically, the method comprises the following steps:
the chip comprises a first electromagnet 4 positioned above a cover plate 2 in a chip, a second electromagnet 5 positioned below a substrate 3 in the chip, and a magnetic plug body 7 positioned in a micro-channel 6 between the substrate 3 and the cover plate 2. It should be noted that, for the high sensitivity of the micro valve control, the first electromagnet 4, the second electromagnet 5 and the magnetic plug 7 are in one-to-one correspondence, and in distribution, the three are distributed on a vertical straight line, that is, from top to bottom: a first electromagnet 4, a magnetic plug 7 and a second electromagnet 5.
Specifically, in one design, the micro flow channel 6 has a groove structure therein, and the magnetic plug 7 is located in the groove structure, and further, the size of the magnetic plug 7 is the same as that of the groove structure. When the magnetic micro valve works, the first electromagnet 4 and the second electromagnet 5 control the position of the magnetic plug body 7 in the groove structure in the micro channel 6, control the opening and closing of the magnetic plug body micro valve, and further control the on-off and flow direction of the micro fluid 1 in the micro channel 6.
Fig. 1(a) is a schematic diagram of the working state of the magnetic plug valve when the first electromagnet 4 is in the de-energized state and the second electromagnet 5 is in the energized state, and it can be known from fig. 1 (a):
when the first electromagnet 4 is in a power-off state and the second electromagnet is in a power-on state, the magnetic plug 7 moves towards the first electromagnet 5 until the whole magnetic plug 7 is located in the groove structure of the micro-channel 6, the upper end face of the magnetic plug 7 is flush with the upper end face of the groove structure in the micro-channel 6, at the moment, the micro-valve of the magnetic plug is in an open state, namely, the micro-channel 6 is in an open state, and the micro-fluid 1 can flow in the micro-channel 6 through the upper part of the groove structure.
Fig. 1(b) is a schematic diagram of the working state of the magnetic plug valve when the first electromagnet 4 is in the energized state and the second electromagnet 5 is in the de-energized state, and it can be known from fig. 1 (b):
when the first electromagnet 4 is in an energized state and the second electromagnet 5 is in a de-energized state, the magnetic plug 7 moves towards the first electromagnet 4 until the part of the micro channel above the groove structure in the micro channel 6 is blocked, at this time, the magnetic plug micro valve is in a closed state, that is, the micro channel 6 is in a disconnected state, and the micro fluid 1 cannot pass above the groove structure and is blocked in the micro channel 6.
The magnetic plug micro valve can be applied to various micro-fluidic chips, and it should be noted that the number of the groove structures and the corresponding magnetic plugs 7 needs to be set correspondingly according to the actual structure and application needs of the micro channel 6, and the number of the first electromagnets 4 and the number of the second electromagnets 5 correspond to the number of the magnetic plugs 7. Therefore, the micro-fluidic chip containing the magnetic plug body micro-valve at least contains one magnetic plug body micro-valve.
In yet another design, the magnetic plug body 7 is made of PDMS coated with magnetic material. Specifically, a casting mold of the magnetic plug body 7 is first prepared, and then the magnetic plug body 7 externally coated with the magnetic material is cast and molded by using PDMS.
The embodiment of the utility model provides a magnetism cock body microvalve utilizes PDMS to adopt the magnetic cock body of the outside cladding magnetic substance of cast method preparation, places the magnetic cock body in the miniflow channel, and the during operation is through the position of outside magnet control magnetism cock body in miniflow channel inner groovy structure to realize the function of control microfluid break-make and flow direction. Because the outer layer of the magnetic plug body is PDMS, the magnetic plug body has no pollution to microfluid and has good sealing property. Meanwhile, the micro valve has the advantages of low energy consumption, quick response, wide application range, simple manufacturing process, low cost, mass production and the like.
In order to better understand the technical solution of the present invention, the following describes a specific embodiment of the present invention, which provides an application of the magnetic plug micro-valve structure in a micro-fluidic chip, and a specific process when the magnetic plug micro-valve is used to control the on-off of a micro-channel.
Example two
Fig. 2(a) is a schematic diagram of a cross-shaped microfluidic chip with a magnetic plug micro valve, that is, fig. 2(a) is an application of the magnetic plug micro valve in the cross-shaped microfluidic chip. As shown in fig. 2(a), the cross-shaped microfluidic chip has a cover plate 2, a substrate 3, and a microchannel 6 between the cover plate 2 and the substrate 3, and further includes a magnetic plug microvalve. The microchannels 6 in this embodiment are cross-shaped structures, with a recess structure in one of the microchannels in the cross-shaped structure, in which recess structure the magnetic plug 7 is located.
Fig. 2(b) is a cross-sectional view of the cross-shaped microfluidic chip when the microvalve is opened, and fig. 2(c) is a cross-sectional view of the cross-shaped microfluidic chip when the microvalve is closed, and as shown in fig. 2(b) and fig. 2(c), the magnetic plug body microvalve in the present embodiment specifically includes: a first electromagnet 4 located above the cover plate 2, a second electromagnet 5 located below the base plate 3, and a magnetic plug 7 located in a grooved structure in the microchannel 6. When the micro-fluidic chip in the second embodiment works, the external magnet controls the position of the magnetic plug 7 in the groove structure in the micro-channel 6, and controls the opening and closing of the magnetic plug valve, so as to control the on-off and flow direction of the micro-fluid 1 in the micro-channel. Specifically, the method comprises the following steps. From the structure in fig. 2(b) and 2(c), it can be seen that the external magnet is composed of a first electromagnet 4 and a second electromagnet 5, wherein the first electromagnet 4 is located above the lid plate 2, the second electromagnet 5 is located below the base plate 3, and the position relation with the magnetic stopper 7 is: the first electromagnet 4, the magnetic plug body 7 and the second electromagnet 5 are arranged from top to bottom in sequence in the vertical direction.
The preparation of the micro-fluidic chip with the magnetic plug body micro-valve and the method for controlling the on-off of the micro-channel by the magnetic plug body micro-valve are described in detail as follows:
1. firstly, preparing a micro-fluidic chip with a magnetic plug body valve structure:
(1) manufacturing a casting mould of the magnetic plug body, and casting and molding the magnetic plug body containing the magnetic material by utilizing PDMS;
(2) the cross micro-fluidic chip cover plate 2 and the cross micro-fluidic chip substrate 3 are manufactured by adopting an injection molding process, the magnetic plug body 7 is arranged in the micro-channel 6, and the cover plate 2 and the cross micro-fluidic chip substrate 3 are sealed by a hot-press sealing process.
2. The method for controlling the opening and closing of the magnetic plug micro valve in the micro-fluidic chip prepared in the step 1 comprises the following steps:
(1) as shown in fig. 2(b), when the first electromagnet 4 is powered off and the second electromagnet 5 is powered on, the magnetic plug 7 moves towards the second electromagnet 5 until the magnetic plug 7 is completely located in the groove structure of the microchannel 6, at this time, the magnetic plug valve is in an open state, and the microfluid 1 flows in the microchannel 6 through the upper end surface of the magnetic plug 7.
(2) As shown in fig. 2(c), when the first electromagnet 4 is powered on and the second electromagnet 5 is powered off, the magnetic plug 7 moves towards the first electromagnet 4 until the upper end surface of the magnetic plug 7 is flush with the upper end of the microchannel, at this time, the magnetic plug valve is in a closed state, the microfluid 1 is blocked, and cannot flow in the microchannel.
The above embodiment is in the utility model discloses technical scheme is under the prerequisite, the detailed micro-fluidic chip's that gives structure to and its preparation technology process and during operation micro-fluidic chip's working process, nevertheless the utility model discloses a scope of protection is not limited to above-mentioned embodiment.
The utility model adopts magnetic force as the driving force of the magnetic plug body valve, and has low energy consumption and high response speed; the outer layer of the magnetic plug body is coated by PDMS material, so that the micro-fluid is pollution-free, and the magnetic plug body has good sealing property, and prevents the liquid leakage phenomenon; meanwhile, the valve is simple in manufacturing process and low in cost, and can be applied to almost all microfluidic chips.
Although the present invention has been described to a certain extent, it is apparent that appropriate changes in various conditions may be made without departing from the spirit and scope of the invention. It is to be understood that the invention is not limited to the described embodiments, but is to be accorded the scope consistent with the claims, including equivalents of each element described. For example, the liquid precursor in the present invention may be a mixture of a plurality of substances, with the purpose of achieving a better coating effect.
The above-mentioned embodiments, further detailed description of the objects, technical solutions and advantages of the present invention, it should be understood that the above description is only the embodiments of the present invention, and is not intended to limit the scope of the present invention, and any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (8)
1. A magnetic plug microvalve for a microfluidic chip, said magnetic plug microvalve comprising at least: the electromagnetic valve comprises a first electromagnet, a second electromagnet and a magnetic plug body; wherein,
the first electromagnet is positioned above the cover plate in the chip;
the second electromagnet is positioned below the substrate in the chip;
the magnetic plug body is positioned in the micro-channel between the substrate and the cover plate;
the first electromagnet and the second electromagnet control the opening and closing of the magnetic plug body micro valve by controlling the position of the magnetic plug body in the micro flow channel.
2. The magnetic plug microvalve of claim 1, wherein each of said first and second electromagnets is in one-to-one correspondence with each of said magnetic plugs.
3. The magnetic plug microvalve of claim 1, wherein the first electromagnet, the second electromagnet and the magnetic plug are distributed in a vertical line.
4. The magnetic plug microvalve of claim 1, wherein the magnetic plug is located in a microchannel between the substrate and the chip, and specifically:
the micro-channel is internally provided with a groove structure, and the magnetic plug body is positioned in the groove structure.
5. The magnetic plug microvalve of claim 4, wherein said magnetic plug is the same size as said groove structure.
6. The magnetic plug microvalve of claim 1, wherein the first and second electromagnets control the opening and closing of the magnetic plug microvalve by controlling the position of the magnetic plug within the microchannel, in particular:
when the first electromagnet is in a power-off state and the second electromagnet is in a power-on state, the magnetic plug body moves towards the direction of the second electromagnet, and at the moment, the magnetic plug body is opened;
and the number of the first and second groups,
when the first electromagnet is in a power-on state and the second electromagnet is in a power-off state, the magnetic plug body moves towards the first electromagnet, and at the moment, the magnetic plug body valve is closed.
7. The magnetic plug microvalve of claim 1, wherein the magnetic plug is made of a magnetic material coated with PDMS.
8. A microfluidic chip characterized in that it comprises at least one magnetic plug microvalve according to any one of claims 1-7.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620683658.1U CN205824328U (en) | 2016-06-30 | 2016-06-30 | A kind of micro-fluidic chip and be applied to the micro-valve of magnetic cock body of micro-fluidic chip |
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| CN201620683658.1U CN205824328U (en) | 2016-06-30 | 2016-06-30 | A kind of micro-fluidic chip and be applied to the micro-valve of magnetic cock body of micro-fluidic chip |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107542973A (en) * | 2017-08-02 | 2018-01-05 | 南京岚煜生物科技有限公司 | Micro-fluidic chip and its application method with Locking type valve |
| CN108333266A (en) * | 2017-12-28 | 2018-07-27 | 西北工业大学 | A kind of high pressure resistant minicore chip liquid chromatogram |
| CN108443579A (en) * | 2018-04-11 | 2018-08-24 | 利多(香港)有限公司 | A kind of micro-valve and micro-fluidic chip that can control liquid flowing |
| CN109058582A (en) * | 2018-09-07 | 2018-12-21 | 深圳市刚竹医疗科技有限公司 | Valve gear |
| CN109114250A (en) * | 2018-09-21 | 2019-01-01 | 昆明理工大学 | A kind of magnetic fluid commutation microvalve device and its application method |
| CN112324929A (en) * | 2020-10-09 | 2021-02-05 | 东南大学 | Aperture type micro-flow control flow regulator |
| CN114768899A (en) * | 2022-03-28 | 2022-07-22 | 广州万德康科技有限公司 | Micro-fluidic chip applying phase change valve and in-vitro diagnostic device |
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- 2016-06-30 CN CN201620683658.1U patent/CN205824328U/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107542973A (en) * | 2017-08-02 | 2018-01-05 | 南京岚煜生物科技有限公司 | Micro-fluidic chip and its application method with Locking type valve |
| CN107542973B (en) * | 2017-08-02 | 2023-11-28 | 南京岚煜生物科技有限公司 | Microfluidic chip with latching valve and method of use thereof |
| CN108333266A (en) * | 2017-12-28 | 2018-07-27 | 西北工业大学 | A kind of high pressure resistant minicore chip liquid chromatogram |
| CN108443579A (en) * | 2018-04-11 | 2018-08-24 | 利多(香港)有限公司 | A kind of micro-valve and micro-fluidic chip that can control liquid flowing |
| CN109058582A (en) * | 2018-09-07 | 2018-12-21 | 深圳市刚竹医疗科技有限公司 | Valve gear |
| CN109114250A (en) * | 2018-09-21 | 2019-01-01 | 昆明理工大学 | A kind of magnetic fluid commutation microvalve device and its application method |
| CN112324929A (en) * | 2020-10-09 | 2021-02-05 | 东南大学 | Aperture type micro-flow control flow regulator |
| CN114768899A (en) * | 2022-03-28 | 2022-07-22 | 广州万德康科技有限公司 | Micro-fluidic chip applying phase change valve and in-vitro diagnostic device |
| CN114768899B (en) * | 2022-03-28 | 2024-04-16 | 广州万德康科技有限公司 | Microfluidic chip applying phase change valve and in-vitro diagnosis device |
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Effective date of registration: 20180510 Address after: 100000 Beijing Haidian District 6 graduated from Tsinghua University. Patentee after: Beijing Tongfang Optical Disk Co., Ltd. Address before: 101500 Room 202, Tsinghua Tongfang information complex, 4 water source road, Miyun Economic and Technological Development Zone, Miyun, Beijing Patentee before: BEIJING TONGFANG BIOCHIP TECHNOLOGY CO., LTD. |
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| CP02 | Change in the address of a patent holder | ||
| CP02 | Change in the address of a patent holder |
Address after: 101500 6 floor, Huaye building, Tsinghua University, Haidian District, Beijing. Patentee after: Beijing Tongfang Optical Disk Co., Ltd. Address before: 100000 Beijing Haidian District 6 graduated from Tsinghua University. Patentee before: Beijing Tongfang Optical Disk Co., Ltd. |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20161221 Termination date: 20190630 |