CN205796243U - A kind of injection device with hollow metal microneedle array for medicine conveying - Google Patents

Abstract

This utility model discloses a kind of injection device with hollow metal microneedle array for medicine conveying, including hollow metal microneedle array, tube for transfusion, liquid chambers and micropump, described tube for transfusion connects liquid chambers, the side of described liquid chambers is provided with hollow metal microneedle array, and described micropump connects tube for transfusion.This utility model can promote drug delivery system usefulness, many groups form arrangement micropin can increase drug delivery system usefulness, each Zhi Weizhen can be transported to medicine in health, the length of hollow metal micropin is shorter, and the diameter of syringe needle is the most relatively small, it is merely able to pierce through epidermis and does not arrive skin corium, pain will not be contacted neural such that it is able to realize painless injection.

Description

A kind of injection device with hollow metal microneedle array for medicine conveying

Technical field

This utility model relates to a kind of injection device with hollow metal microneedle array for medicine conveying.

Background technology

In the technology of medicine conveying, medicine enter the approach of human body have oral, suck, inject, the mode of Cutaneous permeation. Injection is the modal mode of one of which, is to utilize syringe to pass skin with syringe needle, and medicine is sent into health.Have at present The method of multiple different injection includes intradermal, subcutaneous injection, intramuscular injection, intravenous injection, intramuscular injection etc..The whole world There is every day millions of people to need injection of drug, and mainly use general conventional needle, insulin conventional such as at present Injection pen diameter is about one millimeter and length is about two to three millimeters.The entry needle of major diameter the most singly brings misery for patient, note Penetrate caused wound and more increase infection risk.According to patent of invention, a kind of Micro trauma metal battle array being applied to medicine conveying A large amount of manufacture methods of row, can manufacture, by the method, the micropin array that diameter is thinner, only penetrate epidermis thus reduce micropin row The pain that caused of battle array and wound, lower infection risk.

Metal micro-needle array can not be independently operated, needs differently configured injection tool, such as conventional injection syringe and defeated Liquid pump transmits effect with medicine the most at regular time and quantity.Simple device can make metal micro-needle array have high efficiency medicine to pass Send effect.And metal micro-needle array injection device is that the method with intramuscular injection is in drug osmotic to health.Metal micro-needle arranges Battle array injection device, in addition to being capable of painless injection, also to have easy to carry, simple to operate, reliability and durability advantage, These advantages will bring great convenience to patient, and micropin hard, sharp keen, hollow is then to realize transdermal administration most critical Execution unit.Micropin first has to the most sharp-pointed, it is possible to pierce through the epidermis of skin, and the length of micropin will at least 100UM, in order to The suitable degree of depth can be reached and put release medicine.It addition, metal micro-needle has enough intensity, either when thrusting skin, or Can bear when carrying medicine and be not broken from the pressure of all directions.

Utility model content

Technical problem to be solved in the utility model be to provide a kind of for medicine conveying there is hollow metal micropin The injection device of array, with the purpose of up to medicine transmission.This installation cost is low, process design simply, easily install, successfully lead to Cross the test of bio-compatibility, it is possible to fully seal, be difficult to spill and leakage medicine, so that it is guaranteed that the medicine of required deal can be transmitted To internal.

This utility model provide a kind of for medicine conveying the injection device with hollow metal microneedle array, including in Empty metal micro-needle array, tube for transfusion and liquid chambers, described tube for transfusion connects liquid chambers, and the side of described liquid chambers is provided with hollow Metal micro-needle array.

Further, also including micropump, described micropump connects tube for transfusion.

Further, described micropump is infusion pump.

Further, the shape of cross section of described liquid chambers is circular rings, the cross section of described hollow metal microneedle array Generally circular in shape, the internal diameter of described liquid chambers is less than the diameter of hollow metal microneedle array, during the external diameter of described liquid chambers is more than The diameter of empty metal micro-needle array.

Further, the shape of cross section of described liquid chambers is tetracyclic ring, described hollow metal microneedle array transversal Face is shaped as tetragon, and the interior length of side of described liquid chambers is less than the length of side of hollow metal microneedle array, the outside of described liquid chambers The long length of side more than hollow metal microneedle array.

Further, also include wearing guard member, described in wear the sheathed outside with described liquid chambers of guard member.

Further, the material wearing guard member described in is plastics or metal.

Further, the material of described liquid chambers is plastics or metal.

Further, described hollow metal microneedle array has multiple hollow metal micropin, and the plurality of hollow metal is micro- The arrangement of pin square array format or circular arrangement arrangement.

Further, the needlepoint form of each hollow metal micropin is square, circular or triangle.

This utility model has advantages in that

1, drug delivery system usefulness can be promoted

Many groups form arrangement micropin can increase drug delivery system usefulness, and each Zhi Weizhen can be transported to body medicine Internal.

The misery brought when 2, alleviating injection

Hollow metal micropin length is shorter and the diameter of syringe needle is the most relatively small, and it is merely able to pierce through epidermis and does not arrive true Cortex, will not contact pain neural such that it is able to realize painless injection.

3, infection risk is reduced

Hollow metal micropin length is shorter and the diameter of syringe needle is the most relatively small, and the wound caused at skin is less, subtracts Inject the wound scope caused less thus reduce infection risk.

4, convenient use

Hollow metal microneedle array injection device can disposably complete the process of dosing, it is to avoid repeated localised puncture medicine bottle stopper The microgranule caused pollutes.

5, can Quick-adding medicine

Hollow metal microneedle array injection device is easy and simple to handle, it is not necessary to repeatedly aspirate puncture, reduces transfusion bottle stopper easily quilt Inserting bad, chip enters medicine.And the deal of medicine transmission can also control, can accomplish that medicine at regular time and quantity delivers.

6, can fully seal

The liquid chambers of hollow metal micropin array injection device is to fully seal, and is difficult to spill and leakage medicine, so that it is guaranteed that required The medicine of deal can be transferred to internal.

7, easily making difform device, and belong to the manufacture method of low-cost high-efficiency, processing procedure is simply based on gold Belong to the characteristic of intensity, make micropin with it and can make the more attached penetration power of micropin.

8, low equipment cost, device of the present utility model has different designs, is suitable for body parts, and this practicality is new The device design of type can coordinate micropump (infusion pump) to use.

Accompanying drawing explanation

Fig. 1 is that a kind of of this utility model offer has hollow metal microneedle array injection device for what medicine carried Process principle figure；

Fig. 2 is that a kind of of this utility model offer has hollow metal microneedle array injection device for what medicine carried Structural representation.

Detailed description of the invention

The utility model is described in further detail with specific embodiment below in conjunction with the accompanying drawings, so that those skilled in the art This utility model can be better understood from and can be practiced, but illustrated embodiment is not as to restriction of the present utility model.

This utility model provide a kind of for medicine conveying have hollow metal microneedle array injection device have micro- When type pump uses, its process principle figure, structure chart are distinguished the most as shown in Figure 1 and Figure 2, including hollow metal microneedle array 1, tube for transfusion 2 With liquid chambers 3, preferably can also have micropump further, described micropump connects tube for transfusion 2, and described tube for transfusion 2 connects Liquid chambers 3, the side of described liquid chambers 3 is provided with hollow metal microneedle array 1.Micropump is chosen as infusion pump, preferably also Can have further and wear guard member 4, be sheathed on the outside of liquid chambers 3.This utility model is whole by being constituted one with upper-part The delivery system that body is complete.This utility model can carry medicine quickly and safely, can coordinate and preferably have micropump, logical Cross micropump feeding operations easy, decrease infected chance.This utility model also can carry medicine, this device at regular time and quantity Having the liquid chambers 3 of a small volume, medicine by micropump through tube for transfusion 2, then can be delivered to liquid chambers 3, then Pierced through the horny layer (thickness is 20 μm-50 μm) of epidermis again by hollow metal micropin row 1 gust, more slowly arrived by Cutaneous permeation In health, more slowly absorbed.Hollow metal microneedle array 1 needs to be completely covered a side end face of connected liquid chambers 3.One As, described liquid chambers 3 is circular or the annular housing of tetragon, and liquid is located in the cavity of this annular.In being used Empty metal micro-needle array 1 also corresponds to circle or tetragon, and its size is between the interior exocoel size of liquid chambers 3.In if Empty metal micro-needle array 1 is different from the shape of liquid chambers 3, then hollow metal microneedle array 1 needs to be cut into circle to join box The size and shape of liquid chambers 3.When the cross sectional shape of described liquid chambers 3 is circular rings, during the external diameter of described liquid chambers 3 is more than The diameter of empty metal micro-needle array 1, the internal diameter of described liquid chambers 3, less than the diameter of hollow metal microneedle array 1, is just possible to prevent Medicine spills.When the cross sectional shape of described liquid chambers 3 is tetragon, the outside length of described liquid chambers 3 is more than hollow metal micropin The length of side of array 1, the interior length of side of described liquid chambers 3, less than the length of side of hollow metal microneedle array 1, is just possible to prevent medicine to leak Go out.The material of described liquid chambers 3 must have biological dissolubility of holding concurrently, and can include metal, plastics or other avirulent materials.When Liquid chambers 3 has manufactured, can be installed in liquid chambers 3 by hollow metal microneedle array 1, finally can use glue-leakage-resistant by hollow The local good seal that metal micro-needle array 1 is connected with liquid chambers 3.

Relatively more traditional syringe multi-configuration point and long pin, therefore injection when, patient can feel pain, and skin Also can gauffer, cause discomfort.And the injection device that this utility model provides only penetrates epiderm skin thus reduces micropin array institute The pain caused and wound, lower infection risk.

Described hollow metal microneedle array 1 is the most important parts of injection device that this utility model provides, and medicine is logical Cross hollow metal microneedle array 1 and be sent to skin, the most slowly penetrate in health.This hollow metal microneedle array 1 is to utilize The method of electroforming manufactures the effect of the most up to hollow.The material used of this hollow metal microneedle array 1 is metal material, and By the test of the double dissolubility of biology, it is there is no toxicity and irritating material.This hollow metal microneedle array 1 include multiple in Empty metal micro-needle, and square array format is arranged or circular arrangement arrangement, the needlepoint form of each hollow metal micropin is The different shape such as square, circle, triangle, oblique micropin.The hollow metal micropin that hollow metal microneedle array 1 is comprised Quantity can be 4-100.Hollow metal microneedle array 1 can pierce through the epidermis (20-50 m) of skin because of pressure, this Array only can pierce through epidermis and carry out intramuscular injection, will not arrive the position of blood vessel (intravenous injection), thus patient injection time Pain also can reduce.

Described micropump selects infusion pump, and infusion pump control device the most mechanically or electrically, it is defeated by acting on Fluid catheter reaches to control the purpose of transfusion speed.It is usually used in the situation needing strictly to control amount of infusion and dose, according to Drug Matter, the difference of patient's body constitution, speed of intravenous infusion is the most different.Infuse too fast, cross all be difficult to reach intended therapeutic effect, very slowly To affecting nursing safety.Infusion pump is that one can accurately control number of infusion drops or infusion flow rate, it is ensured that medicine can speed equal Even, dose accurately and enters a kind of instrument played a role in patient body safely, is a kind of intelligentized transfusion dress simultaneously Putting, transfusion speed is not affected by human body back pressure and operator, and infusion accurately and reliably, contributes to reducing clinical nursing activity intensity, Improve the accuracy of infusion, safety and nursing quality.

Described tube for transfusion 2 is for connection to the parts of infusion pump and medicine, and medicine is delivered to through tube for transfusion by infusion pump Liquid chambers 3.Tube for transfusion 2 is intended to through fungi-proofing process, also to regularly replace to prevent bacteria breed and infection.

Described liquid chambers 3 is as a composition necessary part of this device, and medicine is delivered to through tube for transfusion 2 by infusion pump Liquid chambers 3, and medicine runs past liquid chambers and slowly penetrates into internal according to the time of infusion pump.Manufacture the material of liquid chambers 3 Can be plastics (acrylonitrile, butadiene and cinnamic copolymer, polylactic acid), metal (gold, silver) etc., these materials all must Must be biocompatible material, can be because skin be caused stimulation or sensitive by life-time service with contacting skin.Liquid chambers 3 straight Footpath size have to be identical with the diameter of hollow metal microneedle array 1, the most just may insure that hollow metal microneedle array 1 and liquid It is to fully seal between body cavity 3, without spill and leakage medicine, so that it is guaranteed that the medicine of required deal can be transferred to internal.

This utility model further preferably has wears guard member 4, and the sheathed outside being arranged at liquid chambers 3, by wearing protection Part 4 protects liquid chambers 3, it is to avoid rubs with clothes when of between hollow metal microneedle array 1 and liquid chambers 3 because wearing and makes Become to damage.The material wearing guard member 4 manufacture can be plastics (acrylonitrile, butadiene and cinnamic copolymer, poly-breasts Acid), metal (gold, silver) etc., these materials must be all bio-compatible, will not because of life-time service with contact skin and to skin Skin causes stimulation or sensitive.

Embodiment described above is only the preferred embodiment lifted by absolutely proving this utility model, this utility model Protection domain be not limited to this.The equivalent that those skilled in the art are made on the basis of this utility model substitutes or becomes Change, all within protection domain of the present utility model.Protection domain of the present utility model is as the criterion with claims.

Claims (10)

1. the injection device with hollow metal microneedle array for medicine conveying, it is characterised in that include hollow gold Belonging to microneedle array, tube for transfusion and liquid chambers, described tube for transfusion connects liquid chambers, and the side of described liquid chambers is provided with hollow metal Microneedle array.

The injection device with hollow metal microneedle array for medicine conveying the most according to claim 1, its feature Being, also including micropump, described micropump connects tube for transfusion.

The injection device with hollow metal microneedle array for medicine conveying the most according to claim 2, its feature Being, described micropump is infusion pump.

The injection device with hollow metal microneedle array for medicine conveying the most according to claim 2, its feature Being, the shape of cross section of described liquid chambers is circular rings, and the shape of cross section of described hollow metal microneedle array is circular, institute Stating the internal diameter diameter less than hollow metal microneedle array of liquid chambers, the external diameter of described liquid chambers is more than hollow metal microneedle array Diameter.

The injection device with hollow metal microneedle array for medicine conveying the most according to claim 2, its feature Being, the shape of cross section of described liquid chambers is tetracyclic ring, and the shape of cross section of described hollow metal microneedle array is four limits Shape, the interior length of side of described liquid chambers is less than the length of side of hollow metal microneedle array, and the outside length of described liquid chambers is more than hollow gold Belong to the length of side of microneedle array.

The injection device with hollow metal microneedle array for medicine conveying the most according to claim 1, its feature Be, also include wearing guard member, described in wear the sheathed outside with described liquid chambers of guard member.

The injection device with hollow metal microneedle array for medicine conveying the most according to claim 6, its feature Be, described in wear the material of guard member be plastics or metal.

The injection device with hollow metal microneedle array for medicine conveying the most according to claim 1, its feature Being, the material of described liquid chambers is plastics or metal.

The injection device with hollow metal microneedle array for medicine conveying the most according to claim 1, its feature Being, described hollow metal microneedle array has multiple hollow metal micropin, the plurality of square battle array of hollow metal micropin The arrangement of row form or circular arrangement arrangement.

The injection device with hollow metal microneedle array for medicine conveying the most according to claim 9, its feature Being, the needlepoint form of each hollow metal micropin is square, circular or triangle.