CN205698140U - A kind of intravascular stent - Google Patents
A kind of intravascular stent Download PDFInfo
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- CN205698140U CN205698140U CN201620292309.7U CN201620292309U CN205698140U CN 205698140 U CN205698140 U CN 205698140U CN 201620292309 U CN201620292309 U CN 201620292309U CN 205698140 U CN205698140 U CN 205698140U
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Abstract
This utility model provides a kind of intravascular stent.Described support (1) includes corrugated circulus (11), two adjacent circuluses (11) are connected by connecting rod (14), described circulus is made up of ripple bar (12) or smooth circular arc (16), wherein, when described intravascular stent expands into plane, the angle of adjacent wave bar or circular arc to angle of circumference more than 90 ° and less than or equal to 175 °.Intravascular stent of the present utility model has the advantage that good mechanical property, good degradation characteristic, the concordance of production process medium-height trestle product and reliability.This makes Biodegradable scaffold provided by the utility model be applicable not only to clinical practice, and is applicable to produce in enormous quantities.
Description
Technical field
This utility model relates to medical field, specifically, relates to a kind of intravascular stent.
Background technology
Currently as treating the Major medical apparatus of angiopathy, coating stent of medicine body one including including cardiovascular etc.
Straight employing inert metal material, how based on 316L medical stainless steel, cochrome, this type of metal rack is as different
Property material implantable intravascular in source will retain in human body always, make treatment become more thorny when there is restenosis.And mesh
Previous crops be the macromolecule of pharmaceutical carrier be also nondegradable material, after drug release, also will forever retain in people
Some patients can be caused fatal subacute thromboembolism or later stage thrombosis by body.
Therefore, research use a kind of can Biodegradable material as the bulk material of support so that it is there is metal rack
Various mechanical properties, and do not change the carrying method of now employing, become Wicresoft's interventional medical device field current
The hot fields of another research.Biodegradable scaffold is after implantable intravascular lesion locations, it is possible to achieve metal rack
Support function, after the release completely of its contained medicine, its body can be gradually degraded as permissible within a period of time
By the material that human body absorbed and had no side effect, until degradable.
At present, domestic for interventional therapy including cardiovascular etc. including the Major medical apparatus medication coat of angiopathy prop up
Frame body has been used up inert metal material, how based on 316L medical stainless steel, cochrome.Due to Ink vessel transfusing
Forever leave over metal and medicine coating carrier brings problems, how to overcome stent restenosis, blood in late period
The problems such as bolt and newborn atherosclerosis become cardiovascular in recent years and get involved the study hotspot in field.
The metal rack as an alternative of Biodegradable scaffold has become as the developing direction of this area.Currently acquired CE
The degradable polymer support of certification listing license has two kinds: the BVS support of Abbott of the U.S. and U.S. Elixir
The DESolve support of Medical company.Domestic aspect, each relevant enterprise and institute all carry out positive
The research of Biodegradable scaffold.
Metal Drugs coating bracket body has been used up inert metal material, how to close with 316L medical stainless steel, cobalt chromium
Jin Weizhu, this type of metal rack will retain in human body as heterologous material implantable intravascular always, when there is restenosis
Treatment is made to become more thorny.And the macromolecule currently as pharmaceutical carrier is also nondegradable material, at medicine
Release also will retain in human body later forever, and some patients can cause fatal subacute thromboembolism or later stage thrombosis.
Biodegradable scaffold aspect, its in vivo degradable be water, carbon dioxide, ethanol and iodotyrosine alkyl
Deng, catabolite side effect almost non-toxic to human body, all can be absorbed by the body or excrete.At present, Abbott Laboratories of the U.S.
The BVS support of company has been enter into clinical experimental stage, but due to reasons such as technical know-hows, does not has technical parameter permissible
Reference.Domestic aspect, Biodegradable scaffold all in development, is referred to also without technical parameter greatly.
Utility model content
A purpose of the present utility model is to provide a kind of intravascular stent；It possesses good mechanics and degradation property；
Another object of the present utility model is to provide the preparation method of described intravascular stent；The processing technique optimized is not
But the above-mentioned performance that can ensure that, and ensure that the Drug loading capacity of support.
For reaching above-mentioned purpose, on the one hand, this utility model provides a kind of intravascular stent, wherein, described support 1
Including corrugated circulus 11, adjacent two circuluses 11 are connected by connecting rod 14, described ring-type
Structure is made up of ripple bar 12 or smooth circular arc 16, wherein, when described intravascular stent expands into plane, and adjacent wave
The angle of bar or circular arc to angle of circumference more than 90 ° and less than or equal to 175 °.
Wherein it is understood that waveform described here refers to that shape is substantially similar to corrugated alternately height and rises and falls
Shape；
The angle of adjacent wave bar refers to be formed (or ripple bar extended line) angle of the ripple bar of crest or trough, such as Fig. 1
Shown α angle；
Circular arc to angle of circumference refer to the angle of circumference that formed corresponding to the smooth circular arc of crest or trough.
According to some specific embodiments of this utility model, wherein, the crest quantity of each circulus 11 is 6-16
Individual；
It should be appreciated that crest described here refers to whole peak shape structures, say, that crest quantity includes
Crest and the sum of trough.
According to some specific embodiments of this utility model, wherein, the company between two adjacent circuluses 11
Extension bar 14 quantity is 2-4.
According to some specific embodiments of this utility model, wherein, a length of 0.5-1.4mm of described connecting rod 14；
The length of connecting rod described in the utility model is defined as follows: i.e. connecting rod 14 and adjacent two circuluses 11
The air line distance (m as shown in Figure 3) of junction point.
According to some specific embodiments of this utility model, wherein, the width of circulus 11 is 0.12-0.24mm；
According to some specific embodiments of this utility model, wherein, connecting rod 14 width is 0.10-0.16mm.
Wherein it is understood that the width of circulus 11 described here, and connecting rod 14 width refers to often
Individual concrete circulus 11 or the width of connecting rod 14 self, the width that d as shown in Figure 2 represents.
According to some specific embodiments of this utility model, wherein, micropore 40, micropore 40 are set at rack outer surface
A diameter of 10-30 μm, the degree of depth is the 1/4-1/2 of support wall thickness；
According to some specific embodiments of this utility model, wherein, the micropore 40 area summation on rack outer surface
It is 0-5% with rack outer surface area ratio.
This utility model by arranging microcellular structure, can the radial direction support force of lifting bracket further, and can be more preferable
Degradation time is controlled.
According to some specific embodiments of this utility model, wherein, described support wall thickness is 120-230 μm.
According to some specific embodiments of this utility model, wherein, formed after rack outer surface area launches with support
Area of plane ratio is 22-35%.
Wherein it is understood that rack outer surface area described here refers to outside support contacts with blood vessel
The area on surface；Wherein it should be appreciated that described exterior surface area should be after throwing except openwork part, ring-type
The outer surface of structure and ripple bar contacts the gross area of side with blood vessel；As it is shown in figure 1, l × h part therein
The area of plane that i.e. described support is formed after launching.
And the area of plane that described support is formed after launching, be equivalent to rack outer surface and contact side with blood vessel
Openwork part adds circulus and the gross area of ripple bar；The most foregoing rack outer surface area and hollow-out parts
Divide gross area sum.
The ratio of the gross area before engraved structure is processed with support by controlling micropore area and rack outer surface area
Example, can still keep good support effect in the case of rack surface arranges microcellular structure.
According to some specific embodiments of this utility model, wherein, the connecting rod at support two ends is respectively provided with a pair use
In the pore structure 15 disposing label.
According to some specific embodiments of this utility model, wherein, described intravascular stent is prepared by degradable polymer；
According to some specific embodiments of this utility model, wherein, described intravascular stent is by long-chain degradable polymer system
For obtaining；
Described degradable polymer and long-chain degradable polymer can use degradable poly commonly used in the art
Laminate material.
According to some specific embodiments of this utility model, wherein, described degradable polymer is selected from the one of following composition
Kind or multiple mixing: Poly-L-lactic acid (PLLA), poly-(lactic acid-ethanol) copolymer (PLGA), poly-(L-
Lactide-co-glycolide) (the co-PDLA of PLLA-, ratio is 70:30), wherein PLLA material proportion is
80%-100%, is 0-20% according to the ratio of design requirement PLGA Yu PLLA-co-PDLA sum.
According to some specific embodiments of this utility model, wherein, described intravascular stent be material be Poly-L-lactic acid
PLLA, the intravascular stent of poly-(lactic acid-ethanol) copolymer p LGA or poly-(L-lactide-co-glycolide).
According to some specific embodiments of this utility model, wherein, described intravascular stent is by degradable polymer tubing warp
Prepare to form described circulus and connecting rod through laser engraving after expanding stretching；
Wherein expanded radially and axial tension must be carried out simultaneously.
According to some specific embodiments of this utility model, wherein, radial drawing ratio (expansion ratio) expanding stretching is
200-600%, axial tensile rate is 0-200%；
According to some specific embodiments of this utility model, wherein, axial tensile rate is 1-200%.
According to some specific embodiments of this utility model, wherein, temperature when expanding stretching is 70-100 DEG C, pressure
For 100-200PSI；
According to some specific embodiments of this utility model, wherein, after expansion stretching, the degree of crystallinity of tubing is 40-55%.
This utility model is found by numerous studies, and tubing polymer molecular chain orientation would tend to diametric(al),
Now tubing can reach the most radially support performance, and the axial tension simultaneously carried out also makes tubing to axial bending
Or bearing capacity during moment of torsion strengthens, wherein expanded radially and stretching must be carried out simultaneously.
Above-mentioned expansion ratio is defined as follows:
Expanded radially is than=(pipe internal diameter before pipe internal diameter expansion after expansion) front pipe internal diameter of/expansion；
Axial length before axial length after the expansion of axial expansion ratio=tubing/tubing expansion.
According to some specific embodiments of this utility model, wherein, described tubing is prepared by extrusion molding, wherein extrudes
Shi Wendu controls below 260 DEG C, and material controls within 30 minutes in this temperature residence time.
According to some specific embodiments of this utility model, wherein, described tubing is prepared by extrusion molding, wherein extrudes
Shi Wendu controls at 180-260 DEG C.
The temperature of material local environment should be reduced in the whole course of processing as far as possible and be in the condition of high temperature (material glass turns
Change more than temperature Tg) time, to avoid long chain polymer molecules chain rupture, to optimize its degradation characteristic.Ensure simultaneously
Long chain polymer molecules distribution in tubing and arrangement are uniformly.
Openwork part on support can use the processing of this area conventional means, such as can by tubing expansion molding with
After can be selected for femtosecond or tubing is carved by picosecond laser, wherein: optical maser wavelength should be greater than 400nm, power
Scope 0.8mW-5W, pulse spacing 60-6000fs；
According to some specific embodiments of this utility model, wherein, the course of processing utilizes the helium of more than 99.99 purity
Gas cools down, and reduces heat effect；
According to some specific embodiments of this utility model, wherein, manual removal island after machining.
On the other hand, this utility model additionally provides the preparation method of described intravascular stent, wherein, described intravascular stent
Prepared by degradable polymer；
According to some specific embodiments of this utility model, wherein, described intravascular stent is by long-chain degradable polymer system
For obtaining；
Described degradable polymer and long-chain degradable polymer can use degradable poly commonly used in the art
Laminate material.
According to some specific embodiments of this utility model, wherein, described degradable polymer includes: Poly-L-lactic acid
PLLA, poly-(lactic acid-ethanol) copolymer p LGA, poly-(L-lactide-co-glycolide) (the co-PDLA of PLLA-,
Ratio is 70:30), wherein PLLA material proportion is 80%-100%, according to design requirement PLGA and PLLA-
The ratio of co-PDLA sum is 0-20%.
According to some specific embodiments of this utility model, wherein, described intravascular stent is by degradable polymer tubing warp
Prepare to form described circulus and connecting rod through laser engraving after expanding stretching；
Wherein expanded radially and axial tension must be carried out simultaneously.
According to some specific embodiments of this utility model, wherein, radial drawing ratio (expansion ratio) expanding stretching is
200-600%, axial tensile rate is 0-200%；
According to some specific embodiments of this utility model, wherein, temperature when expanding stretching is 70-100 DEG C, pressure
For 100-200PSI；
According to some specific embodiments of this utility model, wherein, after expansion stretching, the degree of crystallinity of tubing is 40-55%.
This utility model is found by numerous studies, and tubing polymer molecular chain orientation would tend to diametric(al),
Now tubing can reach the most radially support performance, and the axial tension simultaneously carried out also makes tubing to axial bending
Or bearing capacity during moment of torsion strengthens, wherein expanded radially and stretching must be carried out simultaneously.
Above-mentioned expansion ratio is defined as follows:
Expanded radially is than=(pipe internal diameter before pipe internal diameter expansion after expansion) front pipe internal diameter of/expansion；
Axial length before axial length after the expansion of axial expansion ratio=tubing/tubing expansion.
According to some specific embodiments of this utility model, wherein, described tubing is prepared by extrusion molding, wherein extrudes
Shi Wendu controls below 260 DEG C, and material controls within 30 minutes in this temperature residence time.
Openwork part on support can use the processing of this area conventional means, such as can by tubing expansion molding with
After can be selected for femtosecond or tubing is carved by picosecond laser, wherein: optical maser wavelength should be greater than 400nm, power
Scope 0.8mW-5W, pulse spacing 60-6000fs；
According to some specific embodiments of this utility model, wherein, the course of processing utilizes the helium of more than 99.99 purity
Gas cools down, and reduces heat effect；
According to some specific embodiments of this utility model, wherein, manual removal island after machining.
In sum, this utility model provides a kind of intravascular stent and preparation method thereof.Blood vessel of the present utility model props up
Frame has the advantage that good mechanical property, good degradation characteristic, the concordance of production process medium-height trestle product
And reliability.This makes Biodegradable scaffold provided by the utility model be applicable not only to clinical practice, and is suitable for
In production in enormous quantities.
Intravascular stent of the present utility model is after implantable intravascular lesion locations, it is possible to achieve the support function of metal rack,
After the release completely of its contained medicine, its body can be gradually degraded as can being absorbed by human body within a period of time
And the material having no side effect, until degradable.
Accompanying drawing explanation
Fig. 1 show the internal diameter of Biodegradable scaffold structure and launches schematic diagram.
Fig. 2 show the triangular waveform schematic diagram of connecting rod.
Fig. 3 show the sinusoidal wave form schematic diagram of connecting rod.
Fig. 4 show the external diameter of Biodegradable scaffold structure and launches schematic diagram.
Fig. 5 show in the Biodegradable scaffold course of processing original tube of extrusion.
Fig. 6 show polymer pipe in the Biodegradable scaffold course of processing and expands and thinning schematic diagram.
Detailed description of the invention
Implementation process of the present utility model and the beneficial effect of generation is described in detail, it is intended to side below by way of specific embodiment
Reader is helped to be more fully understood that essence of the present utility model and feature, not as can the restriction of practical range to this case.
The Biodegradable scaffold that this utility model provides is made up of degradable polymer material, including: poly-left-handed breast
Acid PLLA, poly-(lactic acid-ethanol) copolymer p LGA, poly-(L-lactide-co-glycolide) (the co-PDLA of PLLA-,
Ratio is 70:30), wherein PLLA material proportion is 80%-100%, according to design requirement PLGA and PLLA-
The ratio of co-PDLA sum is 0-20%.
The structure of biodegradable stent of the present utility model is described below in conjunction with Fig. 1.
Fig. 1 show the cylinder deployed configuration of this utility model biodegradable stent.As it is shown in figure 1, laterally for propping up in figure
Frame axial direction, is longitudinally support circumferencial direction.In figure, 11 is described circulus, has 19 ring-type knots in figure
Structure, each circulus is closed loop at circumferencial direction, and its width is in the range of 0.12-0.24mm.
In Fig. 1,12 is composition circulus ripple bar, and ripple bar and ripple bar constitute the crest of circulus, ripple bar and ripple bar
Between angle be different for the product of different size, the angle [alpha] between support medium wave bar of the present utility model
More than or equal to 90 °, less than or equal to 175 °.
In Fig. 1, constitute 12 crests 13 between individual ring structure 11 medium wave bar 12 altogether, in this utility model
The crest quantity of individual ring structure can be 6-16.
In Fig. 1, connected by connecting rod 14 between circulus 11, connecting rod 14 be shaped as linear type.In figure
For having 3 connecting rods 14 to connect between adjacent two circuluses, in this utility model between two circuluses
Connecting rod quantity can be 2-4, its width is in the range of 0.10 0.16mm；The length of connecting rod, i.e. two
Distance between circulus is in the range of 0.5 1.2mm；Connected mode between connecting rod and circulus should
Noting, connecting rod is uniformly distributed in a circumferential direction, and in the support determine specification, the size of connecting rod is definite value,
And connecting rod shape is single.
In Fig. 1, being used for placing mark platinum pearl by two pairs of circular holes 15 at the connecting rod of two ends, its effect is to exist at support
Internal conveying is used for demarcating backing positions when placing, and the connecting rod at two pairs of circular hole places differs 180 ° at circumferencial direction.
On the one hand, according to support specification and the difference of radial direction support strength demand, the supporting structure in this utility model can
Arbitrarily to select and combination in the range of above-mentioned parameter.
On the other hand, in supporting structure of the present utility model, wall thickness affects the weight of degradation speed and support intensity the most
Wanting factor, the wall thickness of this utility model medium-height trestle is between 120-230 μm.
Fig. 2 show another form of expression of this utility model connecting rod, i.e. triangular waveform connecting rod.In figure
11 is two adjacent circuluses in supporting structure, and 20 is the triangular waveform connecting rod connecting circulus.
Fig. 3 show another form of expression of this utility model connecting rod, i.e. triangular waveform connecting rod.In figure
11 is two adjacent circuluses in supporting structure, and 30 is the triangular waveform connecting rod connecting circulus.
Fig. 4 show the external diameter of Biodegradable scaffold structure and launches schematic diagram, and wherein 40 is microcellular structure, diameter
10-30 μm, the degree of depth is the 1/4-1/2 of support wall thickness, is uniformly distributed at outer surface.Micropore quantity is according to support model not
With different, micropore area summation on rack outer surface is 0-5% with the ratio range of rack outer surface area；
Shown in Fig. 5 50 process for Biodegradable scaffold in original tube before expansion process, tubing 50 is by extruding
Technique obtains.Tubing 30 has default internal diameter and external diameter.Temperature is strict controlled in by tube extrusion moulding process
Less than 260 DEG C, within high-temperature region residence time is strict controlled in 30 minutes, to ensure polymer long-chain molecule
Chain length.Owing to other expressing technique is known to those skilled in the art, do not repeat them here.
It is true that the internal diameter of original tube and external diameter, be at the beginning of deisgn product according to Metal pylon internal diameter, external diameter with
Expansion ratio in expansion process determines, it possesses relation:
Expanded radially is than=(pipe internal diameter before pipe internal diameter expansion after expansion) front pipe internal diameter of/expansion；
Axial length before axial length after the expansion of axial expansion ratio=tubing/tubing expansion；
Shown in Fig. 6, tubing 50 is placed in special die 60, tubing inner chamber is filled with the gas of high pressure, high purity,
Its pressure in expansion process is made to keep constant, according to the different pressures scope of material mixture ratio at 100 to 200PSI；
Meanwhile, being heated to by tubing near its glass transition temperature (Tg), in expansion process, temperature keeps constant, according to
Its temperature range of practical situation is at 70 to 100 DEG C.Tubing 50 will occur expanded radially at this temperature and pressure,
Its outside dimension is limited by mould internal diameter, and the part wall thickness 61 after expanded radially makes tubing expand is thinning, and internal-and external diameter becomes
Greatly.Meanwhile, tubing is axially stretched, make inflated tube material part the most thinning.Expanded radially ratio
Scope is 200% to 600%, and axial expansion (stretching) ratio is 0 to 200%.(draw in expanded radially and axial expansion
Stretch) complete after need tubing is cooled down rapidly.
Expanded radially in expansion process and axial expansion can make degree of crystallinity and the length of polymer in the tubing after expansion
Chain polymerization thing molecular orientation reaches perfect condition so that in this utility model Biodegradable scaffold mechanical property reach and
Degradation characteristic is to optimal.
The tubing obtained after expanding utilizes the method for Laser Processing to be processed into such as Fig. 1, the supporting structure shown in 4.Swash
Optical wavelength should be greater than 400nm, power bracket 0.8mW-5W, pulse spacing 60-6000fs；The course of processing utilizes
The helium of more than 99.99 purity cools down, and reduces heat effect；Manual removal island after machining.
Two case study on implementation of this utility model preparation method are described below.
Case study on implementation one:
The implementation case chooses the PLLA of 100% as raw material, is first placed into PLLA particle existing with extruder
The drying machine that line connects, is dried 5 hours to ensure that the water content of PLLA particle is less than at a temperature of 55 DEG C
150ppm, is carried out according to extrusion process subsequently, and high-temperature region is less than 260 DEG C, and extrusion head exit connects fine vacuum
Calibration sleeve.Extrusion obtains original tube.
By original tube put in mould, by tubing one end close, the other end is filled with the drying nitrogen of 100PSI also
Keeping constant pressure, and tubing is heated to 100 DEG C, tubing just starts expanded radially after reaching temperature subsequently,
Expand (stretching) the most in the axial direction obtaining tubing according to suitable axial tensile rate 150% is external diameter 3.4mm,
The tubing of internal diameter 3.16mm, definition expanded radially ratio about 600% now.Expansion complete after with about 0 DEG C
Nitrogen tubing is cooled down rapidly, until its reach room temperature and stable after, unloading pressure and fixture, tubing is taken out.
Obtaining supporting structure by Laser Processing subsequently, this structure has 8 circuluses, and width is 120 μm；Often
Individual circulus possesses 6 crests；The connecting rod quantity connecting two adjacent annular structures is 2, and width is 100
μm, a length of 0.5mm；The area of plane ratio that rack outer surface area is formed after launching with support is 22%, this
Time micropore is set on rack outer surface, micro-pore diameter is 10 μm, and the degree of depth is the 1/4 of support wall thickness, micropore
Area summation on frame outer surface is 1% with the ratio of rack outer surface area.Permissible through its radial direction support force of detection
Reach more than 500mmHg.Can control at about 18 months according to the tube forming process degradation time.
Case study on implementation two
The implementation case chooses the PLLA of 80% and the PLGA of 20% as raw material, according to the step of case one
Being 200% at expanded radially ratio, axial expansion (stretching) is than being that 200% to obtain external diameter be that 4.0mm internal diameter is simultaneously
The expansion tubing of 3.54mm.Now utilizing Laser Processing to be processed into by support and possess 16 circuluses, width is
240μm；Each circulus possesses 16 crests；The connecting rod quantity connecting two adjacent annular structures is 4,
Width is 160 μm, a length of 1.4mm；The area of plane ratio that rack outer surface area is formed after launching with support
It is 31%；Arranging micropore at rack outer surface, micro-pore diameter is 30 μm, and the degree of depth is the 1/2 of support wall thickness；Micropore
Area summation on rack outer surface and rack outer surface area ratio are 5%.During according to tube forming process degradation
Between can control at about 36 months.Support radial-deformation is when two wall thickness, and its support force is more than 700mm Hg.
Case study on implementation three
The implementation case is choosing the PLLA of 90% and the PLGA of 10% as raw material, according to the step of case one
Rapid is 400% at expanded radially ratio, axial expansion than be 10% parameter under to obtain external diameter be 2.5mm, internal diameter is
The expansion tubing of 2.2mm, obtains supporting structure by Laser Processing subsequently, and this structure has 12 circuluses,
Width is 180 μm；Each circulus possesses 10 crests；Connect the connecting rod quantity of two adjacent annular structures
Being 3, width is 120 μm, a length of 1mm；The plane face that rack outer surface area is formed after launching with support
Long-pending ratio is 28%, now arranges micropore on rack outer surface, and micro-pore diameter is 20 μm, and the degree of depth is support wall thickness
1/3, the ratio of micropore area summation on rack outer surface and rack outer surface area is 3%.Through detecting it
Radially support force can reach more than 600mmHg.Can control at 24 according to the tube forming process degradation time
About Yue.
Claims (10)
1. an intravascular stent, it is characterised in that described support (1) includes corrugated circulus (11),
Two adjacent circuluses (11) are connected by connecting rod (14), and described circulus is by ripple bar (12) or flat
Sliding circular arc (16) composition, wherein, when described intravascular stent expands into plane, the angle of adjacent wave bar or circle
Arc to angle of circumference more than 90 ° and less than or equal to 175 °.
Intravascular stent the most according to claim 1, it is characterised in that the crest of each circulus (11)
Quantity is 6-16.
Intravascular stent the most according to claim 2, it is characterised in that two adjacent circuluses (11)
Between connecting rod (14) quantity be 2-4.
Intravascular stent the most according to claim 1, it is characterised in that described connecting rod (14) a length of
0.5-1.4mm；Connecting rod (14) width is 0.10-0.16mm.
Intravascular stent the most according to claim 1, it is characterised in that the width of circulus (11) is
0.12-0.24mm。
Intravascular stent the most according to claim 1, it is characterised in that micropore (40) is set at rack outer surface,
Micropore (40) a diameter of 10-30 μm, the degree of depth is the 1/4-1/2 of support wall thickness；Micropore (40) is on rack outer surface
Area summation and rack outer surface area ratio be 0-5%.
Intravascular stent the most according to claim 1, it is characterised in that described support wall thickness is 120-230 μm.
Intravascular stent the most according to claim 1, it is characterised in that rack outer surface area launches with support
The area of plane ratio of rear formation is 22-35%.
Intravascular stent the most according to claim 1, it is characterised in that in the connecting rod (14) at support two ends
On be respectively provided with a pair for the pore structure (15) disposing label.
Intravascular stent the most according to claim 1, it is characterised in that described intravascular stent be material be a poly-left side
Rotation lactic acid PLLA, the blood vessel of poly-(lactic acid-ethanol) copolymer p LGA or poly-(L-lactide-co-glycolide) prop up
Frame.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620292309.7U CN205698140U (en) | 2016-04-08 | 2016-04-08 | A kind of intravascular stent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620292309.7U CN205698140U (en) | 2016-04-08 | 2016-04-08 | A kind of intravascular stent |
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| Publication Number | Publication Date |
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| CN205698140U true CN205698140U (en) | 2016-11-23 |
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ID=57310811
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105902331A (en) * | 2016-04-08 | 2016-08-31 | 南京永明医疗器械有限公司 | Intravascular stent and preparation method thereof |
| CN113648113A (en) * | 2021-08-18 | 2021-11-16 | 上海禾吟企业管理咨询中心 | Degradable support |
-
2016
- 2016-04-08 CN CN201620292309.7U patent/CN205698140U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105902331A (en) * | 2016-04-08 | 2016-08-31 | 南京永明医疗器械有限公司 | Intravascular stent and preparation method thereof |
| CN113648113A (en) * | 2021-08-18 | 2021-11-16 | 上海禾吟企业管理咨询中心 | Degradable support |
| CN113648113B (en) * | 2021-08-18 | 2024-02-02 | 南京友德邦医疗科技有限公司 | Degradable support |
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