CN113648113B - Degradable support - Google Patents

Degradable support Download PDF

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Publication number
CN113648113B
CN113648113B CN202110947256.3A CN202110947256A CN113648113B CN 113648113 B CN113648113 B CN 113648113B CN 202110947256 A CN202110947256 A CN 202110947256A CN 113648113 B CN113648113 B CN 113648113B
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CN
China
Prior art keywords
degradable
closed
rods
bridge
stent
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Active
Application number
CN202110947256.3A
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Chinese (zh)
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CN113648113A (en
Inventor
郭利斌
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Nanjing Youdebang Medical Technology Co ltd
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Nanjing Youdebang Medical Technology Co ltd
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Priority to CN202110947256.3A priority Critical patent/CN113648113B/en
Publication of CN113648113A publication Critical patent/CN113648113A/en
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Publication of CN113648113B publication Critical patent/CN113648113B/en
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/89Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0096Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
    • A61F2250/0098Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00011Metals or alloys
    • A61F2310/00017Iron- or Fe-based alloys, e.g. stainless steel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00011Metals or alloys
    • A61F2310/00035Other metals or alloys
    • A61F2310/00041Magnesium or Mg-based alloys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00011Metals or alloys
    • A61F2310/00035Other metals or alloys
    • A61F2310/00083Zinc or Zn-based alloys

Abstract

The invention discloses a degradable support, which comprises a plurality of closed rings which are arranged at intervals along the axial direction, wherein the closed rings can be radially scaled, two adjacent closed rings are connected through a plurality of bridge rods which are uniformly arranged along the circumferential direction, and a plurality of through holes are uniformly arranged on the bridge rods along the axial direction; the materials of the closed ring and the bridge rod are polylactic acid, polylactic acid-glycolic acid copolymer, zinc, magnesium, iron, zinc alloy, magnesium alloy or degradable polymer. The degradable bracket has good supporting performance.

Description

Degradable support
Technical Field
The invention relates to the technical field of vascular stents, in particular to a degradable stent.
Background
The vascular stent is characterized in that on the basis of the expansion and the formation of a lumen balloon, an inner stent is placed in a lesion section so as to achieve the purposes of supporting a narrow occlusion section blood vessel, reducing the elastic retraction and the reshaping of the blood vessel and keeping the lumen blood flow smooth. Part of the inner stent also has the function of preventing restenosis. Mainly comprises a coronary stent, a cerebral vessel stent, a renal artery stent, a aortic stent and the like.
The existing vascular stent has poor supporting performance, and easily has the defects of collapse, deformation and the like under the action of external force, such as in the process of pressing and holding and releasing, thus forming potential threat to the health of patients.
Disclosure of Invention
The invention aims to provide a degradable stent, which solves the problems in the prior art and improves the supporting performance of a vascular stent.
In order to achieve the above object, the present invention provides the following solutions:
the invention provides a degradable support, which comprises a plurality of closed rings which are arranged at intervals along the axial direction, wherein the closed rings can be radially scaled, two adjacent closed rings are connected through a plurality of bridge rods which are uniformly arranged along the circumferential direction, and a plurality of through holes are uniformly arranged on the bridge rods along the axial direction; the materials of the closed ring and the bridge rod are polylactic acid, polylactic acid-glycolic acid copolymer, zinc, magnesium, iron, zinc alloy, magnesium alloy or degradable polymer.
Preferably, a plurality of the closed rings are uniformly arranged in the axial direction.
Preferably, the closed ring comprises a plurality of end-to-end combined units, the combined units comprise a plurality of connecting rods which are connected in sequence, and the two connecting rods which are connected are inclined relatively; the combined unit is in a curve shape; the two adjacent combined units in the two adjacent closed rings are in one-to-one correspondence, one bridge rod is connected to the joint of the two adjacent combined units in the same closed ring, the two corresponding combined units are connected through the two bridge rods, and the two corresponding combined units and the two bridge rods between the two corresponding combined units form a closed contour.
Preferably, a plurality of the closed contours in the same degradable stent are in a shape of positive 8, oblique 8, diamond or S; the shape of the closure profiles may be the same or different.
Preferably, the central angle occupied by the closed contour in the circumferential direction of the degradable support ranges from 10 degrees to 120 degrees, and the number of the closed contours in the axial direction of the degradable support ranges from 6 to 12 per cm.
Preferably, two adjacent connecting rods in one combined unit are connected through an arc-shaped rod, and the two adjacent connecting rods and the arc-shaped rod form a rhombus-like closed structure; when the degradable support is pressed and held, the arc-shaped rod can be anastomosed with the corresponding connecting rod.
Preferably, an arc-shaped concave part is arranged on the inner wall of each corner of the closed contour, and the arc-shaped concave part is formed by cutting.
Preferably, the connecting rods are curved rods, and the protruding directions of two adjacent connecting rods are opposite.
Preferably, each bridge bar is provided with a plurality of developing marks.
Compared with the prior art, the invention has the following technical effects:
the degradable bracket has good supporting performance. The degradable stent provided by the invention has the advantages that stronger radial supporting force, stability and trafficability are obtained by arranging the closed profile, stress can be eliminated, better flexibility and deformation adaptability are obtained by adding the bridge rod with the through hole, so that the stent is not easy to collapse, deform and other defects in the pressing and holding and releasing processes, the vessel wall is supported more stably, the supporting performance of the stent in the service period after implantation is improved, the surface coverage rate is increased, and the risk of plaque falling off at a lesion part is reduced.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic structural view of a degradable stent according to an embodiment of the present invention;
FIG. 2 is a schematic plan view of a degradable stent according to an embodiment of the present invention;
FIG. 3 is an enlarged view of a portion of FIG. 2;
FIG. 4 is a schematic structural view of a degradable stent according to a second embodiment of the present invention;
FIG. 5 is a schematic structural view of a third degradable stent according to an embodiment of the present invention;
FIG. 6 is a schematic structural diagram of a fourth degradable stent according to an embodiment of the present invention;
FIG. 7 is a schematic structural diagram of a fifth degradable stent according to the embodiment of the present invention;
wherein: 100. a degradable stent; 1. a closed ring; 2. a bridge bar; 3. a combining unit; 4. a closed profile; 5. an arc-shaped rod; 6. a first connecting rod; 7. a second connecting rod; 8. a third connecting rod; 9. a fourth connecting rod; 10. a first curved bar; 11. a second curved bar; 12. a third curved bar; 13. a fourth curved bar; 14. an arc-shaped concave part.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by a person skilled in the art based on the embodiments of the invention without any inventive effort, are intended to fall within the scope of the invention.
The invention aims to provide a degradable stent, which solves the problems in the prior art and improves the supporting performance of a vascular stent.
In order that the above-recited objects, features and advantages of the present invention will become more readily apparent, a more particular description of the invention will be rendered by reference to the appended drawings and appended detailed description.
Example 1
As shown in fig. 1 to 3: the embodiment provides a degradable support 100, including a plurality of closed rings 1 that follow axial even, interval setting, closed ring 1 can radially zoom, and the diameter value range of the radial scalable of closed ring 1 is 0.5mm-20mm, and the value range of degradable support 100's total length is: 2mm-200mm, two adjacent closed rings 1 are connected through a plurality of bridge rods 2 which are uniformly arranged along the circumferential direction, a plurality of through holes are uniformly formed in the bridge rods 2 along the axial direction, the through holes are round, square, slotted hole or polygonal, and stress can be eliminated by arranging the bridge rods 2 with the through holes, so that better flexibility and deformation adaptability can be obtained; the materials of the closed ring 1 and the bridge rod 2 are polylactic acid, polylactic acid-glycolic acid copolymer, zinc, magnesium, iron, zinc alloy, magnesium alloy or a degradable polymer.
The closed ring 1 comprises a plurality of combined units 3 which are connected end to end, the combined units 3 comprise four connecting rods which are sequentially connected, namely a first connecting rod 6, a second connecting rod 7, a third connecting rod 8 and a fourth connecting rod 9, the connecting rods can be one or more of straight rods, S-shaped, V-shaped, L-shaped and arc-shaped, and the two connecting rods which are connected are inclined relatively; in this embodiment, the combination unit 3 is curved, has a plurality of continuous S-shaped structures, increases the trafficability of the bracket in the use process of the bracket, and the first connecting rod 6, the second connecting rod 7, the third connecting rod 8 and the fourth connecting rod 9 are curved rods, and the protruding directions of two adjacent connecting rods are opposite. And any two adjacent connecting rods among the first connecting rod 6, the second connecting rod 7, the third connecting rod 8 and the fourth connecting rod 9 are symmetrically distributed, and the symmetry axis is a straight line which passes through the connecting point of the two adjacent connecting rods and is parallel to the axial direction of the degradable support 100.
The combination units 3 in two adjacent closed rings 1 are in one-to-one correspondence, the connection parts of the two adjacent combination units 3 in the same closed ring 1 are connected with one bridge rod 2, the two corresponding combination units 3 are connected through the two bridge rods 2, the two corresponding combination units 3 and the two bridge rods 2 between the two corresponding combination units 3 form a closed contour 4, and in the embodiment, the closed contour 4 is S-shaped.
The central angle occupied by the closed contour 4 in the circumferential direction of the degradable stent 100 ranges from 10 degrees to 120 degrees, and the number of the closed contour 4 in the axial direction of the degradable stent 100 ranges from 6 to 12 per cm.
Two adjacent connecting rods in one combined unit 3 are also connected through an arc-shaped rod 5, and the two adjacent connecting rods and the arc-shaped rod 5 form a diamond-like closed structure; when the degradable support 100 is pressed and held, the two connecting rods provided with the arc rods 5 are close to each other, meanwhile, the arc rods 5 are pressed, the arc rods 5 can be matched with the corresponding two connecting rods, namely, the outline of the arc rods 5 is matched with the outline of the two connecting rods, so that the final arc rods 5 can be matched with the corresponding two connecting rods, the anti-collapse and anti-deformation capacity of the whole support during pressing and holding is improved, the support performance of the support in the service period after the support is implanted is improved, the surface coverage rate is increased, and the risk of plaque falling off at a lesion part is reduced. It should be noted that, in this embodiment, the arc-shaped rod 5 is symmetrical about the symmetry axis between the two corresponding connecting rods.
Each bridge bar 2 is provided with developing marks, and the number of the developing marks is 2-10.
Example two
As shown in fig. 4: the present embodiment provides a degradable stent 100, and the structure of the degradable stent 100 of the present embodiment is substantially the same as that of the degradable stent 100 of the first embodiment, except that: in this embodiment, the first curved bar 10, the second curved bar 11, the third curved bar 12 and the fourth curved bar 13 which are sequentially connected are adopted to replace the arc-shaped bar 5 of one embodiment, and the combination body formed by combining the first curved bar 10, the second curved bar 11, the third curved bar 12 and the fourth curved bar 13 is symmetrical about the symmetry axis between the two corresponding connecting bars.
Example III
As shown in fig. 5: the present embodiment provides a degradable stent 100, and the structure of the degradable stent 100 of the present embodiment is substantially the same as that of the degradable stent 100 of the first embodiment, except that: in this embodiment, the closing profiles 4 are all in the shape of a positive figure 8.
Example IV
As shown in fig. 6: the present embodiment provides a degradable stent 100, and the structure of the degradable stent 100 of the present embodiment is substantially the same as that of the degradable stent 100 of the first embodiment, except that: in this embodiment, the closed contours 4 are all inclined 8-shaped, and the inner wall at the corner of each closed contour 4 is provided with an arc-shaped concave portion 14, the arc-shaped concave portions 14 are formed by cutting, and the arrangement of the concave portions can increase the flexibility and deformation adaptability of the bracket in the use process of the bracket
Example five
As shown in fig. 7: the present embodiment provides a degradable stent 100, and the structure of the degradable stent 100 of the present embodiment is substantially the same as that of the degradable stent 100 of the first embodiment, except that: the first connecting rod 6, the second connecting rod 7, the third connecting rod 8 and the fourth connecting rod 9 in this embodiment all adopt straight rods.
In the description of the present invention, it should be noted that the terms "first," "second," and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
The principles and embodiments of the present invention have been described in this specification with reference to specific examples, the description of which is only for the purpose of aiding in understanding the method of the present invention and its core ideas; also, it is within the scope of the present invention to be modified by those of ordinary skill in the art in light of the present teachings. In view of the foregoing, this description should not be construed as limiting the invention.

Claims (8)

1. A degradable stent, characterized in that: the device comprises a plurality of closed rings which are arranged at intervals along the axial direction, wherein the closed rings can be radially scaled, two adjacent closed rings are connected through a plurality of bridge rods which are uniformly arranged along the circumferential direction, and a plurality of through holes are uniformly arranged on the bridge rods along the axial direction; the materials of the closed ring and the bridge rod are zinc, magnesium, iron, zinc alloy, magnesium alloy or a degradable polymer;
the closed ring comprises a plurality of end-to-end combined units, wherein each combined unit comprises a plurality of connecting rods which are connected in sequence, and the two connecting rods which are connected are inclined relatively; the combined unit is in a curve shape; the combined units in two adjacent closed rings are in one-to-one correspondence, the connecting parts of the two adjacent combined units in the same closed ring are connected with one bridge rod, the two corresponding combined units are connected through the two bridge rods, and the two corresponding combined units and the two bridge rods between the two corresponding combined units form a closed contour;
two adjacent connecting rods in one combined unit are connected through an arc-shaped rod, and the two adjacent connecting rods and the arc-shaped rod form a diamond-like closed structure; when the degradable support is pressed and held, the arc-shaped rod can be anastomosed with the corresponding connecting rod.
2. The degradable stent of claim 1, wherein: the plurality of closed rings are uniformly arranged along the axial direction.
3. The degradable stent of claim 1, wherein: a plurality of closed contours in the same degradable support are in a shape of positive 8, oblique 8, diamond or S; the shape of the closure profiles may be the same or different.
4. The degradable stent of claim 1, wherein: the value range of the central angle occupied by the closed contour in the circumferential direction of the degradable support is 10 degrees (in terms of the angle) and the number of the closed contour in the axial direction of the degradable support is 6-12 per centimeter.
5. The degradable stent of claim 1, wherein: and arc-shaped concave parts are arranged on the inner walls of the corners of each closed contour, and the arc-shaped concave parts are formed by cutting.
6. The degradable stent of claim 1, wherein: the connecting rods are curved rods, and the protruding directions of two adjacent connecting rods are opposite.
7. The degradable stent of claim 1, wherein: and each bridge rod is provided with a plurality of developing marks.
8. The degradable stent of claim 1, wherein: the degradable polymer is polylactic acid or polylactic acid-glycolic acid copolymer.
CN202110947256.3A 2021-08-18 2021-08-18 Degradable support Active CN113648113B (en)

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Application Number Priority Date Filing Date Title
CN202110947256.3A CN113648113B (en) 2021-08-18 2021-08-18 Degradable support

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Application Number Priority Date Filing Date Title
CN202110947256.3A CN113648113B (en) 2021-08-18 2021-08-18 Degradable support

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CN113648113A CN113648113A (en) 2021-11-16
CN113648113B true CN113648113B (en) 2024-02-02

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103169556A (en) * 2013-02-22 2013-06-26 深圳市信立泰生物医疗工程有限公司 Completely-biodegradable support capable of developing and preparation method thereof
CN103550017A (en) * 2013-08-16 2014-02-05 江苏大学 Intravascular stent applicable to conical blood vessel
CN205698140U (en) * 2016-04-08 2016-11-23 南京永明医疗器械有限公司 A kind of intravascular stent
CN107569299A (en) * 2017-09-04 2018-01-12 上海脉全医疗器械有限公司 A kind of bioabsorbable stent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050261757A1 (en) * 2004-05-21 2005-11-24 Conor Medsystems, Inc. Stent with contoured bridging element
US7476245B2 (en) * 2005-08-16 2009-01-13 Advanced Cardiovascular Systems, Inc. Polymeric stent patterns

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103169556A (en) * 2013-02-22 2013-06-26 深圳市信立泰生物医疗工程有限公司 Completely-biodegradable support capable of developing and preparation method thereof
CN103550017A (en) * 2013-08-16 2014-02-05 江苏大学 Intravascular stent applicable to conical blood vessel
CN205698140U (en) * 2016-04-08 2016-11-23 南京永明医疗器械有限公司 A kind of intravascular stent
CN107569299A (en) * 2017-09-04 2018-01-12 上海脉全医疗器械有限公司 A kind of bioabsorbable stent

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