CN205683649U

CN205683649U - purification column device

Info

Publication number: CN205683649U
Application number: CN201620527090.4U
Authority: CN
Inventors: 胡晓平; 于静潇
Original assignee: BEIJING PET Co Ltd
Current assignee: BEIJING PET Co Ltd
Priority date: 2016-06-02
Filing date: 2016-06-02
Publication date: 2016-11-16
Anticipated expiration: 2026-06-02

Abstract

This utility model embodiment relates to a kind of purification column device, including: post shell and Rule gland；Described post shell is hollow cylindrical, and bottom has Rule outlet, and the inwall on top is provided with two draw-in grooves；Described Rule gland includes access section, fixed part and Access Division；The bottom surface of described access section is connected with the end face one of described fixed part, and the bottom surface of described fixed part is connected with the end face one of described Access Division, and the base area of described fixed part is more than the base area of described access section；The centre of described Rule gland has through hole, through described access section, fixed part and Access Division；Described Access Division is cylindrical, and the external diameter of described Access Division matches with the internal diameter of described post shell；The outer wall of described Access Division is provided with two protuberances, and each protuberance is snapped in a described draw-in groove respectively, makes to snap connection between described Rule gland and described post shell.

Description

Purification column device

Technical field

This utility model relates to pharmaceutical technology field, particularly relates to a kind of purification column device.

Background technology

Solid-Phase Extraction (Solid Phase Extraction, SPE) technology, based on liquid-solid phase chromatographic theory, uses and selects Property absorption, sample is enriched with, separates, purifies by the mode of selective elution, is a kind of physics including liquid phase and solid phase extraction Take process；It can also be regarded as a kind of simple chromatographic process approx.It is mainly used in the separation of sample, purifies and rich Collection.The most conventional solid-phase extraction column is typically the most with cover, relies on gravity to separate, it is impossible to realize separation.Also have It is partially with cover that can be used for separation, but is by adhering and sealing between its cap portion and cylinder body, assemble The most inconvenient, simultaneously because the complexity of sample, may react with viscose glue, generate impurity interference, range of application is limited.

Utility model content

The purpose of this utility model is to provide a kind of purification column device, and simple in construction is applied widely, is particularly suited for using In material isolated and purified needing separation.

For achieving the above object, this utility model provides a kind of purification column device, including: post shell and Rule gland；

Described post shell is hollow cylindrical, and bottom has Rule outlet, and the inwall on top is provided with two draw-in grooves；

Described Rule gland includes access section, fixed part and Access Division；The bottom surface of described access section and described fixed part End face one connects, and the bottom surface of described fixed part is connected with the end face one of described Access Division, the base area of described fixed part Base area more than described access section；The centre of described Rule gland has through hole, through described access section, fixed part and card Meet portion；Described Access Division is cylindrical, and the external diameter of described Access Division matches with the internal diameter of described post shell；Outside described Access Division Wall is provided with two protuberances, and each protuberance is snapped in a described draw-in groove respectively, make described Rule gland and described post shell it Between snap connection.

Preferably, said two draw-in groove is for being symmetrical arranged, and said two protuberance is for being symmetrical arranged.

Preferably, described access section is cylindrical.

It is further preferred that the outer surface of described access section has fluid circuit fixing device.

Preferably, described Rule gland and described post shell are made by polypropylene PP material.

Preferably, described draw-in groove is L-type.

Preferably, it is equipped with sieve plate and resin in described post shell.

It is further preferred that described resin specifically includes: ion exchange resin, adsorbent resin, silica column or amino tree One or more in fat.

Preferably, the outer wall of described post shell having bulge loop, described bulge loop is arranged at the top of described post shell.

The purification column device that this utility model embodiment provides, simple in construction, applied widely, it is particularly suitable for needing Want material isolated and purified of separation.

Accompanying drawing explanation

The schematic diagram of the post shell of the purification column device that Fig. 1 provides for this utility model embodiment；

The partial enlarged drawing of the post shell that Fig. 2 provides for this utility model embodiment；

The perspective view of Rule gland that Fig. 3 provides for this utility model embodiment；

The cross-sectional view of the purification column device that Fig. 4 provides for this utility model embodiment.

Detailed description of the invention

Below by drawings and Examples, the technical solution of the utility model is described in further detail.

The purification column device that this utility model embodiment provides, may be used for alternative adsorptive hindrance impurity, and allow by Survey material flows out.

Purification column device includes post shell and Rule gland.The structure of coupled columns shell and Rule gland is situated between the most respectively Continue.

The schematic diagram of the post shell of the purification column device that Fig. 1 provides for this utility model embodiment.As it is shown in figure 1, post shell 1 is Cylindric, inside is hollow cavity, and bottom has Rule outlet 11, and the inwall on top is provided with two draw-in grooves 12.

The top of post shell 1 outer wall has bulge loop 13 so that post shell 1 is in use easy to place or hand-held.

The structure of draw-in groove 12 can partial enlarged drawing the most as shown in Figure 2, two draw-in grooves 12 are symmetricly set on post shell 1 top Inwall on, be shaped as L-type.

The structure of Rule gland is as shown in Figure 3.What Fig. 3 was given is the perspective view of Rule gland.

Rule gland 2 includes access section 21, fixed part 22 and Access Division 23.The bottom surface of access section 21 and the top of fixed part 22 Face one connects, and the bottom surface of fixed part 22 is connected with the end face one of Access Division 23.The base area of fixed part 22 is more than accessing The base area in portion 21, thus can be played by fixed part 22 and reinforce the effect being connected between access section 21 and Access Division 23, For not having the structure of fixed part 22, the structure that the present embodiment provides is more firm.

Coupling for convenience injects the pipeline of fluid, and access section 21 is cylindrical, and the outer surface of access section 21 has Fluid circuit fixing device 211.Fixing device for pipe 211 can be being symmetrical arranged on access section 21 outer surface shown in figure Two projections, or can be screw thread rib collar.

The centre of Rule gland 2 has through hole 24, and through hole 24 is through access section 21, fixed part 22 and Access Division 23.

Access Division 23 is cylindrical, and the external diameter of Access Division 23 matches with the internal diameter of post shell 1；Set on the outer wall of Access Division 23 Two protuberances 231, two protuberances 231 are had to be symmetrical arranged on the outer wall.The width dimensions of protuberance 231 and the draw-in groove shown in Fig. 2 The width of 12 matches.

Shown in Fig. 1, Fig. 3, post shell 1 and Rule gland 2 snap connection the purification column device constituted described in the present embodiment, Wherein, each protuberance 231 is snapped in a draw-in groove 12, to constitute snapping connection between Rule gland 2 and post shell 1.

The sectional structure chart of the purification column device assembled is as shown in Figure 4.

Post shell 1 and Rule gland 2 are both preferably and are made up of polypropylene (PP) material.

Further, as shown in Figure 4, in post shell 1, according to the requirement of purifying substance, select to put corresponding sieve plate 3 He Resin 4.

Sieve plate 3 can use the materials such as highly purified ultra-high molecular weight polyethylene (UHWMPE) to be that raw material is through processes Form, adsorb low, bubble should not be produced and there is good hydrophilic.

Sieve plate 3 can be two to five, and resin 4 is placed between sieve plate 3, sieve plate 3 has a lot of micropore and (does not shows in figure Go out), the suitable aperture of sieve plate 3 ensure that flow velocity when being purified operation the most under gravity.

Resin 4 can specifically include: the resin materials such as ion exchange resin, adsorbent resin, silica column, amino resins.

In conjunction with earlier figures 1-Fig. 4, when reality is applied, in post shell 1, first add sieve plate 3 and resin 4, then by Rule The protuberance 231 of gland 2 is directed at the draw-in groove 12 of post shell 1, is downwardly in the draw-in groove 12 of L-shaped by protuberance 231, and screws in L-shaped card The bottom of groove 12, makes Rule gland 2 be buckled on post shell 1 and does not comes off.Thus form the purification column device of purifies and separates.Should Device can be used for chromatographic isolation, purification.The top of through hole 24, as the entrance of purification column device, is UNICOM with Rule outlet 11 , need the material of purification to be entered by entrance, through being seated in resin extender therein and making it separate, Shandong below post shell 1 You go out in outlet 11.Just the isolated and purified of different material is can be used for by loading the resin 4 of different purposes.

Owing to snapping connection between Rule gland 2 and post shell 1, therefore go for the isolated and purified of separation Process.

When carrying out separation purification, needing the material pressurization of purification to enter in post shell, its pressure mostlys come from thing The gas pressure used in matter synthesis device, or can be from high-pressure liquid phase pump.Because Rule gland 2 and post shell 1 are cards Button connects, thus without because the pressure of pressor substance causes the situation that gland backed down.In the case of separation, flow velocity The most relevant to the aperture of pressure size, sieve plate 3.

Above-described detailed description of the invention, is entered the purpose of this utility model, technical scheme and beneficial effect One step describes in detail, be it should be understood that and the foregoing is only detailed description of the invention of the present utility model, is not used to limit Fixed protection domain of the present utility model, all within spirit of the present utility model and principle, any amendment, the equivalent made are replaced Change, improvement etc., within should be included in protection domain of the present utility model.

Claims

1. a purification column device, it is characterised in that described purification column device includes: post shell and Rule gland；

Described Rule gland includes access section, fixed part and Access Division；The bottom surface of described access section and the end face of described fixed part One connects, and the bottom surface of described fixed part is connected with the end face one of described Access Division, and the base area of described fixed part is more than The base area of described access section；The centre of described Rule gland has through hole, through described access section, fixed part and clamping Portion；Described Access Division is cylindrical, and the external diameter of described Access Division matches with the internal diameter of described post shell；The outer wall of described Access Division Being provided with two protuberances, each protuberance is snapped in a described draw-in groove respectively, makes between described Rule gland and described post shell Snap connection.

Purification column device the most according to claim 1, it is characterised in that said two draw-in groove for being symmetrical arranged, described two Individual protuberance is for being symmetrical arranged.

Purification column device the most according to claim 1, it is characterised in that described access section is cylindrical.

4. according to the purification column device described in claim 1 or 3, it is characterised in that the outer surface of described access section has fluid Fixing device for pipe.

Purification column device the most according to claim 1, it is characterised in that described Rule gland and described post shell are by poly-third Alkene PP material is made.

Purification column device the most according to claim 1, it is characterised in that described draw-in groove is L-type.

Purification column device the most according to claim 1, it is characterised in that be equipped with sieve plate and resin in described post shell.

Purification column device the most according to claim 7, it is characterised in that described resin specifically includes: ion exchange resin, One or more in adsorbent resin, silica column or amino resins.

Purification column device the most according to claim 1, it is characterised in that on the outer wall of described post shell, there is bulge loop, described Bulge loop is arranged at the top of described post shell.