CN205643257U - Expired gas analysis and detection appearance - Google Patents
Expired gas analysis and detection appearance Download PDFInfo
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- CN205643257U CN205643257U CN201620184260.3U CN201620184260U CN205643257U CN 205643257 U CN205643257 U CN 205643257U CN 201620184260 U CN201620184260 U CN 201620184260U CN 205643257 U CN205643257 U CN 205643257U
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- exhaled gas
- raceway groove
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- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The utility model provides an expired gas analysis and detection appearance, including the FAIMS spectrometer, this FAIMS spectrometer includes sensor chip, sensor chip includes the base plate and sets up the metal level on this base plate, and the shaping has a ion mobility channel on this metal level, and a plurality of ion mobility channels communicate in proper order and form the tracer gas passageway. This technical scheme makes it when applying the voltage lower than traditional parallel electrode structure through figure, width, the breadth depth ratio isoparametric of channel and ion mobility channel and optimal design sensor chip's the ion mobility channel that discharges more, can produce the electric field strength who is higher than 60000Vcm to solved FAIMS technique not enough problem in sensitivity, made it have high sensitivity and high resolution concurrently. And this FAIMS spectrometer can detect all expired gas simultaneously, avoids the mutual interference between each expired gas, specificity strong (reaching more than 90%). Therefore can be used for the diagnosis of lung's disease.
Description
Technical field
This utility model relates to medical treatment detection device technical field, is specifically related to a kind of exhaled gas analysis
Detector.
Background technology
Problem of environmental pollution was day by day serious in recent years, and particularly haze constantly aggravates, and causes pulmonary disease
The sickness rate of (such as pulmonary carcinoma, bronchial asthma, chronic obstructive disease of lung etc.) drastically raises.Cause
The effectively detection of pulmonary disease is become to become more and more important by this.
Clinic includes breast CT, NMR (Nuclear Magnetic Resonance)-imaging and blood to the detection method that pulmonary disease is common at present
Liquid detects.But breast CT, NMR (Nuclear Magnetic Resonance)-imaging all have radiation, detect continually to tester's health not
Profit, blood testing needs to use traumatic sampling mode, for tester equally in certain injury.
By analysis tester's exhaled gas, pulmonary disease is carried out detection and can realize the inspection of safe noinvasive
Survey, be the development trend of following pulmonary disease detection.But human exhalation's complicated component, concentration are low,
The most most of concentration are in picomole or ppt (parts.per-trillion) rank.
In prior art, the detection for exhaled gas mainly uses gas chromatogram (gas
Chromatography, GC) instrument, Electronic Nose and FAIMS (Field Asymmetric Waveform Ion
Mobility Spectrometry, High-Field asymmetric waveform ion mobility spectrometry) spectrometer.Gas chromatograph
Being based respectively on gas chromatogram isolation technics and sensor array design with Electronic Nose, both are former due to self
The restriction of reason, its detection limit does not reaches far away the degree of trace materials in detection exhaled gas.
FAIMS spectrometer is highly sensitive compared to gas chromatograph and Electronic Nose, and its detection limit can reach
10ppm or even 10ppb, but for higher accuracy of detection (the ppt level required by pulmonary disease detection
) the most still cannot not realize.
In sum, generally there is the problem that susceptiveness is low in expired gas monitor device of the prior art,
Thus cause existing expired gas monitor device poor practicability.
Utility model content
Therefore, the technical problems to be solved in the utility model is to overcome in prior art to exhaled gas
The defect that detection sensitivity is low, thus provide a kind of exhaled gas to analyze detector.
A kind of exhaled gas that this utility model provides analyzes detector, including FAIMS spectrometer, this FAIMS
Spectrometer includes that sensor chip, described sensor chip include substrate and the metal being arranged on this substrate
Layer, this metal level forms ion migration raceway groove, and multiple ion migration raceway grooves are sequentially communicated formation inspection
Survey gas passage；
The number of described ion migration raceway groove is that n, n are selected from integer, and 5≤n≤30；
The width of described ion migration raceway groove is a, 25 μm≤a≤50 μm；
The degree of depth of described ion migration raceway groove is b, 5:1≤a/b≤15:1.
Optionally, n is 10, and a is 30 μm, and a/b is 10:1；Or
N is 15, and a is 30 μm, and a/b is 10:1；Or
N is 20, and a is 30 μm, and a/b is 10:1；Or
N is 25, and a is 30 μm, and a/b is 10:1.
Optionally, the multiple serpentine-like arrangements of ion migration raceway groove on described metal level.
Optionally, including carrier gas blood circulation, described carrier gas blood circulation includes being sequentially connected in series as loop
Described FAIMS spectrometer, pump, the first mass flow controller and filter, described FAIMS compose
The gas access end that instrument analyzes detector with this exhaled gas is connected.
Optionally, the end of described pump has been simultaneously connected with described first mass flow controller and the second matter
Amount flow controller.
Optionally, described filter include active carbon filter, molecular sieve filter and activated carbon/point
Son is sieved through filter.
Optionally, the making material of described substrate is selected from glass, pottery or silicon, the system of described metal level
It is metal as material.
Technical solutions of the utility model, have the advantage that
1. a kind of exhaled gas that this utility model provides analyzes detector, its sensor chip bag
Include substrate and the metal level being arranged on substrate, this metal level form ion migration raceway groove,
Multiple ion migration raceway grooves are sequentially communicated formation detected gas passage.By many discharge channels and ion
Migrate raceway groove and optimize the design number of ion migration raceway groove of sensor chip, width, width deeply
The parameters such as ratio so that it is when applying the voltage lower than Conventional parallel electrode structure, can produce
Electric field intensity higher than 60000V/cm.Thus solve FAIMS technology deficiency in sensitivity
Problem so that it is have high sensitivity and high-resolution concurrently.Further, this FAIMS spectrometer can detect simultaneously
All of exhaled gas, it is to avoid interfering between each exhaled gas, high specificity (reaches 90%
Above).Thus may be used for the diagnosis of pulmonary disease.
2. a kind of exhaled gas that this utility model provides analyzes detector, and the detection to pulmonary disease is pacified
Completely without wound, detection speed is fast, it is simple to tester detects for a long time, beneficially the timely diagnosis of disease.
3. a kind of exhaled gas that this utility model provides analyzes detector, and volume is little, Miniaturizable,
Consequently facilitating user carries and uses.And then it is easy to the promotion and application of this equipment.
Accompanying drawing explanation
In order to be illustrated more clearly that this utility model detailed description of the invention or technical side of the prior art
Case, will make simply the accompanying drawing used required in detailed description of the invention or description of the prior art below
Introduce, it should be apparent that, the accompanying drawing in describing below is embodiments more of the present utility model, right
From the point of view of those of ordinary skill in the art, on the premise of not paying creative work, it is also possible to according to
These accompanying drawings obtain other accompanying drawing.
Fig. 1 is the structural principle that a kind of exhaled gas that this utility model embodiment provides analyzes detector
Figure.
Fig. 2 is the structure principle chart of sensor chip in Fig. 1.
Fig. 3 be the sensor chip including different in width exhaled gas analyze detector resolution and
Sensitivity；
Fig. 4 be the sensor chip including various configuration exhaled gas analyze detector resolution and
Sensitivity.
Description of reference numerals:
1-substrate, 2-metal level, 3-ion migration raceway groove.
Detailed description of the invention
Below in conjunction with accompanying drawing, the technical solution of the utility model is clearly and completely described, aobvious
So, described embodiment is a part of embodiment of this utility model rather than whole embodiments.
Based on the embodiment in this utility model, those of ordinary skill in the art are not making creative work
The every other embodiment obtained under premise, broadly falls into the scope of this utility model protection.
Embodiment 1
From figure 1 it appears that this exhaled gas analyzes detector includes carrier gas blood circulation, carrier gas
Blood circulation include being sequentially connected in series the FAIMS spectrometer into loop, pump, the first mass flow controller with
And filter.The gas access end that FAIMS spectrometer analyzes detector with this exhaled gas is connected.
Wherein, filter includes that active carbon filter, molecular sieve filter and activated carbon/molecule are sieved through
Filter.The end of pump has been simultaneously connected with the first mass flow controller and the second mass flow controller.
This FAIMS spectrometer includes sensor chip.Refer to Fig. 2, sensor chip includes substrate 1 He
It is arranged at the metal level 2 on this substrate 1, this metal level 2 forms ion migration raceway groove 3, multiple
Ion migration raceway groove 3 is sequentially communicated formation detected gas passage.
The number of ion migration raceway groove is that n, n are selected from integer, and 5≤n≤30；
The width of ion migration raceway groove is a, 25 μm≤a≤50 μm；
The degree of depth of ion migration raceway groove is b, 5:1≤a/b≤15:1.
The making material of substrate is selected from glass, pottery or silicon, and the making material of metal level is metal.Excellent
Choosing, the multiple serpentine-like arrangements of ion migration raceway groove 3 on metal level 2.
This exhaled gas analyzes the using method of detector:
Thered is provided the power of the carrier gas of described carrier gas blood circulation by described pump, described carrier gas blood circulation exists
After described first mass flow controller and the second mass flow controller are adjusted to suitable flow,
Filtered by described activated carbon/molecular sieve filter and active carbon filter respectively, miscellaneous to avoid bringing into
Matter, then be passed through in described FAIMS spectrometer, after described FAIMS spectrometer, again it is passed through the first mass
Flow controller and the second mass flow controller, to complete circulation；During detection, take testing sample note
Enter sample inlet end, the carrier gas in described carrier gas blood circulation bring in FAIMS spectrometer, Ji Kejin
Row detection.
Embodiment 2
In sensor chip in embodiment 1, the number n of described ion migration raceway groove 3 is 10；Institute
The width a stating ion migration raceway groove 3 is 30 μm；The degree of depth of described ion migration raceway groove 3 is b, a/b
For 10:1.
Embodiment 3
In sensor chip in embodiment 1, the number n of described ion migration raceway groove 3 is 15；Institute
The width a stating ion migration raceway groove 3 is 30 μm；The degree of depth of described ion migration raceway groove 3 is b, a/b
For 10:1.
Embodiment 4
In sensor chip in embodiment 1, the number n of described ion migration raceway groove 3 is 20；Institute
The width a stating ion migration raceway groove 3 is 30 μm；The degree of depth of described ion migration raceway groove 3 is b, a/b
For 10:1.
Embodiment 5
In sensor chip in embodiment 1, the number n of described ion migration raceway groove 3 is 25；Institute
The width a stating ion migration raceway groove 3 is 30 μm；The degree of depth of described ion migration raceway groove 3 is b, a/b
For 10:1.
Embodiment 6
Use the exhaled gas described in embodiment 1-5 to analyze detector to detect, comprise the following steps:
First, gather the gas of 100 healthy people exhalation, certain herbaceous plants with big flowers aldehyde in detection exhaled gas, 1-Phenylethanone.,
The content of 1,3-double (1,1-dimethyl ethyl)-benzene, the meansigma methods calculating each component content respectively is made
For standard control value, and calculate standard variance, as healthy value range, then, take expired gas to be measured
Body is measured, and when each composition measurement value, to be pulmonary carcinoma higher or lower than healthy value range positive, when
Time in healthy value range, it is pulmonary carcinoma negative.
Embodiment 7
Use the exhaled gas described in embodiment 1-5 to analyze detector to detect, comprise the following steps:
First, 100 patients with lung adenocarcinomas and the gas of 100 Lung Squamous Carcinoma Patients exhalation, detection exhalation are gathered
Double (the 1,1-bis-of 2-ethyl-1-hexanol in gas, 1,3-dimethyl-benzene, 1,3-
Methylethyl) amount, calculate the meansigma methods of each component content respectively, as standard control value, and count
Calculate standard variance, as ill value range, then, take exhaled gas to be measured and be measured, Dang Gecheng
Point measured value is adenocarcinoma of lung, when each composition measurement value is at lung squamous cancer value range in adenocarcinoma of lung value range
Inside it is lung squamous cancer.
Embodiment 8
Use the exhaled gas described in embodiment 1-5 to analyze detector to detect, comprise the following steps:
Comprise the following steps: gather 100 optimum patients with lung cancer and 100 pulmonary metastasis patients exhalation
Gas, the amount of the 1-octene contained in the detection exhaled gas in detection exhaled gas, calculate its content
Meansigma methods, as standard control value, and calculate standard variance, as ill value range, then,
Take exhaled gas to be measured to be measured, when each composition measurement value is optimum in optimum pulmonary carcinoma value range
Pulmonary carcinoma, when each composition measurement value is pulmonary metastasis in pulmonary metastasis value range.
Embodiment 9
Use the exhaled gas described in embodiment 1-5 to analyze detector to detect, comprise the following steps:
Comprise the following steps: gather the gas of 100 chronic pulmonary obstruction patients and 100 asthmatic patient exhalation,
Detect styrene, the 1-methyl-2-(1-Methylethyl) contained in the detection exhaled gas in exhaled gas
-benzene, butylated hydroxytoluene, 2,4-dimethyl-1-heptene, propylbenzene, 3,7-Dimethyl-propionic acid ethyl ester
(E)-2,6-octadiene-1-alcohol, (1-Methylethyl) benzene, (1-methyl-propyl) cyclooctane, 2,2-
Neopentanoic acid, 2-ethylhexyl myristyl ester oxalic acid, 2-butyl-1-capryl alcohol, dodecane, 1-chlorine
Nonadecane, 3-ethyl-2,2-dimethyl pentane, 1,1'-oxygen double octane, nitric oxide production amount, respectively
Calculate the meansigma methods of each component content, as standard control value, and calculate standard variance, as ill
Value range, then, takes exhaled gas to be measured and is measured, when each composition measurement value is in chronic pulmonary obstruction
Chronic pulmonary obstruction it is, when each composition measurement value is asthma in asthma value range in value range.
Embodiment 10
Use the exhaled gas described in embodiment 1-5 to analyze detector to detect, comprise the following steps:
Comprise the following steps: gather room air, sample inlet end inject in the device of the present embodiment, inspection
Survey xylene content, when xylene content i.e. exceeds standard more than 50mg/m3.
Experimental example
Experimental example 1
Respectively to include that the exhaled gas of sensor chip that width is 30 μm, 45 μm and 70 μm is divided
Analysis detector, detects following gas: 1-octene, certain herbaceous plants with big flowers aldehyde, 1-Phenylethanone., 1,3-double (1,1-
Dimethyl ethyl)-benzene, 2-ethyl-1-hexanol, 1,3-dimethyl-benzene, double (the 1,1-dimethyl of 1,3-
Ethyl), styrene, 1-methyl-2-(1-Methylethyl)-benzene, butylated hydroxytoluene, 2,4-diformazan
Base-1-heptene, propylbenzene, 3,7-Dimethyl-propionic acid ethyl ester (E)-2,6-octadiene-1-alcohol, (1-
Methylethyl) benzene, (1-methyl-propyl) cyclooctane, 2,2-neopentanoic acid, 2-ethylhexyl 14
Arrcostab oxalic acid, 2-butyl-1-capryl alcohol, dodecane, 1-chlorine nonadecane, 3-ethyl-2,2-dimethyl
Pentane, 1,1'-oxygen double octane, nitric oxide, its resolution and sensitivity (30 μm as shown in Figure 3
Time, resolution and sensitivity overlap).
From the figure 3, it may be seen that include the system of the detection exhaled gas of the sensor chip that width is 30 μm
Resolution and sensitivity be the highest.
Experimental example 2
Respectively to include that the exhaled gas of the sensor chip of embodiment 1-5 analyzes detector, to as follows
Gas detects: double (1,1-the dimethyl ethyl)-benzene of 1-octene, certain herbaceous plants with big flowers aldehyde, 1-Phenylethanone., 1,3-,
2-ethyl-1-hexanol, 1,3-dimethyl-benzene, 1,3-double (1,1-dimethyl ethyl), styrene, 1-
Methyl-2-(1-Methylethyl)-benzene, butylated hydroxytoluene, 2,4-dimethyl-1-heptene, propyl group
Benzene, 3,7-Dimethyl-propionic acid ethyl ester (E)-2,6-octadiene-1-alcohol, (1-Methylethyl) benzene, (1-
Methyl-propyl) cyclooctane, 2,2-neopentanoic acid, 2-ethylhexyl myristyl ester oxalic acid, 2-
Butyl-1-capryl alcohol, dodecane, 1-chlorine nonadecane, 3-ethyl-2,2-dimethyl pentane, 1,1'-
Oxygen double octane, nitric oxide, its resolution and sensitivity are as shown in Figure 4.
Wherein, configuration 1 represents that the exhaled gas described in embodiment 5 analyzes detector, and configuration 2 represents
Exhaled gas described in embodiment 4 analyzes detector, and configuration 3 represents the expired gas described in embodiment 3
Body analyzes detector, and configuration 4 represents that the exhaled gas described in embodiment 2 analyzes detector.
As shown in Figure 4, the exhaled gas described in embodiment 2 analyzes resolution and the sensitivity of detector
It is the highest.
Experimental example 3
Take 50 patients using PET imaging method to be diagnosed as pulmonary carcinoma, use the method in embodiment 1 to enter
The detection of row exhaled gas, wherein the testing result of 48 patients is positive, makes a definite diagnosis with PET imaging method
Result is consistent.Visible, the exhaled gas that this utility model provides analyzes the detector detection standard to pulmonary carcinoma
Really rate is 96%.
Take 50 and be diagnosed as the patient of optimum pulmonary carcinoma, 50 patients being diagnosed as pulmonary metastasis, use
Method in embodiment 8 carries out the detection of exhaled gas.Wherein, the testing result of optimum patients with lung cancer
Consistent with confirmed result for 45, the testing result of pulmonary metastasis patient is consistent with confirmed result
It it is 47.Visible, the exhaled gas that this utility model provides analyzes detector to optimum pulmonary carcinoma and transfer
The Detection accuracy of property pulmonary carcinoma is about 90%.
Obviously, above-described embodiment is only for clearly demonstrating example, and not to embodiment party
The restriction of formula.For those of ordinary skill in the field, the most also may be used
To make other changes in different forms.Here without also all of embodiment being given
With exhaustive.And the obvious change thus extended out or variation are created still in this utility model
Protection domain among.
Claims (7)
1. an exhaled gas analyzes detector, it is characterised in that: include FAIMS spectrometer, this FAIMS
Spectrometer includes that sensor chip, described sensor chip include substrate (1) and be arranged at this substrate (1)
On metal level (2), this metal level (2) forms ion migration raceway groove (3), multiple ions move
Move raceway groove and be sequentially communicated formation detected gas passage；
The number of described ion migration raceway groove (3) is that n, n are selected from integer, and 5≤n≤30；
The width of described ion migration raceway groove (3) is a, 25 μm≤a≤50 μm；
The degree of depth of described ion migration raceway groove (3) is b, 5:1≤a/b≤15:1.
Exhaled gas the most according to claim 1 analyzes detector, it is characterised in that:
N is 10, and a is 30 μm, and a/b is 10:1；Or
N is 15, and a is 30 μm, and a/b is 10:1；Or
N is 20, and a is 30 μm, and a/b is 10:1；Or
N is 25, and a is 30 μm, and a/b is 10:1.
Exhaled gas the most according to claim 1 and 2 analyzes detector, it is characterised in that: institute
State the serpentine-like arrangement of multiple ion migration raceway groove (3) on metal level (2).
Exhaled gas the most according to claim 1 analyzes detector, it is characterised in that: include carrying
Gas blood circulation, described carrier gas blood circulation include being sequentially connected in series the described FAIMS spectrometer into loop,
Pump, the first mass flow controller and filter, described FAIMS spectrometer is analyzed with this exhaled gas
The gas access end of detector is connected.
Exhaled gas the most according to claim 4 analyzes detector, it is characterised in that: described pump
End be simultaneously connected with described first mass flow controller and the second mass flow controller.
Exhaled gas the most according to claim 4 analyzes detector, it is characterised in that: described mistake
Filter includes active carbon filter, molecular sieve filter and activated carbon/molecular sieve filter.
Exhaled gas the most according to claim 1 analyzes detector, it is characterised in that: described base
The making material of plate (1) is selected from glass, pottery or silicon, and the making material of described metal level (2) is
Metal.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108398533A (en) * | 2018-05-03 | 2018-08-14 | 北京物资学院 | Electric nasus system and its air source discriminating in storage and localization method |
| CN111398463A (en) * | 2020-04-02 | 2020-07-10 | 必睿思(杭州)科技有限公司 | Method for detecting content of aldehydes and ketones in exhaled air |
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2016
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108398533A (en) * | 2018-05-03 | 2018-08-14 | 北京物资学院 | Electric nasus system and its air source discriminating in storage and localization method |
| CN111398463A (en) * | 2020-04-02 | 2020-07-10 | 必睿思(杭州)科技有限公司 | Method for detecting content of aldehydes and ketones in exhaled air |
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Effective date of registration: 20190221 Address after: Room 704, New Public Health Building, 38 College Road, Haidian District, Beijing, 100191 Patentee after: Zhou Hui Address before: 100191 No. 1 B1-184, Hutong, Shipping Warehouse, Dongcheng District, Beijing Patentee before: Beijing health far Medical Technology Co., Ltd. |