CN205635573U - Horizontal inside and outside dual cycle airlift bioreactor - Google Patents
Horizontal inside and outside dual cycle airlift bioreactor Download PDFInfo
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- CN205635573U CN205635573U CN201620365499.0U CN201620365499U CN205635573U CN 205635573 U CN205635573 U CN 205635573U CN 201620365499 U CN201620365499 U CN 201620365499U CN 205635573 U CN205635573 U CN 205635573U
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Abstract
The utility model discloses a horizontal inside and outside dual cycle airlift bioreactor, installation extrinsic cycle tedge that left and right sides the broadside on of the horizontal type reaction vessel body is called, the last lower extreme of extrinsic cycle tedge feed through with horizontal type reaction vessel last lower part physically respectively, and air jet is installed to extrinsic cycle tedge lower part to at extrinsic cycle tedge pipe wall periphery installation external heat exchanger, the inner loop draft tube set up in the internal portion of horizontal type reaction vessel and with the central coaxial arrangement of the horizontal type reaction vessel body, be equipped with a plurality of sieve meshes on the inner loop draft tube, the air distribution ware set up in the internal portion of horizontal type reaction vessel and under lieing in the inner loop draft tube, with horizontal type reaction vessel body coaxial arrangement, the bottom surface and air intlet intercommunication of the horizontal type reaction vessel body are worn out to the lower extreme of air distribution ware, built -in heat exchanger setting on the inner wall of the horizontal type reaction vessel body. The utility model discloses under fundamentally has solved conventional gas lift formula reactor high hydrostatic pressure, problem that the dissolved oxygen rate reduces.
Description
Technical field
This utility model relates to fermentable equipment technical field, particularly relates to a kind of horizontal internal-external double circulation airlift bioreactor.
Background technology
Most fermentable is all aerobic, but the dissolubility that oxygen is in fermentation liquid is minimum, and only 0.22mmol/L is the restrictive factor being easiest to become fermentable, leverages the carrying out of biochemical reaction.
Airlift reactor is the one of aerobic reactor, power induced effect when utilizing the air being passed through in reactor to rise and fermentation liquid variable density, it is achieved mash mixes；Structure is divided into interior circulation and two kinds of forms of outer circulation reactor, and its feature includes: simple in construction, energy consumption are low, save steel, operate noiselessness, dress liquid coefficient is high, be not necessary to add defoamer, maintenance operation cleans the features such as simple, minimizing miscellaneous bacteria infection.Airlift fermentor meets technological requirement and economic indicator should at least include 2 points: one is the needs that circulation time has to comply with strain fermentation；Two are intended to select the nozzle of suitable diameter, it is ensured that the supply of oxygen.
But, existing airlift reactor high concentration, high viscosity mash cultivate time circulation time on the most up to standard, cause mash mixing uneven, mass transfer effect is poor；The simple nozzle selecting suitable diameter also can not meet the demand to oxygen of high concentration, full-bodied mash, causes dissolved oxygen insufficient, and fermentation period is long.It addition, the airlift reactor being commercially used for producing greatly is often as high as tens meters, static pressure is serious on dissolved oxygen amount impact.This utility model, from improving high concentration, the gas-liquid Blending Efficiency of Blending of full-bodied macro-organism consersion unit, designs a kind of high dissolved oxygen, high mass transfer, bioreactor that shearing force is little.
Utility model content
This utility model purpose is contemplated to make up the defect of prior art, it is provided that a kind of horizontal internal-external double circulation airlift bioreactor.
This utility model is achieved through the following technical solutions:
nullA kind of horizontal internal-external double circulation airlift bioreactor，Including horizontal reacting kettle、Outer circulation tedge、External heat exchanger、Air nozzle、Air sparger、Built-in heat exchanger and interior circulation guide shell，The installation outer circulation tedge that the left and right sides of horizontal reacting kettle is symmetrical，The upper and lower side of outer circulation tedge top and the bottom with horizontal reacting kettle respectively connect，Outer circulation tedge bottom is provided with air nozzle，And external heat exchanger is installed in outer circulation tedge tube wall periphery，Described interior circulation guide shell is arranged at horizontal reacting kettle inside and installs with horizontal reacting kettle central coaxial，Interior circulation guide shell is provided with multiple sieve aperture，Described air sparger is arranged at horizontal reacting kettle inside and is positioned at immediately below circulation guide shell，It is co-axially mounted with horizontal reacting kettle，The lower end of air sparger passes the bottom surface of horizontal reacting kettle and connects with air intlet，Described built-in heat exchanger is arranged on the inwall of horizontal reacting kettle，Described air intlet is placed in the bottom of horizontal reacting kettle，It is additionally provided with discharging opening in the bottom of horizontal reacting kettle，It is provided with charging aperture and air vent on the top of horizontal reacting kettle.Both interior circulation guide shell and outer circulation tedge act on jointly, and by motive force and the change of density of air, fermentation liquid forms two systemic circulations in reactor, makes mash mix homogeneously, it is achieved high dissolved oxygen, high mass transfer.
The diameter of each sieve aperture of described interior circulation guide shell is between 2-10mm, and becomes larger from bottom to top, and the gross area of sieve aperture accounts for the 20%-60% of interior circulation guide shell area.The gross area of sieve aperture accounts for the 20% ~ 60% of guide shell area, and the diameter of sieve aperture and the gross area are with the different adjustable of fermentative microorganism.This design makes the part incipient bubble in guide shell can be instantaneously transferred in still, increases dissolved oxygen.
Described air sparger includes horizontal seal disk, and described horizontal seal disk connection air intlet, horizontal seal disc surfaces is uniformly arranged multiple air distribution hole.When different fermentation systems and different fermentations interim, cell concentration and oxygen demand are different, and the requirement to cycle period is the most different；By adjusting the speed of air intlet, regulate and control cycle period, meet the microorganism demand to high dissolved oxygen.
Described horizontal reacting kettle is cylindrical shape, and the blade diameter length ratio of tank body is 1.5-3.
Described air nozzle sprays into tedge with the speed of 100～500m/s.
Described built-in heat exchanger is placed in the internal both sides of horizontal reacting kettle or side, plays the effect of regulation reaction temperature, and as baffle plate, mixes fermentation liquid further.
As can be seen from the above technical solutions, this utility model passes through horizontal internal-external double circulation airlift bioreactor, use internal-external double circulation device and air sparger oxygen supply, including the outer circulation tedge with air nozzle, the interior circulation guide shell with different-diameter and gross area ratio, the special disc type air sparger with multiple air distribution holes and external, built-in heat exchanger.No matter the height of fermentation liquid concentration, viscosity, no matter heat is whether, this novel reactor all can make mash mass transfer, heat transfer, dissolved oxygen efficiency high, can shorten fermentation period.
The utility model has the advantages that: this utility model fundamentally solves in conventional airlift reactor under high static pressure, the problem that dissolved oxygen rate reduces, simultaneously, due to the design of uneven sieve aperture on the installation of air nozzle in outer circulation tedge, interior circulation guide shell, and band is uniformly distributed the design of disc type air sparger in hole, the dissolved oxygen rate making kettle each space interior increases rapidly, meets fermentation needs.This utility model horizontal Two-way Cycle airlift bioreactor fundamentally solves conventional airlift reactor and is not suitable for high concentration, full-bodied fermentation system；This utility model uses outer circulation tedge and the internal-external double circulation device of interior circulation guide shell so that fermentation liquid forms inside and outside two systemic circulations, the mixed effect of enhancing reactor inside and outside kettle；And owing to tedge is shorter, high concentration, full-bodied fermentation liquid, by the impetus of the air nozzle being positioned at tedge bottom, can quickly move through, and resistance is less.This utility model mass transfer effect is good, is particularly suitable for high concentration, full-bodied fermentation system.This utility model horizontal Two-way Cycle airlift bioreactor uses double heat exchanger external, built-in, i.e. enhances pipe inside and outside heat transmission, and built-in heat exchanger can strengthen mash mass transfer as baffle plate again；This utility model horizontal internal-external double circulation airlift bioreactor is horizontally-arranged, take up an area less, by agitating device do not realize high concentration, high viscosity fermentation system, energy consumption is little, be greatly saved cost；It addition, this utility model simple in construction, maintenance is convenient, workable.
Accompanying drawing explanation
Fig. 1 is structural representation of the present utility model.
Fig. 2 is circulation guide shell structure chart in this utility model.
Detailed description of the invention
nullSuch as Fig. 1、Shown in 2，A kind of horizontal internal-external double circulation airlift bioreactor，Including horizontal reacting kettle 1、Outer circulation tedge 2、External heat exchanger 3、Air nozzle 4、Air sparger 6、Built-in heat exchanger 7 and interior circulation guide shell 5，The installation outer circulation tedge 2 that the left and right sides of horizontal reacting kettle 1 is symmetrical，The upper and lower side of outer circulation tedge 2 top and the bottom with horizontal reacting kettle 1 respectively connect，Outer circulation tedge 2 bottom is provided with air nozzle 4，And external heat exchanger 3 is installed in outer circulation tedge 2 tube wall periphery，Described interior circulation guide shell 5 is arranged at horizontal reacting kettle 1 inside and installs with horizontal reacting kettle 1 central coaxial，Interior circulation guide shell 5 is provided with multiple sieve aperture 12，Described air sparger 6 is arranged at horizontal reacting kettle 1 inside and is positioned at immediately below circulation guide shell 5，It is co-axially mounted with horizontal reacting kettle 1，The lower end of air sparger 6 passes the bottom surface of horizontal reacting kettle 1 and connects with air intlet 10，Described built-in heat exchanger 7 is arranged on the inwall of horizontal reacting kettle 1，Described air intlet 10 is placed in the bottom of horizontal reacting kettle 1，It is additionally provided with discharging opening 9 in the bottom of horizontal reacting kettle 1，Charging aperture 8 and air vent 11 it is provided with on the top of horizontal reacting kettle 1.Both interior circulation guide shell 5 and outer circulation tedge 2 act on jointly, and by motive force and the change of density of air, fermentation liquid forms two systemic circulations in reactor, makes mash mix homogeneously, it is achieved high dissolved oxygen, high mass transfer.
The diameter of each sieve aperture of described interior circulation guide shell 5 is between 2-10mm, and becomes larger from bottom to top, and the gross area of sieve aperture accounts for the 20%-60% of interior circulation guide shell area.The gross area of sieve aperture accounts for the 20% ~ 60% of guide shell area, and the diameter of sieve aperture and the gross area are with the different adjustable of fermentative microorganism.This design makes the part initial bubbles in guide shell can be instantaneously transferred in still, increases dissolved oxygen.
Described air sparger 6 includes horizontal seal disk, and described horizontal seal disk connection air intlet, horizontal seal disc surfaces is uniformly arranged multiple air distribution hole.When different fermentation systems and different fermentations interim, cell concentration and oxygen demand are different, and the requirement to cycle period is the most different；By adjusting the speed of air intlet, regulate and control cycle period, meet the microorganism demand to high dissolved oxygen.
Described horizontal reacting kettle 1 is cylindrical shape, and the blade diameter length ratio of tank body is 1.5-3.
Described air nozzle 4 sprays into tedge with the speed of 100～500m/s.
Described external heat exchanger 7 is placed in the internal both sides of horizontal reacting kettle or side, plays the effect of regulation reaction temperature, and as baffle plate, mixes fermentation liquid further.
Claims (6)
- null1. a horizontal internal-external double circulation airlift bioreactor，It is characterized in that: include horizontal reacting kettle、Outer circulation tedge、External heat exchanger、Air nozzle、Air sparger、Built-in heat exchanger and interior circulation guide shell，The installation outer circulation tedge that the left and right sides of horizontal reacting kettle is symmetrical，The upper and lower side of outer circulation tedge top and the bottom with horizontal reacting kettle respectively connect，Outer circulation tedge bottom is provided with air nozzle，And external heat exchanger is installed in outer circulation tedge tube wall periphery，Described interior circulation guide shell is arranged at horizontal reacting kettle inside and installs with horizontal reacting kettle central coaxial，Interior circulation guide shell is provided with multiple sieve aperture，Described air sparger is arranged at horizontal reacting kettle inside and is positioned at immediately below circulation guide shell，It is co-axially mounted with horizontal reacting kettle，The lower end of air sparger passes the bottom surface of horizontal reacting kettle and connects with air intlet，Described built-in heat exchanger is arranged on the inwall of horizontal reacting kettle，Described air intlet is placed in the bottom of horizontal reacting kettle，It is additionally provided with discharging opening in the bottom of horizontal reacting kettle，It is provided with charging aperture and air vent on the top of horizontal reacting kettle.
- One the most according to claim 1 horizontal internal-external double circulation airlift bioreactor, it is characterized in that: the diameter of each sieve aperture of described interior circulation guide shell is between 2-10mm, and become larger from bottom to top, the gross area of sieve aperture accounts for the 20%-60% of interior circulation guide shell area.
- One the most according to claim 1 horizontal internal-external double circulation airlift bioreactor, it is characterized in that: described air sparger includes horizontal seal disk, described horizontal seal disk connection air intlet, horizontal seal disc surfaces is uniformly arranged multiple air distribution hole.
- 4. according to the one horizontal internal-external double circulation airlift bioreactor described in any one of claim 1-3, it is characterised in that: described horizontal reacting kettle is cylindrical shape, and the blade diameter length ratio of tank body is 1.5-3.
- One the most according to claim 1 horizontal internal-external double circulation airlift bioreactor, it is characterised in that: described air nozzle sprays into tedge with the speed of 100～500m/s.
- One the most according to claim 1 horizontal internal-external double circulation airlift bioreactor, it is characterised in that: described built-in heat exchanger is placed in the internal both sides of horizontal reacting kettle or side.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620365499.0U CN205635573U (en) | 2016-04-26 | 2016-04-26 | Horizontal inside and outside dual cycle airlift bioreactor |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620365499.0U CN205635573U (en) | 2016-04-26 | 2016-04-26 | Horizontal inside and outside dual cycle airlift bioreactor |
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| CN205635573U true CN205635573U (en) | 2016-10-12 |
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| CN201620365499.0U Expired - Fee Related CN205635573U (en) | 2016-04-26 | 2016-04-26 | Horizontal inside and outside dual cycle airlift bioreactor |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105779273A (en) * | 2016-04-26 | 2016-07-20 | 淮南师范学院 | Horizontal internal and external double-circulation airlift bioreactor |
| CN111635861A (en) * | 2020-06-30 | 2020-09-08 | 江南大学 | Airlift reactor for animal cell culture |
| CN112844280A (en) * | 2020-12-23 | 2021-05-28 | 中国纺织科学研究院有限公司 | Horizontal reaction kettle, functional polyester production system applying same and production method |
-
2016
- 2016-04-26 CN CN201620365499.0U patent/CN205635573U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105779273A (en) * | 2016-04-26 | 2016-07-20 | 淮南师范学院 | Horizontal internal and external double-circulation airlift bioreactor |
| CN111635861A (en) * | 2020-06-30 | 2020-09-08 | 江南大学 | Airlift reactor for animal cell culture |
| CN112844280A (en) * | 2020-12-23 | 2021-05-28 | 中国纺织科学研究院有限公司 | Horizontal reaction kettle, functional polyester production system applying same and production method |
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| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20161012 Termination date: 20180426 |