CN205635440U - Improve umbellate pore furgus polysaccharide biological activity's device - Google Patents
Improve umbellate pore furgus polysaccharide biological activity's device Download PDFInfo
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- CN205635440U CN205635440U CN201620012232.3U CN201620012232U CN205635440U CN 205635440 U CN205635440 U CN 205635440U CN 201620012232 U CN201620012232 U CN 201620012232U CN 205635440 U CN205635440 U CN 205635440U
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- control valve
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- acid anhydride
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Abstract
The utility model discloses an improve umbellate pore furgus polysaccharide biological activity's device, carry centrifugal pump, the former feed liquid of acetyl acid anhydride to carry centrifugal pump, umbellate pore furgus polysaccharide solution to add enthalpy exchanger, the former feed liquid of acetyl acid anhydride including many sugar feedstock of umbellate pore furgus storage tank, acetyl acid anhydride raw materials storage tank, umbellate pore furgus polysaccharide solution and with enthalpy exchanger, air compressor, reactor, evaporimeter, flow controller, proportional controller, air flow controller, acetyl acid anhydride solution temperature controller, umbellate pore furgus polysaccharide solution temperature controller, liquid level controller, first control valve to the 5th control valve, compare with enthalpy exchanger 0, the utility model discloses its substituted du keda 0.3% of acetylation umbellate pore furgus polysaccharide of preparation, does the acetylation umbellate pore furgus polysaccharide prepared all surpass 20 than the umbellate pore furgus polysaccharide under the same concentration in the aspect of cleaing away hydroxy radical and superoxide anion free radical 30%, the explanation the utility model discloses biological activity to improving the umbellate pore furgus polysaccharide is extremely showing, has to promote practical value.
Description
Technical field
This utility model relates to a kind of chemical reaction method, particularly relates to a kind of raising polyporusum bellatus biological
The device of activity.
Background technology
Polysaccharide refers to the polymer being formed by connecting by more than 10 monosaccharide by glycosidic bond, be widely present in plant,
In microorganism, algae and animal body.Polysaccharide, as one of big base substance of vital movement four, has multiple life
Thing activity, such as antiviral, increment, immunoloregulation function etc..But the biological activity of polysaccharide depends primarily on it
Molecular structure, including sugar unit and the glycosidic bond of main chain, the type of side chain, the degree of polymerization and the motility of chain and
Space conformation etc..Numerous studies show, the molecular modification of polysaccharide can dramatically increase its biological activity.
The structural modification of polysaccharide is, by means such as chemistry, physics and biologys, polysaccharide molecule is carried out structure
Transformation, mainly right by the change space structure of polysaccharide, molecular weight and substituent group kind, number and position
Its activity produces impact.The molecular modification of polysaccharide is broadly divided into two big classes at present: a class is grafting and modifying, main
To improve its biological activity by increasing the functional group of polysaccharide and molecular weight, as sulphation, phosphorylation,
Acetylation, alkylation, sulfonylation, carboxy methylation, benzoylation and trace element complexation modification etc.；Second
Class is that degraded is modified, and mainly by reducing the molecular weight of polysaccharide, improves its dissolubility in aqueous phase, carries
Its biological activity high, main method has mechanical degradation, chemical degradation and enzymic degradation etc..
Polyporus, also known as pig manure bacterium, pig Poria, is gained the name because of its sclerotium epidermis normal complexion darkly likeness in form pig manure.Polyporus
It is the traditional Mycophyta Chinese crude drug of China, is used as medicine with dry sclerotium.Polyporus be rich in representational large-scale
Fungus, biological characteristics is the most special, and it is not S fungus, also different from mycorhiza type symbiotic effects,
But one is referred to as the macro fungi of " trophobiosis type in fungus " by scholar.The medicinal part of Polyporus is
Referring to bury the sclerotium being born in underground, its medicinal history was away from existing more than 2500 year of the present, at the ancient medical book nationality that China is famous
Shennong's Herbal, Compendium of Material Medica, " Medical Treasures of the Golden Chamber " etc. are the most on the books.Polysaccharide is the main medicine of Polyporus
One of effect composition, its chemical composition is β-(1 → 3), β-(1 → 4), β-(1 → 6) glucoside
The glucosan of key condensation, polyporusum bellatus has the effects such as anticancer, antiinflammatory, antiviral, enhancing immunity,
Sclerotium is the primary raw material extracting polyporusum bellatus.The at present research to polyporusum bellatus mainly concentrate extraction process and
The aspects such as trace element modification, and the acetylation modification of polyporusum bellatus is had no report.
Utility model content
The purpose of this utility model is that providing a kind of to solve the problems referred to above improves polyporusum bellatus biology
The device of activity.
This utility model is achieved through the following technical solutions above-mentioned purpose:
This utility model one improve the bioactive device of polyporusum bellatus, including polyporusum bellatus raw material storage tank,
Acetyl acid anhydride raw material storage tank, polyporusum bellatus solution centrifugal pumps, acetyl acid anhydride material liquid centrifugal pumps, Polyporus
Polysaccharide solution heating heat exchanger, acetyl acid anhydride material liquid heating heat exchanger, air compressor, reactor, evaporation
Device, flow controller, proportional controller, air flow controller, acetyl anhydride solution temperature controller, pig
Siberian cocklebur polysaccharide solution temperature controller, liquid level controller, the first control valve, the second control valve, the 3rd control valve,
4th control valve and the 5th control valve, the discharge end of described polyporusum bellatus raw material storage tank is many with described Polyporus respectively
The charging aperture of sugar juice centrifugal pumps and the first input end of proportional controller connect, and described polyporusum bellatus is molten
The outfan of liquid centrifugal pumps and the input of the first control valve connect, the outfan of described proportional controller
It is connected with the control end of described first control valve, the second input of described proportional controller and described flow control
The outfan of device processed connects, the discharging opening of described acetyl acid anhydride raw material storage tank defeated with described flow controller respectively
The input entering end and acetyl acid anhydride material liquid centrifugal pumps connects, described acetyl acid anhydride feedstock transportation centrifugal pump
Outfan is connected with the first input end of described 3rd control valve, described polyporusum bellatus solution temperature controller
Outfan is connected with the control end of described 3rd control valve, the outfan of described 3rd control valve and described acetyl
The first input end of acid anhydride material liquid heating heat exchanger connects, the output of described acetyl acid anhydride material liquid heating heat exchanger
End is connected with the first input end of described reactor, the outfan of described first control valve and described polyporusum bellatus
The first input end of solution heating heat exchanger connects, the outfan of described polyporusum bellatus solution heating heat exchanger with
The input of described polyporusum bellatus solution temperature controller and the second input of described reactor connect, described
The control output end of polyporusum bellatus solution temperature controller is connected with the control end of described 4th control valve, described
The input of the 4th control valve is connected with the first outfan of described vaporizer, the output of described 4th control valve
End is connected with the second input of described polyporusum bellatus solution heating heat exchanger, the output of described air compressor
End respectively with the input of described second control valve, the 3rd input and air flow control of described reactor
The input of device connects, the control output end of described air flow controller and the control of described second control valve
Input connects, and the liquid level signal outfan of described reactor connects with the signal input part of described liquid level controller
Connecing, the control output end of described liquid level controller is connected with the control end of described 5th control valve, described reaction
The Liquid level pipeline of device is connected with the input of described vaporizer by described 5th control valve, described evaporation
Second outfan of device is connected with the second input of described acetyl acid anhydride material liquid heating heat exchanger.
Specifically, the outer wall of described reactor covers the glass cotton heat-insulation layer that 15mm is thick.
The beneficial effects of the utility model are:
This utility model is a kind of raising bioactive device of polyporusum bellatus, compared with prior art, this reality
With its substitution value of acetylation polyporusum bellatus of novel preparation up to 0.3%；Prepared acetylation polyporusum bellatus is clear
Except hydroxy radical and ultra-oxygen anion free radical aspect all exceed 20-30% than the polyporusum bellatus under same concentrations,
Illustrate that this utility model is extremely notable to the biological activity improving polyporusum bellatus, have and promote practical value.
Accompanying drawing explanation
Fig. 1 is device distributed architecture schematic diagram of the present utility model.
In figure: the conveying of 1-polyporusum bellatus raw material storage tank, 2-acetyl acid anhydride raw material storage tank, 3-polyporusum bellatus solution is centrifugal
Pump, 4-acetyl acid anhydride material liquid centrifugal pumps, 5-polyporusum bellatus solution heating heat exchanger, 6-acetyl acid anhydride material liquid
Heating heat exchanger, 7-air compressor, 8-reactor, 9-vaporizer, F1C-flow controller, F2C-ratio
Controller, FC-air flow controller, T1C-acetyl anhydride solution temperature controller, T2C-polyporusum bellatus solution
Temperature controller, LC-liquid level controller, K1-the first control valve, K2-the second control valve, K3-the 3rd control
Valve, K4-the 4th control valve, K5-the 5th control valve.
Detailed description of the invention
The utility model is described in further detail below in conjunction with the accompanying drawings:
As shown in Figure 1: this utility model one improves the bioactive device of polyporusum bellatus, many including Polyporus
Sugar raw material storage tank 1, acetyl acid anhydride raw material storage tank 2, polyporusum bellatus solution centrifugal pumps 3, acetyl acid anhydride material liquid
Centrifugal pumps 4, polyporusum bellatus solution heating heat exchanger 5, acetyl acid anhydride material liquid heating heat exchanger 6, air
Compressor 7, reactor 8, vaporizer 9, flow controller F1C, proportional controller F2C, air mass flow control
Device FC processed, acetyl anhydride solution temperature controller T1C, polyporusum bellatus solution temperature controller T2C, liquid level control
Device LC processed, the first control valve K1, the second control valve K2, the 3rd control valve K3, the 4th control valve K4 and
5th control valve K5, the discharge end of described polyporusum bellatus raw material storage tank carries with described polyporusum bellatus solution respectively
The charging aperture of centrifugal pump and proportional controller F2The first input end of C connects, and described polyporusum bellatus solution carries
The input of centrifugal delivery side of pump and the first control valve K1 connects, described proportional controller F2The outfan of C
It is connected with the control end of described first control valve K1, described proportional controller F2Second input of C is with described
Flow controller F1The outfan of C connects, the discharging opening of described acetyl acid anhydride raw material storage tank respectively with described flow
Controller F1The input of C and the input of acetyl acid anhydride material liquid centrifugal pumps connect, and described acetyl acid anhydride is former
The outfan of material centrifugal pumps is connected with the first input end of described 3rd control valve K3, described polyporusum bellatus
Solution temperature controller T2The outfan of C is connected with the control end of described 3rd control valve K3, described 3rd control
The outfan of valve K3 processed is connected with the first input end of described acetyl acid anhydride material liquid heating heat exchanger, described acetyl
The outfan of acid anhydride material liquid heating heat exchanger is connected with the first input end of described reactor, and described first controls
The outfan of valve K1 is connected with the first input end of described polyporusum bellatus solution heating heat exchanger, and described Polyporus is many
The outfan of sugar juice heating heat exchanger and described polyporusum bellatus solution temperature controller T2The input of C and institute
The second input stating reactor connects, described polyporusum bellatus solution temperature controller T2The control output end of C
It is connected with the control end of described 4th control valve K4, the input of described 4th control valve K4 and described evaporation
First outfan of device connects, and the outfan of described 4th control valve K4 changes with the heating of described polyporusum bellatus solution
Hot device second input connect, the outfan of described air compressor respectively with described second control valve K2
The input of input, the 3rd input of described reactor and air flow controller FC connects, described sky
The control output end of throughput controller FC is connected with the control input of described second control valve K2, described
The liquid level signal outfan of reactor is connected with the signal input part of described liquid level controller LC, described liquid level control
The control output end of device LC processed is connected with the control end of described 5th control valve K5, the liquid level of described reactor
Control piper is connected with the input of described vaporizer by described 5th control valve K5, the of described vaporizer
Two outfans are connected with the second input of described acetyl acid anhydride material liquid heating heat exchanger.
Specifically, the outer wall of described reactor covers the glass cotton heat-insulation layer that 15mm is thick.
Implementation of the present utility model comprises the following steps:
(1) weigh a certain amount of polyporusum bellatus fine work refined to be dissolved at ambient temperature in distilled water,
It is made into the polysaccharide solution that concentration is 0.25mg/mL；
(2) regulate polysaccharide solution pH to 9.0 with 1.0mol/LNaOH solution, stand certain time
(10-20min), it is placed in polyporusum bellatus raw material storage tank；
(3) it is heated to through polyporusum bellatus solution heating heat exchanger again by polyporusum bellatus solution centrifugal pumps
After 65-75 DEG C, send into reactor；
(4) acetyl acid anhydride material liquid is placed in acetyl acid anhydride raw material storage tank, centrifugal by the conveying of acetyl acid anhydride material liquid
Pump is heated to 65-75 DEG C through acetyl acid anhydride material liquid heating heat exchanger again, sends in reactor；Passing ratio controls
It is 10:1 that device F2C controls polyporusum bellatus liquid inventory with acetic anhydride flow；
(5) reactor bottom is passed through compressed air and flows in mixed liquor bottom it and be stirred mixed liquor；
Two strands of materials carry out acetylization reaction, response time 4-4.5h in the reactor, and the response time passes through Liquid level
It is 4-4.5h that device LC controls material liquid mean residence time in the reactor；
(6) reacted liquid product flows out after vaporizer carries out being concentrated into three times of concentration, and thermal source is 150 DEG C
Saturated vapor；
(7) indirect steam that vaporizer produces as heating agent in polyporusum bellatus solution heating heat exchanger indirectly
Heating polyporusum bellatus material liquid, produced condensed water enters in condensate collector；
(8) concentrated solution is molten as heating agent indirect heating acetyl acid anhydride in acetyl acid anhydride material liquid heating heat exchanger
Liquid, is cooled to 20-30 DEG C after heat exchange, enters concentrated solution storage tank, then regulates pH with the HCl solution of 5mol/L
Value is to 7.0, and adds the analysis of dehydrated alcohol alcohol, and alcohol analysis concentration is 75%, the centrifugal and dried acetyl of alcohol analysis liquid
Change polyporusum bellatus.
1. Ratio control loop is determined: acetyl acid anhydride material liquid flow sends into flow controller by signal after measuring
F1C, compares with set-point sp afterwards by flow controller F1C output signal giving as flow controller
Value, polyporusum bellatus liquid inventory through measure after with flow controller F1C output signal compares, through ratio control
Device F2Output signal to the first control valve K1 after C computing, regulate polyporusum bellatus liquid inventory, finally make polysaccharide
Liquid inventory and acetic anhydride flow are 10:1.
2. bypass air flow rate control loop: in air compression circuit its flow through measure after with set-point sp
Relatively, send in air flow controller FC, after air flow controller FC computing, output signal to the
Two control valves K2, send into the air mass flow in reactor by bypass fractional distillation regulation, and its flow set-point is with instead
Liquid in device is answered not to be carried over as higher limit.
3. acetyl acid anhydride material liquid heating heat exchanger 6 controls loop: acetyl anhydride solution heats through acetyl acid anhydride material liquid
Measured by temperature instrumentation after heat exchanger 6 (65-75 DEG C need to be heated to) heating, measured value and set-point sp ratio
Send into acetyl anhydride solution temperature controller T more afterwards1C, through acetyl anhydride solution temperature controller T1After C computing defeated
Go out signal give the 3rd control valve K3, by change acetyl anhydride solution Flow-rate adjustment, finally make acetyl anhydride solution
Enter the temperature before reactor and be maintained at 65-75 DEG C.
4. polyporusum bellatus solution heating heat exchanger 5 controls loop: polyporusum bellatus solution adds through polyporusum bellatus solution
Measured by temperature instrumentation after heat exchanger 5 (65-75 DEG C need to be heated to) heating, measured value and set-point sp
Send into polyporusum bellatus solution temperature controller T more afterwards2C, through polyporusum bellatus solution temperature controller T2C transports
The 4th control valve K4 is outputed signal to, by changing the Flow-rate adjustment of vaporizer 8 indirect steam, finally after calculation
Temperature before making polyporusum bellatus solution enter reactor 8 is maintained at 65-75 DEG C.
5. reactor 8 liquid level control loop: reactor 8 liquid level compares with set-point sp after measuring, sends into
Liquid level controller LC, outputs signal to the 5th control valve K5 after the computing of liquid level controller LC, by regulation
After reaction, two strands of material liquids of the flow-control of mixed liquor mean residence time in the reactor is 4-4.5h, it is ensured that
Response time.
Of the present utility model ultimate principle and principal character and of the present utility model excellent have more than been shown and described
Point.Skilled person will appreciate that of the industry, this utility model is not restricted to the described embodiments, above-mentioned reality
Execute and principle of the present utility model is simply described, without departing from this utility model spirit described in example and description
On the premise of scope, this utility model also has various changes and modifications, and these changes and improvements both fall within
In the range of claimed this utility model.This utility model claims scope by appending claims
And equivalent defines.
Claims (2)
1. one kind is improved the bioactive device of polyporusum bellatus, it is characterised in that: include that polyporusum bellatus raw material stores up
Tank, acetyl acid anhydride raw material storage tank, polyporusum bellatus solution centrifugal pumps, acetyl acid anhydride material liquid centrifugal pumps,
Polyporusum bellatus solution heating heat exchanger, acetyl acid anhydride material liquid heating heat exchanger, air compressor, reactor,
Vaporizer, flow controller, proportional controller, air flow controller, acetyl anhydride solution temperature controller,
Polyporusum bellatus solution temperature controller, liquid level controller, the first control valve, the second control valve, the 3rd control
Valve, the 4th control valve and the 5th control valve, the discharge end of described polyporusum bellatus raw material storage tank respectively with described pig
The charging aperture of Siberian cocklebur polysaccharide solution centrifugal pumps and the first input end of proportional controller connect, and described Polyporus is many
The input of the outfan of sugar juice centrifugal pumps and the first control valve connects, described proportional controller defeated
Go out end to be connected with the control end of described first control valve, the second input of described proportional controller and described stream
The outfan of amount controller connects, the discharging opening of described acetyl acid anhydride raw material storage tank respectively with described flow controller
Input and acetyl acid anhydride material liquid centrifugal pumps input connect, described acetyl acid anhydride feedstock transportation be centrifuged
Delivery side of pump is connected with the first input end of described 3rd control valve, and described polyporusum bellatus solution temperature controls
The outfan of device is connected with the control end of described 3rd control valve, and the outfan of described 3rd control valve is with described
The first input end of acetyl acid anhydride material liquid heating heat exchanger connects, described acetyl acid anhydride material liquid heating heat exchanger
Outfan is connected with the first input end of described reactor, the outfan of described first control valve and described Polyporus
The first input end of polysaccharide solution heating heat exchanger connects, the output of described polyporusum bellatus solution heating heat exchanger
End is connected with the described input of polyporusum bellatus solution temperature controller and the second input of described reactor,
The control output end of described polyporusum bellatus solution temperature controller is connected with the control end of described 4th control valve,
The described input of the 4th control valve is connected with the first outfan of described vaporizer, described 4th control valve
Outfan is connected with the second input of described polyporusum bellatus solution heating heat exchanger, described air compressor
Outfan respectively with the input of described second control valve, the 3rd input and air mass flow of described reactor
The input of controller connects, the control output end of described air flow controller and described second control valve
Controlling input to connect, the liquid level signal outfan of described reactor inputs with the signal of described liquid level controller
End connects, and the control output end of described liquid level controller is connected with the control end of described 5th control valve, described
The Liquid level pipeline of reactor is connected with the input of described vaporizer by described 5th control valve, described
Second outfan of vaporizer is connected with the second input of described acetyl acid anhydride material liquid heating heat exchanger.
The bioactive device of raising polyporusum bellatus the most according to claim 1, it is characterised in that: institute
The outer wall stating reactor covers the thick glass cotton heat-insulation layer of 15mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620012232.3U CN205635440U (en) | 2016-01-07 | 2016-01-07 | Improve umbellate pore furgus polysaccharide biological activity's device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620012232.3U CN205635440U (en) | 2016-01-07 | 2016-01-07 | Improve umbellate pore furgus polysaccharide biological activity's device |
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| CN205635440U true CN205635440U (en) | 2016-10-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201620012232.3U Expired - Fee Related CN205635440U (en) | 2016-01-07 | 2016-01-07 | Improve umbellate pore furgus polysaccharide biological activity's device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105713105A (en) * | 2016-01-07 | 2016-06-29 | 陕西理工学院 | Method and device for improving bioactivity of polyporus polysaccharide |
-
2016
- 2016-01-07 CN CN201620012232.3U patent/CN205635440U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105713105A (en) * | 2016-01-07 | 2016-06-29 | 陕西理工学院 | Method and device for improving bioactivity of polyporus polysaccharide |
| CN105713105B (en) * | 2016-01-07 | 2019-01-04 | 陕西理工学院 | A kind of device and method improving grifola polysaccharide bioactivity |
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| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20161012 Termination date: 20180107 |
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| CF01 | Termination of patent right due to non-payment of annual fee |