CN205607940U - Be used for online liquid chromatograph of atmosphere analysis - Google Patents
Be used for online liquid chromatograph of atmosphere analysis Download PDFInfo
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- CN205607940U CN205607940U CN201620444984.7U CN201620444984U CN205607940U CN 205607940 U CN205607940 U CN 205607940U CN 201620444984 U CN201620444984 U CN 201620444984U CN 205607940 U CN205607940 U CN 205607940U
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Abstract
The utility model provides a be used for online liquid chromatograph of atmosphere analysis, includes automatic cleaning system, automatic cleaning system including rinsing runner, transfer pump and control the control circuit of transfer pump, control circuit include: trigger module includes trigger device, can trigger an instantaneous drive signal, the time block with trigger module be coupled, be controlled by the drive signal of the drive signal output time of predetermineeing, drive module with the time block be coupled, be controlled by the drive signal control of the time of predetermineeing the transfer pump carry out work, after the online liquid chromatograph of atmosphere analysis accomplishes the analysis, make automatic cleaning system begin to carry out self - cleaning to the online liquid chromatograph of atmosphere analysis through trigger device, but control circuit controlling infusion pump to the online liquid chromatograph's of atmosphere analysis pipeline input washing liquid, input the predetermined time after the automatic shutdown, realize self - cleaning's effect.
Description
Technical field
This utility model relates to liquid chromatograph field, particularly to one for the online chromatograph of liquid of atmospheric analysis.
Background technology
The separation principle of chromatograph of liquid (LiquidChromatography LC) is exactly that the difference utilizing the affinities such as various materials to be separated partition coefficient in biphase, absorbability separates.Use chromatogram pump that by one, the flowing containing sample is fixed in chromatographic column the fixing phase surface mutually immiscible with flowing mutually.When the mixture carried in flowing mutually flows through fixing phase time, each component in mixture interacts mutually with fixing.Due to component each in mixture difference in character and structure so that it is different that each component is fixed the time retained mutually, thus by a graded by fixing successively outflow in mutually.Detection method is combined after suitable post, it is achieved the separation of each component and detection in mixture.The method has become separate analytical technique important in the ambits such as chemistry, medical science, industry, agronomy, commodity inspection and method inspection.
On the basis of conventional liquid phase chromatograph, developing a kind of two-dimensional liquid chromatography (2D-LC) with sample online treatment or two dimensional separation ability, two-dimensional liquid chromatography is the piece-rate system constituted of being got up by two different and separate for separating mechanism Coupled columns.Sample enters in interface through the chromatographic column of the first dimension liquid phase, by being switched after concentrating, trapping or cut in the chromatographic column and detector entering the second dimension liquid phase.Two-dimensional liquid chromatography generally uses two kinds of different separating mechanisms to analyze sample, the different qualities i.e. utilizing sample is divided into one-component complex mixture (such as peptide), these characteristics include acting on (affine) etc. between molecular dimension, isoelectric point, IP, hydrophilic, electric charge, particular molecule, the component being not completely separated in one-dimensional piece-rate system, preferably may be separated in two-dimentional system, therefore separating power, resolution are greatly improved.
Existing conventional liquid phase chromatograph and Two-dimensional Liquid Chromatography have a common defect, all can not on-line cleaning chromatographic column, filter, stream pipeline or guard column.Owing to sample to be analyzed having the reasons such as impurity, along with chromatographic column uses the increase of time, meeting accumulated impurity in chromatographic column, thus cause chromatogram column efficiency to be deteriorated, and the accuracy of impact analysis, there will be severe stifled post phenomenon, cause using.In prior art, chromatographic column generally uses the most long; the sample analyzed is the dirtiest; degradation speed is the fastest; difference according to degree of deterioration; cause the degree that chromatographic peak deforms different, cause the when of serious chromatographic system collapse and or measurement result inaccurate, therefore it is frequently necessary to clean chromatographic column after finishing sample analysis; the most sometimes insoluble granule meeting blocking pipeline, filter or the protector brought into from sample or flowing mutually, causes the problem such as pipe breakage, system overpressure.
Especially in two-dimensional liquid chromatography, first dimension chromatographic column is generally used for the primary separation of " the dirtiest " sample (such as blood plasma, Chinese medicine crude extract, animal vegetable tissue crude extract etc.), the quantity analyzing sample is the most with number of times, accumulation on a column can not be the most by the material of flowing phase eluting used, sample is also possible to containing small insoluble granule, therefore being easy to chromatographic system stopping state, the most quickly, usual service life is less than 1000 times the degradation speed of chromatographic column.It is thus desirable to insoluble granule in sample is blocked, and the chromatographic column after deterioration is carried out irregular cleaning.After other first dimension chromatographic column lost efficacy, dirty material easily passes to the chromatographic column of rear class, causes the chromatographic system of the second dimension to break down, and therefore the chromatographic column of rear class is also required to irregularly clean；Additionally get over the sample of " dirty ", the easiest precipitation insoluble granule in the pipeline of liquid chromatograph, cause serious system jams even to be collapsed.
One of technology of existing solution problem above is to increase guard column or filter in chromatograph injector with chromatographic column; when guard column or filter effect are deteriorated or cause system pressure to rise when; stop liquid phase chromatographic run; change the guard column or filter lost efficacy; this solution needs more conversion materials, causes cost to increase；Additionally need first to stop analyzing and just can be replaced work, affect the work efficiency of liquid chromatograph；And needing manual operation, to realizing, chromatograph is increasingly automated brings obstacle.
Another technology of existing solution problem above is after sample analysis completes, and stops analyzing, the flowing phase flushing liquor chromatography stronger by eluting power and chromatographic column, partial impurities is rinsed.But this method lost efficacy for the chromatographic column that the strongest impurity of reservation and molecule cause and did not act on；Additionally need and consume a longer time；And can not carry out while analyzing sample, chromatographic increasingly automated operation cannot be realized equally.
The Chinese patent of Application No. CN201410705067.5, including first flow, the second runner, analyzes runner, waste liquid runner etc., also includes cleaning runner, direction switch valve and multiple flow passages switching valve etc..This chromatograph of liquid is by changing the connected relation between each two switching valves; thus change liquid flow path; achieve the first chromatographic column, middle chromatographic column, filter or the function of on-line cleaning of protector respectively; and the first chromatographic column and middle chromatographic column can be carried out on-line cleaning simultaneously; but this kind of chromatograph of liquid needs artificial control when cleaning, it is impossible to enough reach the purpose that automated intelligent controls.
Utility model content
The purpose of this utility model is to provide a kind of for the online chromatograph of liquid of atmospheric analysis, it is possible to realize automatically cleaning after experiment terminates.
Above-mentioned purpose of the present utility model has the technical scheme that
A kind of for the online chromatograph of liquid of atmospheric analysis, including automatic cleaning system, described automatic cleaning system includes cleaning runner, infusion pump and the control circuit of the described infusion pump of control, described control circuit includes: trigger module includes triggering device, an instantaneous driving signal can be triggered, time block couples with described trigger module, it is controlled by the described driving signal driving signal output Preset Time, driving module to couple with described time block, the infusion pump described in signal control that drives being controlled by described Preset Time is operated.
By using technique scheme, after the online chromatograph of liquid of atmospheric analysis completes to analyze, make automatic cleaning system start chromatograph of liquid online to atmospheric analysis by triggering device automatically to clean, the pipeline input cleanout fluid of control circuit controllable infusion pump chromatograph of liquid online to atmospheric analysis, it is automatically stopped after the time that input is preset, it is achieved the effect automatically cleaned.
This utility model can be further arranged to, and this utility model can be further arranged to, and described triggering device is automatic reset switch.
By using technique scheme, can reach to occur the purpose of an instantaneous driving signal by controlling automatic reset switch.
This utility model can be further arranged to, and described time block includes the single-shot trigger circuit that 555 intervalometers are constituted, and described time block is the driving signal of output Preset Time when receiving trailing edge signal.
By using technique scheme, 555 intervalometers play the effect of timing, can export driving signal to control and then reaching to control the purpose of infusion pump work Preset Time of Preset Time after receiving trailing edge signal.
This utility model can be further arranged to, described driving module includes the first driving resistance, the second driving resistance and drives audion, the first described driving resistance drives resistant series ground connection with described second, the first described driving resistance and the described second base stage driving the node of resistance to couple described driving audion, the colelctor electrode of described driving audion couples described infusion pump.
By using technique scheme, first drives resistance and second to drive resistance to provide voltage for the base stage of driving audion, and then reaches to make the purpose of driving triode ON, reaches to control infusion pump work.
This utility model can be further arranged to, and described control circuit is additionally provided with protection module, including the first protective resistance, couples with described infusion pump.
By using technique scheme, infusion pump can be played the effect of protection by the first protective resistance, prevents it from causing because of instantaneous overtension damaging.
This utility model can be further arranged to, and described control circuit is additionally provided with indicating module, and described indicating module includes display lamp.
By using technique scheme, display lamp has the effect of instruction, can indicate infusion pump is operated when.
This utility model can be further arranged to, and described display lamp is connected the second protective resistance.
By using technique scheme, display lamp can be played the effect of protection by the second protective resistance, prevents it from causing because of instantaneous overtension damaging.
In sum, this utility model has the advantages that
After the online chromatograph of liquid of atmospheric analysis completes to analyze, make automatic cleaning system start chromatograph of liquid online to atmospheric analysis by triggering device automatically to clean, the pipeline input cleanout fluid of control circuit controllable infusion pump chromatograph of liquid online to atmospheric analysis, it is automatically stopped after the time that input is preset, realize the effect automatically cleaned, triggering device is automatic reset switch, can reach to occur the purpose of an instantaneous driving signal by controlling automatic reset switch, 555 intervalometers play the effect of timing, driving signal to control and then reaching to control the purpose of infusion pump work Preset Time of Preset Time can be exported after receiving trailing edge signal, control circuit is additionally provided with indicating module, described indicating module includes display lamp, display lamp has the effect of instruction, can indicate infusion pump is operated when.
Accompanying drawing explanation
Fig. 1 is control circuit schematic diagram.
In figure, 110, trigger module；120, time block；130, module is driven；140, protection module；150, indicating module.
Detailed description of the invention
Below in conjunction with accompanying drawing, this utility model is described in further detail.
As shown in Figure 1, control circuit schematic diagram, a kind of for the online chromatograph of liquid of atmospheric analysis, including automatic cleaning system, described automatic cleaning system includes cleaning runner, infusion pump and the control circuit of the described infusion pump of control, described control circuit includes: trigger module 110 includes triggering device, an instantaneous driving signal can be triggered, time block 120 couples with described trigger module 110, it is controlled by the described driving signal driving signal output Preset Time, module 130 is driven to couple with described time block 120, the infusion pump described in signal control that drives being controlled by described Preset Time is operated.
Triggering device is automatic reset switch, can reach to occur the purpose of an instantaneous driving signal by controlling automatic reset switch.
Time block 120 includes the single-shot trigger circuit that 555 intervalometers are constituted, described time block 120 is the driving signal of output Preset Time when receiving trailing edge signal, 555 intervalometers play the effect of timing, can export driving signal to control and then reaching to control the purpose of infusion pump work Preset Time of Preset Time after receiving trailing edge signal.
Module 130 is driven to include the first driving resistance R12, second drives resistance R13 and drives audion Q1, described first driving resistance R12 and the described second driving resistance R13 connects ground connection, the first described driving resistance R12 and the described second base stage driving the node of resistance R13 to couple described driving audion Q1, the colelctor electrode of described driving audion Q1 couples described infusion pump, first drives resistance R12 and second to drive resistance R13 for driving the base stage of audion Q1 to provide voltage, and then reach the purpose making driving audion Q1 turn on, reach to control infusion pump work.
Control circuit is additionally provided with protection module 140, including the first protective resistance R14, couples with described infusion pump, and infusion pump can be played the effect of protection by the first protective resistance R14, prevents it from causing because of instantaneous overtension damaging.
Control circuit is additionally provided with indicating module 150; described indicating module 150 includes display lamp L; display lamp L has the effect of instruction; can indicate infusion pump is operated when; described display lamp L connects the second protective resistance R15; display lamp L can be played the effect of protection by the second protective resistance R15, prevents it from causing because of instantaneous overtension damaging.
This specific embodiment is only to explanation of the present utility model; it is not to restriction of the present utility model; the present embodiment can be made after reading this specification by those skilled in the art as required does not has the amendment of creative contribution, but as long as all being protected by Patent Law in right of the present utility model.
Claims (7)
1., for the online chromatograph of liquid of atmospheric analysis, including automatic cleaning system, described automatic cleaning system includes cleaning runner, infusion pump and the control circuit of the described infusion pump of control, it is characterized in that, described control circuit includes
Trigger module (110), including triggering device, can trigger an instantaneous driving signal；
Time block (120), couples with described trigger module (110), is controlled by the described driving signal driving signal output Preset Time；
Driving module (130), couple with described time block (120), the infusion pump described in signal control that drives being controlled by described Preset Time is operated.
One the most according to claim 1 is used for the online chromatograph of liquid of atmospheric analysis, it is characterized in that: described triggering device is automatic reset switch.
One the most according to claim 1 is used for the online chromatograph of liquid of atmospheric analysis, it is characterized in that: described time block (120) includes the single-shot trigger circuit that 555 intervalometers are constituted, described time block (120) is the driving signal of output Preset Time when receiving trailing edge signal.
One the most according to claim 1 is used for the online chromatograph of liquid of atmospheric analysis, it is characterized in that: described driving module (130) includes the first driving resistance, the second driving resistance and drives audion, the first described driving resistance drives resistant series ground connection with described second, the first described driving resistance and the described second base stage driving the node of resistance to couple described driving audion, the colelctor electrode of described driving audion couples described infusion pump.
One the most according to claim 1 is used for the online chromatograph of liquid of atmospheric analysis, it is characterized in that: described control circuit is additionally provided with protection module (140), including the first protective resistance, couples with described infusion pump.
One the most according to claim 1 is used for the online chromatograph of liquid of atmospheric analysis, it is characterized in that: described control circuit is additionally provided with indicating module (150), and described indicating module (150) includes display lamp.
One the most according to claim 6 is used for the online chromatograph of liquid of atmospheric analysis, it is characterized in that: described display lamp is connected the second protective resistance.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620444984.7U CN205607940U (en) | 2016-05-16 | 2016-05-16 | Be used for online liquid chromatograph of atmosphere analysis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620444984.7U CN205607940U (en) | 2016-05-16 | 2016-05-16 | Be used for online liquid chromatograph of atmosphere analysis |
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| Publication Number | Publication Date |
|---|---|
| CN205607940U true CN205607940U (en) | 2016-09-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620444984.7U Expired - Fee Related CN205607940U (en) | 2016-05-16 | 2016-05-16 | Be used for online liquid chromatograph of atmosphere analysis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113533541A (en) * | 2020-04-15 | 2021-10-22 | 中国科学院上海药物研究所 | Nano-liter liquid phase system with automatic cleaning function and control method |
-
2016
- 2016-05-16 CN CN201620444984.7U patent/CN205607940U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113533541A (en) * | 2020-04-15 | 2021-10-22 | 中国科学院上海药物研究所 | Nano-liter liquid phase system with automatic cleaning function and control method |
| CN113533541B (en) * | 2020-04-15 | 2022-07-08 | 中国科学院上海药物研究所 | Nano-liter liquid phase system with automatic cleaning function and control method |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160928 |
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| CF01 | Termination of patent right due to non-payment of annual fee |