CN205538646U - Micro - device of optoacoustic based on LED - Google Patents
Micro - device of optoacoustic based on LED Download PDFInfo
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- CN205538646U CN205538646U CN201620096812.5U CN201620096812U CN205538646U CN 205538646 U CN205538646 U CN 205538646U CN 201620096812 U CN201620096812 U CN 201620096812U CN 205538646 U CN205538646 U CN 205538646U
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- led
- ring array
- data acquisition
- ultrasonic detector
- driving source
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Abstract
The utility model discloses a micro - device of optoacoustic based on LED, it relates to biomedical formation of image and medical instrument technical field, LED driving source and clock circuit connection, the clock circuit is connected with the data acquisition subassembly, the data acquisition subassembly respectively with signal preprocessing circuit and computer link, signal preprocessing circuit is connected with multiple ring array ultrasonic detector, holophote, collimating mirror and focusing mirror, multiple ring array ultrasonic detector sets up in metal casing, the computer is connected with motor -drive circuit, motor -drive circuit and two -dimentional electric translation stage are connected, the two dimension electric translation stage be connected with metal casing, metal casing's below is provided with the basin. It is through adopting multiple ring array detector to receive the optoacoustic signal, and accuse focus is mutually carried out to the data of accessible collection, can realize the micro - formation of image of the burnt optoacoustic of portable copolymerization, the LED driving source have the luminous efficacy height, power consumptive less, long service life, small, low price, safety and stability and maintenance characteristics such as simple.
Description
Technical field:
This utility model relates to a kind of LED-based optoacoustic microscope equipment, belongs to biomedical one-tenth
Picture and technical field of medical instruments.
Background technology:
Opto-acoustic microscopic imaging is a kind of new lossless medical imaging procedure of development in recent years, its knot
The high contrast features of pure optical imagery and the high-penetration depth characteristic of pure ultra sonic imaging are closed
Advantage, it is provided that the high-resolution tissue image of hundreds of micron to tens Nano grades.
In opto-acoustic microscopic imaging, conventional excitation light source mostly is pulsed or tunable pulse at present
Laser instrument, and such laser instrument generally has that volume is big, expensive, service life is limited,
Numerous shortcomings such as repetition rate is low, Maintenance Difficulty, and it is difficult to realize the miniaturization of system and industrialization,
There is significant limitation in actual applications.
Summary of the invention:
For the problems referred to above, the technical problems to be solved in the utility model be to provide a kind of based on
The optoacoustic microscope equipment of LED.
One of the present utility model LED-based optoacoustic microscope equipment, it comprise LED driving source,
Clock circuit, data acquisition components, signal pre-processing circuit, computer, multi-ring array are ultrasonic
Detector, metal shell, motor-drive circuit, two dimension motorized precision translation stage, completely reflecting mirror, standard
Straight mirror, focus lamp, tank, LED driving source includes that LED power modulation module and LED are luminous
Module, LED driving source is connected by wire with clock circuit, clock circuit and data acquisition group
Part connects, and data acquisition components is connected with signal pre-processing circuit and computer respectively, and signal is pre-
Process circuit to be connected with multi-ring array ultrasonic detector by wire, multi-ring array ultrasonic detector
Being arranged in metal shell, computer is connected with motor-drive circuit, motor-drive circuit and two
Dimension motorized precision translation stage connects, and two dimension motorized precision translation stage and metal shell pass through to be mechanically connected, metal
Being additionally provided with completely reflecting mirror, collimating mirror and focus lamp in shell, the lower section of metal shell is provided with
Tank.
As preferably, the luminescent spectrum of described LED driving source is visible ray and near infrared light,
Visible spectrum is 400nm-760nm, and near infrared light spectral region is 760nm-
1600nm, becomes light-pulse generator, warp after the chopped device of continuous light sent or impulse modulation power supply
It is focused into diameter at tens microns to several by the focus lamp of high-NA again after collimating mirror collimation
The focus of ten nanometers, is radiated on sample by the printing opacity entrant sound elastic film in tank and is excited
Photoacoustic signal.
As preferably, described LED driving source is that single led driving source, multiple LED swash
Encourage the combination in source, in order to realize photoacoustic functionality imaging, two wavelength or multiple wavelength can be used
Combination.
As preferably, described data acquisition components is multi-channel parallel capture card, its port number
Array number no less than multi-ring array ultrasonic detector.
As preferably, the material of described multi-ring array ultrasonic detector is piezoelectric ceramics or compound
Material, the mid frequency of multi-ring array ultrasonic detector is 10MHz-50MHz, multi-ring array
The array number of ultrasonic detector is 4,6 or 8, each array element of multi-ring array ultrasonic detector
Gather data simultaneously, after being stored in computer, dynamic phase-control focusing can be realized by data, from
And realize sound focusing point and the coincidence of light focus point, it is achieved common focusing-detection photoacoustic signal.
As preferably, described motor-drive circuit drives two dimension motorized precision translation stage by driving gold
Genus shell makes focusing laser do laser on sample and does two-dimensional scan, and the photoacoustic signal excited passes through
After the printing opacity entrant sound elastic film of bottom of gullet in tank water by multi-ring array supersonic sounding
Device receives, and after being then amplified by signal pre-processing circuit, is entered by data acquisition components
It is transfused to computer stored after row data acquisition, rebuilds finally by image reconstruction algorithm and obtain phase
The two dimension answered or three-dimensional optoacoustic micro-image.
As preferably, the bottom of described tank is provided with circular hole, and circular hole is arranged
There is printing opacity entrant sound elastic film, and sealed by printing opacity entrant sound elastic film, printing opacity entrant sound
Using ultrasonic coupling agent coupling ultrasonic between elastic film and sample, this ultrasonic coupling agent is non-liquid
Body shape ultrasonic coupling agent, is coated on sample, fills with water or mineral oil is used as ultrasonic coupling in tank
Mixture coupling ultrasonic.
The beneficial effects of the utility model: it by use LED driving source as light acoustic excitation sources,
Have luminous efficiency height, little power consumption, length in service life, volume is little, low price, safety are steady
The features such as fixed and maintenance is simple, by using multi-ring array detector to receive photoacoustic signal, can lead to
Cross the data gathered and carry out phase-control focusing, so that sound focusing point overlaps with light focus point, it is achieved
Copolymerization Jiao's optoacoustic is micro-.
Accompanying drawing illustrates:
For ease of explanation, this utility model is embodied as and accompanying drawing is made with in detail by following
Describe.
Fig. 1 is structural representation of the present utility model；
Fig. 2 is the structural representation of multi-ring array ultrasonic detector in this utility model.
1-LED driving source；2-clock circuit；3-data acquisition components；4-Signal Pretreatment electricity
Road；5-computer；6-multi-ring array ultrasonic detector；7-metal shell；8-motor drives
Circuit；9-two dimension motorized precision translation stage；10-completely reflecting mirror；11-collimating mirror；12-focus lamp；
13-tank.
Detailed description of the invention:
Such as Fig. 1, shown in Fig. 2, this detailed description of the invention by the following technical solutions: it comprises
LED driving source 1, clock circuit 2, data acquisition components 3, signal pre-processing circuit 4, meter
Calculation machine 5, multi-ring array ultrasonic detector 6, metal shell 7, motor-drive circuit 8, two dimension
Motorized precision translation stage 9, completely reflecting mirror 10, collimating mirror 11, focus lamp 12, tank 13, LED
Driving source 1 includes LED power modulation module and LED light module, LED driving source 1 and time
Clock circuit 2 is connected by wire, and clock circuit 2 is connected with data acquisition components 3, data acquisition
Collection assembly 3 is connected with signal pre-processing circuit 4 and computer 5 respectively, signal pre-processing circuit
4 are connected with multi-ring array ultrasonic detector 6 by wire, and multi-ring array ultrasonic detector 6 sets
Putting in metal shell 7, computer 5 is connected with motor-drive circuit 8, motor-drive circuit
8 are connected with two dimension motorized precision translation stage 9, and two dimension motorized precision translation stage 9 passes through machine with metal shell 7
Tool connects, and is additionally provided with completely reflecting mirror 10, collimating mirror 11 and focus lamp 12 in metal shell 7,
The lower section of metal shell 7 is provided with tank 13.
Wherein, the luminescent spectrum of described LED driving source 1 is visible ray and near infrared light, can
Seeing that light spectral region is 400nm-760nm, near infrared light spectral region is 760nm-1600nm,
Light-pulse generator, collimated mirror is become after the chopped device of continuous light sent or impulse modulation power supply
It is focused into diameter at tens microns to tens by the focus lamp 12 of high-NA again after 11 collimations
The focus of nanometer, is radiated on sample by the printing opacity entrant sound elastic film in tank 13 and is swashed
Luminous acoustical signal；Described LED driving source 1 be single led driving source, multiple LED swash
Encourage the combination in source, in order to realize photoacoustic functionality imaging, two wavelength or multiple wavelength can be used
Combination；Described data acquisition components 3 is multi-channel parallel capture card, and its port number is many
Array number in multi-ring array ultrasonic detector；The material of described multi-ring array ultrasonic detector 6
Material is piezoelectric ceramics or composite, and the mid frequency of multi-ring array ultrasonic detector 6 is
10MHz-50MHz, the array number of multi-ring array ultrasonic detector 6 is 4,6 or 8, multi-ring
Each array element of array ultrasonic sensors 6 gathers data simultaneously, after being stored in computer, can lead to
Cross data and realize dynamic phase-control focusing, thus realize sound focusing point and the coincidence of light focus point, real
Now common focusing-detection photoacoustic signal；Described motor-drive circuit 8 drives two dimension electric translation
Platform 9 does two-dimensional scan by driving metal shell 7 to make focusing laser do laser on sample, swashs
The photoacoustic signal sent out through after the printing opacity entrant sound elastic film bottom tank 13 in tank 13
Water is received by multi-ring array ultrasonic detector 6, is then put by signal pre-processing circuit 4
After great, it be transfused to computer 5 after carrying out data acquisition by data acquisition components 3 and store,
Rebuild by image reconstruction algorithm afterwards and obtain the most two-dimentional or three-dimensional optoacoustic micro-image；Described
The bottom of tank 13 be provided with circular hole, circular hole is provided with printing opacity entrant sound elastic
Thin film, and sealed by printing opacity entrant sound elastic film, printing opacity entrant sound elastic film and sample
Between use ultrasonic coupling agent coupling ultrasonic, this ultrasonic coupling agent is on-liquid shape ultrasonic coupling agent,
It is coated on sample, fills with water in tank 13 or mineral oil is used as ultrasonic coupling agent coupling ultrasonic.
The formation method of this detailed description of the invention: the pulse laser that a, LED driving source 1 sends
By completely reflecting mirror 10 directive collimating mirror 11, laser is collimated to be carried out by focus lamp 12
Focusing on, the light beam after focusing is by being radiated at sample behind the center of multi-ring array ultrasonic detector 6
Go up and produce photoacoustic signal；B, each array element of multi-ring array ultrasonic detector 6 receive this
The photoacoustic signal of position, by data after signal pre-processing circuit carries out preposition amplification to signal
Acquisition component is stored in computer 5 after signal is carried out A/D conversion；C, computer 5 pass through
Motor-drive circuit 8 drives two dimension motorized precision translation stage 9, thus drives metal shell 7 to make focusing
Luminous point does photoscanning on sample, repeats step b simultaneously and receives the photoacoustic signal every time received；
D, utilize Matlab data processing software to write image reconstruction program, obtain two dimension or three-dimensional light
Sound micro-image.
This detailed description of the invention, by using LED driving source as light acoustic excitation sources, has luminescence
Efficiency height, little power consumption, length in service life, volume are little, low price, safety and stability and maintenance
The feature such as simple, by using multi-ring array detector to receive photoacoustic signal, can be by gathering
Data carry out phase-control focusing, so that sound focusing point overlaps with light focus point, it is achieved copolymerization Jiao's light
Sound is micro-.
Of the present utility model ultimate principle and principal character and this practicality have more than been shown and described
Novel advantage.Skilled person will appreciate that of the industry, this utility model is not by above-mentioned enforcement
Described in the restriction of example, above-described embodiment and description, principle of the present utility model is simply described,
On the premise of without departing from this utility model spirit and scope, this utility model also has various change
Change and improve, in the range of these changes and improvements both fall within claimed this utility model.This
Utility model claims scope and is defined by appending claims and equivalent thereof.
Claims (4)
1. a LED-based optoacoustic microscope equipment, it is characterised in that: it comprises LED and swashs
Encourage source (1), clock circuit (2), data acquisition components (3), signal pre-processing circuit (4), meter
Calculation machine (5), multi-ring array ultrasonic detector (6), metal shell (7), motor-drive circuit (8),
Two dimension motorized precision translation stage (9), completely reflecting mirror (10), collimating mirror (11), focus lamp (12), water
Groove (13), LED driving source (1) includes LED power modulation module and LED light module, LED
Driving source (1) is connected by wire with clock circuit (2), clock circuit (2) and data acquisition group
Part (3) connect, data acquisition components (3) respectively with signal pre-processing circuit (4) and computer (5)
Connecting, signal pre-processing circuit (4) is connected with multi-ring array ultrasonic detector (6) by wire,
Multi-ring array ultrasonic detector (6) is arranged in metal shell (7), and computer (5) drives with motor
Galvanic electricity road (8) connects, and motor-drive circuit (8) is connected with two dimension motorized precision translation stage (9), two dimension
Motorized precision translation stage (9) and metal shell (7) are by being mechanically connected, and metal shell also sets up in (7)
Having completely reflecting mirror (10), collimating mirror (11) and focus lamp (12), the lower section of metal shell (7) sets
It is equipped with tank (13).
One the most according to claim 1 LED-based optoacoustic microscope equipment, it is special
Levy and be: the luminescent spectrum of described LED driving source (1) is visible ray and near infrared light, can
Seeing that light spectral region is 400nm-760nm, near infrared light spectral region is 760nm-1600nm.
One the most according to claim 1 LED-based optoacoustic microscope equipment, it is special
Levy and be: described data acquisition components (3) is multi-channel parallel capture card, and its port number is not
Array number less than multi-ring array ultrasonic detector.
One the most according to claim 1 LED-based optoacoustic microscope equipment, it is special
Levy and be: the bottom of described tank (13) is provided with circular hole, and circular hole is provided with
Printing opacity entrant sound elastic film.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620096812.5U CN205538646U (en) | 2016-01-29 | 2016-01-29 | Micro - device of optoacoustic based on LED |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620096812.5U CN205538646U (en) | 2016-01-29 | 2016-01-29 | Micro - device of optoacoustic based on LED |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205538646U true CN205538646U (en) | 2016-08-31 |
Family
ID=56773543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620096812.5U Expired - Fee Related CN205538646U (en) | 2016-01-29 | 2016-01-29 | Micro - device of optoacoustic based on LED |
Country Status (1)
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| CN (1) | CN205538646U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107782791A (en) * | 2017-09-04 | 2018-03-09 | 中国航空工业集团公司基础技术研究院 | A kind of sound micro imaging method for tooth body |
| CN111948147A (en) * | 2020-09-25 | 2020-11-17 | 广东工业大学 | Non-blind-zone full-field ultrasonic microscope imaging system and method thereof |
-
2016
- 2016-01-29 CN CN201620096812.5U patent/CN205538646U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107782791A (en) * | 2017-09-04 | 2018-03-09 | 中国航空工业集团公司基础技术研究院 | A kind of sound micro imaging method for tooth body |
| CN111948147A (en) * | 2020-09-25 | 2020-11-17 | 广东工业大学 | Non-blind-zone full-field ultrasonic microscope imaging system and method thereof |
| CN111948147B (en) * | 2020-09-25 | 2023-07-25 | 广东工业大学 | Non-blind area full-field ultrasonic microscope imaging system and method thereof |
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|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160831 Termination date: 20170129 |
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| CF01 | Termination of patent right due to non-payment of annual fee |