CN205538425U - Quick pathological tissue hydroextractor - Google Patents

Abstract

The utility model relates to an equipment of biological tissue sample paraffin section preparation relates to a quick pathological tissue hydroextractor, a quick pathological tissue hydroextractor, including quick -witted box and intelligent operation panel, inside specimen processing case, paraffin case, vacuum pump, a plurality of reagent bucket, the supersonic generator of being provided with of machine box, specimen processing incasement portion is the microwave cavity, the microwave cavity is connected with the microwave source, all be connected through duct assembly between specimen processing case and paraffin case, a plurality of reagent bucket and the vacuum pump. The utility model discloses collection microwave, ultrasonic wave and vacuum are as an organic whole and join in marriage and special reagent, can organize the processing time from 16~22 hours traditional, shorten to 20 minutes~3 hours, can accomplish fixed, dehydration, transparent, waxdip, film -making and diagnostic procedure in 2 hours are sent to to little sample, pathological diagnosis can be made in 32 hours to the radical cure sample, have shortened the time that the patient waited for disease diagnosis, have reduced to feel anxious painstakingly, especially accept the special treatment to needs, if operation, targeted therapy's patient has won the time, reduce patient's length of stay and reduced hospital bills, the economic benefits of hospital has also been increased simultaneously.

Description

A kind of rapid pathology tissue processor

Technical field

This utility model relates to the equipment that a kind of biological tissue specimens paraffin section makes, and is specifically related to a kind of rapid pathology tissue Dewaterer.

Background technology

At present, the pathologic diagnosis during domestic and international commonly used frozen section technique and other quick diagnosis technology solve operation. Although frozen section technology remains first-selected, but often have due to this technology that section is the thickest, histiocyte form fuzzy, ice crystal is artificial Illusion and section preparation can not the shortcomings such as preservation for a long time.It addition, about traditional quick paraffin sections method master of non-frozen section technique If utilizing alcohol burner, electric furnace or water-bath to directly heat process tissue, to shorten fixing, the dehydration of tissue, transparent and waxdip Time, but the shortcoming of this kind of method the least, the heated time that is requirement tissue specimen volume and degree are difficult to control exactly, time Often cause and organized crisp or processed insufficient, thus affect diagnosis.The most existing ultrasound wave or microwave rapid tissue dehydration dress Put be only capable of meeting quick paraffin sections substantially apply requirement, though it has certain advantage, but could not well play equipment Performance, and manual operations can only be used, consume manpower, consume reagent, it is often more important that the said equipment is not existed Popularization and application in routine pathology diagnosis.Therefore, a kind of intelligence degree of invention is high, reliable and stable, can play again microwave, ultrasonic Ripple and the equipment of three kinds of device performances of vacuum, and it is widely used in the pathological diagnosis work that hospital is conventional, it is very important.

Also having and improve prior art, Chinese patent CN203191234U discloses at a kind of speed dual-purpose list specimen Reason cylinder automated biological tissue processor, is made up of cabinet bulk, sample disposal cabinet, reagent cabinet, computerized control system and display screen, One sample disposal cylinder and two deposit wax cylinders are installed in sample disposal cabinet, are equipped with sealing ring in sample disposal face cashier's office in a shop Sample disposal cylinder cap and deposit wax cylinder cap, be provided with four reagent kettles, two abluent kettles, two waste liquids discharges in reagent cabinet Tap, pressure vacuum pump, supersonic generator and computerized control system, pressure vacuum pump is below abluent kettle, and ultrasound wave is sent out Raw device and computerized control system are at reagent kettle rear, and described sample disposal cylinder includes the cylinder cap equipped with sealing ring, heater, liquid Level sensor, ultrasonic transducer, agitator, temperature sensor, sample disposal cylinder reagent fluid path gateway, sample disposal cylinder Reagent fluid path gateway filter screen, sample disposal cylinder gas circuit gateway, Sample basket and reagent liquid level, described each reagent kettle is with clear Lotion kettle is all connected with sample disposal cylinder reagent fluid path gateway by electromagnetic valve and reagent cartridge, described each deposit wax cylinder All being connected with sample disposal cylinder reagent fluid path gateway by electromagnetic valve and reagent cartridge, described pressure vacuum pump passes through electromagnetism Valve, pressure transducer and gas piping connect malleation gas cylinder and negative pressure gas cylinder is connected with sample disposal cylinder gas circuit gateway.Use There is following defect in this device: 1. is internally heated sample disposal case by arranging heater in sample disposal case, uses this kind Although structure is capable of the basic demand of heating, but uses this kind of mode of heating penetration capacity more weak, it is impossible to realize well Drying effect, and the time spent is longer；2. reagent kettle is four, not only extends the time of pathological tissue dehydrating, and Owing to the more meeting of reagent barrel causes the consumption of reagent to increase；3. due in the deposit wax case in this device, reagent kettle and cleaning kettle It is not provided with heater, causes the paraffin flowing in sample disposal case, reagent to be room temperature state, need to enter from room temperature state Row heating, so may result in heat time heating time elongated, thus extends the time of pathological tissue dehydrating；4. dehydration liquid and cleanout fluid All can not reuse.

Utility model content

This utility model is in order to solve the problem that prior art exists, it is provided that a kind of integrate microwave, ultrasound wave and vacuum, Coordinate special agent, traditional organized processing time can be shortened to from 16～22 hours 20 minutes～3 hours, send at small sample Can complete in reaching 2 hours to fix, be dehydrated, transparent, waxdip, film-making and diagnotor, radical cure specimen can be made in 32 hours Pathological diagnosis, shorten patient wait medical diagnosis on disease time, decrease anxiety bitter, especially needs are accepted special treatment, As operation, the patient of targeted therapy have won the time, decreased patient's length of stay and reduce hospitalization cost, also be able to simultaneously Increase the rapid pathology tissue processor of the economic benefit of hospital.

This utility model is realized by following technical measures: a kind of rapid pathology tissue processor, including cabinet bulk and intelligence Operating board, described cabinet bulk is internally provided with sample disposal case, paraffin case, vacuum pump, multiple reagent barrel, supersonic generator, Described sample disposal case is internal be microwave cavity, and the connection of described microwave cavity has a microwave source, described sample disposal case and paraffin case, multiple All it is attached by conduit assembly between reagent barrel and vacuum pump.

According to another kind of improvement of the present utility model, described sample disposal case is positioned at cabinet bulk inner upper, described rectangle microwave chamber It is internally provided with rectangle extract hurdle, the sidewall of described microwave cavity is provided with temperature sensor, liquid level sensor and vacuum transducer, The top of described microwave cavity is provided with the capping with visual window.

According to another kind of improvement of the present utility model, described microwave source is located in the exterior side wall of sample disposal case.

According to another kind of improvement of the present utility model, described supersonic generator is arranged on the outer wall bottom of sample disposal case.

According to another kind of improvement of the present utility model, described vacuum pump is placed on cabinet bulk lower inside, described vacuum pump and specimen It is attached by the first pipeline between treatment box.

According to another kind of improvement of the present utility model, described paraffin case is positioned at the lower section of sample disposal case, described paraffin case private side It is provided with temperature sensor and liquid level sensor on wall, described paraffin bottom face and/or side are provided with heating plate, described paraffin It is provided with second pipe and the 3rd pipeline of parallel connection between case and sample disposal case, described second pipe is provided with the second electromagnetic valve, Being provided with the 3rd electromagnetic valve on described 3rd pipeline, described second electromagnetic valve connects the second electromagnetic pump or the second positive and negative press pump, Connect on described 3rd electromagnetic valve and have the 3rd electromagnetic pump or the 3rd positive and negative press pump.

According to another kind of improvement of the present utility model, the plurality of reagent barrel is five, including a fixative bucket, two dehydrations Liquid bucket, two cleanout fluid buckets, described five reagent barrel internal side wall are respectively provided with heating rod, temperature sensor and level sensing Device, is attached by the 4th pipeline between said two dehydration liquid bucket, is entered by the 5th pipeline between said two cleanout fluid bucket Row connects, and described 4th pipeline is provided with the 4th electromagnetic valve, and described 4th electromagnetic valve connects just is having the 4th electromagnetic pump or the 4th Negative pressure pump, described 5th pipeline is provided with the 5th electromagnetic valve, described 5th electromagnetic valve is just being provided with the 5th electromagnetic pump or the 5th Negative pressure pump, described fixative bucket, one of them reagent barrel, one of them cleanout fluid bottom of the barrel are provided with discharge conduit, described Stop valve it is provided with on discharge conduit.

Another kind of improving according to of the present utility model, described second pipe is divided into five branch pipe(tube)s by the second electromagnetic valve, and described five Individual branch pipe(tube) is respectively protruding in five reagent barrels.

According to another kind of improvement of the present utility model, described intelligent operation platform is arranged on the outer upper ends of cabinet bulk.

Compared with prior art, this utility model at least has the advantage that

This utility model integrates microwave, ultrasound wave and vacuum, has concentrated the advantage of microwave, ultrasound wave, accelerates fixing de- Water reagent penetrates the speed of tissue, makes tissue moisture evaporation faster under the effect of vacuum, has reached to organize the effect of fast dewatering, Three kinds of equipment are integrated, and have exceeded a certain or effect of two kinds of equipment；

Paraffin case is arranged on below sample disposal case, and beneficially paraffin backflow is more thorough；

Join and special agent, make organized processing step reduce.Can shorten to by traditional organized processing time from 16～22 hours 20 minutes～3 hours, can complete to fix in small sample sends to 2 hours, be dehydrated, transparent, waxdip, film-making and diagnotor, Radical cure specimen can make pathological diagnosis in 32 hours, shortens patient and waits the time of medical diagnosis on disease, decreases the hardship of anxiety, especially It accepts special treatment to needs, as operation, the patient of targeted therapy have won the time, decreases patient's length of stay and reduces Hospitalization cost, too increases the economic benefit of hospital simultaneously；

This utility model has given full play to above-mentioned 3 kinds of equipment and the performance of intelligent assembly, had both saved manpower and materials, and had made again tissue Fixing, dehydration, transparent and waxdip time shorten, and chipping qualities more good stable also can meet wanting of rapid pathological diagnosis simultaneously The various demands of summation routine pathology film-making, thus it is short to reach the organized processing time, chipping qualities is high, and diagnosis speed is fast, is suitable for The purpose that scope is wide；

Paraffin case and reagent barrel are provided with heater, during practical operation, only paraffin case and reagent barrel need to be heated in advance, Just can shorten the later stage to heat the required time in sample disposal case, thus shorten the time of pathological tissue dehydrating.

The setting of the 4th pipeline between two dehydration liquid buckets, it is possible to realize the recycling of dehydration liquid；

The setting of the 5th pipeline between two cleanout fluid buckets, it is possible to realize the recycling of cleanout fluid.

Accompanying drawing explanation

Fig. 1 is the overall structure schematic diagram of this utility model a kind of rapid pathology tissue processor.

Fig. 2 is the structural representation of sample disposal case.

Fig. 3 is the partial enlarged drawing in Fig. 1 at F.

Fig. 4 is the partial enlarged drawing in Fig. 1 at E.

Fig. 5 is the structural representation of paraffin case.

Fig. 6 is the partial enlarged drawing in Fig. 1 at G.

Wherein, 1-intelligent operation platform, 2-sample disposal case, 3-the 3rd pipeline, 4-the 3rd electromagnetic valve, 5-the 3rd electromagnetic pump, 6- Supersonic generator, 7-paraffin case, 8-fixed plate, 9-the first pipeline, 10-heating plate, 11-the 4th branch pipe(tube), 12-the 5th arm Road, 13-cabinet bulk, 14-vacuum pump, 15-wheel, 16-the second cleanout fluid bucket, 17-the first cleanout fluid bucket, 18-temperature sensor, 19-heating rod, 20-second is dehydrated liquid bucket, and 21-first is dehydrated liquid bucket, 22-fixative bucket, 23-liquid level sensor, 24-second Pipeline, 25-the 3rd branch pipe(tube), 26-the first branch pipe(tube), the positive and negative press pump of 27-second, 28-the second electromagnetic valve, 29-second pipe, 30- Microwave source, 31-sealing strip, 32-covers, 33-visual window, 34-vacuum transducer, 35-microwave cavity, 36-the 4th pipeline, 37-the Four electromagnetic valves, 38-the 4th electromagnetic pump, 39-the 5th pipeline, 40-the 5th electromagnetic valve, 41-the 5th electromagnetic pump, 42-rectangle extract hurdle, 43-discharge conduit, 44-stop valve.

Detailed description of the invention

With specific embodiment, this utility model is further described below with reference to accompanying drawings.

As shown in figs 1 to 6, this utility model is a kind of rapid pathology tissue processor, including cabinet bulk 13 and intelligent operation Platform 1, cabinet bulk 13 is internally provided with sample disposal case 2, paraffin case 7, vacuum pump 14, multiple reagent barrel, ultrasound wave generation Device 6, sample disposal case 2 is internal be microwave cavity 35, and microwave cavity 35 connects microwave source 30, sample disposal case 2 and paraffin case 7, All it is attached by conduit assembly between multiple reagent barrels and vacuum pump 14.

Sample disposal case 2 is positioned at cabinet bulk 13 inner upper, and microwave cavity 35 is internally provided with rectangle extract hurdle 42, microwave cavity Being provided with temperature sensor 18, liquid level sensor 23 and vacuum transducer 34 on the sidewall of 35, the top of microwave cavity 35 is arranged There is the capping 32 with visual window, capping 32 is provided with visual window 33 and sealing strip 31.

Microwave source 30 is located in the exterior side wall of sample disposal case 2.

Supersonic generator 6 is arranged on the outer wall bottom of sample disposal case 2.

Vacuum pump 14 is placed on cabinet bulk 13 lower inside, by the first pipeline 9 between vacuum pump 14 and sample disposal case 2 It is attached.

Paraffin case 7 is positioned at the lower section of sample disposal case 2, and paraffin case 7 internal side wall is provided with temperature sensor 18 and liquid level Sensor 23, paraffin case 7 bottom surface and side is provided with heating plate 10, is provided with between paraffin case 7 and sample disposal case 2 Second pipe 29 in parallel and the 3rd pipeline 3, second pipe 29 is provided with the second electromagnetic valve 28, and the 3rd pipeline 3 is arranged Having the 3rd electromagnetic valve 4, the second electromagnetic valve 28 connects the second positive and negative press pump 27, and the 3rd electromagnetic valve 4 connects the 3rd electromagnetism Pump 5.

Second pipe 29 is divided into five branch pipe(tube)s by the second electromagnetic valve 28, and five branch pipe(tube)s are respectively protruding in five reagent barrels, Five branch pipe(tube)s are respectively first branch pipe(tube) the 26, second branch pipe(tube) the 24, the 3rd branch pipe(tube) the 25, the 4th branch pipe(tube) 11 and the 5th Branch pipe(tube) 12.

Multiple reagent barrels are five, are dehydrated liquid bucket 21, second including fixative bucket 22, first and are dehydrated the 20, first cleaning of liquid bucket Liquid bucket 17 and the second cleanout fluid bucket 16, five reagent barrel internal side wall are respectively provided with heating rod 19, temperature sensor 18 and liquid Level sensor 23, is attached by the 4th pipeline 36 between the first dehydration liquid bucket 21 and the second dehydration liquid bucket 20, and first is clear It is attached by the 5th pipeline 39 between washing liquid bucket 17 and the second cleanout fluid bucket 16, the 4th pipeline 36 is provided with the 4th electricity Magnet valve 37, the 4th electromagnetic valve 37 connects and has the 4th electromagnetic pump 38, the 5th pipeline 39 is provided with the 5th electromagnetic valve 40, the Being provided with the 5th electromagnetic pump 41 on five electromagnetic valves 40, fixative bucket 22, first is dehydrated liquid bucket 21 and first cleanout fluid bucket 17 end Portion is provided with discharge conduit 43, and discharge conduit 43 is provided with stop valve 44.

Intelligent operation platform 1 is arranged on the outer upper ends of cabinet bulk 13.

Concrete operation step:

Add fixative, dehydration liquid, cleanout fluid, paraffin arrive 22, two, fixative bucket dehydration liquid bucket, two cleanout fluid respectively In bucket, paraffin case 7.Touch operation platform relative program, in paraffin case 7, hard paraffin begins to warm up, and within 30 minutes, reaches 30-75 DEG C And continue constant；Five internal heating rods 19 that pass through of reagent barrel heat simultaneously, within 30 minutes, reach 30-90 DEG C and continue constant. This step belongs in advance to paraffin case 7 and five reagent barrel heating, uses this kind of method can shorten the later stage right in microwave cavity 35 Paraffin and reagent carry out heating required time.

Pending pathological anatomy specimen is placed in rectangle extract hurdle 42 by pathology technicians, and rectangle extract hurdle 42 is placed on micro- In ripple chamber 35, cover capping 32.

By associated control procedures, the second electromagnetic valve 28 is opened, the fixative in fixative bucket 22 is injected in microwave cavity 35, When fixative arrives the liquid level of regulation, in microwave cavity 35, liquid level sensor 23 performs to control to stop liquid feeding.

Open microwave source 30, supersonic generator 6 and vacuum pump 14, be heated in microwave cavity 35 by microwave source 30 30-90 DEG C, by vacuum pump 14 act on microwave cavity 35 in form negative pressure-1000 to-100mbar, after continuing 5-40 minute Close microwave source 30, supersonic generator 6 and vacuum pump 14.

Control to return fixative bucket 22 by relative program by the fixative in microwave cavity 35.

Open microwave source 30 and vacuum pump 14, in microwave cavity 35, be heated to 30-90 DEG C by microwave source 30, pass through vacuum Pump 14 act on microwave cavity 35 in form negative pressure-1000 to-100mbar, and close microwave source 30 He after continuing 5-40 minute Vacuum pump 14.

Dehydration liquid in first dehydration liquid bucket 21 and the second dehydration liquid bucket 20 is processed pathologic group successively in microwave cavity by above-mentioned steps Knit.

The paraffin dissolved in advance in paraffin case 7 is injected in microwave cavity 35.

Open microwave source 30, supersonic generator 6 and vacuum pump 14, be heated to 30-80 DEG C, negative pressure-1000 to-100mbar, Microwave source 30, supersonic generator 6 and vacuum pump 14 is closed after continuing 5-40 minute.

Control to return paraffin case 7 by relative program by the paraffin in microwave cavity 35.

After whole sample disposal process completes, from microwave cavity 35, take out specimen carry out embedding, cut into slices and dyeing.

After tissue specimen processing procedure completes, by the heating rod 19 in two cleanout fluid buckets by two cleanout fluid buckets every time Cleanout fluid is heated to 30-80 DEG C, first passes through associated control procedures and controls the second electromagnetic valve 28, by the first cleanout fluid bucket 17 Cleanout fluid is injected in microwave cavity 35 execution cleaning function, then by controlling the second electromagnetic valve 28, by the second cleanout fluid bucket 16 In cleanout fluid be injected in microwave cavity 35 execution cleaning function.

Need to change after the reagent in five reagent barrels uses a period of time, but now second be dehydrated the dehydration in liquid bucket 20 Liquid also meets use standard, at this moment can open the 4th electromagnetic valve 37 by the dehydration in the second dehydration liquid bucket 20 by relative program Liquid is injected in the first dehydration liquid bucket 21 and is continuing with.In like manner, now the cleanout fluid in the second cleanout fluid bucket 16 meets equally and makes By standard, at this moment can open the 5th electromagnetic valve 40 by associated control procedures and the cleanout fluid in the second cleanout fluid bucket 16 is injected It is continuing with in the first cleanout fluid bucket 17.

Last it is noted that above-described each embodiment is merely to illustrate the technical solution of the utility model, rather than it is limited System；Although this utility model being described in detail with reference to previous embodiment, it will be understood by those within the art that: Technical scheme described in previous embodiment still can be modified by it, or carries out wherein part or all of technical characteristic Equivalent；And these amendments or replacement, do not make the essence of appropriate technical solution depart from this utility model each embodiment technical side The scope of case.

Claims (9)

1. a rapid pathology tissue processor, including cabinet bulk and intelligent operation platform, described cabinet bulk is internally provided with sample disposal case, paraffin case, vacuum pump, multiple reagent barrel, supersonic generator, it is characterized in that, described sample disposal case is internal is microwave cavity, described microwave cavity connects a microwave source, described sample disposal case and paraffin case, is all attached by conduit assembly between multiple reagent barrel and vacuum pump.

2. rapid pathology tissue processor as claimed in claim 1, it is characterized in that, described sample disposal case is positioned at cabinet bulk inner upper, described microwave cavity is internally provided with rectangle extract hurdle, being provided with temperature sensor, liquid level sensor and vacuum transducer on the sidewall of described microwave cavity, the top of described microwave cavity is provided with the capping with visual window.

3. rapid pathology tissue processor as claimed in claim 1, it is characterised in that described microwave source is located in the exterior side wall of sample disposal case.

4. rapid pathology tissue processor as claimed in claim 1, it is characterised in that described supersonic generator is arranged on the outer wall bottom of sample disposal case.

5. rapid pathology tissue processor as claimed in claim 1, it is characterised in that described vacuum pump is placed on cabinet bulk lower inside, is attached by the first pipeline between described vacuum pump and sample disposal case.

6. rapid pathology tissue processor as claimed in claim 1, it is characterized in that, described paraffin case is positioned at the lower section of sample disposal case, it is provided with temperature sensor and liquid level sensor in described paraffin case internal side wall, it is provided with heating plate on described paraffin bottom face and/or side, second pipe and the 3rd pipeline of parallel connection it is provided with between described paraffin case and sample disposal case, the second electromagnetic valve it is provided with on described second pipe, it is provided with the 3rd electromagnetic valve on described 3rd pipeline, connect on described second electromagnetic valve and have the second electromagnetic pump or the second positive and negative press pump, connect on described 3rd electromagnetic valve and have the 3rd electromagnetic pump or the 3rd positive and negative press pump.

null7. rapid pathology tissue processor as claimed in claim 1，It is characterized in that，The plurality of reagent barrel is five，Including a fixative bucket、Two dehydration liquid buckets、Two cleanout fluid buckets，It is respectively provided with heating rod in described five reagent barrel internal side wall、Temperature sensor and liquid level sensor，It is attached by the 4th pipeline between said two dehydration liquid bucket，It is attached by the 5th pipeline between said two cleanout fluid bucket，It is provided with the 4th electromagnetic valve on described 4th pipeline，Connect on described 4th electromagnetic valve and have the 4th electromagnetic pump or the 4th positive and negative press pump，It is provided with the 5th electromagnetic valve on described 5th pipeline，It is provided with the 5th electromagnetic pump or the 5th positive and negative press pump on described 5th electromagnetic valve，Described fixative bucket、One of them reagent barrel、One of them cleanout fluid bottom of the barrel is provided with discharge conduit，It is provided with stop valve on described discharge conduit.

8. rapid pathology tissue processor as claimed in claim 6, it is characterised in that described second pipe is divided into five branch pipe(tube)s by the second electromagnetic valve, and described five branch pipe(tube)s are respectively protruding in five reagent barrels.

9. the rapid pathology tissue processor as according to any one of the claims 18, it is characterised in that described intelligent operation platform is arranged on the outer upper ends of cabinet bulk.