CN205515739U - Lavage equipment in tissue - Google Patents
Lavage equipment in tissue Download PDFInfo
- Publication number
- CN205515739U CN205515739U CN201620039412.0U CN201620039412U CN205515739U CN 205515739 U CN205515739 U CN 205515739U CN 201620039412 U CN201620039412 U CN 201620039412U CN 205515739 U CN205515739 U CN 205515739U
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- CN
- China
- Prior art keywords
- lavation
- storehouse
- tissue
- pressurization
- lavage
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
The utility model discloses a lavage equipment in tissue, include: the pressurization bin subassembly: integrated four possess the pressurized compartment that independently exhausts the hole and each other do not communicate, and one end is connected with the force (forcing) pump, one end and porous lavage support connnection, and whole pressurizing assembly is connected the inclosed lavage environment of constitution with the lavage storehouse, the lavage storehouse: its one end with the pressurization bin subassembly is connected, the other end in lavage storehouse is equipped with a lavage storehouse outlet, a plurality of porous lavage posts: its with the pressurization bin subassembly is connected and is located inside the lavage storehouse. The utility model discloses can handle whole piece shape tissue (like tendon, ligament tissue), the biology characteristics of the tendon tissue of normally being grown up can be simulated to its diameter and length, satisfy further clinical practice experiment requirement, take off the unnecessary organizational structure who destroys the tendon of cell in -process, detergent concentration and operational time are filled in the furthest reduction, can realize that different lavage concentration, lavage component and lavage time block parallel go on, improve experimental efficiency.
Description
Technical field
This utility model relates to medical instruments field, particularly relates to lavation equipment in a kind of tissue.
Background technology
Along with the raising of people's living standard, and the highlighting of the problem of an aging population, inflammation, regression, machinery and motion are caused
Acute and chronic articular ligament injuries and case day by day increase (most commonly seen with cruciate ligament), lead because of tumor, wound simultaneously
The limb tissue defect caused is also often accompanied by tendon and ligament defect.Above-mentioned situation the most easily causes function of joint impaired, physical disabilities,
Have a strong impact on patients ' life quality.Owing to organizational structure and biomechanical property are close, articular ligament severe injury and tendon tissue
Defect is mainly repaired by autologous tendon transplantation or Tendon allograft.Through the development of decades, ligament and tendon
Recovery technique becomes better and approaching perfection day by day, and therapeutic effect is satisfactory.But overhaul and many tendons after increasing articular ligament is transplanted
During the case of defect, tendon tissue source becomes the Main Bottleneck restricting the development of this technology.Autologous tendon transplantation exists for district to be had
The drawback that limit, damage increase.And there is immunoreation, disease propagation, the problem such as expensive in tendon allograft.
Utilize tissue engineering structure to have good function and the Xenogeneic organ of biocompatibility and tissue is to solve graft at present
The main direction of studying of source shortage problem.Nearly ten years, utilize de-cell technology preparation to eliminate immunogenicity, have former simultaneously
Bit organization organ structure and promotion and induction seed cell oriented growth grow biological tissue's support of microenvironment becomes research heat
Point, biological tissue's support such as skin, cardiac valve and bladder has begun to be applied to clinic.Tendon tissue due to lack blood vessel and
Less cell content and there is good immunologic tolerance, make to utilize xenogenesis (pig) tendon to prepare biological support and be possibly realized.
But tendon tissue compact structure, cell component is buried in collagen fiber, further by fibre bundle film and tendon membrane bound,
It is unfavorable for being removed with cell and immunogenicity substrate.
De-cell technology currently for tendon tissue mainly includes physical damage and chemical washing two ways, and the former includes ultrasonic
Technology and multigelation technology, the latter mainly includes the detergent rinsing of different component.Whether physical interventions or chemical washing
Being all the de-cellular modalities of a kind of ecto-entad, therefore its cell free effect is closely related with tissue thickness, and current document shows
Thickness less than 10mm, there is no the report carrying out de-cellular processes for whole tendon.Along with carrying out of lavation technology,
Application detergent utilizes the blood vessel network of histoorgan to carry out de-cell manipulation more effectively, the most complete at heart and kidney
The preparation of whole de-cytoskeleton is successful in testing.Tendon is carried out from inside to outside by this prompting, equally distributed group of pressure load
Knit interior lavation and can obtain the most de-cell effect.Do not possess the vasoganglion that can be used for lavation due to tendon, therefore cannot apply existing
Some lavation equipment carries out de-cell manipulation, and prior art has the disadvantage in that
1, whether physical damage or chemical rinses technology are all only limitted to act on tissue slice (thickness ＜ 10mm), it is impossible to process
Complete tendon tissue；
2, all have passed through slicing treatment due to tissue slice, destroy adventitia and the inner membrance of tendon tissue, make fibre bundle directly expose
In physical stimulation and chemical detergent, it is impossible to keep tendon its own shape and biomechanical property；
3, multigelation and ultrasonic Treatment can destroy the micro structure of tendon fibre bundle, affect biology performance；
4, in the chemical detergent of high concentration and long rinsing (24～48h) can cause destruction and the organization bracket of micro structure
Detergent remains, and is unfavorable for implanting again of biomechanical property and seed cell；
5, existing malleation irrigation system cannot be applied to the tendon tissue not having blood vessel structure.
Utility model content
The purpose of this utility model is to provide lavation equipment in a kind of tissue, and this equipment and positive pressure pump are used in combination and can complete tendon
The de-cell manipulation of tissue, and many group parallel requirements carried out of experiment can be met.
This utility model is by the following technical solutions:
Lavation equipment in a kind of tissue, including:
Pressurization storehouse assembly, its one end can connect a force (forcing) pump:
Lavation storehouse, its one end is connected with described pressurization storehouse assembly, and the other end in described lavation storehouse is provided with a lavation storehouse discharge outlet；
Some porous lavation posts, it is connected with described pressurization storehouse assembly and is located at inside described lavation storehouse.
Described porous lavation post includes:
Lavation post main body:
The fixing end of lavation post, it is located at described lavation post main body one end；
Cutting tip, it is located at the other end of described lavation post main body；
Side opening, it is located in described lavation post main body.
Any one described side opening is 90 degree with the angle of the line of adjacent two side holes.
Described pressurization storehouse assembly includes:
Pressurization storehouse top cover, it connects positive pressure pump by the some pressurization storehouses joint which is provided with；
Pressurization storehouse base, it removably connects with described pressurization storehouse top cover, and described pressurization storehouse base is connected with described lavation storehouse.
Also include:
Some bins, it is located at described pressurization storehouse chassis interior；
Pressurization storehouse lavation joint union joint, it is connected with described porous lavation post；
Pressurization bin draining/QI KOU, it is located on described bin.
Described pressurization storehouse joint, bin, pressurization storehouse lavation joint union joint and porous lavation post are equipped with four.
Also including one first seal washer, it is located between described pressurization storehouse top cover and described pressurization storehouse base.
Also including one second seal washer, it is located between described lavation storehouse and described pressurization storehouse base.
Also including a base, it is fixed on described pressurization storehouse assembly and the bottom in lavation storehouse.
Described base also includes a scalable callosity, on its described base of fixing support.
The utility model has the advantages that: this utility model can process complete tendon tissue, its diameter and length can simulate normal muscle
The Biological characteristics of tendinous tissue, meets further zoopery requirement；De-cell processes need not destroy the organizational structure of tendon；
Reduce perfusion detergent concentration and action time to greatest extent；Different lavation concentration, lavation component and irrigation time group can be realized put down
Row is carried out, and improves conventional efficient.
Accompanying drawing explanation
Below in conjunction with embodiment and accompanying drawing, this utility model is described in detail, wherein:
Fig. 1 is structural representation of the present utility model.
Fig. 2 a is pressurization storehouse of the present utility model top cover front schematic view.
Fig. 2 b is pressurization storehouse of the present utility model top cover reverse side schematic diagram.
Fig. 3 a is pressurization storehouse of the present utility model base front surface schematic diagram.
Fig. 3 b is pressurization storehouse of the present utility model base reverse side schematic diagram.
Fig. 4 a is lavation storehouse of the present utility model front schematic view.
Fig. 4 b is lavation storehouse of the present utility model reverse side schematic diagram.
Fig. 5 is the structural representation of porous lavation post of the present utility model.
Detailed description of the invention
Of the present utility model detailed description of the invention be expanded on further below in conjunction with the accompanying drawings:
As it is shown in figure 1, the utility model discloses lavation equipment in a kind of tissue, including: pressurization storehouse assembly 13, lavation storehouse 10
With some porous lavation posts 9, pressurization assembly 13 one end, storehouse can connect a force (forcing) pump, and one end, lavation storehouse 10 is connected with described pressurization
Organizing 14 connections, the other end in described lavation storehouse 10 is provided with a lavation storehouse discharge outlet 11；Porous lavation post 9 and pressurization storehouse assembly
13 connect and are located at inside, lavation storehouse 10.When this utility model uses, porous lavation post is placed in complete tendon, due to many
Hole lavation post is provided with multiple, therefore can process simultaneously and organize tendon more, can carry out organizing parallel laboratory test more simultaneously, and owing to porous fills
Washing post can extend into inside tendon, therefore tendon can be carried out in the case of not destroying tendon integrity degree by this utility model,
Complete tendon tissue can be processed.
As it is shown in figure 5, porous lavation post of the present utility model includes: lavation post main body 91, cutting tip 92, fixing end 92 and
Side opening 94: the fixing end 93 of lavation post is located at described lavation post main body 92 one end；Cutting tip 92 is located at described lavation post main body
The other end, side opening 94 is located in described lavation post main body 91. and the line of any one described side opening 94 and adjacent two side holes 94
Angle is 90 degree, and the air line distance of adjacent two side holes 94 is 4mm.It is connected with pressurization storehouse assembly by fixing end 93, thus
The washing liquid of positive pressure pump can be incorporated into lavation post main body 91 internal, spray from side opening 94, thus complete the process cleaned, and by
In angle and the setting of distance of adjacent two side holes 94, can make to clean more comprehensively, there is not the dead angle of cleaning.
Described pressurization storehouse of the present utility model assembly 14 includes: pressurization storehouse joint 1, pressurization storehouse top cover the 2, first seal washer 3,
Pressurization storehouse base 4, some bins 5, pressurization bin draining/QI KOU 6, pressurization storehouse lavation joint union joint 7 and the second sealing gasket
Circle 8.Pressurization storehouse top cover 2 connects positive pressure pump by the some pressurization storehouses joint 1 which is provided with；Pressurization storehouse base 4 adds with described
Pressure storehouse top cover 2 removably connects, and described pressurization storehouse base 4 is connected with described lavation storehouse 10.Some bins 5 add described in being located at
Pressure storehouse base 4 is internal；Pressurization storehouse lavation joint union joint 7 is connected with described porous lavation post 9；Pressurization bin draining/QI KOU 6
It is located on described bin 5.First seal washer 3 is located between described pressurization storehouse top cover and described pressurization storehouse base.Second seals
Packing ring 8 is located between described lavation storehouse 10 and described pressurization storehouse base 4, as Fig. 2 a, Fig. 2 b, Fig. 3 a, Fig. 3 b, Fig. 4 a,
And shown in Fig. 4 b.
Pressurization storehouse joint 1, bin 5, pressurization storehouse lavation joint union joint 7 and porous lavation post 9 in of the present utility model are all provided with
There are four, therefore can carry out four groups of parallel laboratory tests, it is possible to be designed to many groups as required simultaneously.
This utility model also includes a base 12, and it is fixed on described pressurization storehouse assembly 14 and the bottom in lavation storehouse 10.Base 12
Also include a scalable callosity 13, on its described base 12 of fixing support, by this scalable callosity 13, scalable entirety
Highly, as shown in Figure 1.
This utility model is connected with force (forcing) pump is applied in combination by pipeline.Wherein pressurization storehouse footstock and pressurization storehouse bottom constitute pressurization storehouse,
Pressurization storehouse is stainless steel metal material, and each porous lavation post corresponding is divided into four bin Hu Bu UNICOMs, each bin inside it
Possess an inlet opening, steam vent, a lavation column joint, in four encapsulation and a complete cylindrical container, and possess
Pressurization storehouse bottom, pressurization storehouse bottom is sealed by the first sealing ring, it is simple to dismantles, keep in repair and cleans.Lavation storehouse is quartz material,
Its a size of 110x200mm, has processing corrosion-resistant, easy, transparent feature, and in cylinder, one end is closed and possesses lavation
Storehouse discharge outlet, one end is connected with lavation storehouse with screw socket, and is sealed by the second sealing ring.Porous lavation post is by injection rustless steel
Prepared by syringe needle, lavation hole is symmetric, and is spaced 4mm, and according to different experiments needs, lavation pore size distribution length has 20mm and 50mm
Two kinds, can meet 30mm～80mm length, diameter more than the complete tendon of 5mm lavation operation.Base is stainless steel, uses
In placing whole device, and possess three fixing callosities and a scalable callosity for adjusting level.
Pressurization storehouse of the present utility model joint is connected with positive pressure pump, is docked by screw socket with pressurization storehouse top cover 2, is convenient for changing；Add
Pressure storehouse top cover 2 is connected, detachably with pressurization storehouse base by screw socket；First seal washer 3, is used for pressurizeing storehouse top cover 2 and adding
Sealing between pressure storehouse base 3, pressurization storehouse base is pressurization storehouse main part, is divided into four independent bins, with pressurization storehouse top cover
2 and lavation storehouse 10 all docked by screw socket, independent bin 5, each bin have independent lavation joint and pressurization bin draining/
QI KOU 6, and screw socket water discharging valve can be installed, pressurization storehouse lavation interface union joint 7 connects pressurization storehouse by screw socket, passes through buckle
It is connected with porous lavation post 9, and replaceable；Second seal washer 8, close for pressurize between storehouse base 4 and lavation storehouse 10
Envelope.Porous lavation post, connects 10 by buckle and 7, and quartz material lavation storehouse, by screw socket and 4 connections 11, lavation storehouse is arranged
The mouth of a river, can install screw socket water discharging valve 12, base, is used for disposing complete equipment 13, scalable callosity, adjusts for base level
Joint.
This utility model can carry out four groups of parallel tests simultaneously, it is possible to processes diameter complete in 30～60mcm of 5～10mm length
Whole tendon tissue (can process longer tendon tissue) after HardwareUpgring, need not destroy the organizational structure of tendon in de-cell processes,
Need not physical treatment, be experimentally verified that detergent concentration can reduce 75%, rinsing time is down to 6 hours, at utmost keeps
The biomechanical property of tendon.Length can be made exceed by increasing the length in lavation storehouse and the method in tail end adjunction pressurization storehouse
The de-cell biological tendon scaffold of 120mm, meets clinical tendon transplantation needs.Fill by connecting vacuum suction at lavation storehouse tail end
Putting can be formation negative pressure state in storehouse, strengthens the effect of malleation lavation, and is likely applied to muscular tissue, hollow organ etc.
The de-cell manipulation of organization bracket.By perpendicular for lavage apparatus dress, coordinate with magnetic stirring apparatus, eddy current can be formed in lavation storehouse
The de-cell manipulation of the organization brackets such as flushing, strengthens the effect of malleation lavation, and be likely applied to muscular tissue, hollow organ
Right.
This utility model can process complete tendon tissue, and its diameter and length can simulate the Biological characteristics of normal muscle tendinous tissue,
Meet further zoopery requirement；Can complete the pressurization lavation process to tendon from-inner-to-outer, pressure meets and is evenly distributed,
Reach comprehensive de-cell requirement；De-cell processes need not destroy the organizational structure of tendon；Reduce perfusion detergent to greatest extent
Concentration and action time；Can realize different lavation concentration, lavation component is parallel with irrigation time group carries out, and improves conventional efficient；
Field-replaceable unit is for processing longer tendon or other allied organizations.
The foregoing is only preferred embodiment of the present utility model, not in order to limit this utility model, all new in this practicality
Any amendment, equivalent and the improvement etc. made within the spirit of type and principle, should be included in protection model of the present utility model
Within enclosing.
Claims (10)
1. lavation equipment in a tissue, it is characterised in that including:
Pressurization storehouse assembly, its one end can connect a force (forcing) pump:
Lavation storehouse, its one end is connected with described pressurization storehouse assembly, and the other end in described lavation storehouse is provided with a lavation storehouse discharge outlet；
Some porous lavation posts, it is connected with the independently pressurized room interface of described pressurization storehouse assembly and is located at inside described lavation storehouse.
Lavation equipment in tissue the most according to claim 1, it is characterised in that described porous lavation post includes:
Lavation post main body:
The fixing end of lavation post, it is located at described lavation post main body one end；
Cutting tip, it is located at the other end of described lavation post main body；
Side opening, it is located in described lavation post main body.
Lavation equipment in tissue the most according to claim 2, it is characterised in that the company of any one described side opening and adjacent two side holes
The angle of line is 90 degree, and spacing is 4mm.
Lavation equipment in tissue the most as claimed in any of claims 1 to 3, it is characterised in that described pressurization Cang Zujianbao
Include:
Pressurization storehouse top cover, it connects positive pressure pump by the some pressurization storehouses joint which is provided with；
Pressurization storehouse base, it removably connects with described pressurization storehouse top cover, and described pressurization storehouse base is connected with described lavation storehouse.
Lavation equipment in tissue the most according to claim 4, it is characterised in that also include:
Some bins, it is located at described pressurization storehouse chassis interior；
Pressurization storehouse lavation joint union joint, it is connected with described porous lavation post；
Pressurization bin draining/QI KOU, it is located on described bin.
Lavation equipment in tissue the most according to claim 5, it is characterised in that described pressurization storehouse joint, bin, pressurization storehouse fill
Wash joint union joint and porous lavation post is equipped with four.
Lavation equipment in tissue the most according to claim 4, it is characterised in that also include one first seal washer, it is located at institute
State between pressurization storehouse top cover and described pressurization storehouse base.
Lavation equipment in tissue the most according to claim 4, it is characterised in that also include one second seal washer, it is located at institute
State between lavation storehouse and described pressurization storehouse base.
Lavation equipment in tissue the most according to claim 4, it is characterised in that also include a base, it is fixed on described pressurization
Storehouse assembly and the bottom in lavation storehouse.
Lavation equipment in tissue the most according to claim 9, it is characterised in that described base also includes a scalable callosity,
For its described base of fixing support of whole device horizontal adjustment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620039412.0U CN205515739U (en) | 2016-01-15 | 2016-01-15 | Lavage equipment in tissue |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620039412.0U CN205515739U (en) | 2016-01-15 | 2016-01-15 | Lavage equipment in tissue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205515739U true CN205515739U (en) | 2016-08-31 |
Family
ID=56764037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620039412.0U Expired - Fee Related CN205515739U (en) | 2016-01-15 | 2016-01-15 | Lavage equipment in tissue |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN205515739U (en) |
-
2016
- 2016-01-15 CN CN201620039412.0U patent/CN205515739U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160831 Termination date: 20170115 |