CN205506850U - A reagent storehouse for external diagnostic equipment - Google Patents

Abstract

The utility model provides a reagent storehouse for external diagnostic equipment, including reagent strorage device and reagent mixing conveyer, be provided with the heat preservation in reagent strorage device's periphery, reagent strorage device installs on reagent mixing conveyer, reagent mixing conveyer includes transfer device and drive arrangement, transfer device includes conveying mechanism and mixing mechanism. Reagent storehouse reagent memory space is big, can transport reagent to the reagent collection position of analysis appearance accurately. And can be in transportation reagent, effective mixing of realization reagent.

Description

Agent bin for in-vitro diagnosis equipment

Technical field

This utility model relates to medical instruments field, particularly to the agent bin of a kind of in-vitro diagnosis equipment.

Background technology

Fully-automated synthesis analyser can be automatically performed from sample-adding, reagent adding, react, detects, goes out the sequence of operations steps such as testing result.Use fully-automated synthesis analyser to determine the content of certain composition in tested sample, become the most universal.Such as Full-automatic chemiluminescence immunoassay analysis meter, including sample storehouse, agent bin, reaction warehouse and detection storehouse.The detection process of analyser generally comprises: first sample and reagent are respectively put into sample storehouse and agent bin, then sample and reagent are joined in reaction cup, make again reaction cup respectively through incubation, separate, the system such as cleaning, finally make reaction cup enter airtight darkroom and complete to measure.

Chemiluminescence immune assay (chemiluminescence immunoassay, CLIA), it is to combine having highly sensitive chemical luminescent detecting technology with the immunoreation of high specific, so as to the analytical technology of the various antigen of detection by quantitative, hapten, antibody, hormone, enzyme, fatty acid, vitamin and medicine etc..Needing plurality of reagents in chemiluminescence immune assay, including solid-phase reagent, conventional solid-phase reagent is the magnetic particle of labelling.Require during use that magnetic particle reagent concentration is evenly distributed, and magnetic particle the most easily precipitates, and causes uneven.If magnetic particle reagent participates in correlated response again after precipitating will have a strong impact on stability and the reliability of test result.So needing to be mixed before using magnetic particle reagent.

Current Full-automatic chemiluminescence immunoassay analysis meter uses rabbling mechanism to be stirred magnetic particle reagent mixing, but this mode not only mixing time length, weak effect, and it is easily created cross-contamination.And handle up with high frequency or concussion method mixing magnetic particle reagent, it is impossible to meet the requirement that the magnetic particle reagent in multiple test kit mixes simultaneously, the detection speed of fully-automatic analyzer can be reduced.Using transmission to coordinate in the method for mixing magnetic particle reagent, analytical tool includes test kit transport unit and magnetic particle reagent mixing portion.Corresponding test kit can be transported to the reagent collection position of analyser according to detection purpose needs by fully-automatic analyzer by transport unit, and during transporting test kit, magnetic particle reagent is mixed by the way of transmission coordinates by mixing portion.But in existing design, transport unit and mixing partly belong to separate movement system.These relatively independent scattered structures, can reduce operation accuracy and the reliability of analyser, increase complexity and the cost of the manufacturing that analyser assembles.The module of frame for movement is complicated and various, also can increase the volume of analyser itself, makes analyser the hugest, needs to take more lab space.

In existing fully-automated synthesis analyser, the cooperation between test kit and test kit bracket, it usually needs by complicated fit structure parts such as hook members to keep test kit position on test kit bracket.Thus not only time-consuming during manufacturing test kit and test kit bracket, and cost is high.Between test kit and bracket, structure is the compactest, and volume is big.Mechanical noise, the accuracy of detection of impact analysis instrument can be produced between assembling fittings, and increase follow-up maintenance difficulty and cost.

At detection analysis field, generally require the detection using plurality of reagents to go a project.When utilizing fully-automated synthesis analyser detection project, plurality of reagents can be integrated in a test kit, and this test kit is put into fully-automatic analyzer.Having multiple reagent bottle storage chamber in test kit, different reagent is installed in different reagent bottle.These are placed in advance in test kit storage chamber equipped with the reagent bottle of reagent.

When detecting different projects, need to change the test kit in analyser.Or the reagent in test kit used up, it is also desirable to change test kit.Using the test kit not having handle, operator must catch the body of test kit to be taken out by test kit.If test kit discharges very tight in analyser, i.e. test kit is mutually close to, and the space so leaving operator's finger grip test kit for is little, and this allows the taking-up of test kit become very inconvenient.And on some test kit, can additionally increase a handle, although operator extracts test kit and becomes very convenient, but due to the existence of handle, it needs to take the space that instrument is certain, adds the overall volume of instrument.This not only increases the material cost of instrument, also therefore can take more lab space.

According to the needs of medical science detection, sometimes one sample has needed multiple detection project.Such as analyze whether patient exists certain infectious disease, it is necessary to the sample of patient is carried out the detection of HSV-I, HSV-II, RV, HCMV and the TOXO in HBsAg, HBsAb, HBeAg, HBeAb, HBcAb, HCV, ToRCH series, Chlamydia, Gonorrhea, HIV, Syphilis etc..Analyze and whether clinical samples exists tumor markers, need to detect such as PSA, Cyfra21-1, AFP, CEA, NSE, CA19-9, CA15-3, CA72-4, CA125, CA 50, ProGRP, Fer, TPS, GPC3 etc..In order to understand whether detected person exists Drug Abuse, the detection project of needs includes MOP, AMP, BAR, COC, MET, THC, BZO, MDMA, MTD, OPI, PCP etc..Different detection projects needs to use different detectable.It is thus desirable to the agent bin in fully-automatic analyzer can disposably put into abundant test kit, with the requirement of satisfied detection.If it is insufficient that the test kit of agent bin deposits position, same detection series can be caused, such as, during the detection of infectious disease series, need to be put into by corresponding detection test kit in batches analyser completes detection in batches.First putting in analyser by the test kit of detection HBsAg, HBsAb, HBeAg, HBeAb, HBcAb, HCV, Chlamydia, Gonorrhea, now the test kit of the agent bin of analyser is deposited position and has been piled, and then starts detection.After first project has detected, take out first test kit used, then place into the detection kit of HSV-I, HSV-II, RV, HCMV, TOXO, Chlamydia, Gonorrhea, HIV, Syphilis in ToRCH series.This have impact on the progress analyzing detection.

Utility model content

For the problems of the prior art solved, this utility model provides a kind of agent bin for in-vitro diagnosis equipment, transporter is mixed including reagent storage device and reagent, the periphery of reagent storage device is provided with heat-insulation layer, reagent storage device is arranged on reagent mixing transporter, described reagent mixing transporter includes transporter and driving means, described transporter includes that conveyer and mixing mechanism, conveyer and mixing mechanism mutually connect together composition bearing arrangement.

Further, conveyer and mixing mechanism are circular ring structure, and conveyer is arranged in the centre bore of mixing mechanism, and driving means includes driving motor and drive end, and drive end is arranged in the centre bore of conveyer.

Further, conveyer is inner gear structure, and mixing mechanism is external gear structure, driving tooth bar it is provided with on drive end, described driving tooth bar engages each other with the internal gear of conveyer, and described tumbler is gear, and described tumbler gear engages each other with the external gear of mixing mechanism.

Further, agent bin also includes agent bin refrigerating plant.

Further, agent bin also includes position clearing device.

Further, described reagent storage device includes test kit bracket and test kit, and test kit includes several reagent storage chambeies, and the horizontal cross-section of containing cavities and test kit is fan annular.

Further, between described containing cavities, be provided with dividing plate, dividing plate upper edge be provided with test kit positioning port, the two side of test kit includes the keeper suitable with described positioning port.

Agent bin volume described in the utility model is little, and structure is ingenious, simple and reliable, be easily assembled, and complete machine operational reliability is high, low cost of manufacture.And magnetic particle blending manner of the present utility model is simple and reliable, Blending Efficiency of Blending is good, no cross contamination risk and can simultaneously mix several magnetic particle reagent.Described detectable storing unit efficiently utilizes space, increases reagent amount of storage.By keeper and the cooperation of positioning port between test kit and test kit bracket, can be more securely placed in agent bin by test kit, this matching mechanism is effectively reduced the shake of test kit, reduces the noise of analyser.Described reagent bottle and the fit structure of the shackle member of test kit, while mentioning reagent bottle, it is possible to is mentioned together by test kit box body, maintains the balance of whole box body, and is unlikely to because tilting, the danger that reagent pours occurs.

Accompanying drawing explanation

The schematic diagram that Fig. 1 test kit box body separates with reagent bottle.

Fig. 2 test kit box body schematic diagram together with reagent bottle combination.

Fig. 3 test kit puts into test kit bracket schematic diagram.

The schematic diagram that the keeper that Fig. 4 shifts to install coordinates with the positioning port on bracket.

The schematic diagram that the keeper of the corresponding setting of Fig. 5 coordinates with the positioning port on bracket.

It is provided with, on Fig. 6 test kit only one of which sidewall, the schematic diagram that keeper coordinates with the positioning port of bracket.

Fig. 7 projection puts into the top view of test kit box body along fastener passage.

Fig. 8 projection turns to the top view under lid eaves.

Fig. 9 projection puts into the Local map of test kit box body along fastener passage.

Figure 10 projection turns to the Local map under lid eaves.

The schematic diagram that on Figure 11 reagent bottle, L-type structural member coordinates with inverted concave structural member in box body.

The schematic diagram that on Figure 12 reagent bottle, buckling piece coordinates with buckling groove in box body.

The schematic diagram that Figure 13 reagent storage device coordinates with reagent mixing transporter.

Figure 14 reagent mixing transporter schematic diagram.

Figure 15 reagent mixing transporter schematic diagram.

Figure 16 agent bin top view.

Figure 17 is the agent bin sectional view in Figure 16 A-A direction.

Figure 18 puts into the agent bin schematic diagram of test kit.

Figure 19 is with the agent bin schematic diagram of refrigerating plant.

The internal structure schematic diagram of Figure 20 Full-automatic chemiluminescence immunoassay analysis meter.

Figure 21 Full-automatic chemiluminescence immunoassay analysis meter schematic diagram.

Figure 22 removes the Full-automatic chemiluminescence immunoassay analysis meter of sample storehouse side shield.

Detailed description of the invention

Further describe this utility model below in conjunction with the accompanying drawings with embodiment, but protection domain of the present utility model is not limited to this.

A kind of Full-automatic chemiluminescence immunoassay analysis meter 9000, if Figure 20 is to including sample storehouse 9300, agent bin 9400, reaction cup storage warehouse 9500 shown in 22, hatching storehouse 9600, cleaning storehouse 9700 and detection storehouse 9800.When sample to be tested carries out component analysis, first sample and reagent being respectively put into sample storehouse and agent bin, Full-automatic chemiluminescence immunoassay analysis meter takes out reaction cup from reaction cup storage warehouse 9500, and puts it into and hatch in storehouse.Then by predetermined program, sample and reagent are joined in reaction cup, start and hatch program, cleaning procedure, finally make reaction cup enter detection storehouse and complete sample component analysis.Wherein said sample storehouse includes that identity information reading device, described agent bin include that reagent mixes transporter.

As illustrated in fig. 1 and 2, box body 2 and mixing chamber 3 is included for depositing the test kit 1 of detectable, needing the reagent of mixing when described mixing chamber 3 is for depositing detection, described reagent can be directly loadable into this mixing intracavity, or places in mixing chamber 3 after being previously charged into reagent bottle.If it is required, test kit can also include storage chamber 4, when described storage chamber 4 is for depositing detection, mixing being required the highest reagent, described reagent can be directly loadable in this storage chamber, or places in storage chamber 4 after being previously charged into reagent bottle.

In the embodiment shown in fig. 1, the reagent that need to mix is previously charged in mixing reagent bottle 5, and described mixing reagent bottle 5 is provided with tumbler 6.Mixing reagent bottle 5 equipped with reagent puts into the mixing chamber 3 of test kit, and tumbler 6 has driven mixing reagent bottle 5 to rotate in mixing chamber 2 when rotating, make the reagent in reagent bottle 5 because rotating and being in suspension mixing state.Tumbler 6 can be the structure that mixing reagent bottle 5 carries, and the most as shown in Figure 1 before reagent bottle 5 puts into mixing chamber, tumbler 6 is inherently already installed on reagent bottle 5.Tumbler 6 can also is that single parts, and after mixing reagent bottle 5 puts into mixing chamber 3, mixing reagent bottle coordinates with tumbler, thus reagent bottle 5 and tumbler 6 is fitted together.When tumbler is as separate part, it may be mounted on test kit, or be arranged on the matching used instrument of test kit.In the embodiment depicted in figure 2, after reagent bottle 5 puts into mixing chamber 3, tumbler 6 is positioned at the breach 31 in mixing chamber 3.

It is provided with positioning port 104 in the cavity wall in test kit storage chamber and/or mixing chamber, corresponding on reagent bottle 11 tube wall is provided with keeper 7.Before reagent bottle is put into storage chamber and/or mixing chamber, first reagent bottle keeper 7 is directed at positioning port 104, then allows reagent bottle down into containing cavities and/or mixing intracavity, so can ensure that reagent bottle is accurately placed at containing cavities and/or mixing intracavity.The upper surface of keeper 7 is concordant with the upper surface of reagent bottle, and the degree of depth of positioning port 104 is identical with the depth degree of depth of keeper 7.After reagent bottle keeper inserts along positioning port, if the upper surface of keeper is concordant with the upper surface of positioning port, this explanation reagent bottle is put into position the most exactly.

In another embodiment, the inwall of storage chamber also includes a shell fragment, the reagent bottle being placed in storage chamber for clamping.

At detection field, such as, in chemiluminescence immunoassay detection, the detection completing a project needs plurality of reagents, including the reagent of band solid phase, such as, contains the reagent of magnetic particle.Therefore selecting described in the utility model with mixing chamber 3 and the test kit of multiple storage chamber 4, described mixing reagent bottle put into by the reagent equipped with magnetic particle.

During detection, test kit corresponding for the project that detects is put in analyser.In one embodiment, analyser includes the test kit bracket for carrying test kit, according to detection purpose kind, corresponding detection kit is put into the relevant position of described test kit bracket, start and once can complete the detection of multiple project realizing analyser.

Test kit bracket 100 as shown in Figure 3 includes inner ring 101 and dividing plate 102, and dividing plate is arranged on inner ring, and forming a horizontal cross-section between two dividing plates 102 is the containing cavities 103 fanning annular, and containing cavities is used for placing test kit 1.In one embodiment, the number of containing cavities 103 is arranged in the way of volume test kit can be received by test kit bracket.Such set-up mode, can meet more detection project, in series detects, avoids the need for putting at twice test kit.

In one embodiment, the upper edge of test kit bracket dividing plate 102 is provided with positioning port 104, corresponding to being provided with keeper 7 at dividing plate positioning port 104 on test kit as shown in Figure 2.Before test kit is put into the containing cavities of bracket, first test kit keeper is directed at positioning port, then allow test kit down in containing cavities, so can ensure that test kit is accommodated in containing cavities 103 exactly, ensure that when detection process gathers reagent, the liquid device of adopting of analyser can enter reagent storage chamber like clockwork or mix intracavity, and is unlikely to adopt liquid device and encounters the upper cover of test kit, has damaged and has adopted liquid device.In another embodiment, in order to reduce analyser weight, test kit bracket containing cavities is up/down perforation, is not provided with the base plate for supporting test kit bottom containing cavities.Therefore the cooperating of keeper and positioning port, has an effect supported to the test kit being placed in containing cavities 103.The depth degree of depth of keeper 7 is identical with the degree of depth of positioning port 104, and after test kit puts into containing cavities, if the upper surface of keeper is concordant with the upper surface of positioning port, this explanation test kit has been put into position, meets the requirement that analyser runs.In embodiment as shown in Figures 1 to 3, the upper surface 71 of keeper 7 is concordant with the upper surface 8 of test kit, and the degree of depth of positioning port 104 is identical with the depth degree of depth of keeper 7.After test kit keeper inserts along positioning port, if the upper surface of keeper 71 is concordant with the upper surface of positioning port, this explanation test kit has been put into position.The design that the upper surface 71 of keeper 7 is concordant with the upper surface 8 of test kit, can allow operator observe whether test kit is put into position more easily.

In one embodiment, the interlaced arrangement of keeper on test kit two side.Specifically, test kit the first side wall being provided with keeper, keeper on test kit the second sidewall is also not arranged on the position that the first side wall keeper is corresponding.Being further illustrated, as it is shown in figure 1, include interposition keeper 72 on one sidewall of test kit, another sidewall of test kit includes left keeper 73 and right keeper 74, left and right keeper lays respectively at the both sides that interfix part is corresponding.As shown in Figure 4, according to the method shown in the present embodiment, three pieces of dividing plates 102 with identical positioning port 104 set-up mode constitute two containing cavities 103, have after two test kits 1 of identical keeper set-up mode put into described containing cavities, and two test kits lean against the both sides of same dividing plate closely.The interfix part 72 of the first test kit coordinates with dividing plate positioning port interlacedly with the left keeper 73 of the second test kit and right keeper 74.The left keeper 73 of the first test kit and right keeper 74 coordinate with dividing plate positioning port interlacedly with the 3rd test kit interfix part 72.The interfix part 72 of the second test kit left and right keeper with the 4th test kit again is staggered.Such design reduces the usage quantity of dividing plate, thus reduces the volume of analyser.And test kit two side all has membrane support, it is ensured that test kit shelf stability in containing cavities.The embodiment illustrated in fig. 4 design compared to Fig. 5, often depositing two test kits, test kit bracket just less with one piece of dividing plate, thus can reduce the space that test kit bracket takies, also allowing test kit bracket because reducing dividing plate number, and vacateing more space and depositing more test kit.The keeper 7 of the test kit two side shown in Fig. 5 is mutually correspondingly arranged, when two test kits put into containing cavities, it is necessary to use four pieces of dividing plates 102.Executing the example design compared to Fig. 6 shown in Fig. 4, test kit is deposited more stable.As shown in Figure 6, can put down two test kits to realize the containing cavities of three pieces of dividing plate compositions, test kit is only provided with keeper 7 on a sidewall.After test kit puts into containing cavities 103, not having the test kit side of keeper not have dividing plate 102 to support, this is the most built on the sand in making test kit be placed on containing cavities.

May also include test kit positioning and guiding groove 105 on test kit bracket inner ring, test kit is provided with guide 9.When test kit puts into containing cavities, guide 9 is inserted in gathering sill 105, and moves down along gathering sill.Gathering sill and the matching design of guide, allow test kit can put into containing cavities quickly and accurately.In embodiment as shown in Figures 2 and 3, gathering sill 105 is positioned at the centre position of two dividing plates, and guide 9 is positioned at the outer middle side part of test kit narrow end.In another embodiment, guide being also equipped with stop block 10, the width of stop block is more than the width of rebate of gathering sill.As it is shown on figure 3, after guide 9 is inserted into gathering sill, stop block 10 is positioned at the outside of gathering sill 105, further define test kit position in containing cavities.

The inner side of test kit bracket inner ring may also include a reinforced wall 106, and described reinforced wall 106 is further ensured that test kit bracket shape, such as circular.In analyser running, the test kit bracket of dimensionally stable, it is ensured that reagent sampling accuracy.After test kit puts into containing cavities, the upper surface of described reinforced wall 106 bottom stop block 10, can also be resisted against, play the effect supporting test kit further.

For the reagent storage device of full-automatic vitro diagnosis assays instrument, including test kit 1 described in the utility model and test kit bracket 100.Test kit bracket includes containing cavities 103, and the number of described containing cavities 103 is arranged in the way of volume test kit can be received by this test kit bracket.Test kit includes reagent storage chamber 4 and/or mixing chamber 3.Described storage chamber 4 and/or the number in mixing chamber 3 and its volume are arranged in the way of this test kit can be received most kind reagent and/or most reagent amount of storage.At test kit as shown in Figure 1, it is positioned at the reagent mixing chamber 3 of test kit narrow end including three circular reagent storage chambeies 4 and 1.It is provided with the storage chamber being relatively large in diameter at the middle part of test kit, at test kit width end, is arranged side by side two identical storage chambers of diameter.The outward flange in described storage chamber and mixing chamber is tangent with the inwall of test kit.In one embodiment, storage chamber fills up whole test kit.

In one embodiment, the horizontal cross-section of containing cavities and test kit is fan annular.The number in the number of containing cavities and reagent storage chamber is combined so that the amount of reagent that reagent storage device can be deposited reaches reagent storage device can deposit the maximum of amount of reagent.

In one embodiment, described reagent bottle 11 includes fastener, described storage chamber 4 includes block piece.Block piece is used for stopping that fastener leaves storage chamber.When block piece stops fastener, while mentioning reagent bottle, it is possible to test kit box body is mentioned together.Keep the balance of whole box body, and be unlikely to tilt, the danger that reagent pours occurs.

In Fig. 1 and Fig. 7 to the embodiment shown in 10, test kit 1 includes box body 2 and storage chamber 4, and storage chamber is for depositing reagent or the reagent bottle equipped with reagent.Include fastener on described reagent bottle 11, described storage chamber 4 includes block piece and fastener passage 12.In one embodiment, described fastener is the projection 13 being arranged on reagent bottle outer wall.Block piece is the lid eaves 14 of box body upper cover, and described lid eaves belongs to a part for box body upper cover, lid eaves 14 than the inwall of storage chamber 3 closer to the center of storage chamber cross section.Described fastener Channel 12-Bit is at upper cover and adjacent with block piece.Projection 13 is entered by fastener passage 12 or is left storage chamber.As shown in figures 7 and 9, when needs put into reagent bottle 11 in box body 1, first the projection 13 on reagent bottle being directed at fastener passage 12, then reagent bottle is toward transferring to storage chamber.As shown in figures 8 and 10, after reagent bottle arrives position set in advance, rotating reagent bottle, the projection 13 (i.e. fastener) on reagent bottle turns to the lower section of lid eaves 14 (i.e. block piece), now reagent bottle cannot leave from box body.When mentioning reagent bottle, box body is raised the most together, the most just can be put in analytical tool by test kit, or takes out from analytical tool.When rotating reagent bottle, projection is gone at fastener passage 12, make projection 13 be no longer at the lower section of lid eaves 14, thus reagent bottle can remove from box body.In a preferred version, the tail end of described projection includes a stop member 131, and the height of described stop member is higher than the bottom surface of lid eaves.When projection turns to the lower section of lid eaves, stop member will not pass through lid eaves, so that it is determined that projection has forwarded position to.

In embodiment as shown in figure 11, described fastener is L-type structural member 15, and described block piece is inverted concave structural member 16.After reagent bottle arrives position set in advance, rotating reagent bottle, turn in inverted concave structural member 16 by the L-type structural member 15 on reagent bottle, now reagent bottle cannot leave from box body.While mentioning reagent bottle, it is possible to box body is mentioned together.

In embodiment as shown in figure 12, described fastener is a buckling piece, and buckling piece includes elastic snap arm 17 and card base 18, and one end of snap arm 17 is arranged on the outer wall of reagent bottle.Described block piece is buckling groove 19.When reagent bottle is put into storage chamber, snap arm 17 is pressed to reagent bottle outer wall, and descending along the riser 20 of buckling groove 19, and until card base 18 snaps in buckling groove 19, the riser 20 of buckling piece stops card base to move upward out storage chamber.When reagent bottle changed by needs, as long as again snap arm 17 being pressed to reagent bottle outer wall, card base 18 is made to leave buckling groove 19, such that it is able to taken out from box body by reagent bottle.

Reagent mixing transporter includes transporter and driving means, and transporter includes that conveyer 201 and mixing mechanism 202, conveyer 201 and mixing mechanism 202 mutually connect together composition bearing arrangement.Conveyer is used for placing test kit, and test kit is sent to the relevant position of analyser.Mixing mechanism 202 coordinates with tumbler 6, for mixing the reagent needing mixing in test kit.Driving means includes drive end 301 and power part 302.Driving means drives conveyer 201 to produce relative motion with mixing mechanism, is used between tumbler 6 and the mixing mechanism 202 of reagent mixing and produces transmission, thus realizes transhipment and the mixing of detectable.

In Figure 13 to the embodiment shown in 17, conveyer 201 and mixing mechanism 202 are circular ring structure, and conveyer is arranged in the centre bore of mixing mechanism, and both are assembled to each other becomes a bearing arrangement.In embodiment as shown in figure 15, between conveyer 201 and mixing mechanism 202, it is provided with ball 203.Mixing mechanism is fixedly mounted on analyser.The drive end 301 of driving means is arranged in the centre bore of conveyer.In one embodiment, conveyer 201 is inner gear structure, and mixing mechanism 202 is external gear structure, and drive end 301 is provided with driving tooth bar, and described driving tooth bar engages with the internal gear of conveyer, and power part 302 is motor.Test kit mixing intracavity as shown in Figure 2 includes the bottom mixing reagent bottle 5 with tumbler 6, and reagent bottle is built with the magnetic particle reagent of needs mixing, and described tumbler 6 is gear structure.When test kit 1 is positioned on conveyer 201, the external gear being installed on the gear bottom reagent bottle (tumbler) and mixing mechanism 202 engages each other.Opening motor makes drive end rotate, and drive end drives conveyer to rotate, and the test kit being placed on conveyer rotates the most together, makes gear produce transmission with the external gear of mixing mechanism.There is rotation with the reagent bottle of tumbler in bottom under mixing mechanism with tumbler engaged transmission, makes the reagent being contained in reagent bottle mix because of rotation.In the present embodiment, mixing mechanism is fixedly mounted on analyser, and mixing mechanism can not rotate, and conveyer rotates around the central shaft of mixing mechanism.In another scheme, conveyer and mixing mechanism can also rotate against around same central shaft.

The kind of drive between described drive end 301 and conveyer 201 is also selected from the modes such as meshed transmission gear, frictional drive, pulley drive.The kind of drive between mixing mechanism 202 and tumbler 6 can also be from the mode such as meshed transmission gear, frictional drive.

Conveyer and mixing mechanism are fitted together with bearing arrangement form, conveyer and the mixing mechanism coefficient of friction in motor process can be reduced, lower mechanical noise when machine runs, reduce the energy consumption that analyser runs, extend the service life of analyser.Compared to prior art needing respectively conveyer and mixing mechanism are installed to analyser step by step, conveyer described in the utility model and mixing mechanism can be as an integral installation in analysers, this makes to install simple, convenient, is conducive to regularly maintaining, cleans, changes.And parastate that conveyer and mixing mechanism horizontal plane keep mutual can be effectively ensured, so that it is guaranteed that both position relationships are stable, keeps higher dynamic equilibrium state, the running precision of raising analyser.In long-term running so that the cooperation of tumbler and mixing machine component is stable, it is not easy to the phenomenon of tooth occurs to beat.Conveyer and mixing mechanism are assembled into bearing arrangement, and on analyser, corresponding assembly parts will reduce, thus saves the installing space of analyser parts.Drive end is arranged in conveyer centre bore, make use of the idle space of analyser well so that the volume of analyser entirety becomes less.

In another embodiment, mixing mechanism 202 is arranged in the centre bore of conveyer 201, and both are assembled to each other becomes bearing arrangement.Conveyer 201 is external gear structure, and mixing mechanism 202 is inner gear structure, and drive end is arranged on the outer side edges of conveyer.

In one embodiment, conveyer includes pedestal and mounting seat, and pedestal is positioned at the centre bore of mixing mechanism, and interconnects in the way of bearing with mixing mechanism, and mounting seat is arranged on described pedestal, and mounting seat is used for placing test kit.The driving member coordinated with drive end is included in mounting seat.Drive end drive installation seat rotates, and mounting seat drives conveyer to rotate relative to mixing mechanism, and the test kit being placed in mounting seat rotates the most together, makes tumbler produce transmission with mixing mechanism.There is rotation with the reagent bottle of tumbler in bottom under mixing mechanism with tumbler transmission, makes the reagent being contained in reagent bottle mix because of rotation.In another embodiment, conveyer does not include the driving member coordinated with drive end, and mixing mechanism does not include the driving member coordinated with tumbler, and conveyer and mixing mechanism are assembled to each other and become bearing arrangement.Described driving member, such as gear, brake pad, as independent parts, be separately mounted to the relevant position of conveyer and mixing mechanism.

The agent bin 400 of fully-automatic analyzer includes reagent storage device and reagent mixing transporter.Described reagent mixing transporter includes transporter and driving means, and transporter includes that conveyer 201 and mixing mechanism 202, conveyer 201 and mixing mechanism 202 mutually connect together composition bearing arrangement.Reagent storage device includes that test kit and test kit bracket, described test kit bracket 100 are arranged on described conveyer 201, and test kit 1 puts into test kit bracket 100.The tumbler 6 being connected with the reagent bottle equipped with mixing reagent cooperates with the driving member of mixing mechanism 202.Driving means includes drive end 301 and power part 302.When reagent mixing transporter runs, driving means drives conveyer 201 to produce relative motion with mixing mechanism, is transported to test kit detect corresponding position.Simultaneously along with the rotation of conveyer, producing transmission between tumbler and the mixing mechanism of reagent mixing, there is rotation in reagent bottle under mixing mechanism with tumbler transmission in test kit, makes the reagent being contained in this reagent bottle mix because of rotation.

As depicted in figs. 18-19 agent bin 400 also include heat-insulation layer 401 and Cang Gai, make agent bin be in relatively insulation and airtight state.Reagent storage device is surrounded within it by heat-insulation layer, keeps the reagent in agent bin to be in temperature constant state.Described agent bin also includes agent bin refrigerating plant 403, for the refrigeration of agent bin.In one embodiment, semiconductor chilling plate elected as by described refrigerating plant.In one embodiment, at the bottom of refrigerating plant is arranged on the storehouse of agent bin.Agent bin also includes reagent bottle null pick-up 404, for judging the initial position of agent bin.

A kind of reagent mixing method of fully-automatic analyzer, the test kit that first will be equipped with detectable is put into agent bin, and is positioned on test kit bracket described in the utility model.Described test kit bracket cooperates with reagent described in the utility model mixing transporter.When reagent mixing transporter runs, the driving means of fully-automatic analyzer drives conveyer 201 to produce relative motion with mixing mechanism, and according to detection purpose needs, corresponding test kit is transported to the reagent of analyser and gathers position by conveyer.Simultaneously along with the rotation of conveyer, producing transmission between tumbler and the mixing mechanism of reagent mixing, there is rotation in reagent bottle under mixing mechanism with tumbler transmission in test kit, makes the reagent being contained in this reagent bottle mix because of rotation.

Claims (7)

1. for the agent bin of in-vitro diagnosis equipment, transporter is mixed including reagent storage device and reagent, the periphery of reagent storage device is provided with heat-insulation layer, reagent storage device is arranged on reagent mixing transporter, described reagent mixing transporter includes transporter and driving means, described transporter includes conveyer and mixing mechanism, it is characterised in that conveyer and mixing mechanism mutually connect together composition bearing arrangement.

Agent bin the most according to claim 1, it is characterized in that, conveyer and mixing mechanism are circular ring structure, and conveyer is arranged in the centre bore of mixing mechanism, driving means includes driving motor and drive end, and drive end is arranged in the centre bore of conveyer.

Agent bin the most according to claim 2, it is characterised in that conveyer is inner gear structure, mixing mechanism is external gear structure, and drive end is provided with driving tooth bar, and described driving tooth bar engages each other with the internal gear of conveyer.

Agent bin the most according to claim 1, it is characterised in that agent bin also includes agent bin refrigerating plant.

Agent bin the most according to claim 1, it is characterised in that agent bin also includes position clearing device.

Agent bin the most according to claim 1, it is characterised in that described reagent storage device includes test kit bracket and test kit, test kit includes several reagent storage chambeies, and the horizontal cross-section of containing cavities and test kit is fan annular.

Agent bin the most according to claim 6, it is characterised in that be provided with dividing plate between described containing cavities, is provided with test kit positioning port in the upper edge of dividing plate, and the two side of test kit includes the keeper suitable with described positioning port.