CN205374454U - Multichannel toy inhalation anesthetic dosimetry inductions case - Google Patents
Multichannel toy inhalation anesthetic dosimetry inductions case Download PDFInfo
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- CN205374454U CN205374454U CN201620012523.2U CN201620012523U CN205374454U CN 205374454 U CN205374454 U CN 205374454U CN 201620012523 U CN201620012523 U CN 201620012523U CN 205374454 U CN205374454 U CN 205374454U
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Abstract
The utility model relates to a multichannel toy inhalation anesthetic dosimetry inductions case who can carry out many little animal experiment simultaneously, save the gaseous state narcotic drug, experimental efficiency is high, including the transparent induced case of square or cylinder type and with the sealed case lid of transparent induced case looks adaptation, transparent induced case and sealed case lid enclose the synthetic test chamber, be provided with the air inlet from the gaseous state narcotic drug to the test cavity and the carminative gas outlet that let in on the transparent induced case, be provided with the concentration monitor on the gas outlet, be provided with a plurality of baffles in the test cavity, the baffle is separated into the test cavity and is linked together between a plurality of unit experimental cavity and two the adjacent unit experimental cavity, set up the external trompil of intercommunication on every unit experimental cavity's the wall, the diameter of trompil is 4mm -6mm.
Description
Technical field
This utility model relates to a kind of anesthetis measurement apparatus, particularly relates to a kind of multichannel toy inhalation anesthetic dosimetry induction case.
Background technology
In anesthesiology zooscopy field, conventional anaesthesia experiment frequently involves the mensuration toy sensitivity to inhalation anesthesia medicine, it can be used for the toy studying some gene mutation sensitivity to existing inhalation anesthesia medicine to determine the action target spot of inhalation anesthesia medicine, also can be used for the anaesthetic effect studying Novel narcotics to toy.In order to measure the toy application dose to inhalation anesthesia medicine, need to measure effective dosage ranges or the amount effect curve of this inhalation anesthesia medicine, it is specifically related to two kinds of test experiments: one, measure the experiment of the effective dosage ranges of the inhalation anesthesia medicine making toy can not maintain righting reflex, righting reflex refers to when toy back is placed down, reflexive can return to stance and maintenance is not fallen down under toy normal condition；Two, measuring the experiment of effective dosage ranges of the inhalation anesthesia medicine of the whipping loss for reaction making toy, whipping reaction refers to and clamps toy tail with certain pressure, the reaction that toy is felt pain and jerked the tail from side to side.Specifically can referring to " TheJournalofpharmacologyandexperimentaltherapeutics " (" pharmacology and experimental therapeutic magazine " (2007, No. 3 924 934, volume 323)) in, the exaggeration cognitive dysfunction of nocturnalism is shown and report that volatility inhalation anesthetic drug susceptibility is reduced by mice: halothane anesthesia is to induce in the chest of a 5L size and maintain about knock out mice, it is placed on the radiator of top to maintain in chest temperature 33-34 DEG C (the anus temperature after mouse anesthesia is between 35.9-38.7 DEG C with the body temperature that keeps mice in anaesthesia process.Zero difference between different genotype group).Oxygen flow is 4L/min, and halothane is volatilized by Fluotec3 Volatile anesthetic.Carbon dioxide and halothane concentration are monitored by Capnomax-Ultima monitor.Soda lime granule is placed in induction bottom portion, makes gas concentration lwevel be maintained at less than 0.3%.In the equilibration time of 20 minutes, check the righting reflex of mice every 2min, mice is overturn to dorsal position, as mice all can not right for three times, then it is assumed that mice righting reflex loss, writes down anesthetic concentration now for continuous three times.After righting reflex loss, continue to stay mice in chest until balancing 20min and detecting its folder tail reflection.Thereafter, after the anesthetics balance 20min of higher concentration, the reflection of little mousetrap tail is detected.Mosquito forceps head folder mousetail near-end 5s, mice is without quadruped locomotion and reaction of nodding, it is believed that little mousetrap tail areflexia, and mosquito forceps upper caldding layer plastic adhesive tape prevents damage mousetail skin.Halothane concentration is that 0.5,0.7,0.9,1.1,1.3, and1.5%. Sevoflurane concentration is similar to halothane, but oxygen flow is 7L/min, and equilibration time is 6min.Isoflurane concentration is 0.6,0.9,1.2,1.5, and1.8%., equilibration time 12min.
nullIn prior art，Carry out above two test experiments，It is generally adopted the volume closed induction case be more than or equal to 5L to toy by only measuring，Closed induction case offers two macropores in case, conveniently put into toy and stretch into operation for staff，On each macropore, adaptive removable cover of installing with sealing or is opened，But，Operation of stretching out one's hand can cause gaseous state loss in closed induction case、Circulate mutually with extraneous gaseous state and cause that anesthesia gaseous state concentration reduces，In order to ensure anesthesia gaseous state concentration，After being typically in stretching out one's hand end of operation，Shut removable cover immediately with sealing，It is continually fed into the gaseous anaesthetic medicine of flow up to 4L/min so that concentration balance is to setting concentration in case，Drug level reaches balance in induction case to be needed 20 minutes，Owing to this method there will be the problem expending substantial amounts of gaseous anaesthetic medicine because closed induction case volume is big；Additionally, due to single experiment is just for single toy, and to draw and to realize results needed, at least 30 toys need to be tested.To sum up, time length, waste gaseous anaesthetic medicine, ineffective deficiency used by the experiment of existing closed induction case.
Utility model content
For the deficiencies in the prior art, this utility model be in that to provide a kind of save gaseous anaesthetic medicine, multichannel toy inhalation anesthetic dosimetry induction case that conventional efficient is high.
A kind of multichannel transparent induction case of toy inhalation anesthetic dosimetry of the present utility model, transparent induction case and the sealed platform cover suitable with described transparent induction case including square or column type, described transparent induction case and sealed platform cover enclose test cavity, described transparent induction case arranges oriented described test cavity and passes into the air inlet of gaseous anaesthetic medicine and the gas outlet of aerofluxus, described air inlet and gas outlet are oppositely arranged on the opposite sides of described transparent induction case, described gas outlet is provided with concentration monitor, the wall of test cavity offers the perforate that connection is extraneous, the diameter of described perforate is 4mm-6mm.
Further, described transparent induction case is rotatably connected on support, and the junction of described support and described transparent induction case seals.
Further, being provided with some dividing plates in described test cavity, described test cavity is separated between several unit experiment chambeies and adjacent two unit experiment chambeies and is connected, the wall in each unit experiment chamber is equipped with described perforate by described dividing plate.
Further, there is gap with described sealed platform cover in perpendicular and described dividing plate the upper side edge of each dividing plate and described sealed platform cover, all the other sides of described dividing plate are connected with described transparent induction case respectively.
Further, the spacing of the upper side edge of described dividing plate and described sealed platform cover is 1/4-1/2 times of described transparent induction case height.
Further, described air inlet and gas outlet are all 3/4-1 times of described transparent induction case height to the distance in transparent induction bottom portion.
Further, described perforate is 2mm-5mm to the distance in transparent induction bottom portion, and the diameter of described perforate is 5mm.
Further, outside described transparent induction case, described tapping is provided with fixture.
Further, described transparent induction case is made by lucite or PVC or acrylic.
Compared with prior art, the beneficial effects of the utility model are: one, when the experiment that the whipping carrying out toy reacts, can be selected for the transparent induction case of square, toy is put into unit experiment intracavity and the tail of toy is extracted case extenal fixation from perforate, cover sealed platform cover, gaseous anaesthetic medicine is passed into from air inlet to test cavity, owing to perforate is blocked by the tail of toy, and and press from both sides tail operation carry out outside case, therefore whole operation is not only without influence on the gaseous anaesthetic concentration in test cavity, and when needing to change mensuration concentration, the gaseous anaesthetic concentration of experiment intracavity can be rapidly achieved prescribed concentration, whole experiment greatly reduces the waste of anesthetics；Two, when carrying out the Righing reflex of toy, can be selected for the transparent induction case of column type, and by plugging holes, toy is put into unit experiment intracavity and covers sealed platform cover, gaseous anaesthetic medicine is passed into from air inlet to test cavity, the transparent induction case of slewing circle column type can make toy back down, therefore whole operation is not only without influence on the gaseous anaesthetic concentration in test cavity, and when needing to change mensuration concentration, the gaseous anaesthetic concentration of experiment intracavity can be rapidly achieved prescribed concentration, and whole experiment greatly reduces the waste of anesthetics；Three, this utility model adopt semi-enclosed transparent induction case and sealed platform cover with the use of, form multiple-unit experiment chamber to realize once measuring many toys, single measurement toy quantity is many compared with traditional induction case, and work efficiency significantly improves.
Accompanying drawing explanation
Fig. 1 is the structural representation of this utility model multichannel toy inhalation anesthetic dosimetry induction case (square)；
Fig. 2 is the structural representation that a kind of anesthesia measures inducible system (embodiment one)；
Fig. 3 is this utility model multichannel toy inhalation anesthetic dosimetry induction case (column type) structural representation；
Fig. 4 is the structural representation that another kind of anesthesia measures inducible system (embodiment two).
Detailed description of the invention
Below in conjunction with drawings and Examples, detailed description of the invention of the present utility model is described in further detail.Following example are used for illustrating this utility model, but are not limited to scope of the present utility model.
Toy involved in this enforcement is mice or rat.
Embodiment one:
Referring to Fig. 1 and Fig. 2, a kind of anesthesia of this utility model one preferred embodiment measures inducible system, including by O2/CO2nullGas cylinder gas cylinder 5、Anaesthetic Volatile anesthetic 6、Gas exhaust piping 8 and multichannel toy inhalation anesthetic dosimetry induction case，Multichannel toy inhalation anesthetic dosimetry induction case includes the transparent induction case 1 of square be made up of lucite and the sealed platform cover 2 suitable with transparent induction case 1，The length of transparent induction case 1 is 345mm、Width is 150mm、Height is 120mm，Transparent induction case 1 and sealed platform cover 2 enclose test cavity，Transparent induction case 1 arranges oriented test cavity and passes into the air inlet 11 of gaseous anaesthetic medicine and the gas outlet 12 of aerofluxus，Air inlet 11 and gas outlet 12 are oppositely arranged on the both sides, front and back of transparent induction case 1，And air inlet 11 and gas outlet 12 are all 100mm to the distance bottom transparent induction case 1，Gas outlet 12 is provided with concentration monitor (not shown) to detect exhaust concentration in good time，The dividing plate 3 of 3 black being parallel to each other it is provided with in test cavity，Each dividing plate 3 is perpendicular with sealed platform cover 2 and the upper side edge of dividing plate 3 is 60mm with the spacing of sealed platform cover 2，All the other sides of dividing plate 3 are connected with transparent induction case 1 respectively，Test cavity is separated between 4 unit experiment chambeies and adjacent two unit experiment chambeies and is connected by dividing plate 3，The length in unit experiment chamber is about 80mm，The wall in each unit experiment chamber offers the extraneous perforate 13 of connection and perforate 13 is 3mm to the distance bottom transparent induction case 1，The diameter of perforate 13 is 5mm，Outside transparent induction case 1, perforate 13 place is provided with fixture 4；O2/CO2The gas outlet of gas cylinder gas cylinder 5 is connected by the air inlet of pipeline with anaesthetic Volatile anesthetic 6, the gas outlet of anaesthetic Volatile anesthetic 6 is connected by the air inlet of sebific duct with transparent induction case 1, the gas outlet of transparent induction case 1 is connected with gas exhaust piping 8 by sebific duct, and anaesthetic Volatile anesthetic 6 is provided with concentration controller 7.
The anesthesia of the present embodiment measures inducible system can be measured making the effective dosage ranges of inhalation anesthesia medicine that mice or rat can not maintain Tall Flick Reflex, in experimentation, 4 mices are respectively put into unit experiment intracavity, and the tail of mice penetrated in perforate 13 and fix with fixture, soda lime granule is placed in induction bottom portion, radiator is placed to maintain in chest temperature 33-34 DEG C above transparent induction case 1, keep mice body temperature in anaesthesia process (the anus temperature after mouse anesthesia between 35.9-38.7 DEG C, zero difference between different genotype group).Anaesthetic Volatile anesthetic 6 is built with anaesthetic, gaseous anaesthetic medicine and oxygen, carbon dioxide carries out being sufficiently mixed and gaseous anaesthetic drug level is controlled by being provided with concentration controller 7 on anaesthetic Volatile anesthetic 6, observe the concentration monitor at QI KOU 12 place to judge whether gaseous anaesthetic drug level reaches the stable case of set value and concentration, pain jerks the tail from side to side and is intended to shake off mice to be made to feel by mosquito forceps clamping rat-tail, after reaching certain anesthetic concentration, mice no longer feels that pain no longer jerks the tail from side to side and shakes off, the experiment reaction of mice can be directly observed by transparent induction case 1 and record related data.
Embodiment two:
Referring to Fig. 3 and Fig. 4, a kind of anesthesia of this utility model one preferred embodiment measures inducible system, including by O2/CO2nullGas cylinder gas cylinder 5、Anaesthetic Volatile anesthetic 6、Gas exhaust piping 8 and 4 multichannel toy inhalation anesthetic dosimetry induction casees，Each multichannel toy inhalation anesthetic dosimetry induction case includes the transparent induction case 1 of column type be made up of acrylic and the sealed platform cover 2 suitable with transparent induction case 1，The length of transparent induction case 1 is 150mm、Diameter is 70mm，Transparent induction case 1 and case lid enclose cylindrical lab chamber，Transparent induction case 1 arranges oriented test cavity and passes into the air inlet 11 of gaseous anaesthetic medicine and the gas outlet 12 of aerofluxus，Air inlet 11 and gas outlet 12 are oppositely arranged on the left and right sides of transparent induction case 1 and air inlet 11 and gas outlet 12 connection diameter is the sebific duct of 6mm，Gas outlet 12 is provided with concentration monitor (not shown) to detect exhaust concentration in good time，The wall in experiment chamber offers the extraneous perforate 13 of connection and perforate 13 is 3mm to the distance bottom transparent induction case 1，The diameter of perforate 13 is 5mm，Outside transparent induction case 1, perforate 13 place is provided with the fixture 4 tail with fixing mice or rat，Fixture 4 can be selected for adhesive tape；Transparent induction case 1 is rotatably connected in support (not shown), and the junction of support and transparent induction case 1 seals；O2/CO2The gas outlet of gas cylinder gas cylinder 5 is connected by the air inlet of pipeline with anaesthetic Volatile anesthetic 6, the gas outlet of anaesthetic Volatile anesthetic 6 is connected by the air inlet of sebific duct with multichannel adaptor 9 with transparent induction case 1, the gas outlet of transparent induction case 1 is connected with gas exhaust piping 8 with multichannel adaptor 10 by sebific duct, and anaesthetic Volatile anesthetic 6 is provided with concentration controller 7.
The anesthesia of the present embodiment measures inducible system can be measured making the effective dosage ranges of inhalation anesthesia medicine that mice or rat can not maintain righting reflex, anaesthetic concentration can be controlled by being provided with on anaesthetic Volatile anesthetic 6 concentration controller 7, and observe the concentration monitor at QI KOU 12 place to judge whether concentration reaches the stable case of set value and concentration, the transparent induction case 1 of slewing circle column type can make toy back down, and the experiment of mice or rat reaction can be directly observed by transparent induction case 1 and record related data.
A kind of multichannel toy inhalation anesthetic dosimetry induction case of the present embodiment can be combined in experimental implementation and uses to accelerate experiment process or carry out with reference to experiment, generally choose 3 to 6 measure induction case and be equipped with multichannel adaptor 9, 10 carry out integrating use, that can greatly save anaesthetic makes consumption, such as, statistical analysis is carried out in the anesthesia sensitive experiment result measuring mice or rat, for halothane (2000 yuan/100ml), narcotics total value 20,000 yuan/mice can be saved, compared with traditional induction case, single experiment completes, the narcotics total amount needed for mensuration anesthetics effective dose can be made to decline about 20 times.
Below it is only preferred implementation of the present utility model; it should be pointed out that, for those skilled in the art, under the premise without departing from this utility model know-why; can also making some improvement and modification, these improve and modification also should be regarded as protection domain of the present utility model.
Claims (9)
1. a multichannel toy inhalation anesthetic dosimetry induction case, it is characterized in that: include transparent induction case and the sealed platform cover suitable with described transparent induction case, described transparent induction case and sealed platform cover enclose test cavity, described transparent induction case arranges oriented described test cavity and passes into the air inlet of gaseous anaesthetic medicine and the gas outlet of aerofluxus, described air inlet and gas outlet are oppositely arranged on the opposite sides of described transparent induction case, described gas outlet is provided with concentration monitor, the wall of test cavity offers the perforate that connection is extraneous, the diameter of described perforate is 4mm-6mm.
2. multichannel toy inhalation anesthetic dosimetry induction case as claimed in claim 1, it is characterised in that: described transparent induction case is rotatably connected on support, and the junction of described support and described transparent induction case seals.
3. multichannel toy inhalation anesthetic dosimetry induction case as claimed in claim 1, it is characterized in that: in described test cavity, be provided with some dividing plates, described test cavity is separated between several unit experiment chambeies and adjacent two unit experiment chambeies and is connected, the wall in each unit experiment chamber is equipped with described perforate by described dividing plate.
4. multichannel toy inhalation anesthetic dosimetry induction case as claimed in claim 3, it is characterized in that: perpendicular and described dividing plate the upper side edge of each dividing plate and described sealed platform cover exists gap with described sealed platform cover, and all the other sides of described dividing plate are connected with described transparent induction case respectively.
5. multichannel toy inhalation anesthetic dosimetry induction case as claimed in claim 4, it is characterised in that: the spacing of the upper side edge of described dividing plate and described sealed platform cover is 1/4-1/2 times of described transparent induction case height.
6. multichannel toy inhalation anesthetic dosimetry induction case as claimed in claim 1, it is characterised in that: described air inlet and gas outlet to 3/4-1 times that the distance in transparent induction bottom portion is all described transparent induction case height.
7. multichannel toy inhalation anesthetic dosimetry induction case as claimed in claim 1, it is characterised in that: described perforate is 2mm-5mm to the distance in transparent induction bottom portion, and the diameter of described perforate is 5mm.
8. multichannel toy inhalation anesthetic dosimetry induction case as claimed in claim 1, it is characterised in that: outside described transparent induction case, described tapping is provided with fixture.
9. multichannel toy inhalation anesthetic dosimetry induction case as claimed in claim 1, it is characterised in that: described transparent induction case is made by lucite or PVC or acrylic.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201620012523.2U CN205374454U (en) | 2016-01-07 | 2016-01-07 | Multichannel toy inhalation anesthetic dosimetry inductions case |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201620012523.2U CN205374454U (en) | 2016-01-07 | 2016-01-07 | Multichannel toy inhalation anesthetic dosimetry inductions case |
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| CN205374454U true CN205374454U (en) | 2016-07-06 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105527416A (en) * | 2016-01-07 | 2016-04-27 | 徐州医学院 | Multichannel induction box for measuring dosage of anaesthetic sucked by small animals |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105527416A (en) * | 2016-01-07 | 2016-04-27 | 徐州医学院 | Multichannel induction box for measuring dosage of anaesthetic sucked by small animals |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160706 Termination date: 20170107 |