CN205199435U - PH sensitive material preparation facilities based on gel method - Google Patents
PH sensitive material preparation facilities based on gel method Download PDFInfo
- Publication number
- CN205199435U CN205199435U CN201521138817.1U CN201521138817U CN205199435U CN 205199435 U CN205199435 U CN 205199435U CN 201521138817 U CN201521138817 U CN 201521138817U CN 205199435 U CN205199435 U CN 205199435U
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- China
- Prior art keywords
- shaft
- paddle
- power transmission
- mixing
- gel method
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000000463 material Substances 0.000 title claims abstract description 65
- 238000002360 preparation method Methods 0.000 title claims abstract description 26
- 238000000034 method Methods 0.000 title claims abstract description 25
- 238000003756 stirring Methods 0.000 claims abstract description 26
- 230000005540 biological transmission Effects 0.000 claims abstract description 23
- 230000007246 mechanism Effects 0.000 claims abstract description 16
- 230000008676 import Effects 0.000 claims description 7
- 239000002184 metal Substances 0.000 claims description 4
- 229910052751 metal Inorganic materials 0.000 claims description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 3
- 229910052802 copper Inorganic materials 0.000 claims description 3
- 239000010949 copper Substances 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 3
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- 238000004804 winding Methods 0.000 abstract 1
- 239000000499 gel Substances 0.000 description 10
- 230000008569 process Effects 0.000 description 7
- 239000003814 drug Substances 0.000 description 6
- 229920000642 polymer Polymers 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 150000004703 alkoxides Chemical class 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000000017 hydrogel Substances 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
Landscapes
- Mixers Of The Rotary Stirring Type (AREA)
Abstract
The utility model provides a PH sensitive material preparation facilities based on gel method of easy and simple to handle, easy realization, including comminuted ware and material mixing stirrer, the comminuted ware is through arranging material pipe and material mixing stirrer intercommunication, material mixing stirrer includes interior bucket and outer bucket, it is inside that outer bucket is located to interior bucket, including on the interior bucket outer wall between bucket and the outer bucket winding have around managing, material mixing stirrer is still including the stirring unit, the stirring unit includes agitator motor, the power transmission disc of being connected with this agitator motor's power output shaft, still be provided with central rabbling mechanism and eccentric rabbling mechanism in the below of power transmission disc, the center rabbling mechanism includes first (mixing) shaft, set up in the first stirring rake of this first (mixing) shaft lower extreme, first (mixing) shaft is fixed in the center of power transmission disc, eccentric rabbling mechanism includes the second (mixing) shaft, sets up in the epaxial second stirring rake of second stirring, and the second (mixing) shaft is fixed in the eccentric position department at power transmission disc center.
Description
Technical field
The utility model relates to pH sensitive material preparation technique field, particularly relates to a kind of pH sensitive material preparation facilities based on gel method.
Background technology
Hydrogel be a kind of can in water the swelling but macromolecule network that can not dissolve, medicine can be protected not by enzymolysis or by stomach acids destroy, again can by changing the structure control insoluble drug release of hydrogel.PH sensitive aqueous gel is the high-molecular gel of volume energy with environment pH, ionic strength change; utilize its this character can the diffusion of medicine and rate of release in regulation and control gel easily; using such polyalcohol hydrogel as carrier; protected protein and polypeptide drug; and this kind of medicine is discharged in the position (as colon) that condition is relatively gentle, thus realizes the validity of this kind of medicine through gastrointestinal administration.
Example is prepared as with gel method, the preparation of gel method is for primary raw material with metal alkoxide, catalyst and other solvents, the first step of its preparation process produces the homogeneous phase solution that comprises alkoxide and water, to ensure that the hydrolysis of alkoxide carries out in the uniform level of molecule; And strong agitation must be imposed to the mixed liquor of above-mentioned preparation, thus harm stops, and volatile component in course of reaction is lost causes composition change, also need to add widely different stream condensing unit in the process stirred simultaneously, to keep the constant of temperature, and its reliable in quality and stable product will be worth, the mixing in its early stage, the holding of stirring and temperature are factors crucial in whole process, simultaneously in order to ensure the uniformity mixed, the uniformity of its raw material particle size and size are also the key factors affecting whole process.
Summary of the invention
The purpose of this utility model is to overcome the deficiencies in the prior art, adapts to reality need, provides a kind of easy and simple to handle, pH sensitive material preparation facilities based on gel method that can provide stability fundamental for producing out high-quality pH sensitive material.
In order to realize the purpose of this utility model, the technical scheme that the utility model adopts is:
Design a kind of pH sensitive material preparation facilities based on gel method, it comprises material crusher and mixing of materials agitator, and the discharging opening of described material crusher lower end is communicated with described mixing of materials agitator by drainage conduit; Described mixing of materials agitator it comprise Inner bucket and outer barrel, tub is located at by described Inner bucket, and forms cavity between the outer wall of described Inner bucket and the inwall of outer barrel, and described Inner bucket is made of metal; Inner bucket outer wall in described cavity is also wound with around pipe, all should be arranged at the outside of outer barrel around the import of pipe and outlet; Described mixing of materials agitator it also comprise the agitating unit be arranged in described Inner bucket, its power transmission disk of comprising stirring motor, being connected with the power output shaft of this stirring motor of described agitating unit, center rabbling mechanism and eccentric rabbling mechanism is also provided with in the below of described power transmission disk, described center rabbling mechanism comprises the first shaft, is arranged at the first paddle of this first shaft lower end, described first shaft is fixed on the center of described power transmission disk, and described first paddle is arranged at the middle and upper part of described Inner bucket; Described eccentric rabbling mechanism comprises the second shaft, the second paddle be arranged on described second shaft, described second shaft is fixed on the eccentric position place of described power transmission disc centre, and described second paddle is positioned at the below of described first paddle.
Preferably, described power transmission disk is also provided with weight linear meter, and described weight linear meter and described second shaft are about the Central Symmetry of described power transmission disk.
Preferably, the second paddle be arranged on described second shaft is two, and two the second paddles be arranged on described second shaft are all positioned at the below of described first paddle.
Preferably, described first paddle and described second paddle are pusher paddle or paddle paddle.
Preferably, described stirring motor is the adjustable variable-frequency motor of speed.
Preferably, to be describedly made up of copper pipe around pipe.
Preferably, the described import around pipe is arranged at the bottom of described outer barrel, and described outlet is arranged at the top of described outer barrel.
Preferably, described Inner bucket is made up of stainless steel.
The beneficial effects of the utility model are:
1. the serialization preparation of pH sensitive material can be realized in the application by the design, namely in producing can in advance by raw material by the material crusher in the design carry out early stage shatter process, material is realized to pulverize as nano level graininess as much as possible, during mixing of materials agitator is afterwards uniformly mixed, the effective mixing to material and stirring can be realized, be conducive to the Homogeneous phase mixing of each material and the stable polymer of forming property, the more important thing is to improve and produce efficiency in preparation process, also for the high-quality of the polymer after preparation provides reliable guarantee.
2. the design in use can for providing stable temperature guarantee in the preparation process of mixing of materials agitator around pipe, what be conducive between the material of each component and catalyst is fully fused.
3. the utility model also has other advantages, will propose in the lump with corresponding structure in an embodiment.
Accompanying drawing explanation
Fig. 1 is the cross-sectional view of primary structure of the present utility model and mixing of materials agitator;
In figure: 1. outer barrel; 2. Inner bucket; 3. cavity; 4,5. around pipe; 6. around the outlet of pipe; 7. around the import of pipe; 8. stirring motor; 9. power transmission disk; 10. the power output shaft of stirring motor; 11. second shafts; 12. second paddles; 13. first shafts; 14. first paddles; 15. weight linear meters; 16. drainage conduit; 17. material crushers; Stirring motor in 18. material crushers.
Detailed description of the invention
Below in conjunction with drawings and Examples, the utility model is further illustrated:
Embodiment 1: a kind of pH sensitive material preparation facilities based on gel method, see Fig. 1, it comprises material crusher 17 and mixing of materials agitator, and the discharging opening of described material crusher 17 lower end is communicated with described mixing of materials agitator by drainage conduit 16; In the design, its material crusher 17 adopts commercially available material crusher 17, what provide this material crusher 17 can realize material to carry out early stage shatters process, makes its material form nano level granular material as much as possible after stirring the early stage of material crusher 17; Further, in the design, described mixing of materials agitator it comprise Inner bucket 2 and outer barrel 1, it is inner that outer barrel 1 is located at by described Inner bucket 2, and forming cavity 3 between the outer wall of described Inner bucket 2 and the inwall of outer barrel 1, the bucket of Inner described in the design 2 is made of metal, and Inner bucket is made up of stainless steel; Inner bucket 2 outer wall in described cavity 3 is also wound with around pipe 4,5, describedly to be made up of copper pipe around pipe 4,5, and should around the import 7 of pipe and the outside that all should be arranged at outer barrel around the outlet 6 of pipe, the concrete described import 7 around pipe is arranged at the bottom of described outer barrel 1, and the described outlet 6 around pipe is arranged at the top of described outer barrel 1.By above-mentioned design, by the design around pipe, in use can pass into liquid in pipe, to realize temperature when stirring in stable Inner bucket.
Further, described mixing of materials agitator it also comprise the agitating unit be arranged in described Inner bucket 2, its power transmission disk 9 of comprising stirring motor 8, being connected with the power output shaft 10 of this stirring motor 8 of described agitating unit, in the design, described stirring motor is the adjustable variable-frequency motor of speed.Further, center rabbling mechanism and eccentric rabbling mechanism is also provided with in the below of described power transmission disk 9, in the design, described center rabbling mechanism comprises the first shaft 13, is arranged at the first paddle 14 of this first shaft 13 lower end, described first shaft 13 is fixed on the center of described power transmission disk 9, and described first paddle 14 is arranged at the middle and upper part of described Inner bucket; Described eccentric rabbling mechanism comprises the second shaft 11, the second paddle 12 be arranged on described second shaft 11, described second shaft 11 is fixed on the eccentric position place at described power transmission disk 9 center, and described second paddle 12 is positioned at the below of described first paddle 14; In the design, the second paddle 12 be arranged on described second shaft 11 is two, and two the second paddles 12 be arranged on described second shaft 11 are all positioned at the below of described first paddle 14, and described first paddle 14 and described second paddle 12 are pusher paddle or paddle paddle.Can realize carrying out effective immixture to the material of Inner bucket inside by the stirring action of above-mentioned first paddle 14 and described second paddle 12, namely effective stir process be can carry out to the bottom of the middle and upper part in Inner bucket, Inner bucket sidepiece and middle part when stirring, stirring efficiency and quality improved.
As the further improvement of the design, described power transmission disk 9 is also provided with weight linear meter 15, and described weight linear meter 15 and the Central Symmetry of described second shaft 11 about described power transmission disk 9, the use of this weight linear meter 15 can contribute to improving the mixing of materials agitator stability in the design.
To sum up, the serialization preparation of pH sensitive material can be realized in the application by the design, namely in producing can in advance by raw material by the material crusher in the design carry out early stage shatter process, material is realized to pulverize as nano level graininess as much as possible, during mixing of materials agitator is afterwards uniformly mixed, the effective mixing to material and stirring can be realized, be conducive to the Homogeneous phase mixing of each material and the stable polymer of forming property, the more important thing is to improve and produce efficiency in preparation process, also for the high-quality of the polymer after preparation provides reliable guarantee.
What embodiment of the present utility model was announced is preferred embodiment; but be not limited thereto; those of ordinary skill in the art; very easily according to above-described embodiment; understand spirit of the present utility model; and make different amplifications and change, but only otherwise depart from spirit of the present utility model, all in protection domain of the present utility model.
Claims (8)
1. based on a pH sensitive material preparation facilities for gel method, it is characterized in that: it comprises material crusher and mixing of materials agitator, the discharging opening of described material crusher lower end is communicated with described mixing of materials agitator by drainage conduit; Described mixing of materials agitator it comprise Inner bucket and outer barrel, tub is located at by described Inner bucket, and forms cavity between the outer wall of described Inner bucket and the inwall of outer barrel, and described Inner bucket is made of metal; Inner bucket outer wall in described cavity is also wound with around pipe, all should be arranged at the outside of outer barrel around the import of pipe and outlet; Described mixing of materials agitator it also comprise the agitating unit be arranged in described Inner bucket, its power transmission disk of comprising stirring motor, being connected with the power output shaft of this stirring motor of described agitating unit, center rabbling mechanism and eccentric rabbling mechanism is also provided with in the below of described power transmission disk, described center rabbling mechanism comprises the first shaft, is arranged at the first paddle of this first shaft lower end, described first shaft is fixed on the center of described power transmission disk, and described first paddle is arranged at the middle and upper part of described Inner bucket; Described eccentric rabbling mechanism comprises the second shaft, the second paddle be arranged on described second shaft, described second shaft is fixed on the eccentric position place of described power transmission disc centre, and described second paddle is positioned at the below of described first paddle.
2. as claimed in claim 1 based on the pH sensitive material preparation facilities of gel method, it is characterized in that: on described power transmission disk, be also provided with weight linear meter, and described weight linear meter and described second shaft are about the Central Symmetry of described power transmission disk.
3. as claimed in claim 1 based on the pH sensitive material preparation facilities of gel method, it is characterized in that: the second paddle be arranged on described second shaft is two, and two the second paddles be arranged on described second shaft are all positioned at the below of described first paddle.
4., as claimed in claim 3 based on the pH sensitive material preparation facilities of gel method, it is characterized in that: described first paddle and described second paddle are pusher paddle or paddle paddle.
5. as claimed in claim 1 based on the pH sensitive material preparation facilities of gel method, it is characterized in that: described stirring motor is the adjustable variable-frequency motor of speed.
6. as claimed in claim 1 based on the pH sensitive material preparation facilities of gel method, it is characterized in that: to be describedly made up of copper pipe around pipe.
7., as claimed in claim 1 based on the pH sensitive material preparation facilities of gel method, it is characterized in that: the described import around pipe is arranged at the bottom of described outer barrel, and described outlet is arranged at the top of described outer barrel.
8., as claimed in claim 1 based on the pH sensitive material preparation facilities of gel method, it is characterized in that: described Inner bucket is made up of stainless steel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201521138817.1U CN205199435U (en) | 2015-12-18 | 2015-12-18 | PH sensitive material preparation facilities based on gel method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201521138817.1U CN205199435U (en) | 2015-12-18 | 2015-12-18 | PH sensitive material preparation facilities based on gel method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205199435U true CN205199435U (en) | 2016-05-04 |
Family
ID=55837180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201521138817.1U Expired - Fee Related CN205199435U (en) | 2015-12-18 | 2015-12-18 | PH sensitive material preparation facilities based on gel method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN205199435U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109758293A (en) * | 2019-03-11 | 2019-05-17 | 山东煜和堂药业有限公司 | Postpartum Warn uterus paste and application method and manufacture the equipment that material is organized in the postpartum Warn uterus paste |
| CN111298705A (en) * | 2020-03-14 | 2020-06-19 | 刘红梅 | Environment-friendly printing ink multi-degree-of-freedom processing equipment and printing ink processing technology |
-
2015
- 2015-12-18 CN CN201521138817.1U patent/CN205199435U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109758293A (en) * | 2019-03-11 | 2019-05-17 | 山东煜和堂药业有限公司 | Postpartum Warn uterus paste and application method and manufacture the equipment that material is organized in the postpartum Warn uterus paste |
| CN111298705A (en) * | 2020-03-14 | 2020-06-19 | 刘红梅 | Environment-friendly printing ink multi-degree-of-freedom processing equipment and printing ink processing technology |
| CN111298705B (en) * | 2020-03-14 | 2020-11-10 | 武汉宇恩防伪技术有限公司 | Environment-friendly printing ink multi-degree-of-freedom processing equipment and printing ink processing technology |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20201109 Address after: No.9788, Luocheng section, Weigao Road, Luocheng street, Shouguang City, Weifang City, Shandong Province Patentee after: Weifang Hongchang New Material Technology Co.,Ltd. Address before: 262700 Shandong Blue Economic Engineering Research Institute, Weifang science and Technology College, No. 1299 golden light East Street, Shouguang City, Shandong, Weifang Patentee before: Feng Lijuan |
|
| TR01 | Transfer of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160504 |