CN205163735U - Degradable support - Google Patents
Degradable support Download PDFInfo
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- CN205163735U CN205163735U CN201520876939.4U CN201520876939U CN205163735U CN 205163735 U CN205163735 U CN 205163735U CN 201520876939 U CN201520876939 U CN 201520876939U CN 205163735 U CN205163735 U CN 205163735U
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- biodegradable
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Abstract
The utility model discloses a degradable support, including magnesium base support and cladding in the magnesium base support outside, and form the biodegradable copolymer fixed membrane of tube -shape. When the patient need use degradable support, put into the required position of disease with degradable support. Because magnesium base support surface is equipped with biodegradable copolymer fixed membrane, temporarily avoid magnesium to lead to its quick corruption because of contact A corrosive environment through surperficial biodegradable copolymer fixed membrane, moreover because magnesium base support surface biodegradable copolymer fixed membrane and magnesium itself all have degradability, after the degradation of biodegradable copolymer fixed membrane, the basic support of the magnesium that begins to degrade has prolonged degradation time of degradable support effectively.
Description
Technical field
This utility model relates to field of medical article technology, particularly a kind of biodegradable stent.
Background technology
The esophagus of human body, bile duct and intestinal tube etc. operationally, play the effect of transport food, bile and nutrient substance, but occur narrow problem along with pathological changes pipeline swimming suit, and be introduced for esophagostenosis below, other pipeline is similar.
Esophagostenosis refers to the esophagus pathologic stenosis caused by disease, and it comprises the malignant stricture that the benign stricture that caused by infection, operation, wound, burn etc. and tumor cause, and wherein also has mucosa ring, esophageal lumen that the external pressure of mediastinum tissue causes narrow.By support is inserted esophagus, eliminate because of the esophagostenosis caused by esophageal benign and malignant malignant change, the problem such as to block, the symptom of effective reduction of patient dysphagia, in wide clinical application.
Traditional support mainly contains clad stainless steel membrane support and polymeric stent two kinds, although metal rack has good mechanics spreading performance, if when taking out, due to the high strength of metal, cause it not easily to take out.And patient can cause the complication such as pain, perforation, hemorrhage and strong foreign body reaction after taking out by force.Polymeric stent is mainly coated by high-molecular film support due to material, utilizes the performance of metal rack, covers one deck polymeric coating layer more outside, realizes the parcel to metal rack and compliance.But still there is the complication such as pain, perforation, hemorrhage and strong foreign body reaction easily caused when later stage tinsel takes out in such support.
In order to solve the problem, Wholly-degradable support is subject to people and uses.Wherein, play mechanical support effect in a short time after the skeleton implantation of support, after effect to be treated completes, support is degradable, avoids stimulating the long-term foreign body of tube wall tissue, effectively prevents postoperative restenosis.Magnesium, as a kind of novel degradable embedded material, has excellent biocompatibility and comprehensive mechanical property.Therefore, Mg-based hydrogen storage, as timbering material, has the performance being much better than other degradable polymeric material.But because the corrosion resisting property of Mg-based hydrogen storage is poor, especially all the more so in containing chloride ion and other corrosive environment, if biodegradable stent list is propped up by magnesio and is configured to, the degradation time of biodegradable stent is shorter, wherein, there are the problems referred to above in the inside such as bile duct, intestinal tube in biodegradable stent, is difficult to the therapeutic effect reaching expection equally.
Therefore, how extending the degradation time of biodegradable stent, is those skilled in the art's technical problems urgently to be resolved hurrily.
Utility model content
The purpose of this utility model is to provide a kind of biodegradable stent, and the degradation time of this biodegradable stent extends.
For achieving the above object, this utility model provides a kind of biodegradable stent, comprises magnesio support, also comprises and is coated on described magnesio stent outer, and the biodegradable copolymer forming tubular fixes film.
Preferably, described biodegradable copolymer fixes film is the copolymer coated film of PCL degradable elasticity.
Preferably, described biodegradable copolymer fixes film is the copolymer coated film of PTMC degradable elasticity.
Preferably, described biodegradable copolymer fixes film is the copolymer coated film of PCL-PTMC degradable elasticity.
Preferably, described biodegradable copolymer fixes film is polylactic acid degradable elastocopolymer coated film.
Preferably, described biodegradable copolymer fixes film is the copolymer coated film of polyurethane degradable elasticity.
Preferably, described biodegradable copolymer fixes film is polyamino acid and amino acid copolymer coated film.
Preferably, described magnesio support is netted braiding frame.
Preferably, institute's magnesio support is magnesium alloy bracket.
Preferably, described magnesio support is the network of the outside flaring of both ends open.
In technique scheme, the biodegradable stent that this utility model provides comprises magnesio support and is coated on magnesio stent outer, and the biodegradable copolymer forming tubular fixes film.When needs of patients uses biodegradable stent, biodegradable stent is put into sufferer desired location.Film is fixed because magnesio rack surface is provided with biodegradable copolymer, fixing film by surface biological degraded copolymer temporarily avoids magnesium to cause its fast erosion because of contact corrosion environment, and fix film due to magnesio rack surface biodegradable copolymer and magnesium itself all has degradability, after biodegradable copolymer fixes membrane degradation, start magnesio support of degrading, effectively extend the degradation time of biodegradable stent.
Accompanying drawing explanation
The structural representation of the biodegradable stent that Fig. 1 provides for this utility model embodiment;
The top view of the biodegradable stent that Fig. 2 provides for this utility model embodiment;
The structural representation of the magnesio support that Fig. 3 provides for this utility model embodiment;
The curve chart of the biodegradable stent reduction length that Fig. 4 provides for this utility model embodiment and resistance;
The resilience curve chart of the biodegradable stent reduction length that Fig. 5 provides for this utility model embodiment and compression time;
The biodegradable stent that Fig. 6 provides for this utility model and the weight distribution curve figure of traditional magnesio support under pH7.4 condition;
The biodegradable stent that Fig. 7 provides for this utility model and the weight distribution curve figure of traditional magnesio support under pH4.0 condition.
Wherein in Fig. 1-7: 1-magnesio support, 2-biodegradable copolymer fix film.
Detailed description of the invention
Core of the present utility model is to provide a kind of biodegradable stent, and the degradation time of this biodegradable stent extends.
In order to make those skilled in the art understand the technical solution of the utility model better, below in conjunction with drawings and embodiments, the utility model is described in further detail.
Please refer to Fig. 1 to Fig. 7, in a kind of detailed description of the invention, the biodegradable stent that this utility model provides comprises magnesio support 1 and is coated on outside magnesio support 1, and the biodegradable copolymer forming tubular fixes film 2.Magnesio support 1 outer surface is specifically as follows corrugated support.Concrete, magnesio support 1 is specifically as follows simple magnesium bracket.Biodegradable copolymer is fixed film 2 and is specifically as follows PCL (Polycaprolactone, polycaprolactone) the copolymer coated film of degradable elasticity or the copolymer coated film of PTMC (PolytrimethyleneCarbonate, PTMC) degradable elasticity.Certainly, biodegradable copolymer fixes film 2 for the copolymer coated film of PCL-PTMC degradable elasticity.Certainly, biodegradable copolymer fixes film 2 can also for polylactic acid degradable elastocopolymer coated film, the copolymer coated film of Merlon degradable elasticity, the copolymer coated film of polyurethane degradable elasticity or polyamino acid and amino acid copolymer coated film, also can the copolymer of above-mentioned various material or mixture.
When biodegradable copolymer fixes film 2 for polyamino acid and amino acid copolymer coated film, because polyamino acid and amino acid copolymer have good biocompatibility and biological degradability, its catabolite is to the harmless effect of human non-toxic, and the pendant groups of responding property of amino acid chain end band, can be used for fixing and there is bioactive molecule, the interaction of material and cell can be improved.
Preferably, magnesio support 1 is magnesium alloy bracket, and wherein magnesium-base metal material has following outstanding advantage: magnesium-base metal material has high specific strength and specific stiffness, and processing characteristics is good.The specific strength of pure magnesium is 133GPa/ (g/cm3), and the specific strength of superhigh strength magnesium alloy has reached 480GPa/ (g/cm3).By the corrosion resistance magnesium alloy of special process process, its mechanical performance can be improved, extend degradation time simultaneously.
When needs of patients uses biodegradable stent, biodegradable stent is put into sufferer desired location.
Known by foregoing description, in the biodegradable stent that this utility model specific embodiment provides, film 2 is fixed because magnesio support 1 surface is provided with biodegradable copolymer, fixing film 2 by surface biological degraded copolymer temporarily avoids magnesium to cause its fast erosion because of contact corrosion environment, and fix film 2 due to magnesio support 1 surface biological degraded copolymer and magnesium itself all has degradability, after biodegradable copolymer fixes film 2 degraded, start magnesio support 1 of degrading, biodegradable stent maintains mechanical property and the rebound performance of metal rack, there is Wholly-degradable characteristic simultaneously.In addition, film 2 can be fixed by surface biological degraded copolymer and temporarily avoid magnesium to cause its fast erosion because of contact corrosion environment, effectively extend the degradation time of biodegradable stent.Wherein about in Fig. 4, because experiment number is more, and numerical value is comparatively close, and line density is larger.As can be seen from Fig. 6 and Fig. 7, close neutral, especially in acid condition, the degradation time of the biodegradable stent that the application provides extends relative to only having the biodegradable stent of magnesio support.
Be applied to the esophagus of human body, the different demand of the different parts such as bile duct and intestinal tube and degradation time according to biodegradable stent, the length of biodegradable stent and the shape of magnesio support 1 can specifically adjust, and the application does not do concrete restriction.
For the ease of install biodegradable stent, preferably, magnesio support 1 is spiral surrounding network, when needs by support installing in vivo time, by stent collapses to less shape, after reaching assigned address, biodegradable stent struts.
In order to alleviate the weight of biodegradable stent while ensureing biodegradable stent intensity, preferably, magnesio support 1 is netted braiding frame, concrete, netted braiding frame can be the magnesio support 1 of triangular open space or quadrilateral-shaped apertures, for the ease of processing magnesio support 1, preferred magnesio support 1 is integral type structure.
On the basis of above-mentioned each scheme, preferably, magnesio support 1 is the network of the outside flaring of both ends open.Due to the network that magnesio support 1 is the outside flaring of both ends open, while guarantee magnesio support 1 intensity, alleviate the weight of magnesio support 1, and be convenient to biodegradable stent to be fixed on sufferer desired location.
In this description, each embodiment adopts the mode of going forward one by one to describe, and what each embodiment stressed is the difference with other embodiments, between each embodiment identical similar portion mutually see.
To the above-mentioned explanation of the disclosed embodiments, professional and technical personnel in the field are realized or uses this utility model.To be apparent for those skilled in the art to the multiple amendment of these embodiments, General Principle as defined herein when not departing from spirit or scope of the present utility model, can realize in other embodiments.Therefore, this utility model can not be restricted to these embodiments shown in this article, but will meet the widest scope consistent with principle disclosed herein and features of novelty.
Claims (10)
1. a biodegradable stent, comprises magnesio support (1), it is characterized in that, also comprise and be coated on described magnesio support (1) outside, and the biodegradable copolymer forming tubular fixes film (2).
2. biodegradable stent according to claim 1, is characterized in that, described biodegradable copolymer fixes film (2) for the copolymer coated film of PCL degradable elasticity.
3. biodegradable stent according to claim 1, is characterized in that, described biodegradable copolymer fixes film (2) for the copolymer coated film of PTMC degradable elasticity.
4. biodegradable stent according to claim 1, is characterized in that, described biodegradable copolymer fixes film (2) for the copolymer coated film of PCL-PTMC degradable elasticity.
5. biodegradable stent according to claim 1, is characterized in that, described biodegradable copolymer fixes film (2) for polylactic acid degradable elastocopolymer coated film.
6. biodegradable stent according to claim 1, is characterized in that, described biodegradable copolymer fixes film (2) for the copolymer coated film of polyurethane degradable elasticity.
7. biodegradable stent according to claim 1, is characterized in that, described biodegradable copolymer fixes film (2) for polyamino acid and amino acid copolymer coated film.
8. biodegradable stent according to claim 1, is characterized in that, described magnesio support (1) is netted braiding frame.
9. biodegradable stent according to claim 1, is characterized in that, institute's magnesio support (1) is magnesium alloy bracket.
10. the biodegradable stent according to any one of claim 1-9, is characterized in that, the network that described magnesio support (1) is the outside flaring of both ends open.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520876939.4U CN205163735U (en) | 2015-11-05 | 2015-11-05 | Degradable support |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520876939.4U CN205163735U (en) | 2015-11-05 | 2015-11-05 | Degradable support |
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| Publication Number | Publication Date |
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| CN205163735U true CN205163735U (en) | 2016-04-20 |
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| CN201520876939.4U Active CN205163735U (en) | 2015-11-05 | 2015-11-05 | Degradable support |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105925847A (en) * | 2016-05-12 | 2016-09-07 | 管仁国 | Novel biodegradable zinc-based metal material and ureteral expandable stent obtained through material |
| CN113509290A (en) * | 2021-07-09 | 2021-10-19 | 乐普（北京）医疗器械股份有限公司 | Biliary tract stent, sealed storage box and loader |
-
2015
- 2015-11-05 CN CN201520876939.4U patent/CN205163735U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105925847A (en) * | 2016-05-12 | 2016-09-07 | 管仁国 | Novel biodegradable zinc-based metal material and ureteral expandable stent obtained through material |
| CN105925847B (en) * | 2016-05-12 | 2018-06-29 | 管仁国 | A kind of biodegradable zinc-base metal material and the ureterectasia stent obtained using the material |
| CN113509290A (en) * | 2021-07-09 | 2021-10-19 | 乐普（北京）医疗器械股份有限公司 | Biliary tract stent, sealed storage box and loader |
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| C14 | Grant of patent or utility model | ||
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| TR01 | Transfer of patent right |
Effective date of registration: 20220113 Address after: 201914 room d3-969, No. 58 Fumin Branch Road, Hengsha Township, Chongming District, Shanghai (Shanghai Hengtai Economic Development Zone) Patentee after: Shanghai Huikang Health Technology Center Address before: 215123 No. 199 benevolence Road, Suzhou Industrial Park, Jiangsu, China Patentee before: SOOCHOW University |
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| TR01 | Transfer of patent right | ||
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Effective date of registration: 20220307 Address after: 202156 No. 825, Xinkaihe Road, Xinhe Town, Chongming District, Shanghai (Shanghai Xinhe economic community) Patentee after: Shanghai antuopuruo Technology Development Center Address before: 201914 room d3-969, No. 58 Fumin Branch Road, Hengsha Township, Chongming District, Shanghai (Shanghai Hengtai Economic Development Zone) Patentee before: Shanghai Huikang Health Technology Center |
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Effective date of registration: 20230420 Address after: Room 128, 2nd Floor, 8802, Zone C, Walker Park, Hainan Ecological Software Park, Old Town High tech Industry Demonstration Zone, Chengmai County, Hainan Province, 571924 Patentee after: Hainan Dramick Investment Co.,Ltd. Address before: 202156 No. 825, Xinkaihe Road, Xinhe Town, Chongming District, Shanghai (Shanghai Xinhe economic community) Patentee before: Shanghai antuopuruo Technology Development Center |