CN205133475U - Disposable high -efficient filter equipment - Google Patents
Disposable high -efficient filter equipment Download PDFInfo
- Publication number
- CN205133475U CN205133475U CN201520858483.9U CN201520858483U CN205133475U CN 205133475 U CN205133475 U CN 205133475U CN 201520858483 U CN201520858483 U CN 201520858483U CN 205133475 U CN205133475 U CN 205133475U
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- Prior art keywords
- housing
- casing
- filter
- effective filter
- disposable effective
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Abstract
Disposable high -efficient filter equipment, including casing (2), the top terminal surface of casing (2) links to each other with the liquid outlet of feed liquor pipe (6), still be equipped with the blast pipe on the top terminal surface of casing (1), the exit of blast pipe is equipped with jam (1), lower part in casing (1) is along transversely being equipped with deep filter or deep filtration membrane (3) that can carry out the defecation to the solution that flows past, be located in casing (1) deep filter (3) but below along chromatography membrane (4) that transversely are equipped with isolated protein, the bottom of casing (1) is equipped with bottom plate (5), be equipped with fluid -discharge tube (7) on bottom plate (5). Its aim at provides one kind can filter, can play again chromatography effect, but furthest reduces R&D institution, enterprise's time cost, economic cost, let product quality better, more guaranteed disposable high -efficient filter equipment.
Description
Technical field
The utility model relates to a kind of disposable effective filter.
Background technology
Market being filtered the general film product of class is all only have filteration, and because membrane material is different with process principle, filtration efficiency is relatively low, the demand of scientific research and enterprise's filtration can not be met very well, especially not high at the filtration yield of vaccine, Chinese medicine, medicine preparation by antibody industry, cause enterprise to filter high expensive.In reality, after enterprise filters, even just can carry out chromatographic separation albumen after multiple times of filtration, such time cost, Financial cost are all relatively high, and on market, urgent appearance one class can be filtered and can play the product of chromatography effect.
Utility model content
The purpose of this utility model is to provide one to filter, can play chromatography effect again, can reduce R&D institution, enterprise's time cost, Financial cost to greatest extent, allow quality product better, more guaranteed disposable effective filter.
The disposable effective filter of the utility model, comprise housing, the top end face of housing is connected with the liquid outlet of liquid-inlet pipe, the top end face of housing is also provided with vapor pipe, the exit of vapor pipe is provided with blocking, bottom in described housing is transversely provided with the deep bed filter or Depth Filtration film that can clarify the solution flow through, the below being positioned at deep bed filter in housing is transversely provided with the chromatographic film of separable albumen, the bottom of housing is provided with base plate, base plate is provided with liquid discharge pipe, the below of base plate is provided with bell jar, bell jar comprises the intubate vertically arranged, cannula sleeve is contained on the outer side wall of liquid discharge pipe, the bottom end outlet of intubate is connected with the import of clamshell top middle portion, the circle that the cross section of clamshell increases from top to bottom gradually or rectangle or trilateral or hexagon or octagon, the bottom of clamshell is opening end.
Disposable effective filter of the present utility model, on wherein said vapor pipe or the top end face of the described housing safety valve that is provided with tensimeter or automatically can opens when exceeding setting pressure.
Disposable effective filter of the present utility model, the cross section of wherein said housing is circular, and the volume of the cavity in housing is not less than 80ml.
Disposable effective filter of the present utility model, the volume being positioned at the cavity above deep bed filter in wherein said housing is 100ml or 200ml or 500ml or 1000ml.
Disposable effective filter of the present utility model, wherein the middle part of hull outside wall is transversely provided with installation retaining ring.
The industrialization product of current life science and field of biological pharmacy carrys out autoreactor fermentation mostly, fermented liquid is all that the two-stage process that first direct filtration clarifies chromatography again obtains target (being protein product mostly), this process time is long, and process risk is large; Disposable effective filter of the present utility model is combined with chromatography high efficiency filter clarification; single stage method is adopted to process; not only good filtration effect; also reach chromatography object; can greatly reduce business economic cost and time cost like this; also reduce process risk, bell jar wherein also can play the effect of insulation blocking simultaneously, can realize the feed liquid of sterile collection clarification thus.Therefore utilize disposable effective filter of the present utility model can reduce R&D institution, enterprise's time cost, Financial cost to greatest extent, allow quality product better, more guaranteed, the working efficiency of personnel is also higher.
Below in conjunction with accompanying drawing, disposable effective filter of the present utility model is described in further detail.
Accompanying drawing explanation
Fig. 1 is the stereographic map of the structural representation of disposable effective filter of the present utility model.
Embodiment
As shown in Figure 1, disposable effective filter of the present utility model, comprise housing 2, the top end face of housing 2 is connected with the liquid outlet of liquid-inlet pipe 6, the top end face of housing 1 is also provided with vapor pipe, the exit of vapor pipe is provided with blocking 1, bottom in described housing 1 is transversely provided with the deep bed filter or Depth Filtration film 3 that can clarify the solution flow through, the below being positioned at deep bed filter 3 in housing 1 is transversely provided with the chromatographic film 4 of separable albumen, the bottom of housing 1 is provided with base plate 5, base plate 5 is provided with liquid discharge pipe 7, the below of base plate 5 is provided with bell jar 8, bell jar 8 comprises the intubate vertically arranged, cannula sleeve is contained on the outer side wall of liquid discharge pipe 7, the bottom end outlet of intubate is connected with the import of clamshell top middle portion, the circle that the cross section of clamshell increases from top to bottom gradually or rectangle or trilateral or hexagon or octagon, the bottom of clamshell is opening end.Bell jar 8 can play the effect of insulation blocking, can realize the feed liquid of sterile collection clarification thus.
As further improvement of the utility model, on above-mentioned vapor pipe or the top end face of described housing 2 safety valve that is provided with tensimeter or automatically can opens when exceeding setting pressure.
As further improvement of the utility model, the cross section of above-mentioned housing 2 is circular, and the volume of the cavity in housing 2 is not less than 80ml.
As further improvement of the utility model, the volume being positioned at the cavity above deep bed filter 3 in above-mentioned housing 2 is 100ml or 200ml or 500ml or 1000ml.
As further improvement of the utility model, the middle part of above-mentioned housing 2 outer side wall is transversely provided with installation retaining ring.
In bio-pharmaceuticals monoclonal antibody field, the production 80% of monoclonal antibody medicine is by expressing cho cell, the cell grown in bio-reactor, meeting expresses the albumen needed for us in exocytosis, also have a large amount of dead cell and cell debris etc. in feed liquid simultaneously, most enterprises removes cell and cell debris etc. by the mode of repeatedly centrifugal (Centrifuge) and membrane filtration (Filtration), and the filtrate eliminating cell debris enters storage tank, enters next step chromatography stage again.
Disposable effective filter of the present utility model, remains general liquid-inlet pipe 6, liquid discharge pipe 7, does not change scientific research and enterprise's use habit.Housing 2 is the ghosts that can hold 100ml solvent, and design can improve speed and filtration yield like this, and is easy to amplify making, thus can meet life science scientific research and Biopharmaceutical Enterprises demand very well.Vapor pipe can play scavenging action, and design can be released the pressure like this, lays tensimeter herein, plays control pressure effect, and design is also consistent with enterprise scale up test needs like this, and safety, meets GMP needs.And deep bed filter or Depth Filtration film 3 and chromatographic film 4, play a role in filtering respectively and the effect of chromatographic separation albumen, can clarify when the solution filtered is through layer strainer or Depth Filtration film 3, rete so again through chromatographic film 4 is analysed, some foreign proteins will be adsorbed, and target protein will wear out from liquid discharge pipe 7 stream and collect, the dual function of filtration and chromatographic separation albumen is played in this design, efficient fast.
Because the space of housing 2 is larger, can filter process in by feed liquid, (solution that namely will filter adds the diatomite of suitable proportion, as filtered antibody, add the diatomite of 1.5% volume) in add diatomite, play the effect strengthening filtration treatment amount, housing 2 spatial design larger, treatment capacity is larger, consider practical application and enterprise's needs, the general pre-allowance adopting about 100ml; And the increasing of filtration treatment amount, analyse treatment capacity own with the rete of chromatographic film 4 can match greatly, so, deep bed filter or Depth Filtration film 3 and chromatographic film 4 have played maximum effect effect separately, thus for scientific research and enterprise's filtration chromatography efficiency and great benefit of having controlled cost.
Best using state: according to material liquid volume, first add the diatomite of 1.5% volume, then press material liquid volume (L) and membrane area (cm
2) than 1: 20, and filtration velocity 0.5ml/min/cm
2process feed liquid, a step realizes clarification filtration and chromatographic effect.
The industrialization product of current life science and field of biological pharmacy carrys out autoreactor fermentation mostly, fermented liquid is all that the clarification of first direct filtration, the again two-stage process of chromatography obtain target (being protein product mostly), this process time is long, and process risk is large; The utility model is combined with chromatography high efficiency filter clarification, adopts single stage method to process, not only good filtration effect, also reach chromatography object, can greatly reduce business economic cost and time cost like this, also reduce process risk simultaneously, make the quality of product more stable, quality is also better.
Claims (5)
1. disposable effective filter, it is characterized in that: comprise housing (2), the top end face of housing (2) is connected with the liquid outlet of liquid-inlet pipe (6), the top end face of housing (1) is also provided with vapor pipe, the exit of vapor pipe is provided with blocking (1), bottom in described housing (1) is transversely provided with the deep bed filter or Depth Filtration film (3) that can clarify the solution flow through, the below being positioned at deep bed filter (3) in housing (1) is transversely provided with the chromatographic film (4) of separable albumen, the bottom of housing (1) is provided with base plate (5), base plate (5) is provided with liquid discharge pipe (7), the below of base plate (5) is provided with bell jar (8), bell jar (8) comprises the intubate vertically arranged, cannula sleeve is contained on the outer side wall of liquid discharge pipe (7), the bottom end outlet of intubate is connected with the import of clamshell top middle portion, the circle that the cross section of clamshell increases from top to bottom gradually or rectangle or trilateral or hexagon or octagon, the bottom of clamshell is opening end.
2. disposable effective filter according to claim 1, is characterized in that: on described vapor pipe or the top end face of described housing (2) safety valve that is provided with tensimeter or automatically can opens when exceeding setting pressure.
3. disposable effective filter according to claim 2, is characterized in that: the cross section of described housing (2) is for circular, and the volume of the cavity in housing (2) is not less than 80ml.
4. disposable effective filter according to claim 3, is characterized in that: the volume being positioned at the cavity of deep bed filter (3) top in described housing (2) is 100ml or 200ml or 500ml or 1000ml.
5. disposable effective filter according to claim 4, is characterized in that: the middle part of described housing (2) outer side wall is transversely provided with installation retaining ring.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520858483.9U CN205133475U (en) | 2015-11-02 | 2015-11-02 | Disposable high -efficient filter equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520858483.9U CN205133475U (en) | 2015-11-02 | 2015-11-02 | Disposable high -efficient filter equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205133475U true CN205133475U (en) | 2016-04-06 |
Family
ID=55619286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520858483.9U Expired - Fee Related CN205133475U (en) | 2015-11-02 | 2015-11-02 | Disposable high -efficient filter equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN205133475U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108017713A (en) * | 2016-11-04 | 2018-05-11 | 郑州伊美诺生物技术有限公司 | One step membrane filter method separates the device and method of milk antibodies |
| CN114921457A (en) * | 2022-05-16 | 2022-08-19 | 硅羿科技（上海）有限公司 | Method for extracting dsRNA |
-
2015
- 2015-11-02 CN CN201520858483.9U patent/CN205133475U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108017713A (en) * | 2016-11-04 | 2018-05-11 | 郑州伊美诺生物技术有限公司 | One step membrane filter method separates the device and method of milk antibodies |
| CN114921457A (en) * | 2022-05-16 | 2022-08-19 | 硅羿科技（上海）有限公司 | Method for extracting dsRNA |
| CN114921457B (en) * | 2022-05-16 | 2023-09-29 | 硅羿科技（上海）有限公司 | Method for extracting dsRNA |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160406 Termination date: 20161102 |