CN205120588U - Novel surface plasmon biosensor that resonates - Google Patents
Novel surface plasmon biosensor that resonates Download PDFInfo
- Publication number
- CN205120588U CN205120588U CN201520394515.4U CN201520394515U CN205120588U CN 205120588 U CN205120588 U CN 205120588U CN 201520394515 U CN201520394515 U CN 201520394515U CN 205120588 U CN205120588 U CN 205120588U
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- Prior art keywords
- surface plasmon
- prism
- plasmon resonance
- novel surface
- nano
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 38
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 19
- 239000000463 material Substances 0.000 claims abstract description 9
- 239000004793 Polystyrene Substances 0.000 claims abstract description 8
- 229920002223 polystyrene Polymers 0.000 claims abstract description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 25
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims description 18
- 229910021389 graphene Inorganic materials 0.000 claims description 15
- 239000012528 membrane Substances 0.000 claims description 15
- 239000002077 nanosphere Substances 0.000 claims description 11
- 239000004411 aluminium Substances 0.000 claims description 3
- 229910052782 aluminium Inorganic materials 0.000 claims description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 3
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 2
- 239000010931 gold Substances 0.000 claims description 2
- 229910052737 gold Inorganic materials 0.000 claims description 2
- 229910052751 metal Inorganic materials 0.000 abstract description 5
- 239000002184 metal Substances 0.000 abstract description 5
- 230000035945 sensitivity Effects 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 3
- 230000003647 oxidation Effects 0.000 abstract description 2
- 238000007254 oxidation reaction Methods 0.000 abstract description 2
- -1 graphite alkene Chemical class 0.000 abstract 5
- 239000002105 nanoparticle Substances 0.000 abstract 5
- 229910002804 graphite Inorganic materials 0.000 abstract 3
- 239000010439 graphite Substances 0.000 abstract 3
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000010408 film Substances 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- 238000005229 chemical vapour deposition Methods 0.000 description 2
- 239000005308 flint glass Substances 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- XOCUXOWLYLLJLV-UHFFFAOYSA-N [O].[S] Chemical compound [O].[S] XOCUXOWLYLLJLV-UHFFFAOYSA-N 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 230000005672 electromagnetic field Effects 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 239000003574 free electron Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000007970 homogeneous dispersion Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000001755 magnetron sputter deposition Methods 0.000 description 1
- 239000011807 nanoball Substances 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 238000000985 reflectance spectrum Methods 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
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- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The utility model provides a lower surface, silica film (3) cover on nano particle array (2), and graphite alkene (4) cover on silica film (3), its characterized in that: that novel surface plasmon biosensor that resonates, by constituteing in prism (1), nano particle array (2), silica film (3), graphite alkene (4) and sample cell (5), nano particle array (2) are located prism (1) prism (1) is high -index material, and nano particle array (2) are constituteed by covering metallic film (7) outside the polystyrene nanometer ball (6). The utility model discloses both utilized the nano particle array to excite SPP's sensitive characteristic, and utilized the geometry characteristics of graphite alkene self to strengthen the absorption to the molecule that awaits measuring again, and also played the protection metal simultaneously and not by the effect of oxidation, realized the purpose that has improved the biosensor sensitivity and the degree of accuracy.
Description
Technical field
The utility model relates to a kind of novel surface plasmon resonance biology sensor, belongs to nanometer technology, biological technology field.
Background technology
In recent years, considerable progress is achieved to the research of metal surface phasmon (SPP).SPP refers to the collective oscillation by external electromagnetic field (as light wave) inducing metal micro-nano structure surface free electron, it has an outstanding feature can realize surface plasmon resonance (SurfacePlasmonResonance exactly, SPR), during resonance, internal field can increase thousands of times.Therefore the action effect of electric field and material can be improved greatly, very extensive in the application of bio-sensing field, become the strong technological means of people's amalyzing substances concentration.The utility model proposes a kind of novel SPR sensing technology, adopt outside nanosphere and cover metallic film as sensing unit, and with Graphene encapsulation, have the advantages that sensitivity is high and applied widely.
Summary of the invention
The utility model technical issues that need to address are: overcome the deficiencies in the prior art, provide a kind of highly sensitive, have wide range of applications, a kind of novel surface plasmon resonance biology sensor of price economy.
Technical solution of the present utility model is:
A kind of novel surface plasmon resonance biology sensor, be made up of prism (1), nano-grain array (2), silica membrane (3), Graphene (4) and sample cell (5), nano-grain array (2) is positioned at the lower surface of prism (1), silica membrane (3) covers on nano-grain array (2), Graphene (4) covers on silica membrane (3), prism (1) is high-index material, and nano-grain array (2) forms by covering metallic film (7) outside polystyrene nanospheres (6).
Described prism (1) is greater than the material of silica membrane (3) for refractive index, and is low-loss relative to incident light, is preferably dense flint glass or seleno oxygen sulphur glass or silicon.
Described polystyrene nanospheres (6) diameter is 50nm ~ 80nm, individual layer next-door neighbour arrangement.
Described metallic film (7) material is gold or silver-colored or aluminium, and thickness is 10nm ~ 80nm.
Described silica membrane (3) thickness is between 10nm and 0.25 times incident wavelength.
Described Graphene (4) number of plies is 1 ~ 8 layer.
The utility model compared with prior art tool has the following advantages:
1. the sensitivity of superelevation.The surface plasmon resonance biosensor of the utility model design improves 1 magnitude nearly with traditional biology sensor phase specific sensitivity.
2. test substance sensing range kind is wide.This biology sensor overcomes the limited shortcoming of testing sample states of matter, can carry out liquid state detection and can carry out gaseous state detection, applied range again.
3. long service life.Graphene has very strong oxidation resistance, can the not oxidized and corrosion of guard metal layer, increases serviceable life of sensor.
4. operative wavelength is wide.The prism material that the utility model is selected has wider operative wavelength, can detect at different-waveband to sample.
Accompanying drawing explanation
Fig. 1 is structural representation of the present utility model;
Fig. 2 surface plasmon resonance peak;
The resonance peak that Fig. 3 tests sample moves.
Embodiment
Below in conjunction with drawings and Examples, the utility model is described in further detail.
As shown in Figure 1, the utility model is made up of prism (1), nano-grain array (2), silica membrane (3), Graphene (4) and sample cell (5), nano-grain array (2) is positioned at the lower surface of prism (1), silica membrane (3) covers on nano-grain array (2), and Graphene (4) covers on silica membrane (3).When prism (1) is dense flint glass, metallic film (7) is silver, and thickness h is 10nm, and silica membrane (3) thickness is 25nm, when Graphene (4) thickness is 0.34nm, is the surface plasmon resonance that incident wavelength 700nm is used.
When incident by the 700nm LASER Light Source of TM polarization, after prism (1) refraction, arrive nano-grain array (2).After incident angle is greater than the cirtical angle of total reflection, produce evanescent waves in the interface of prism (1) and nano-grain array (2), this evanescent waves is by excitating surface plasmon resonance pattern.When to be covered in metallic film (7) thickness h on polystyrene nanospheres (6) be 10nm ~ 80nm, can significantly strengthen this resonance mode, its effect is similar to nano ball shell.When resonance occurs, internal field increases, and incident light is absorbed, and energy of reflection light is sharply declined, and reflectance spectrum occurs surface plasmon resonance peak, as shown in Figure 2.This resonance peak is very responsive to the change of sample refractive index, and when the sample refraction index changing adsorbed by Graphene (4), resonant positions will change, and realize the detection to sample, as shown in Figure 3.Graphene (4) specific inductive capacity has larger imaginary part, at a visible light wave range order of magnitude larger than Ag.When this can cause surface plasmon resonance, loss increases, and causes resonance peak to broaden, the accuracy of sensor is reduced.Between metallic film (7) and Graphene (4), add the effective dielectric constant that silica membrane (3) regulates film system, thickness is between 10nm and 0.25 times incident wavelength.
Concrete making step of the present utility model is as follows:
A. polystyrene nanospheres homogeneous dispersion is coated in prism lower surface, forms the individual layer nanosphere array of next-door neighbour; B. adopt magnetron sputtering metal-coated films on the nanosphere array of prism lower surface under vacuum environment, thickness is 10nm ~ 80nm; C. adopt liquid-phase deposition technique method (LPD) silicon dioxide thin film growth on argent or aluminium film, thickness is 10nm ~ 0.25 times incident wavelength; D. adopt chemical vapour deposition technique (CVD) growing graphene, thickness is 0.34nm ~ 2.72nm; E. clean, dry, complete making.
Claims (6)
1. a novel surface plasmon resonance biology sensor, by prism (1), nano-grain array (2), silica membrane (3), Graphene (4) and sample cell (5) composition, nano-grain array (2) is positioned at the lower surface of prism (1), silica membrane (3) covers on nano-grain array (2), Graphene (4) covers on silica membrane (3), it is characterized in that: prism (1) is high-index material, nano-grain array (2) forms by covering metallic film (7) outside polystyrene nanospheres (6).
2. novel surface plasmon resonance biology sensor according to claim 1, is characterized in that: described prism (1) is greater than the material of silica membrane (3) for refractive index, and is low-loss relative to incident light.
3. novel surface plasmon resonance biology sensor according to claim 1, is characterized in that: described polystyrene nanospheres (6) diameter is 50nm ~ 80nm, individual layer next-door neighbour arrangement.
4. novel surface plasmon resonance biology sensor according to claim 1, it is characterized in that: described metallic film (7) covers on polystyrene nanospheres (6), distance nanosphere top thickness h is 10nm ~ 80nm, and material is gold or silver-colored or aluminium.
5. novel surface plasmon resonance biology sensor according to claim 1, is characterized in that: described silica membrane (3) thickness is between 10nm and 0.25 times incident wavelength.
6. novel surface plasmon resonance biology sensor according to claim 1, is characterized in that: described Graphene (4) number of plies is 1 ~ 8 layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520394515.4U CN205120588U (en) | 2015-06-09 | 2015-06-09 | Novel surface plasmon biosensor that resonates |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520394515.4U CN205120588U (en) | 2015-06-09 | 2015-06-09 | Novel surface plasmon biosensor that resonates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205120588U true CN205120588U (en) | 2016-03-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520394515.4U Expired - Fee Related CN205120588U (en) | 2015-06-09 | 2015-06-09 | Novel surface plasmon biosensor that resonates |
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| CN (1) | CN205120588U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105004698A (en) * | 2015-06-09 | 2015-10-28 | 安徽师范大学 | Novel surface plasmon resonance biosensor |
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2015
- 2015-06-09 CN CN201520394515.4U patent/CN205120588U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105004698A (en) * | 2015-06-09 | 2015-10-28 | 安徽师范大学 | Novel surface plasmon resonance biosensor |
| CN105004698B (en) * | 2015-06-09 | 2018-01-09 | 安徽师范大学 | A kind of Biosensors Based on Surface Plasmon Resonance device |
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| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160330 Termination date: 20170609 |
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| CF01 | Termination of patent right due to non-payment of annual fee |