CN204994406U - Experimental device for be used for preparing spinal cord veutro damage animal models - Google Patents
Experimental device for be used for preparing spinal cord veutro damage animal models Download PDFInfo
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- CN204994406U CN204994406U CN201520582990.4U CN201520582990U CN204994406U CN 204994406 U CN204994406 U CN 204994406U CN 201520582990 U CN201520582990 U CN 201520582990U CN 204994406 U CN204994406 U CN 204994406U
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- spinal cord
- elevating lever
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Abstract
The utility model relates to a laboratory instruments technical field specifically is an experimental device for be used for preparing spinal cord veutro damage animal models, including operation platform, stand and crossbeam, wherein: operation platform's upper surface is equipped with the four limbs fixation clamp, the stand stands on this work platform's side, and the stand is connected the crossbeam hangs the lifter perpendicularly on, " L " style of calligraphy oppression pole is connected to the bottom of this lifter. The beneficial effects of the utility model are that, in clinical real work, by original from the spinal cord outer by the veutro impact with the experimental method that oppress, change into and outwards carry out the tractive by experimental animals's spinal cord inboard, simulate the degree that the spinal cord oppression harmd, better simulation the situation of human spinal cord injury.
Description
Technical field
The utility model relates to Laboratory Instruments technical field, specifically a kind of experimental provision for the preparation of ventral side of spinal cord injured animal model.
Background technology
Along with developing rapidly of communications and building industry, the incidence of disease of spinal cord injury (SpinalCordInjury, SC) rises year by year.According to statistics, whole world spinal cord injury incidence reaches 23%, annual newly-increased about 180,000 cases.In the U.S., only within 2010 1 year, just have 12400 routine new cases, according to estimates to the year two thousand fifty, the morbidity numeral of spinal cord injury number may more than 17560 examples, its seriously crippling family and the society of giving bring white elephant.
Because the pathophysiological mechanism after spinal cord injury is complicated, current result for the treatment of is still undesirable.Research spinal cord injury mechanism and methods for the treatment of thereof, animal spinal cord damage model is most important.Mainly containing following several animal spinal cord damage model at present: 1, contusion type spinal cord injury, is of short duration, acute spinal cord injury, and the percussion device of employing mainly comprises weight pendant and hits device, electromagnetism beating device, air gun beating device etc.; 2, compressive spinal cord injury is the spinal cord injury of decompression, causes compressing to simulate the decompression damage of the spinal cords such as vertebral fracture, dislocation, waist dish outstanding by modes such as artery clamp, air bags to spinal cord; 3, ischemia-reperfusion injury of spinal cord model, play an important role to studying Reperfusion Injury of Spinal Cord and damaging rear pathomechanism change, the method for this model of making mainly contains at present: blood vessel embolism method, blood vessel clip close method, photochemical method, coagulation is bright closes method etc.; 4, transection lesion type, completely cross-section or partial cross section spinal cord injury model is widely used in the Regeneration and Repair after tissue engineering spinal cord damage, and this model is conducive to the assessment regeneration capacity of aixs cylinder and the functional rehabilitation of spinal cord; 5, the damage of other types, comprises stretch injury type and chemical damage type.In view of the complexity of human myeloid's damage, still do not have a kind of model can simulating human spinal cord injury completely at present.
The feature that animal spinal cord damage model should possess: 1, clinical similarities, namely spinal cord injury model is similar to clinical spinal cord injury situation; 2, Modulatory character, namely needs to quantize spinal cord injury size according to research; 3, repeatable, namely studying spinal cord injury mechanism and treating needs a large amount of laboratory animal, therefore will be easy to make.
In clinical practice work, the bursting fracture of backbone and dislocation are clashed into and compressing spinal cord from ventral side of spinal cord often, instead of cause damage from the dorsal part of spinal cord, therefore make controllable, animal model that is easy to operate, that more can simulate clinical spinal cord injury is most important.
Application number is " 200920255035.4 ", Authorization Notice No. is " CN201542752U ", name is called that the Chinese utility model patent of " a kind of experimental provision for the preparation of animal model with spinal cord damnification " discloses a kind of experimental provision for the preparation of animal model with spinal cord damnification, include: a testing stand, the middle part of this experimental bench is the table plane of a depression, surrounding is protruding pedestal, and on pedestal, be provided with several lanyard fixed legs for fixing laboratory animal; Several support bars be made up of vertical slide bar and horizontal sliding bar, are movably connected in both sides and the rear side of experimental bench respectively; For the hook of fixing operation pincers, be connected to the horizontal sliding bar front end being positioned at 2 support bars in experimental bench both sides; A vertical impact device, be fixed on experimental bench Backside support bar, comprise vertical impact passage and an impact bar of a hollow, vertical impact passage is vertically fixed on the front end of support bar horizontal sliding bar by impacting passage guide holder, the impact bar that diameter is slightly less than vertical impact channel internal diameter can be positioned in vertical impact passage, falls along vertical impact channel vertical.What propose in this utility model patent can not the effect of simulating human spinal cord injury completely by the mode of impacting from experimental model.
Utility model content
The purpose of this utility model is to overcome the deficiencies in the prior art, provide a kind of can the experimental provision for the preparation of ventral side of spinal cord injured animal model of simulating human spinal cord injury situation better.
In order to achieve the above object, the utility model provides a kind of experimental provision for the preparation of ventral side of spinal cord injured animal model, comprises operating platform, column and crossbeam, wherein:
The upper surface of described operating platform is provided with four limbs geometrical clamp;
Described column stands on the side of this operating platform, and this column connects described crossbeam, vertical hanging elevating lever on this crossbeam, and the bottom of this elevating lever connects "L" shaped compressing bar.During experiment, first the four limbs of laboratory animal are clamped by four limbs geometrical clamp, be fixed on the operational platform, cut the dorsal skin of laboratory animal, be successively separated hypodermis and expose after 9-10 saves centrum spinous process, between centrum, micro rongeur is inserted in gap, sting except side vertebra, exposing spinal cord, then insert described "L" shaped compressing bar, by the tractive height regulating the height of elevating lever to drive "L" shaped compressing pole pair laboratory animal spinal cord, simulate the degree of spinal cord compression injury.
Preferably, described crossbeam and the hang of elevating lever are:
Described elevating lever is equidistantly provided with clamping recess, the crossbeam of this elevating lever side arranges clamping block, the crossbeam of this elevating lever opposite side is arranged petal knob, described petal knob and described crossbeam carry out axis hole and are connected, this petal knob is provided with clamping lobe around its center of circle, and described clamping lobe and clamping recess carry out clamping.Described clamping lobe and clamping recess match clamping, and when after rotation petal knob, clamping lobe falls into corresponding clamping recess and drives the lifting of elevating lever.
Preferably, described crossbeam and the hang of elevating lever are:
Described crossbeam is provided with cross locating slot;
Described elevating lever is equidistantly provided with spring, and the two ends of this spring connect holding rod respectively, each holding rod are provided with the positioning wedged block of the convex corresponding with described locating slot end shape.Pin the holding rod of spring both sides with forefinger and thumb, be fixed in cross locating slot.
Preferably, described crossbeam and the hang of elevating lever are:
Described crossbeam is longitudinally provided with through hole, in this through hole, is provided with thread groove;
The outer surface of described elevating lever is provided with external screw thread, and the external screw thread of this elevating lever and the thread groove of described through hole cooperatively interact;
The outer surface of described elevating lever is provided with graduation mark.Rotate elevating lever, the lower surface of the graduation mark of differing heights with crossbeam through hole is agreed with mutually, to reach the object regulating the different tractive height of compressing pole pair laboratory animal spinal cord.
Preferably, described crossbeam and the hang of elevating lever are:
Described crossbeam is provided with substrate, this substrate is installed power transmission shaft, drive sprocket, chain and driven sprocket;
Described power transmission shaft is connection reducer, motor and by-pass cock successively, and described elevating lever is connected on chain.
Preferably, described operating platform is provided with illuminating lamp.
Preferably, the side of described operating platform is provided with slideway;
Slide in the bottom of described column in slideway.The position of adjusting post in slideway, thus be convenient to compressing bar on the laboratory animal secured, better find the experimental point needing to carry out spinal cord injury.
Preferably, the radical of described column is two, is separately positioned on the offside of operating platform.Two root posts add the degree of stability of this experimental provision.
Preferably, the upper surface of described operating platform is provided with concave surface.Zooperal body can be accommodated in the inner by set concave surface, improves fixed effect, has good positioning function.
Preferably, describedly the animals such as SD rat, experiment mice, experimental rabbit are comprised for the animal carrying out the experiment of ventral side of spinal cord injured animal model.
The beneficial effects of the utility model are, in clinical practice work, by original experimental technique being undertaken clashing into and oppress from spinal cord by veutro, change into the degree of outwards to carry out tractive inside the spinal cord by laboratory animal, simulating spinal cord compression injury, the better the situation simulating human myeloid's damage.
Accompanying drawing explanation
Fig. 1 is structural representation of the present utility model;
Fig. 2 is the enlarged diagram of part A in Fig. 1;
Fig. 3 is the another structural representation of the utility model;
Fig. 4 is the enlarged diagram of part B in Fig. 3;
Fig. 5 be Fig. 4 D to cutaway view;
Fig. 6 is the front view of crossbeam shown in Fig. 3;
Fig. 7 is the schematic diagram of suspended structure shown in Fig. 3;
Fig. 8 is another structural representation of the utility model;
Fig. 9 is the enlarged diagram of C part in Fig. 8;
Figure 10 is the utility model structural representation again.
Wherein:
1-operating platform 2-column 3-crossbeam
4-elevating lever 5-"L" shaped compressing bar 6-illuminating lamp
7-slideway 11-four limbs geometrical clamp 12-concave surface
31-clamping block 32-petal knob 321-clamping lobe
33-locating slot 34-through hole 35-substrate
41-clamping recess 42-spring 43-holding rod
44-positioning wedged block 45-graduation mark 50-by-pass cock
51-motor 52-decelerator 53-power transmission shaft
54-drive sprocket 55-chain 56-driven sprocket
Embodiment
Below in conjunction with the drawings and specific embodiments, the utility model is described further.
Embodiment 1:
The experimental provision for the preparation of ventral side of spinal cord injured animal model as shown in Fig. 1 ~ 2, comprises operating platform 1, column 2 and crossbeam 3, wherein:
The upper surface of described operating platform 1 is provided with four limbs geometrical clamp 11;
Described column 2 stands on the side of this operating platform 1, and column 2 connects described crossbeam 3, vertical hanging elevating lever 4 on crossbeam 3, and the bottom of this elevating lever 4 connects "L" shaped compressing bar 5.During experiment, first the four limbs of laboratory animal are clamped by four limbs geometrical clamp 11, be fixed on operating platform 1, cut the dorsal skin of laboratory animal, successively be separated hypodermis and expose after 9-10 saves centrum spinous process, between centrum, micro rongeur is inserted in gap, sting except side vertebra, exposing spinal cord, insert described "L" shaped compressing bar 5 again, by the tractive height regulating the height of elevating lever 4 to drive "L" shaped compressing bar 5 pairs of laboratory animal spinal cords, simulate the degree of spinal cord compression injury.
Wherein, described crossbeam 3 and the hang of elevating lever 4 are specially:
Described elevating lever 4 is equidistantly provided with clamping recess 41, the crossbeam 3 of this elevating lever 4 side arranges clamping block 31, the crossbeam 3 of this elevating lever 4 opposite side arranges petal knob 32, described petal knob 32 carries out axis hole with crossbeam 3 and is connected, petal knob 32 is provided with clamping lobe 321 around its center of circle, and described clamping lobe 321 carries out clamping with clamping recess 41.Described clamping lobe 321 and clamping recess 41 match clamping, and when after rotation petal knob 32, clamping lobe falls into corresponding clamping recess 41 and drives the lifting of elevating lever 42.
Described operating platform 1 is provided with illuminating lamp 6.
The side of described operating platform 1 is provided with slideway 7.The position of adjusting post 2 in slideway 7, thus be convenient to compressing bar 5 on the laboratory animal secured, better find the experimental point needing to carry out spinal cord injury.
The radical of described column 2 is two, is separately positioned on the offside of operating platform 1.Two root posts 2 add the degree of stability of this experimental provision.
The upper surface of described operating platform 1 is provided with concave surface 12.Zooperal body can be accommodated in the inner by set concave surface 12, improves fixed effect, has good positioning function.
Embodiment 2:
The experimental provision for the preparation of ventral side of spinal cord injured animal model as shown in figure 3 to figure 7, comprises operating platform 1, column 2 and crossbeam 3, wherein:
The upper surface of described operating platform 1 is provided with four limbs geometrical clamp 11;
Described column 2 stands on the side of this operating platform 1, and column 2 connects described crossbeam 3, vertical hanging elevating lever 4 on crossbeam 3, and the bottom of this elevating lever 4 connects "L" shaped compressing bar 5.During experiment, first the four limbs of laboratory animal are clamped by four limbs geometrical clamp 11, be fixed on operating platform 1, cut the dorsal skin of laboratory animal, successively be separated hypodermis and expose after 9-10 saves centrum spinous process, between centrum, micro rongeur is inserted in gap, sting except side vertebra, exposing spinal cord, insert described "L" shaped compressing bar 5 again, by the tractive height regulating the height of elevating lever 4 to drive "L" shaped compressing bar 5 pairs of laboratory animal spinal cords, simulate the degree of spinal cord compression injury.
Wherein, described crossbeam 3 and the hang of elevating lever 4 are specially:
Described crossbeam 3 is provided with cross locating slot 33;
Described elevating lever 4 is equidistantly provided with spring 42, and the two ends of this spring 42 connect holding rod 43 respectively, each holding rod 43 are provided with the positioning wedged block 44 of the convex corresponding with described locating slot 33 end shape.Pin the holding rod 43 of spring 42 both sides with forefinger and thumb, cross locating slot 33 will be fixed on.
Embodiment 3:
All the other are with embodiment 2, the experimental provision for the preparation of ventral side of spinal cord injured animal model as shown in Fig. 8 ~ 9, and wherein, described crossbeam 3 and the hang of elevating lever 4 are specially:
Described crossbeam 3 is longitudinally provided with through hole 34, in this through hole 34, is provided with thread groove;
The outer surface of described elevating lever 4 is provided with external screw thread, and the external screw thread of this elevating lever 4 and the thread groove of described through hole 34 cooperatively interact;
The outer surface of described elevating lever 4 is provided with graduation mark 45.
Embodiment 4:
All the other are with embodiment 2, the experimental provision for the preparation of ventral side of spinal cord injured animal model as shown in Figure 10, and wherein, described crossbeam 3 and the hang of elevating lever 4 are specially:
Described crossbeam 3 is provided with substrate 35, this substrate is installed power transmission shaft 53, drive sprocket 54, chain 55 and driven sprocket 56;
Described power transmission shaft 53 is connection reducer 52, motor 51 and by-pass cock 50 successively, and described elevating lever 4 is connected on chain 55.
Below the preferred embodiment that the utility model is created is illustrated, but the utility model is created and is not limited to described embodiment, those of ordinary skill in the art can also make all equivalent modification or replacement under the prerequisite without prejudice to the utility model creative spirit, and these equivalent modifications or replacement are all included in the application's claim limited range.
Claims (9)
1. for the preparation of an experimental provision for ventral side of spinal cord injured animal model, it is characterized in that: comprise operating platform (1), column (2) and crossbeam (3), wherein:
The upper surface of described operating platform (1) is provided with four limbs geometrical clamp (11);
Described column (2) stands on the side of this operating platform (1), this column (2) connects described crossbeam (3), the upper vertical hanging elevating lever (4) of this crossbeam (3), the bottom of this elevating lever (4) connects "L" shaped compressing bar (5).
2. the experimental provision for the preparation of ventral side of spinal cord injured animal model according to claim 1, is characterized in that, described crossbeam (3) and the hang of elevating lever (4) are:
Described elevating lever (4) is equidistantly provided with clamping recess (41), the crossbeam (3) of this elevating lever (4) side arranges clamping block (31), the crossbeam (3) of this elevating lever (4) opposite side arranges petal knob (32), described petal knob (32) is carried out axis hole with described crossbeam (3) and is connected, this petal knob (32) is provided with clamping lobe (321) around its center of circle, and described clamping lobe (321) and clamping recess (41) carry out clamping.
3. the experimental provision for the preparation of ventral side of spinal cord injured animal model according to claim 1, is characterized in that, described crossbeam (3) and the hang of elevating lever (4) are:
Described crossbeam (3) is provided with cross locating slot (33);
Described elevating lever (4) is equidistantly provided with spring (42), the two ends of this spring (42) connect holding rod (43) respectively, each holding rod (43) are provided with the positioning wedged block (44) of the convex corresponding with described locating slot (33) end shape.
4. the experimental provision for the preparation of ventral side of spinal cord injured animal model according to claim 1, is characterized in that, described crossbeam (3) and the hang of elevating lever (4) are:
Described crossbeam (3) is upper is longitudinally provided with through hole (34), and this through hole is provided with thread groove in (34);
The outer surface of described elevating lever (4) is provided with external screw thread, and the external screw thread of this elevating lever (4) and the thread groove of described through hole (34) cooperatively interact;
The outer surface of described elevating lever (4) is provided with graduation mark (45).
5. the experimental provision for the preparation of ventral side of spinal cord injured animal model according to claim 1, is characterized in that, described crossbeam (3) and the hang of elevating lever (4) are:
Described crossbeam (3) is provided with substrate (35), this substrate is installed power transmission shaft (53), drive sprocket (54), chain (55) and driven sprocket (56);
Described power transmission shaft (53) is connection reducer (52), motor (51) and by-pass cock (50) successively, and described elevating lever (4) is connected on chain (55).
6. the experimental provision for the preparation of ventral side of spinal cord injured animal model according to claim 1, is characterized in that: described operating platform (1) is provided with illuminating lamp (6).
7. the experimental provision for the preparation of ventral side of spinal cord injured animal model according to claim 1, is characterized in that: the side of described operating platform (1) is provided with slideway (7);
Slide in the bottom of described column (2) in slideway (7).
8. the experimental provision for the preparation of ventral side of spinal cord injured animal model according to claim 1, is characterized in that: the radical of described column (2) is two, is separately positioned on the offside of operating platform (1).
9. the experimental provision for the preparation of ventral side of spinal cord injured animal model according to claim 1, is characterized in that: the upper surface of described operating platform (1) is provided with concave surface (12).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520582990.4U CN204994406U (en) | 2015-08-05 | 2015-08-05 | Experimental device for be used for preparing spinal cord veutro damage animal models |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520582990.4U CN204994406U (en) | 2015-08-05 | 2015-08-05 | Experimental device for be used for preparing spinal cord veutro damage animal models |
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| Publication Number | Publication Date |
|---|---|
| CN204994406U true CN204994406U (en) | 2016-01-27 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201520582990.4U Expired - Fee Related CN204994406U (en) | 2015-08-05 | 2015-08-05 | Experimental device for be used for preparing spinal cord veutro damage animal models |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105147411A (en) * | 2015-08-05 | 2015-12-16 | 中国人民解放军第二军医大学 | Construction method and equipment for SCI (spinal cord injury) animal model |
| CN109009538A (en) * | 2018-08-16 | 2018-12-18 | 新乡医学院第附属医院 | A kind of spinal cord injury simulated experiment percussion device |
-
2015
- 2015-08-05 CN CN201520582990.4U patent/CN204994406U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105147411A (en) * | 2015-08-05 | 2015-12-16 | 中国人民解放军第二军医大学 | Construction method and equipment for SCI (spinal cord injury) animal model |
| CN105147411B (en) * | 2015-08-05 | 2017-11-03 | 中国人民解放军第二军医大学 | The construction method and structure equipment of animal model with spinal cord damnification |
| CN109009538A (en) * | 2018-08-16 | 2018-12-18 | 新乡医学院第附属医院 | A kind of spinal cord injury simulated experiment percussion device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160127 Termination date: 20160805 |
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| CF01 | Termination of patent right due to non-payment of annual fee |