CN204989122U - Load homogenate jar and filling device of high performance liquid chromatography post - Google Patents
Load homogenate jar and filling device of high performance liquid chromatography post Download PDFInfo
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- CN204989122U CN204989122U CN201520581320.0U CN201520581320U CN204989122U CN 204989122 U CN204989122 U CN 204989122U CN 201520581320 U CN201520581320 U CN 201520581320U CN 204989122 U CN204989122 U CN 204989122U
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- performance liquid
- lid
- homogenate
- tank body
- chromatographic column
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Abstract
Load the homogenate jar of high performance liquid chromatography post, include: the jar body (10), one first lid (20), one second lid (30), one high -pressure pipe fittings (40) and one last air bleeding valve (60). The jar body has a feed end and a discharge end, and the discharge end has one discharging channel (12), first lid sets up in the feed end of the jar body, high pressure pipe fittings wears to locate first lid, and it can communicate jar inner chamber of the body and high -voltage tube (70) of a high -pressure pump being used for loading, go up the air bleeding valve and also wear to locate the inner chamber of first lid, its one end intercommunication jar body, the second lid sets up in the discharge end of the jar body, and it can communicate discharging channel and high performance liquid chromatography post. This homogenate jar is under high pressure effect, and during wherein filler homogenate can be loaded minor diameter chromatogram column jacket fast, it was higher to load the success rate. The utility model discloses the filling device who loads the high performance liquid chromatography post is still provided.
Description
Technical field
The utility model relates to homogenate tank and the filling device of filling performance liquid chromatographic column, is particularly useful for the performance liquid chromatographic column loading internal diameter 0.8mm to 2.1mm.
Background technology
At microanalysis separation field, Ultra Performance Liquid Chromatography (UltraPerformanceLiquidChromatography, be called for short UPLC) with traditional high performance liquid chromatography (HighPerformanceLiquidChromatography, be called for short HPLC) compare, there is high separation (highresolution), high speed (highspeed) and the advantage of more environmental protection.UPLC system many employings particle diameter is used to be only the silicon dioxide microsphere of 1.7 μm, its chromatographic column internal diameter is generally 0.8mm to 2.1mm, post effect is that 4.0mm to 4.6mm chromatographic column can exceed 70% than the internal diameter of filling with 5 μm of particle diameter silicon dioxide microspheres, and the chromatographic column of filling than 3.5 μm of particle diameter silicon dioxide microspheres exceeds 40%.In addition, use the silica gel microball of 1.7 μm effectively can reduce column length, and when not affecting post effect, can run under the flow velocity exceeding common chromatographic column 3 times, velocity of separation improve 9 times.Use UPLC also can improve the sensitivity of analysis, save sample simultaneously and in a large number as the organic solvent of mobile phase, make the waste liquid of generation less, more environmental protection.
Chromatographic column is the core that efficient liquid phase chromatographic analysis is separated, in UPLC system, the grain diameter of filler is less, chromatographic column comparatively thin (internal diameter is about 0.8mm to 2.1mm), the filling process of chromatographic column is very easily subject to the impact of the factors such as gas meter surface tension, liquid viscosity, and it is lower to use current filling device to be packed into power.
Utility model content
The purpose of this utility model is to provide a kind of homogenate tank loading performance liquid chromatographic column, and that can improve little internal diameter chromatographic column is packed into power.
Another object of the present utility model is to provide a kind of filling device loading performance liquid chromatographic column, and that can improve little internal diameter chromatographic column is packed into power.
Utility model the utility model provides the homogenate tank of filling performance liquid chromatographic column, and it comprises: a tank body, first lid, second lid, a connecting piece for high-pressure pipe and a upper vent valve.Tank body has a feed end and a discharge end, and discharge end has a tapping channel; First lid is arranged at the feed end of tank body; Connecting piece for high-pressure pipe is arranged in the first lid, and it can be communicated with the inner chamber of tank body and the high-voltage tube of a high-pressure pump for loading; Upper vent valve is also arranged in the first lid, and its one end is communicated with the inner chamber of tank body; Second lid is arranged at the discharge end of tank body, and it can be communicated with tapping channel and performance liquid chromatographic column.
In the another kind of exemplary embodiment of the homogenate tank of filling performance liquid chromatographic column, homogenate tank also comprises a lower vent valve, and its one end is communicated with tapping channel.This structure in use can accelerate the efflux velocity of gas in tapping channel and the second lid passage, improves filling efficiency.
In also a kind of exemplary embodiment of the homogenate tank of filling performance liquid chromatographic column, one end of lower vent valve is communicated to the discharging port of tapping channel.
In also a kind of exemplary embodiment of the homogenate tank of filling performance liquid chromatographic column, tank inner chamber is cylindrical close to the part of feed end, and the part close to discharge end is conical, and conical cone top part connects tapping channel.Such structure is conducive to liquid in tank body fast and flow out from tapping channel equably, can improve efficiency and the filling quality of performance liquid chromatographic column filling.
In also a kind of exemplary embodiment of the homogenate tank of filling performance liquid chromatographic column, the first lid comprises: first tamponade, its salable inner side being connected to tank body feed end; With the fastening nut of a ring-type, it can connect the outside of tank body feed end, and against the first tamponade, to prevent the first tamponade from coming off from tank body, support equipment normally runs.
In also a kind of exemplary embodiment of the homogenate tank of filling performance liquid chromatographic column, the first lid also comprises the first packing washer of a ring-type between tank body and fastening nut.This structure can further improve the sealing of tank body, prevents leakage, improves efficiency and the success ratio of filling.
In also a kind of exemplary embodiment of the homogenate tank of filling performance liquid chromatographic column, the second lid comprises: second tamponade being connected to tank body discharge end; And the second packing washer of a ring-type between the second tamponade and tank body.This structure can improve the sealing of tank body, prevents leakage, improves efficiency and the success ratio of filling.
The utility model additionally provides the filling device of filling performance liquid chromatographic column, and it comprises: a high-pressure pump and an above-mentioned homogenate tank, homogenate tank is communicated with the high-voltage tube of this high-pressure pump by connecting piece for high-pressure pipe.
The homogenate tank of the filling performance liquid chromatographic column that utility model the utility model provides is particularly useful for the gc column tube of internal diameter 0.8mm to 2.1mm, effectively can reduce gas meter surface tension, liquid viscosity to the impact being packed into power.This homogenate tank is under High Pressure, and the filler homogenate in homogenate tank can be quickly loaded in minor diameter gc column tube, is packed into power higher.Upper vent valve can, when installation the first lid, make the gas in inner chamber discharge rapidly, can improve be packed into power and make the column performance of filling more efficiently, more stable.
Hereafter by clearly understandable mode, accompanying drawings preferred embodiment, is further described the above-mentioned technical characteristic of the homogenate tank of filling performance liquid chromatographic column and filling device, advantage and implementation thereof.
Accompanying drawing explanation
The following drawings only schematically illustrates the utility model and explains, does not limit scope of the present utility model.
Fig. 1 is the structural representation of a kind of exemplary embodiment of homogenate tank of the present utility model.
Fig. 2 is the structural representation of a kind of exemplary embodiment of filling device of the present utility model.
Fig. 3 is the structural representation of the another kind of exemplary embodiment of homogenate tank of the present utility model.
Label declaration
10 tank bodies
12 tapping channels
14 discharging ports
20 first lids
22 first tamponades
24 first packing washers
26 fastening nuts
30 second lids
32 second tamponades
34 second packing washers
40 connecting piece for high-pressure pipes
42 high-pressure pipe connectors
44 seal joints
50 times vent valves
Vent valve on 60
70 high-voltage tubes
100 homogenate tanks
200 high-pressure pumps
300 gc column tubes.
Embodiment
In order to the technical characteristic to utility model, object and effect have understanding clearly, now contrast accompanying drawing and embodiment of the present utility model is described, label identical in the various figures represents that structure is identical or structure is similar but the parts that function is identical.
In this article, " schematically " expression " serves as example, example or explanation ", not should by being described to any diagram of " schematically " in this article, embodiment is interpreted as a kind of preferred or have more the technical scheme of advantage.
For making simplified form, only schematically show the part relevant to the utility model in each figure, they do not represent its practical structures as product and actual proportions.In addition, being convenient to for making simplified form understand, there are the parts of identical structure or function in some figure, only schematically depict one of them, or only having marked one of them.
In this article, " on ", D score etc. only for representing the position relationship between relevant portion, and their absolute position non-limiting.In this article, " first ", " second " etc. only for differentiation each other, but not represent they significance level and order etc.
Refer to Fig. 1, Fig. 1 is the structural representation of a kind of exemplary embodiment of homogenate tank of the present utility model.The homogenate tank of filling performance liquid chromatographic column comprises: a tank body 10, first lid, 20, second lid, 30, connecting piece for high-pressure pipe 40 and a upper vent valve 60.Tank body 10 has a feed end and a discharge end, and discharge end has a tapping channel 12.First lid 20 is arranged at the feed end of tank body 10.Connecting piece for high-pressure pipe 40 is arranged in the first lid 20, it can be communicated with the inner chamber of tank body 10 and the high-voltage tube 70 of a high-pressure pump (not illustrating in figure) for loading, and displacement fluid during use in high-pressure pump enters the inner chamber of tank body 10 by high-voltage tube 70 and connecting piece for high-pressure pipe 40.Upper vent valve 60 is arranged in the first lid 20, and its one end is communicated with the inner chamber of tank body 10, in order to be discharged by the gas in tank body 10.Second lid 30 is arranged at the discharge end of tank body 10, and it can be communicated with tapping channel 12 and performance liquid chromatographic column, and filler homogenate during use in tank body 10 is filled to performance liquid chromatographic column by the second lid 30.
In this exemplary embodiment, tank body 10 inner chamber is cylindrical close to the part of feed end, and the part close to discharge end is conical, and conical cone top part connects tapping channel 12.Such structure is conducive to liquid in tank body 10 fast and flow out from tapping channel 12 equably, can improve efficiency and the filling quality of performance liquid chromatographic column filling.
In this exemplary embodiment, the first lid 20 comprises the fastening nut 26 of first tamponade 22 and a ring-type.The first salable inner side being connected to tank body 10 feed end of tamponade 22; Fastening nut 26 can connect the outside of tank body 10 feed end, and against the first tamponade 22.When homogenate tank uses, can produce higher hydraulic pressure in tank body 10, fastening nut 26 can effectively prevent the first tamponade 22 at elevated pressures from coming off from tank body 10, and support equipment normally runs.Fastening nut 26 and tank body 10 are such as by being threaded, or other dismountable connected modes.
In other exemplary embodiment, the first lid 20 also can comprise the first packing washer 24 of a ring-type between tank body 10 and fastening nut 26 further, can enhanced leaktightness further, pressure when ensureing to use in tank body 10.The material of the first packing washer 24 can be such as teflon.
In this exemplary embodiment, second lid 30 comprises the second packing washer 34 of second tamponade 32 and a ring-type, second tamponade 32 is connected to tank body 10 discharge end, second packing washer 34 between the second tamponade 32 and tank body 10, the second packing washer 34 can ensure use time tank body 10 in pressure.The material of the second packing washer 34 can be such as polyetheretherketone.
In this exemplary embodiment, connecting piece for high-pressure pipe 40 comprises a high-pressure pipe connector 42 and a seal joint 44.High-pressure pipe connector 42 in order to connect high-voltage tube 70, and makes it not easily rock upon connection.Seal joint 44 is in order to sealing, and prevent leakage, its material can be such as polyetheretherketone.
The utility model additionally provides the filling device of filling performance liquid chromatographic column.Fig. 2 is the structural representation of a kind of exemplary embodiment of filling device of the present utility model.As shown in the figure, the filling device of filling performance liquid chromatographic column comprises a high-pressure pump 200 and a homogenate tank 100 as shown in Figure 1, and homogenate tank 100 is communicated with the high-voltage tube 70 of high-pressure pump 200 by connecting piece for high-pressure pipe 40.
Above-mentioned filling device can be used for loading performance liquid chromatographic column, and wherein, packing method comprises the following steps:
A, by filled homogenate preparation liquid gc column tube 300 be connected to tank body 10 by the second lid 30;
B, unloading the first lid 20 from tank body 10, in tank body 10, adding homogenate preparation liquid, to filling tapping channel 12;
C, knock tank body 10 gently, if the liquid level of homogenate preparation liquid declines in tapping channel 12, again add homogenate preparation liquid and knock tank body 10 gently, repeatable operation until in tapping channel 12 liquid level of homogenate preparation liquid no longer decline;
D, in tank body 10, add filler homogenate, to the nominal volume reaching tank body 10;
E, high-voltage tube 70 is connected to connecting piece for high-pressure pipe 40, restarts high-pressure pump 200, to high-voltage tube 70, be full of displacement fluid;
F, upper vent valve 60 to be opened, the first lid 20 is arranged on tank body 10, close after installation and close vent valve 60;
G, again startup high-pressure pump 200 start to fill post, and cut out high-pressure pump 200 after dress post completes, unloads the gc column tube 300 loaded.
Solution used when wherein homogenate preparation liquid is preparation filler homogenate, wherein not containing filler.Filler homogenate needs through ultrasonic process after preparation completes, to remove wherein unnecessary gas.
Above-mentioned packing method is particularly useful for the gc column tube of internal diameter 0.8mm to 2.1mm.By the step c of above-mentioned packing method, effectively can discharge gas residual in tapping channel 12 and the second lid 30 passage, improve the success ratio of dress post.By the step f of above-mentioned packing method, gas unnecessary in tank body 10 be can effectively discharge, the efficiency of hydraulic pressure and the success ratio of dress post improved.
Fig. 3 is the structural representation of the another kind of exemplary embodiment of homogenate tank of the present utility model.Repeat no more with the same or analogous part of homogenate tank shown in Fig. 1 in the homogenate tank of this exemplary embodiment, difference is that it also comprises a lower vent valve 50 with it, and one end of lower vent valve 50 is communicated with tapping channel 12.One end of lower vent valve 50 can be communicated to discharging port 14 by tapping channel 12 as shown in the figure.
When the filling device comprising the filling performance liquid chromatographic column of homogenate tank as shown in Figure 3 and high-pressure pump uses, except there is the step of above-mentioned packing method, also comprise: in step c, first open lower vent valve 50, then knock tank body 10 gently; Until the liquid level of homogenate preparation liquid closes lower vent valve 50 after no longer declining in tapping channel 12.So can accelerate the efflux velocity of gas in tapping channel 12 and the second lid 30 passage, improve filling efficiency.
Be to be understood that, although this instructions describes according to each embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of instructions is only for clarity sake, those skilled in the art should by instructions integrally, technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
A series of detailed description listed is above only illustrating for possible embodiments of the present utility model; they are also not used to limit protection domain of the present utility model; allly do not depart from the utility model skill equivalent embodiments of doing of spirit or change; as the combination of feature, segmentation or repetition, all should be included within protection domain of the present utility model.
Claims (8)
1. load the homogenate tank of performance liquid chromatographic column, it comprises:
A tank body (10), it has a feed end and a discharge end, and described discharge end has a tapping channel (12);
First lid (20) being arranged at described tank body (10) feed end;
A connecting piece for high-pressure pipe (40) being arranged in described first lid (20), it can be communicated with the inner chamber of described tank body (10) and the high-voltage tube (70) of a high-pressure pump for loading; With
Second lid (30) being arranged at described tank body (10) discharge end, it can be communicated with described tapping channel (12) and performance liquid chromatographic column;
It is characterized in that, described homogenate tank also comprises the upper vent valve (60) that is arranged in described first lid (20), and its one end is communicated with the inner chamber of described tank body (10).
2. the homogenate tank of filling performance liquid chromatographic column as claimed in claim 1, wherein said homogenate tank also comprises a lower vent valve (50), and its one end is communicated with described tapping channel (12).
3. the homogenate tank of filling performance liquid chromatographic column as claimed in claim 2, one end of wherein said lower vent valve (50) is communicated to the discharging port (14) of described tapping channel (12).
4. the homogenate tank of filling performance liquid chromatographic column as claimed in claim 1, wherein said tank body (10) inner chamber is cylindrical close to the part of feed end, part close to discharge end is conical, and described conical cone top part connects described tapping channel (12).
5. the homogenate tank of filling performance liquid chromatographic column as claimed in claim 1, wherein said first lid (20) comprising:
First tamponade (22), its salable inner side being connected to described tank body (10) feed end; With
The fastening nut (26) of a ring-type, it can connect the outside of described tank body (10) feed end, and against described first tamponade (22), comes off from tank body (10) to prevent described first tamponade (22).
6. the homogenate tank of filling performance liquid chromatographic column as claimed in claim 5, wherein said first lid (20) also comprises the first packing washer (24) that is positioned at the ring-type between described tank body (10) and described fastening nut (26).
7. the homogenate tank of filling performance liquid chromatographic column as claimed in claim 1, wherein said second lid (30) comprising:
Second tamponade (32) being connected to described tank body (10) discharge end; With
Second packing washer (34) being positioned at the ring-type between described second tamponade (32) and described tank body (10).
8. load the filling device of performance liquid chromatographic column, it is characterized in that comprising:
A high-pressure pump; With
A homogenate tank as claimed in claim 1, it is communicated with the high-voltage tube (70) of this high-pressure pump by described connecting piece for high-pressure pipe (40).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520581320.0U CN204989122U (en) | 2015-08-05 | 2015-08-05 | Load homogenate jar and filling device of high performance liquid chromatography post |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520581320.0U CN204989122U (en) | 2015-08-05 | 2015-08-05 | Load homogenate jar and filling device of high performance liquid chromatography post |
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| Publication Number | Publication Date |
|---|---|
| CN204989122U true CN204989122U (en) | 2016-01-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520581320.0U Withdrawn - After Issue CN204989122U (en) | 2015-08-05 | 2015-08-05 | Load homogenate jar and filling device of high performance liquid chromatography post |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN204989122U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106442822A (en) * | 2015-08-05 | 2017-02-22 | 无锡加莱克色谱科技有限公司 | Homogenate tank filled with high performance liquid chromatographic column, filling device and filling method |
-
2015
- 2015-08-05 CN CN201520581320.0U patent/CN204989122U/en not_active Withdrawn - After Issue
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106442822A (en) * | 2015-08-05 | 2017-02-22 | 无锡加莱克色谱科技有限公司 | Homogenate tank filled with high performance liquid chromatographic column, filling device and filling method |
| CN106442822B (en) * | 2015-08-05 | 2018-06-12 | 无锡加莱克色谱科技有限公司 | Load homogenate tank, filling device and the method for performance liquid chromatographic column |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20160120 Effective date of abandoning: 20180612 |
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| AV01 | Patent right actively abandoned |