CN204841034U - Load homogenate jar and filling device of chromatographic column - Google Patents
Load homogenate jar and filling device of chromatographic column Download PDFInfo
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- CN204841034U CN204841034U CN201520581331.9U CN201520581331U CN204841034U CN 204841034 U CN204841034 U CN 204841034U CN 201520581331 U CN201520581331 U CN 201520581331U CN 204841034 U CN204841034 U CN 204841034U
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- homogenate
- chromatographic column
- pressure pipe
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Abstract
Load the homogenate jar of chromatographic column, include: the jar body (10), one upper cover (20) and one high -pressure pipe fittings (40). The jar body (10) has a feed end and a discharge end. Upper cover (20) set up in the feed end of the jar body (10). High pressure pipe fittings (40) detachably wears to locate upper cover (20), its high -pressure pump that can communicate jar inner chamber of the body (10) and be used for loading. The one end of the inner chamber of high pressure pipe fittings (40) the orientation jar body (10) is provided with a plurality of edges high -pressure pipe fittings (40) circumference evenly distributed discharging channel (46), and the axis of discharging channel (46) is 45 to 90 degrees with the contained angle of the axis of high -pressure pipe fittings (40). To the impact of filler homogenate when this homogenate jar has reduced high -pressure displacing liquid and gets into the homogenate jar, the homogeneity of chromatographic column post bed has been improved. The utility model discloses the filling device including above -mentioned homogenate jar is still provided.
Description
Technical field
The utility model relates to homogenate tank for loading chromatographic column and filling device, is particularly useful for the homogenate method filling of the preparative scale chromatography post of internal diameter 20mm to 100mm.
Background technology
At present, at biological and chemical field, in order to preparative separation target product more quickly and accurately, high performance liquid chromatography piece-rate system is widely used, particularly pharmaceutical industry.On whole separation of produced line, high performance liquid chromatography piece-rate system is the core of production line.And in piece-rate system, the most key with preparative scale chromatography post.
The quality of preparative scale chromatography post is mainly reflected in stability, volume containing the sample and separating degree, and the uniformity of chromatographic column post bed is one of principal element affecting these parameters.The packing method of preparative scale chromatography post mainly comprises: axial compression completion method and homogenate method.At present, in homogenate method, the impact to filler homogenate when filling device also cannot avoid high pressure displacement fluid to enter homogenate tank, makes the preparative scale chromatography post post bed of filling even not, affects the separating effect of chromatographic column.In addition, these filling devices are uncontrollable and solve the bounce-back of post bed filler when filling preparative scale chromatography post unloads post, and make the preparative scale chromatography post post bed of filling tight not, chromatographic column is of low quality, service life is short.
Utility model content
The purpose of this utility model is to provide a kind of homogenate tank loading chromatographic column, and it can reduce the impact to filler homogenate when high pressure displacement fluid enters homogenate tank, improves the uniformity of chromatographic column post bed.
Another object of the present utility model is to provide a kind of homogenate tank loading chromatographic column, and it can reduce the bounce-back of post bed filler when filling preparative scale chromatography post unloads post, makes chromatographic column post bed even and tight.
Also object of the present utility model is to provide a kind of filling device of chromatographic column, and it can reduce the impact to filler homogenate when high pressure displacement fluid enters homogenate tank, improves the uniformity of chromatographic column post bed.
Also object of the present utility model is to provide a kind of filling device of chromatographic column, and it can reduce the bounce-back of post bed filler when filling preparative scale chromatography post unloads post, makes chromatographic column post bed even and tight.
The utility model provides the homogenate tank of filling chromatographic column, and it comprises: tank body, a upper cover and a connecting piece for high-pressure pipe.Tank body has a feed end and a discharge end.Upper cover is arranged at the feed end of tank body.Connecting piece for high-pressure pipe is removably arranged in upper cover, and it can be communicated with the inner chamber of tank body and a high-pressure pump for loading.Connecting piece for high-pressure pipe is provided with a plurality of along the equally distributed tapping channel of connecting piece for high-pressure pipe circumference towards one end of the inner chamber of tank body, the angle of the axis of tapping channel and the axis of connecting piece for high-pressure pipe is 45 to 90 to spend.
In the another kind of exemplary embodiment of the homogenate tank of filling chromatographic column, the angle of the axis of tapping channel and the axis of connecting piece for high-pressure pipe is 90 degree.
In also a kind of exemplary embodiment of the homogenate tank of filling chromatographic column, the quantity of tapping channel is 3 to 20.
In also a kind of exemplary embodiment of the homogenate tank of filling chromatographic column, homogenate tank also comprises a fastening nut, and it can connect upper cover and extrude fixing connecting piece for high-pressure pipe with upper cover.
In also a kind of exemplary embodiment of the homogenate tank of filling chromatographic column, homogenate tank also comprises a discharging bolt, and the discharge end of tank body is communicated with gc column tube by discharging bolt; The internal diameter of discharging bolt is 1:4 to 1:10 with the ratio of the internal diameter of gc column tube.This structure can reduce the bounce-back of post bed filler when filling preparative scale chromatography post unloads post, makes chromatographic column post bed more even, tight.
In also a kind of exemplary embodiment of the homogenate tank of filling chromatographic column, the inner chamber of tank body is cylindrical close to the part of feed end, and the part close to discharge end is taper shape, and this conical cone top part is towards discharge end.Such structure is conducive to liquid in tank body fast and flow out from discharge end equably, can improve efficiency and the filling quality of chromatographic column filling.
The utility model additionally provides the filling device of chromatographic column, and it comprises: a high-pressure pump and an above-mentioned homogenate tank, homogenate tank is communicated with this high-pressure pump by connecting piece for high-pressure pipe.
The homogenate tank of the filling chromatographic column that the utility model provides and filling device, be particularly useful for the homogenate method filling of the preparative scale chromatography post of internal diameter 20mm to 100mm.In its use procedure, high pressure displacement fluid enters tank body by the tapping channel of connecting piece for high-pressure pipe, forms column and presses down, and the filler homogenate constant speed in tank body is declined and reaches uniform settlement.This homogenate tank reduces the impact to filler homogenate when high pressure displacement fluid enters homogenate tank, improves the uniformity of chromatographic column post bed.
Hereafter by clearly understandable mode, accompanying drawings preferred embodiment, is further described the above-mentioned technical characteristic of the homogenate tank of filling chromatographic column and filling device, advantage and implementation thereof.
Accompanying drawing explanation
The following drawings only schematically illustrates the utility model and explains, does not limit scope of the present utility model.
Fig. 1 is the structural representation of a kind of exemplary embodiment of homogenate tank of the present utility model.
Fig. 2 to Fig. 4 is the structural representation of the connecting piece for high-pressure pipe of the tank of homogenate shown in Fig. 1, wherein Fig. 4 be along in Fig. 3 I-I to sectional view.
Fig. 5 is the structural representation of the another kind of exemplary embodiment of connecting piece for high-pressure pipe of the present utility model.
Fig. 6 is the structural representation of connecting piece for high-pressure pipe of the present utility model also a kind of exemplary embodiment.
Fig. 7 is the structural representation of the another kind of exemplary embodiment of homogenate tank of the present utility model.
Label declaration
10 tank bodies
12 sealing rings
20 upper covers
22 charging apertures
30 fastening nuts
40,41,42 connecting piece for high-pressure pipes
46,47,48 tapping channels
50 discharging bolts
60 bolted nuts
70 gc column tubes.
Detailed description of the invention
In order to the technical characteristic to utility model, object and effect have understanding clearly, now contrast accompanying drawing and detailed description of the invention of the present utility model is described, label identical in the various figures represents that structure is identical or structure is similar but the parts that function is identical.
In this article, " schematically " expression " serves as example, example or explanation ", not should by being described to any diagram of " schematically " in this article, embodiment is interpreted as a kind of preferred or have more the technical scheme of advantage.
For making simplified form, only schematically show the part relevant to the utility model in each figure, they do not represent its practical structures as product and actual proportions.In addition, being convenient to for making simplified form understand, there are the parts of identical structure or function in some figure, only schematically depict one of them, or only having marked one of them.
In this article, " on " only for representing the position relationship between relevant portion, and their absolute position non-limiting.
Except as otherwise noted, number range herein not only comprises the gamut in two end points, also comprises the some subranges be contained in wherein.
Fig. 1 is the structural representation of a kind of exemplary embodiment of homogenate tank of the present utility model, and the homogenate tank of filling chromatographic column comprises: a tank body 10, upper cover 20 and a connecting piece for high-pressure pipe 40.Tank body 10 has a feed end and a discharge end, and during use, discharge end can connect gc column tube.Upper cover 20 is arranged at the feed end of tank body 10, and upper cover 20 and tank body 10 are such as by Flange joint, or other dismountable connected modes.Upper cover 20 has a charging aperture 22.Connecting piece for high-pressure pipe 40 is removably arranged in upper cover 20 by charging aperture 22, and it can be communicated with the inner chamber of tank body 10 and a high-pressure pump for loading.When connecting piece for high-pressure pipe 40 is installed on upper cover 20, namely charging aperture 22 is blocked by connecting piece for high-pressure pipe 40; When connecting piece for high-pressure pipe 40 unloads from upper cover 20, charging aperture 22 can be communicated with the inner chamber of tank body 10.
Fig. 2 to Fig. 4 is the structural representation of the connecting piece for high-pressure pipe of the tank of homogenate shown in Fig. 1, wherein Fig. 4 be along in Fig. 3 I-I to sectional view.Connecting piece for high-pressure pipe 40 is provided with six along the circumferential equally distributed tapping channel 46 of connecting piece for high-pressure pipe 40 towards one end of the inner chamber of tank body 10.Connecting piece for high-pressure pipe 40 is by the inner space of tapping channel 46 with tank body 10.In this exemplary embodiment, the angle α of the axis of tapping channel 46 and the axis of connecting piece for high-pressure pipe 40 is 90 degree (see Fig. 3).In other exemplary embodiment, the angle of the axis of tapping channel 46 and the axis of connecting piece for high-pressure pipe 40 can be the unspecified angle within the scope of 45 to 90 degree.Such as in the exemplary embodiment of the connecting piece for high-pressure pipe shown in Fig. 5, the angle β of the axis of tapping channel 47 and the axis of connecting piece for high-pressure pipe 41 is 45 degree.In use procedure, high pressure displacement fluid enters tank body 10 by tapping channel, forms column and presses down, and the filler homogenate constant speed in tank body 10 is declined and reaches uniform settlement.This homogenate tank reduces the impact to filler homogenate when high pressure displacement fluid enters homogenate tank, improves the uniformity of chromatographic column post bed.
In exemplary embodiment, homogenate tank also comprises a fastening nut 30, and it can connect upper cover 20 and extrude fixing connecting piece for high-pressure pipe 40 with upper cover 20.When connecting piece for high-pressure pipe 40 unloads from upper cover 20 by needs, need first unload fastening nut 30, then connecting piece for high-pressure pipe 40 is taken out from upper cover 20.Fastening nut 30 is such as hand-screw nut, to be easy for installation and removal.
In exemplary embodiment, the quantity of tapping channel 46 is six, and in other exemplary embodiment, the quantity of tapping channel can be three to two ten, such as in the exemplary embodiment of the connecting piece for high-pressure pipe shown in Fig. 6, the quantity of tapping channel 48 is eight.
In this exemplary embodiment, the inner chamber of tank body is cylindrical close to the part of feed end, and the part close to discharge end is conical, and this conical cone top part is towards discharge end.Such structure is conducive to liquid in tank body fast and flow out from discharge end equably, can improve efficiency and the filling quality of chromatographic column filling.
In exemplary embodiment, homogenate tank also comprises a sealing ring 12 between its tank body 10 and upper cover 20.The material of sealing ring 12 is such as EPDM.This structure can improve the sealing of homogenate tank, prevents leakage, improves efficiency and the success rate of filling.
The utility model additionally provides the filling device of chromatographic column, and it comprises: a high-pressure pump and a homogenate tank as shown in Figure 1, and homogenate tank is communicated with this high-pressure pump by connecting piece for high-pressure pipe 40.
Above-mentioned filling device can be used for filling preparative scale chromatography post, is particularly useful for the preparative scale chromatography post of internal diameter 20mm to 100mm.Packing method comprises the following steps: a, ready gc column tube is connected to the discharge end of tank body 10; B, unload connecting piece for high-pressure pipe 40 from upper cover 20, to tank body 10, add filler homogenate from charging aperture 22, to the nominal volume reaching tank body 10, then connecting piece for high-pressure pipe 40 is mounted to upper cover 20; C, high-pressure pump is connected to connecting piece for high-pressure pipe 40, starts high-pressure pump and start to fill post; Cut out high-pressure pump after dress post completes, unloads the chromatographic column of having loaded.Filler homogenate needs through ultrasonic process after preparation completes, to remove wherein unnecessary gas.
Wherein, after step c starts high-pressure pump, first the high pressure displacement fluid in high-pressure pump enters connecting piece for high-pressure pipe 40, then enters tank body 10 after shunting by tapping channel 46.When high pressure displacement fluid enters tank body 10, owing to having higher hydraulic pressure, the axis direction of its liquid flow direction and tapping channel 46 is basically identical, finally rush at the inwall of tank body 10 at a certain angle (in the exemplary embodiment shown in Fig. 1, this angle is 90 degree, and namely liquid flow direction is perpendicular to the inwall of tank body 10), and non-immediate impacts the filler homogenate in tank body 10, high pressure displacement fluid like this can form column and press down, and the filler homogenate constant speed in tank body is declined and reaches uniform settlement.
Fig. 7 is the structural representation of the another kind of exemplary embodiment of homogenate tank of the present utility model.The same or analogous part of homogenate tank shown in the homogenate tank of this exemplary embodiment and Fig. 1 repeats no more, and difference is that it also comprises a discharging bolt 50 with it, and the discharge end of tank body 10 is communicated with gc column tube 70 by discharging bolt 50; The internal diameter of discharging bolt 50 is 1:4 to 1:10 with the ratio of the internal diameter of gc column tube 70.
In exemplary embodiment, homogenate tank also comprises a bolted nut 60, and it can connect the discharge end of tank body 10 and extrude fixing discharging bolt 50 with the discharge end of tank body 10.Between the discharge end of discharging bolt 50 and tank body 10, an EPDM sealing ring also can be set, to improve the sealing of homogenate tank.
Comprise the filling device of the chromatographic column of homogenate tank as shown in Figure 7 and high-pressure pump, the bounce-back of post bed filler when filling preparative scale chromatography post unloads post can be reduced, make chromatographic column post bed more even, tight, improve product quality and the qualification rate of chromatographic column.
Be to be understood that, although this description describes according to each embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
A series of detailed description listed is above only illustrating for possible embodiments of the present utility model; they are also not used to limit protection domain of the present utility model; allly do not depart from the utility model skill equivalent embodiments of doing of spirit or change; as the combination of feature, segmentation or repetition, all should be included within protection domain of the present utility model.
Claims (8)
1. load the homogenate tank of chromatographic column, it comprises:
A tank body (10), it has a feed end and a discharge end;
A upper cover (20) being arranged at the feed end of described tank body (10); With
A connecting piece for high-pressure pipe (40,41,42) being removably arranged in described upper cover (20), it can be communicated with the inner chamber of described tank body (10) and a high-pressure pump for loading;
It is characterized in that, described connecting piece for high-pressure pipe (40,41,42) one end towards the inner chamber of described tank body (10) is provided with a plurality of along described connecting piece for high-pressure pipe (40,41,42) circumferential equally distributed tapping channel (46,47,48), the axis of described tapping channel (46,47,48) and described connecting piece for high-pressure pipe (40,41,42) angle of axis is 45 to 90 degree.
2. the homogenate tank of filling chromatographic column as claimed in claim 1, wherein, the angle of the axis of described tapping channel (46) and the axis of described connecting piece for high-pressure pipe (40) is 90 degree.
3. the homogenate tank of filling chromatographic column as claimed in claim 1, wherein, the quantity of described tapping channel (46,47,48) is 3 to 20.
4. the homogenate tank of filling chromatographic column as claimed in claim 1, wherein, described homogenate tank also comprises a fastening nut (30), and it can connect described upper cover (20) and extrude fixing described connecting piece for high-pressure pipe (40,41,42) with described upper cover (20).
5. the homogenate tank of filling chromatographic column as claimed in claim 1, wherein, described homogenate tank also comprises a discharging bolt (50), and the discharge end of described tank body (10) is communicated with gc column tube by described discharging bolt (50); The described internal diameter of discharging bolt (50) is 1:4 to 1:10 with the ratio of the internal diameter of described gc column tube.
6. the homogenate tank of filling chromatographic column as claimed in claim 5, wherein, described homogenate tank also comprises a bolted nut (60), and it is connected to described discharge end and extrudes fixing described discharging bolt (50) with described discharge end.
7. the homogenate tank of filling chromatographic column as claimed in claim 1, wherein, the inner chamber of described tank body (10) is cylindrical close to the part of feed end, and the part close to discharge end be taper shape, and described conical cone top part is towards described discharge end.
8. the filling device of chromatographic column, is characterized in that, comprising:
A high-pressure pump; With
A homogenate tank as claimed in claim 1, described connecting piece for high-pressure pipe (40,41,42) is communicated with this high-pressure pump.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520581331.9U CN204841034U (en) | 2015-08-05 | 2015-08-05 | Load homogenate jar and filling device of chromatographic column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520581331.9U CN204841034U (en) | 2015-08-05 | 2015-08-05 | Load homogenate jar and filling device of chromatographic column |
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| Publication Number | Publication Date |
|---|---|
| CN204841034U true CN204841034U (en) | 2015-12-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201520581331.9U Active CN204841034U (en) | 2015-08-05 | 2015-08-05 | Load homogenate jar and filling device of chromatographic column |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106474769A (en) * | 2016-12-30 | 2017-03-08 | 北京创新通恒科技有限公司 | A kind of discharge member and chromatographic column |
| CN106621463A (en) * | 2015-08-05 | 2017-05-10 | 无锡加莱克色谱科技有限公司 | Homogenizing pot filling with chromatographic column and filling device |
-
2015
- 2015-08-05 CN CN201520581331.9U patent/CN204841034U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106621463A (en) * | 2015-08-05 | 2017-05-10 | 无锡加莱克色谱科技有限公司 | Homogenizing pot filling with chromatographic column and filling device |
| CN106474769A (en) * | 2016-12-30 | 2017-03-08 | 北京创新通恒科技有限公司 | A kind of discharge member and chromatographic column |
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| GR01 | Patent grant |