CN204953359U - Article quality index difference automated inspection equipment - Google Patents

Article quality index difference automated inspection equipment Download PDF

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Publication number
CN204953359U
CN204953359U CN201520010687.7U CN201520010687U CN204953359U CN 204953359 U CN204953359 U CN 204953359U CN 201520010687 U CN201520010687 U CN 201520010687U CN 204953359 U CN204953359 U CN 204953359U
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sample
article
capsule
sampling
controller
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韩杰
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Abstract

The utility model discloses an article quality index difference automated inspection equipment. Wherein, the method includes: controller control sampling device carries out automatic sampling to the article of producing on the line, controller control censorship device will quality index measuring device is carried one by one to the sample of every group that the sampling device acquireed, controller control quality index measuring device measures the quality index of the sample of carrying every group of coming one by one and the quality index value of the sample that obtains the measurement return to the controller, the controller according to the quality index value of predetermined article, article quality index acceptance condition and the quality index value of the sample that the measurement obtained is judged whether the sample of every group is qualified. Through the utility model discloses a to article quality index's automated inspection, compare prior art and improved the efficiency and the degree of accuracy.

Description

A kind of article quality indicator difference automatic checkout equipment
Technical field
The present invention relates to article content uniformity detection field, particularly relate to a kind of method and apparatus of automatic test item content uniformity.
Background technology
Various pharmaceutical dosage form all has least unit when producing, as a powder pin, and a capsules, a tablet, one bag of granule, an ointment, an injection, one bottle of oral liquid etc.The weight or volume of institute's powder charge thing in medicine loading amount and least unit, whether loading amount meets the requirements is weigh the very important index of drug quality.Ideally, the actual loading amount of the medicine of the same specification of same kind all should equal standard value, but because each dosage forms of medicine can be subject to the impact of the many factors such as people, machine, material, method, ring in process of production, make the actual loading amount moment of institute's output medicine in production process there is fluctuation, standard value can be departed from, and can not be consistent between each powder, what have is partially light, and what have lays particular stress on, and some volumes are on the high side, some volumes are on the low side, Here it is content uniformity.Certainly, the index weighing drug quality is not limited only to loading amount, and therefore content uniformity belongs to the one of drug quality indicator difference.Due to the particularity of medicine, make to necessarily require its content uniformity to be stabilized in a narrower scope, off-limits is then defective medicine.
The most effective mode controlled production process Quality Evaluation of Chinese Medicinal figureofmerit is exactly measure one by one the medicine of institute's output, choose the defective products not meeting loading amount and require, but because pharmaceutical production amount is very large and the speed of production of pharmaceutical equipment is very high, for capsule, the speed of present capsule filler reached 7000 per minute, and the high speed tablet press producing tablet is per hour up to 1,500,000 especially, even the injection water injection of ampoule bottle splendid attire is also up to 600 per minute.So, cannot realize to control drug quality the mode that all medicines are measured one by one with online mode, and some formulation do quality index difference check time must be destructive, such as the liquid drugs injection of ampoule bottle splendid attire is done to the ampoule bottle just must breaking disconnected glass material when content uniformity checks, liquid is poured out and measures its volume, so more cannot be checked the content uniformity of product by the mode entirely examined.
Under prior art condition, all take Principle of Statistics as the artificial sampling inspection technique of foundation to the control method of content uniformity in drug production process, formulation for weight as content uniformity measurement index, its concrete grammar is as follows: operating personnel often extract (such as half an hour) sample of some in process of production at regular intervals from production unit, as a sample sets, electronic balance is used to weigh by grain, and weighing result is recorded in chronological order in preprepared space record table, this record sheet is called as " content uniformity inspection record ".When operating personnel in sampling check process find to there is the underproof sample of content uniformity, that failed test sample directly will to be picked out and as defective work process, after one group of sample inspection record, there are several super upper and lower warning values according to allowing in predetermined one group, allow the regulation that there are several super upper lower limit values whether qualified to judge this whole group of sample, namely whether sample sets is qualified, if when the grain number of super upper and lower warning value or bound limit value exceeds regulation, then this sample sets is judged to defective, according to the order of severity of sample sets abnormal conditions, operating personnel will carry out corresponding action, such as immediately the risk product of current output is isolated, and adjust production unit or shutdown and search and cause abnormal reason, for capsule, even need nib sampling one by one so that finding out abnormal sample is which nib specifically coming from filling machine etc., to adjust equipment in time, prevent that nib from continuing the underproof product of output content uniformity.In whole production process, operating personnel must repeat single sample inspection work at set intervals, terminate, and the everything in whole content uniformity checking process are all completed by manual operation until produce.After production terminates, content uniformity inspection record is preserved as important bath manufacturing records file, and inspection record not only will record the loading amount data of weighed sample, simultaneously also can record product out of Memory (as the name of an article, specification, lot number, product loading amount standard value, upper and lower warning value, upper lower limit value etc.), also to record production information (as the date of manufacture, local nume, production unit is numbered, ambient temperature and humidity, order of classes or grades at school, current operating personnel, quality inspection personnel, auditor etc.), the enterprise of part high request even also can require that operating personnel are at measurement loading amount numerical value, while filling in inspection record table, according to the loading amount value real-time change curve measuring the data obtained drafting institute test sample product, with other ASSOCIATE STATISTICS chart, to reflect the quality condition of entire block and the operation conditions of production equipment by the quality condition of sample, inspection record is very important quality document, properly will be preserved and pass judgment on as medicine integral installation water gaging is flat, equipment capacity is analyzed, the important evidence that drug quality is looked back and quality accident is reviewed.
But under artificial content uniformity test mode, operating personnel are difficult in strict accordance with requiring to carry out to sample and weigh and strictly according to the facts and timely record check result, even if operating personnel all carry out tightened sampling inspection in strict accordance with requiring to loading amount, but owing to being limited to sampling observation frequency, still can not guarantee that content uniformity does not go wrong.And what is more important, under the mode of current manual's sampling check, operating personnel must be all one whole group sampling check terminate after could according to exist in this group several super warning values, several transfinite value in conjunction with predetermined evaluation criterion judge this time content uniformity check whether qualified, namely whether this sample sets is qualified, found sample sets extremely and just started the product on production line to carry out isolation processing.Due to from sampling to weighing by grain, record, to whole group of result out, find that sample sets is defective through statistics and judgement again, this has at least needed the time of a few minutes, when production unit efficiency is so high, time a few minutes is enough to the product producing considerable amount, so certainly in these a few minutes the product of institute's output to there is defective work risk the highest, but cannot be isolated out, but be treated as normal product and return in the normal product before isolation.
The problems referred to above appear at other equally and have in the content uniformity testing process of the article of similar requirement, are certainly present in the process of other quality index Difference test of article too.
Summary of the invention
The object of the present invention is to provide a kind of article quality indicator difference automatic testing method and equipment, can realize the automatic detection to article quality index, its efficiency is high and simple to operate.
Based on above-mentioned purpose, embodiments provide a kind of article quality indicator difference automatic testing method, comprising:
Controller controls sampling apparatus and automatically samples to the article on production line;
The sample often organized that described sampling apparatus obtains by described controller control feeding device for inspection is transported to quality index measurement mechanism one by one;
Described controller controls the quality index of described quality index measurement mechanism to the sample often organized transported and measures one by one and the quality indicator value measuring the sample obtained is back to described controller;
According to the quality indicator value of the sample that the quality indicator value of article preset, article quality qualified condition and described measurement obtain, described controller judges that whether the described sample often organized is qualified.
Preferably, whether described often to organize the single sample that the whether qualified each sample comprised in group of sample judges according to quality index standard and acceptance condition qualified, and whether the whole sample sets that whole group of sample judges according to sample sets evaluation criterion is qualified.Described sample sets evaluation criterion be according to the degree that exceeds standard of single sample exceeded standard and quantity pre-set.
Preferably, the method also comprises:
Described controller controls described quality index measurement mechanism by qualified sample delivery to the first non-defective unit container in every group and by underproof sample delivery to the first defective products container in every group.
Preferably, the method also comprises:
Described controller controls sectioning to carry out segmentation and keeps in by the article on production line;
If the sample sets corresponding with the article of certain temporary segmentation is qualified, then described controller controls sectioning by article delivery to the second non-defective unit container of described segmentation, if the sample sets corresponding with the article of certain temporary segmentation is defective, then described controller controls sectioning by article delivery to the second defective products container of described segmentation.
Preferably, described controller control sampling apparatus carries out automatically sampling comprising to the article on production line: described controller controls sampling apparatus and automatically samples to the article that the production unit of at least two on production line is produced;
Described article quality indicator difference automatic testing method also comprises: the corresponding relation of described each sample of controller track record and production unit;
Described controller is according to the article quality indicators standard value preset, article quality qualified condition and described sample quality desired value judge that whether the described sample often organized is qualified and comprise: described controller is according to the article quality indicators standard value preset, article quality qualified condition, whether each sample that described sample quality desired value and described sample and the corresponding relation of production unit judge in described often group is qualified and judge that whether the described production unit that described sample is corresponding is working properly.
Preferably,
Described article quality indicator difference automatic testing method also comprises:
Described controller is when determining certain sample described or certain sample sets is defective, and output alarm information is reported to the police to warning device;
And/or;
Described controller receives article essential information, article production information, sampling parameter, mode of operation, default article quality indicators standard value and the article quality qualified condition that user inputs, and carry out statistical analysis according to described article essential information, article production information, described sampling parameter, mode of operation, default article quality indicators standard value, article quality qualified condition and described sample contents quality desired value, obtain the first analysis result
Described controller controls sampling apparatus to carry out automatically sampling comprising to the article on production line: described controller controls sampling apparatus and automatically samples according to described sampling parameter to the article on production line; Described sampling parameter comprises sampling time interval and/or often organizes the number of sample.
Preferably, described controller carries out statistical analysis according to described article essential information, article production information, described sampling parameter, mode of operation, default article quality indicators standard value, article quality qualified condition and described sample contents quality desired value and comprises: calculate process capability index, and described process capability index comprises any one in following parameter or is combined:
Ca, Cp and Cpk.
Preferably, described method also comprises:
Described first analysis result is shown, prints, far call and/or monitoring.
Present invention also offers a kind of article quality indicator difference automatic checkout equipment, comprising:
Controller, sampling apparatus, feeding device for inspection and quality index measurement mechanism;
Described controller, for sending sampling control signal to described sampling apparatus, sends censorship and controls signal to described feeding device for inspection and for sending measuring control signal to described quality index measurement mechanism;
Described sampling apparatus is for automatically sampling to the article on production line according to described sampling control signal;
Described feeding device for inspection be used for according to described censorship control signal by sampling arrangement samples to the sample often organized be transported to described quality index measurement mechanism one by one;
Described quality index measurement mechanism is used for measuring one by one the quality index of the sample often organized transported and is back to described controller by measuring the sample loading amount value obtained;
Described controller, also for judging that whether the described sample often organized is qualified according to article quality indicators standard value, article quality qualified condition and the described sample quality desired value preset.
Preferably, whether described often to organize the single sample that the whether qualified each sample comprised in group of sample judges according to quality index standard and acceptance condition qualified, and whether the whole sample sets that whole group of sample judges according to sample sets evaluation criterion is qualified.Described sample sets evaluation criterion be according to the degree that exceeds standard of single sample exceeded standard and quantity pre-set.
Preferably, described controller, also for when determining described sample passes, sending sample passes signal to described quality index measurement mechanism and for when determining described failed sample, sending failed sample signal to described quality index measurement mechanism;
Described quality index measurement mechanism, also for when receiving described sample passes signal, by the sample delivery to the first of correspondence non-defective unit container, and for when receiving described failed sample signal, by the sample delivery to the first of correspondence defective products container.
Preferably, described article quality index automatic checkout equipment also comprises sectioning;
Described controller, also for sending, segmentation is temporary controls signal to described sectioning;
Article on production line to be carried out segmentation and temporary for keeping in control signal according to described segmentation by described sectioning;
Described controller, also for sending corresponding group sample passes signal when counter sample combines lattice to described sectioning, and for the transmission corresponding group failed sample signal when counter sample group is defective to described sectioning;
Described sectioning, also for organizing sample passes signal by segmentation article delivery to the second non-defective unit container of correspondence according to described correspondence, and for working as corresponding segmentation article delivery to the second defective products container according to described correspondence group failed sample signal.
Preferably,
Described sampling apparatus is for automatically sampling to the article that the production unit of at least two on production line is produced according to described sampling control signal;
Described controller, also for the corresponding relation of track record sample and production unit, whether each sample judged in described often group according to article quality indicators standard value, article quality qualified condition, described sample quality desired value and the described sample preset and the corresponding relation of production unit is qualified and judge that whether the described production unit that described sample is corresponding is working properly.
Preferably,
Described article quality indicator difference automatic checkout equipment also comprises: human-computer interaction device, printing equipment, warning device and/or long-distance monitorng device;
Described controller, for when determining certain sample or certain sample sets is defective, output alarm information is reported to the police to warning device;
And/or;
Described controller, for receiving article essential information, article production information, sampling parameter, mode of operation, default article quality indicators standard value and article quality qualified condition that user inputs, and carry out statistical analysis according to described article essential information, article production information, described sampling parameter, mode of operation, default article quality indicators standard value, article quality qualified condition and described sample contents quality desired value, obtain the first analysis result; Described sampling control signal comprises described sampling parameter; Described sampling parameter comprises sampling time interval and/or often organizes the number of sample.
Preferably, described controller carries out statistical analysis according to described article essential information, article production information, described sampling parameter, mode of operation, default article quality indicators standard value, article quality qualified condition and described sample contents quality desired value and comprises: calculate process capability index, and described process capability index comprises any one in following parameter or is combined:
Ca, Cp and Cpk.
Preferably,
Described quality index measurement mechanism is weighing device, and described weighing device comprises: for accept from described send claim the charging tray of weighing of the sample that transports of device, for described sample of weighing in charging tray is weighed weighing unit, for by the feeding groove of sample delivery to the first non-defective unit container or the first defective products container, the push unit being used for described sample to push to from described charging tray of weighing described feeding groove;
Described feeding groove and described container can be movable relatively, and described weighing unit is also for being sent to described controller by weighing results, and described controller is used for controlling described feeding groove according to analysis result or described container moves.
Preferably,
Described weighing device also comprises buffering charging tray and charging ram;
Described buffering charging tray, send from described the sample claiming device to transport for directly accepting;
Described charging ram, for weighing charging tray be used for described sample of weighing in charging tray to push to described feeding groove described in being delivered to one by one by the sample in described buffering charging tray.
Preferably, described push unit is the second valve.
Preferably,
Described sampling apparatus comprises: import and production unit export be connected sampling overall channel, for detecting sample channel that the first detecting sensor, the import that whether have article to export out from production unit be connected with described sampling overall channel, for article to be switched to the sampling valve of described sample channel or non-sample channel from described sampling overall channel; Described first detecting sensor is used for testing result to transfer to described controller, and the control signal that described sampling valve is used for sending according to described controller performs corresponding operating;
Described sending claims device to comprise: for accepting the sample hopper of the sample exported from the outlet of described sample channel, be used to open or close described sample hopper outlet to discharge the discharge door of clout, lower probe tube, import is plugged in the upper probe tube that can move along its length direction in described sample hopper, import to be plugged in described upper probe tube and to export the elastic telescopic pipe be plugged in described lower probe tube, be located at the sampling block in described lower probe tube exit, for detecting the second detecting sensor whether having sample to fall in described sampling block, described second detecting sensor is used for testing result to transfer to described controller, and described sampling block is used for described sample to be released into weighing device one by one,
Or;
Described sending claims device to comprise: for the temporary sample transported from described sample channel sample cell, to be located at below described sample cell and be located at multiple stock layout hole stock layout plate, for hold the sample in described stock layout plate the 3rd supporting plate, better enter stock layout hole for auxiliary sample and the hairbrush of the dust the sample in described sample cell can be removed; Described stock layout plate can rotate relative to its central axis, and described 3rd supporting plate is provided with the fall sample hole of dust fall hole and for making the sample in described stock layout hole be released into described weighing device.
Preferably,
Described sampling apparatus also comprises import and exports with described sample channel the sample conveying tube and the first valve that are connected;
Described first valve is used for the sample in described sample conveying tube to blow to described sample hopper (or by conveyor-belt apparatus by sample delivery to sample hopper).
Preferably,
Described article are capsule shape;
Described production unit is the nib on capsule filler;
Described sampling apparatus comprises: adopt capsule pipe for what carry the article that exported by corresponding nib, the only bag hole of capsule pipe side is adopted described in being located at, can along the only capsule bar of described only bag hole inwall movement, can relative to described in adopt capsule pipe move and be provided with described adopt capsule pipe corresponding get capsule nib get capsule block, get described in being located at capsule block exit can relative to described in get the second supporting plate of capsule block movement, for accepting from the first defeated capsule pipe getting the sample of capsule nib release of correspondence and being located at the 3rd detecting sensor detecting and whether have sample to fall in the first corresponding defeated capsule pipe,
The described nib one_to_one corresponding adopted on capsule pipe and described capsule filler, described first defeated capsule pipe and describedly get capsule nib one_to_one corresponding, described only bag hole and only capsule bar coordinate, for when get capsule block be about to move to above the first defeated capsule pipe adopt capsule pipe outlet below time, only capsule bar temporarily stops the sample adopted in capsule pipe and prevents it from continuing to fall; Described capsule block of getting is when moving to primary importance, described in adopt capsule pipe, corresponding get capsule nib for being released into by sample; When described get capsule block move to the second place time, described in adopt capsule pipe, for sample is released into non-sample channel;
Described 3rd detecting sensor is connected with described controller, and the corresponding relation of the nib in the result oneself detected and the sample detected and capsule filler transfers to described controller;
Described controller, the corresponding relation between the nib in the sample loading amount value and capsule filler of sample, described sample described in the outcome record that returns according to described 3rd detecting sensor and weighing device;
Described sending claims device to comprise: for accepting the second defeated capsule pipe of the sample exported in the described first defeated capsule pipe of correspondence, lower probe tube, the upper probe tube that can move along its length direction, import are plugged in described upper probe tube and outlet being plugged in elastic telescopic pipe in described lower probe tube, being located at the sampling block in described lower probe tube exit, for detecting the second detecting sensor whether having sample to fall in described sampling block; The outlet of described second defeated capsule pipe is plugged in described upper probe tube import department, and the result that described second detecting sensor is used for detecting controlling oneself transfers to described controller, and described sampling block is used for described sample to be released into corresponding weighing device one by one.
Preferably,
Described send claim device also to comprise to be located at the only sample hole of described lower probe tube side, can along the only sample bar of described only sample hole inwall movement be located at described probe tube exit can relative to the first supporting plate of described lower probe tube movement, described only sample bar and only sample hole coordinate, for intercepting described sample one by one, described first supporting plate is provided with junk hole, when described first supporting plate moves to the described lower probe tube outlet position corresponding with described junk hole, the sample in described lower probe tube is released into described weighing device through described junk hole;
Or;
Described send claim device also to comprise to be located at the upper only sample hole of described lower probe tube side, down only sample hole, can along the upper only sample bar of described only sample hole inwall movement and lower only sample bar, described upper only sample bar and lower only sample bar coordinate, for intercepting described sample one by one, and discharge described sample one by one to described weighing device;
Or;
Described send claim device also to comprise to be located at described sampling block import department can relative to the upper sampling plate of described sampling block movement, be located at described sampling block exit can relative to the lower sampling plate of described sampling block movement, described upper sampling plate and described lower sampling plate coordinate, for intercepting one by one in described sample to described sampling block, and discharge described sample one by one to described weighing device.
Preferably,
Described article quality indicator difference automatic checkout equipment also comprises sectioning;
Described sectioning comprises: for accept total material pipe of the sample exported from described non-sample channel, at least two isocons being located at described total material pipe exit, export for controlling flow divider that synchronization only has an isocon import to open, with described isocon one_to_one corresponding and for temporary described isocon article buffer memory cabin, be located in each described buffer memory cabin and seperating vale for article being separated to the second non-defective unit container or the second defective products container.
The invention has the beneficial effects as follows:
Article quality indicator difference automatic testing method of the present invention and equipment, can all realize automation to the link such as sampling, measurement that article quality indicator difference detects, its efficiency is high, and simple to operate.Further, the present invention also by carrying out segmentation to article while sampling, both having achieved the separation to defective work in sample, having carried out timely separation again by the product section that there is quality risk of testing result to production line output of sample.Whether further, the present invention can also carry out differentiation statistical analysis to the article of the production of different production unit, thus automatically can detect production unit and go wrong.Visible, present device possesses mass data record and graph making analytic function, possesses risk product isolation processing ability timely, possesses the ability of production unit being carried out to statistical analysis one by one, and can print true and reliable simultaneously, the article quality indicator difference inspection record of information completely, can directly as bath manufacturing records file, simultaneity factor is by the different operating right of the personnel setting of cryptographic system to different rights, equipment is operated under slave mode all the time, realize electronical record and electronic signature simultaneously, meet 21CFRPart11 requirement, the article quality in production process and production equipment ruuning situation is allowed to be in all the time under monitoring, achieve article quality index S PC management and control truly, simultaneously also can to related data, information, chart, equipment operation condition, parameter carries out far call and/or monitoring.
Accompanying drawing explanation
The article quality indicator difference automatic checkout equipment structure chart that Fig. 1 provides for the embodiment of the present invention;
Fig. 2 A is the structure chart of the article quality indicator difference automatic checkout equipment in the embodiment of the present invention one;
Fig. 2 B send title structure drawing of device in the embodiment of the present invention;
Fig. 3 is the structure chart of the article quality indicator difference automatic checkout equipment in the embodiment of the present invention two;
Fig. 4 is Fig. 3 partial enlarged drawing;
Fig. 5 is the structure chart of the weighing device in the embodiment of the present invention three; ;
Fig. 6-Fig. 9 is the structure chart of the weighing device in the embodiment of the present invention four;
Figure 10 A, 10B are the structure chart of the article quality indicator difference automatic checkout equipment in the embodiment of the present invention five;
Figure 11 A, 11B, 11C are the fundamental diagram of the article quality indicator difference automatic checkout equipment in the embodiment of the present invention five;
Figure 12 is the flow chart of a kind of article quality indicator difference automatic testing method provided by the invention;
Figure 13 A, 13B are embody rule scene flow chart of the present invention.
Detailed description of the invention
Below in conjunction with the accompanying drawing in the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
The present invention aims to provide a kind of article quality indicator difference automatic testing method and equipment, by the automation of control unit as the control realization all processes of computer, to raise the efficiency, reduces complexity, and then improves the degree of accuracy detected.
As Figure 12, be a kind of article quality indicator difference automatic testing method provided by the invention, it comprises:
S11, controller control sampling apparatus and automatically sample to the article on production line;
The sample often organized that described sampling apparatus obtains by S12, described controller control feeding device for inspection is transported to quality index measurement mechanism one by one;
S13, described controller control the quality index of described quality index measurement mechanism to the sample often organized transported and measure one by one and be back to described controller by measuring the sample quality desired value obtained;
According to article quality indicators standard value, article quality qualified condition and the described sample quality desired value preset, S14, described controller judge that whether the described sample often organized is qualified.
Concrete, lattice are with card and whether often organize sample entirety qualified to need to judge each sample, and namely whether sample sets is qualified.
The present invention under the control of the controller, achieves the automatic sampling to article, conveying and quality index is measured, and result can be automatically returned to controller and judge, achieves the automation of whole testing process, avoids the defect adopting manual method to have.
Preferably, described article quality indicator difference automatic testing method also comprises:
S15, described controller control described quality index measurement mechanism ought qualified sample delivery to the first non-defective unit container often in group control described quality index measurement mechanism by underproof sample delivery to the first defective products container in every group.
Preferably, described article quality indicator difference automatic testing method also comprises:
S16, described controller control sectioning to carry out segmentation and keeps in by the article on production line;
If the sample sets that S17 is corresponding with the article of certain temporary segmentation is qualified, then described controller controls sectioning by article delivery to the second non-defective unit container of described segmentation, if the sample sets corresponding with the article of certain temporary segmentation is defective, then described controller controls sectioning by article delivery to the second defective products container of described segmentation.
In specific embodiment, step S11 comprises: described controller controls sampling apparatus and automatically samples to the article that the production unit of at least two on production line is produced;
Described article loading amount quality index automatic testing method also comprises: the corresponding relation of described each sample of controller track record and production unit;
Described controller is according to the article quality indicators standard value preset, article quality qualified condition and described sample quality desired value judge that whether the described sample often organized is qualified and comprise: described controller is according to the article quality indicators standard value preset, article quality qualified condition, whether each sample that described sample quality desired value and described sample and the corresponding relation of production unit judge in described often group is qualified and judge that whether the described production unit that described sample is corresponding is working properly.
For realizing reporting to the police and print, described article quality indicator difference automatic testing method also comprises:
Described controller is when determining certain sample described or certain sample sets is defective, and output alarm information is reported to the police to warning device;
And/or;
Described controller receives the article essential information of user's input, article production information, sampling parameter, mode of operation, the article quality indicators standard value preset and article quality qualified condition, and according to described article essential information, article production information, described sampling parameter, mode of operation, the article quality indicators standard value preset, article quality qualified condition and described sample contents quality desired value, quality index Value Data is needed in conjunction with various input information and user, carry out statistical analysis, as automatically calculated Ca, Cp, the process capability indexes such as Cpk, draw a diagram and carry out showing and/or printing, and/or to related data, information, chart, equipment operation condition, parameter carries out far call and/or monitoring.
Described controller controls sampling apparatus to carry out automatically sampling comprising to the article on production line: described controller controls sampling apparatus and automatically samples according to described sampling parameter to the article on production line; Described sampling parameter comprises sampling time interval and/or often organizes the number of sample.
Figure 13 A, 13B are the concrete operations flow process of test item content uniformity in the inventive method, Figure 13 A shows sampling, send title, weighs, the separation process of segmentation and non-defective unit and defective products, and Figure 13 B shows according to testing result automatic form filling, the process of drawing various analytic statistics chart, preservation, printing and inquiry.
Present invention also offers the equipment for realizing test item content uniformity, as shown in Figure 1, it comprises:
Controller 1, sampling apparatus 2, send and claim device 3 and weighing device 4.
Wherein, controller 1, for sending sampling control signal to sampling apparatus 2, send title to control signal to send and claims device 3 and for sending Weighing control signal to weighing device 4.
Sampling apparatus 2 is for automatically sampling to the article on production line according to sampling control signal.
Send and claim device 3 to send the sample often organized claiming control signal to be sampled by sampling apparatus 2 to be transported to weighing device 4 one by one for basis.
In practice, sampling apparatus 2 doublely can also send title device, and this sampling apparatus claims device just to become a device with sending, such as, can be realized by manipulator.
Weighing device 4 is for weigh one by one to the sample often organized transported and the sample loading amount value obtained weighing is back to controller 1.
Controller 1, also for judging that whether each sample is qualified and whether each sample sets is qualified according to article loading amount standard value, article loading amount acceptance condition and the sample loading amount value preset.
The acceptance condition of above-mentioned article loading amount sample sets can be such as exceed warning value in all article (as 20) of one group of selective examination must not be individual more than N (2), and must not have that Y (1) is individual exceeds the upper limit or lower limit, otherwise this time content uniformity inspection is defective, and namely this sample sets is defective.Certainly, sample sets acceptance condition can be arranged as required voluntarily.
It should be noted that, above-mentioned default article loading amount standard value, article loading amount acceptance condition, sample sets acceptance condition etc. all can input setting by human-computer interaction device 5 by user in advance.Certainly, user can also input the essential information of other information as medicine by human-computer interaction device 5 and (comprises the name of an article, specification, lot number), the loading amount scope that setting allows (comprises article loading amount standard value, upper warning value, lower warning value, higher limit, lower limit), input article production information (comprises the date of manufacture, local nume, pharmaceutical production device numbering, content uniformity automatic checkout equipment is numbered, production environment humiture, order of classes or grades at school, operator's name, Quality Inspector's name, reviewing officer's name etc.) and sampling parameter (comprise sampling time interval and/or often organize the number of sample), the mode of operation of equipment (comprises automatic sampling interval duration, the sample size of each weighing, balance automatic Verification frequency, inspection record printing type etc.) and article loading amount acceptance condition, sample sets acceptance condition, what such as, exceed upper and lower warning value in 20 samples of a group must not more than 2, and 1 must not be had to exceed the upper limit or lower limit, otherwise namely this sample sets is judged to defective, the product section corresponding with it is also judged to risk section isolates.
Above-mentioned human-computer interaction device 5 not only has input function, also can have the function of display data, as the various information of display user input and the various data of controller 1.
As controller 1 can according to as described in article essential information, article production information, as described in sampling parameter, mode of operation, default article loading amount standard value, article loading amount acceptance condition and as described in sampling article loading amount value in conjunction with various input information and user's request, statistical analysis is carried out to loading amount Value Data, specifically automatically can calculate the process capability indexes such as Ca, Cp, Cpk, the distribution proportion of automatic calculation sample actual loading amount value in each loading amount interval, normal distribution of automatic drafting sample loading amount numerical value etc., is sent to human-computer interaction device 5 and shows after drawing a diagram.
Above-mentioned human-computer interaction device 5 can integrate with controller 1, also can arrange separately.
Consult for convenience and retain data, present device also comprises printing equipment 7.Concrete, controller 1 and can be sent to the article essential information received by human-computer interaction device 5, article production information, sampling parameter, mode of operation, default article loading amount standard value and article loading amount acceptance condition printing equipment 7 in conjunction with the chart that weighing results is drawn and print.
For distinguishing qualified samples and failed test sample, in the present invention, controller 1, also for when determining a certain sample passes, sends sample passes signal to weighing device 4 and for when determining a certain failed sample, sends failed sample signal to weighing device 4.
Weighing device 4, also for when receiving sample passes signal, by the sample delivery to the first of correspondence non-defective unit container, and for when receiving failed sample signal, by the sample delivery to the first of correspondence defective products container.With this, qualified samples and failed test sample are separated.
In addition, present device also can comprise warning device 6, and when controller 1 determines a certain sample or sample sets is defective, output alarm information is reported to the police to warning device 6.Warning device 6 can be buzzer also can be LED etc., when failed sample and sample sets defective time, warning device can carry out warning in various degree, can slightly report to the police when measuring certain failed sample, such as can only flicker twice LED operating personnel be reminded suitably to note, or the picture of display flicker once corresponding region by means of only human-computer interaction device; Then seriously report to the police when certain sample sets is defective, because sample sets is defective imply that problem is comparatively serious, warning device can by long-time buzzing and the LED etc. that glimmers reminds operating personnel to take seriously, even can jump out warning dialog box by the display of human-computer interaction device and remote monitoring display, to remind site operation personnel and remote monitoring personnel.Certainly; it is only remind operating personnel to pay close attention to product quality and production unit operation conditions that above-mentioned warning belongs to production status abnormal alarm; equipment can not be shut down; and when equipment itself breaks down; warning device also can be reported to the police; this kind of warning belongs to equipment operation exception and reports to the police, and shows that equipment self has occurred fault in running.
Meanwhile, the present invention also can also comprise teledata and exchange or supervising device, can carry out far call and/or monitoring by networking mode to related data, information, chart, equipment operation condition, warning message, parameter.
In the prior art, must be all whether could organize appreciation condition after having detected one whole group of sample per sample qualified to judge the content uniformity of this group sample, namely whether sample sets is qualified, when determining sample sets and being defective, the product produced afterwards can only be taken measures, but there is no method with sample with the product that the period produces and take rational measure.Consider above-mentioned problem, in the present embodiment, preferably can also comprise sectioning 8.
Controller 1, also for sending, segmentation is temporary controls signal to sectioning 8.
Article on production line to be carried out segmentation and temporary for keeping in control signal according to segmentation by sectioning 8.
Controller 1, also for sending corresponding group sample passes signal when counter sample combines lattice to sectioning 8, and for sending correspondence group failed sample signal when counter sample group is defective to sectioning 8.
Sectioning 8, also for according to segmentation article delivery to the second non-defective unit container of correspondence group sample passes signal by correspondence, and for will when corresponding segmentation article delivery to the second defective products container according to correspondence group failed sample signal.
Embodiments provide two kinds of concrete segmentation methods:
Method one, segmentation again of first sampling is kept in, and comprises the steps:
First, according to predetermined time interval or according to predetermined quantity interval, from the quality index of (can be the article flow that production line continues output) compartment of terrain sampling Detection many groups article article flow.To determine segmented mode with many groups of sampling Detection article in method one, can be separated by between many groups article of sampling Detection the identical time interval or identical quantity interval, can select flexibly as required in practice, certain those skilled in the art should be understood that and are not limited to this implementation, precision or shortening such as in order to improve discovery disqualified goods within certain period find the time delay of disqualified goods, the time interval between many groups article that can shorten sampling Detection in this period or or reduce sampling Detection in this period many groups article between quantity interval.
Then, the article between the two groups of article detected by adjacent samples in above-mentioned steps carry out segmentation as one section to the article on production line.
In this example, carrying out segmentation to the article on production line is be foundation with many groups of sampling Detection article, and many groups article of sampling Detection are positioned at the end points place of segmentation, or is called and has been separated out each section of article between many group article.
Finally, when the two groups of article i.e. quality indicator value of two sample sets that adjacent samples detects is all qualified, it is qualified that the quality index of one section of article between these two groups of article is just judged to be, otherwise judge that the quality index of one section of article between these two groups of article is defective.
As can be seen here, in this example, if the quality index of the article of one group of sampling Detection is defective, then the quality index of two sections of article through the article both sides of this group sampling Detection all can be judged as defective.
After whether the quality index determining one section of article is qualified, can control by underproof one section of article storage in specific location, to isolate this section of article.
By the method in the present embodiment can be tighter article quality is controlled.
Method two, the temporary sampling Detection again of first segmentation, comprises the steps:
First, according to the number of articles presetting time span or preset, segmentation is carried out to the article on production line and keeps in.
In this example, the length of segmentation can adopt identical time span or with identical number of articles, above-mentioned time span and number of articles can be selected in practice as required flexibly.Certain those skilled in the art should be understood that and are not limited to this implementation, such as, within certain period, find the precision of disqualified goods in order to improving, can shorten the time span of segmentation or reduce the number of articles of segmentation within this period.
Then, each section of article separated are sampled respectively, to detect the quality index of sampling article.In method two, often group article and the sample sets of sampling Detection are positioned at the inside of segmentation.
Finally, when one group of article of sampling Detection and the quality indicator value of sample sets defective time, then the quality indicator value of one section of article at this group article place is judged to be defective, otherwise be judged to be qualified.
In method two, because each group of article of sampling Detection are all in one section of article of the segmentation of correspondence, therefore can using the standard of the quality indicator value of each group of article as the quality indicator value of one section of article at its place of measurement.
It should be noted that, in this example, if the frequency of segmentation is enough high, namely enough hour of every section of number of articles, is just only had the article of an one group of sampling Detection i.e. sample sets corresponding with it by every section of article of keeping in.
The sectioning of above-mentioned setting, article corresponding for sample sets are carried out relevant treatment by testing result timely that can organize per sample.Improve the control to article quality indicator difference.
The difference of article quality index is very likely because the fault of production equipment itself causes.An existing production equipment often has multiple production unit.To produce the capsule filler of capsule medicine, it has multiple nib, the impact being subject to nib size etc. is (concrete because wherein each nib correspond to a fixing filling bar, impact by the wearing and tearing of filling bar, off normal, spring breakage or sticking phenomenon), may the product loading amount produced of each nib also different.For the article produced each production unit detect respectively, to determine whether and to be that fault has appearred in which production unit.
For this reason, in the embodiment of the present invention, sampling apparatus 2 may be used for carrying out difference sampling automatically according to sampling control signal to the article that the production unit of at least two on production line is produced.
Controller 1, also for the corresponding relation of track record sample and production unit, whether each sample judged in described often group according to article loading amount standard value, article loading amount acceptance condition, described sample loading amount value and the described sample preset and the corresponding relation of production unit is qualified and judge that whether the described production unit that described sample is corresponding is working properly.
Based on this, the present invention can judge it is that fault has appearred in which production unit, to handle it targetedly according to testing result.
Below detailed description is several specific implementations of the article quality indicator difference automatic checkout equipment in the present invention, it should be noted that, be all loading amount with quality index in each specific implementation following for example is described, and to weigh loading amount take weight as standard.Those skilled in the art should be understood that, automatic detection and control can also be carried out in above-mentioned sampling observation mode to other quality index of article, only need to change corresponding quality index detecting unit, such as detect the hardness of tablet, as long as the weight sensor in weighing device is replaced by hardness transducer.
Embodiment one
As shown in Figure 2 A, wherein, the sampling apparatus of the article quality indicator difference automatic checkout equipment in the present embodiment comprises: import and production unit 100 export be connected sampling overall channel 201, for detecting sample channel 203 that the first detecting sensor 208, the import that whether have article to export out from production unit 100 be connected with sampling overall channel 201, for article to be switched to the sampling valve 204 of sample channel 203 or non-sample channel 202 from overall channel 201 of sampling.First detecting sensor 208 is for transferring to controller by testing result, and sampling valve 204 performs corresponding operating for the control signal sent according to described controller.
Wherein sampling valve 204 can rotate around sampling valve rotating shaft 205, with when turning to a certain position, sample channel 203 import is closed, the import of non-sample channel 202 is opened, make article enter non-sample channel 202, and can turn to another location, sample channel 203 import is opened, non-sample channel 202 import is closed, makes article enter sample channel 203.
Preferably, sampling apparatus also comprises import and exports with sample channel 203 sample conveying tube 207 and the first valve 206 that are connected;
Described first valve 206 for the sample in described sample conveying tube 207 is blown in subsequent sample hopper 309, certainly, in the present invention also can with conveyor-belt apparatus by sample delivery to sample hopper 309.
Send and claim device to comprise: for accepting the sample hopper 309 of the sample exported from the outlet of sample channel 203, for discharging the discharge door 311 of clout, lower probe tube 303, import plugs the upper probe tube 301 that can move along its length direction (above-below direction shown in Fig. 2 A) in sample hopper, import to be plugged in probe tube 301 and to export the elastic telescopic pipe 302 be plugged in lower probe tube 303, be located at the only sample hole 304 of lower probe tube 303 side, can along the only sample bar 305 of only sample hole 304 inwall movement, for detecting the second detecting sensor 306 whether having sample to fall in lower probe tube 303, that is located at lower probe tube 303 exit can relative to the first supporting plate 307 of lower probe tube 303 movement.First supporting plate 307 is provided with junk hole 308.
Title device can be sent by not being finished in hopper sample discharge by the unlatching of discharge door 311.And upper probe tube 301 moves up and down, can by sample as capsule etc. to be arranged into elastic telescopic pipe 302 one by one, elastic telescopic pipe 302 is kept in sample and sample is expelled to one by one lower probe tube 303.Stopping sample bar 305 and stop sample hole 304 and coordinate, once sampling a sample at the most for making in lower probe tube 303.When second detecting sensor 306 is for detecting that sample falls into, send a signal to controller.First supporting plate 307 is for holding lower probe tube 303, when controller know have sample to fall into time, control the first supporting plate 307 when moving to corresponding with described junk hole 308 position of lower probe tube 303 outlet, the sample in lower probe tube 303 is released into described weighing device through described junk hole 308.
Above-mentioned sending claims device also can comprise discharge door rotating shaft 310, and discharge door 311 is rotated around it.
As shown in Figure 2 B, title device is sent for another kind of structure, comprise: for accepting the article hopper 309 of the article exported from the external world, for the discharge door 311 of the clout in discharge articles hopper 309, lower probe tube 303, import plugs the upper probe tube 301 that can move along its length direction (above-below direction shown in Fig. 2 B) stated in article hopper, , import to be plugged in probe tube 301 and to export the elastic telescopic pipe 302 be plugged in lower probe tube 303, be located at the only sample hole 304 of lower probe tube 303 side, 3041 can along the only sample bar 305 of only sample hole 304 inwall movement, 3051.The diameter of upper probe tube 301, lower probe tube 303 and described elastic telescopic pipe 302 is all slightly larger than the diameter of the article that will transport, and namely its horizontal direction can hold article at the most.
Upper probe tube 301 moves up and down, can by the article in article hopper 309 as capsule etc. is arranged into elastic telescopic pipe 302 one by one, and elastic telescopic pipe 302 is kept in article and article is expelled to one by one lower probe tube 303.Two are stopped sample bar 305,3051 and work in coordination, and when an insertion correspondence stops sample hole, one is stopped sample hole from correspondence and extracts out, to intercept article one by one.Specifically, when stopping sample bar 305 from when only sample hole 304 is extracted out, article fall, and now only sample bar 3051 insertion stops sample hole 3041 for intercepting the article of whereabouts.Only sample bar 305 inserts only sample hole 304 afterwards, article are no longer fallen, and only sample bar 3051 is extracted out from 3041, with the article intercepted before discharging, as long as two spacing only between sample hole be not more than two article length and, so once above-mentioned most actions can intercept and discharge article.
In the present invention, lower probe tube 303 can also level move to side, to depart from only sample bar, supporting plate or sampling block, and moves apart the detecting sensor be originally positioned at below it, directly to be discharged by the stagnant article deposited in pipe.Such as go up when getting stuck in probe tube, elastic telescopic pipe, because probe tube and elastic telescopic pipe horizontal direction hold described article at the most only, so just easily there is the phenomenon that gets stuck when there are the article of abnormality in outer shape, at this moment its lower port is made to open wide easily the material blocked is cleared with regard to needing to move lower probe tube to side; For another example when the quantity of sampling reaches requirement, do not need to have sampled by grain again, probe tube will action together with the discharge door of product catching device at present for this, respectively the unnecessary article be arranged in probe tube, elastic telescopic pipe and the unnecessary article left in product catching device is emptied discharge articles conveying device.
Weighing device comprises: for accept from send claim the sample that transports of device charging tray 502 of weighing, for described sample of weighing in charging tray 502 is weighed weighing unit 501, for by the feeding groove 504 of sample delivery to the first non-defective unit container 505 or the first defective products container 506, the push unit being used for sample to push to from described charging tray 502 of weighing feeding groove 504.
Feeding groove 504 and container 505,506 can be movable relatively, and weighing unit 501 is also for being sent to described controller by weighing results, and described controller is used for controlling described feeding groove 504 according to analysis result or described container 505,506 moves.The structure of control described feeding groove 504 movement has been shown in Fig. 2.
Above-mentioned push unit can be the second valve 503, for sample is pushed to feeding groove 504 from described charging tray 502 of weighing.
As Fig. 2 A, present device also comprises sectioning, specifically comprises: for accept the sample exported from described non-sample channel 202 total material pipe 401, be located at described total material pipe 401 exit at least two isocons 402,403, the buffer memory cabin of the article that export for controlling flow divider 404 that synchronization only has an isocon import to open, with described isocon one_to_one corresponding and for temporary described isocon 406,407, be located in each described buffer memory cabin and seperating vale for article being separated to the second non-defective unit container 411 or the second defective products container 412.
Concrete, seperating vale can comprise non-defective unit valve 409 and defective products valve 408, and as Fig. 2 A, when 408 open, during 409 closedown, article will enter the second defective products container 412, otherwise, enter the second non-defective unit container 411.
In addition, sectioning also can arrange flow divider rotating shaft 405 and seperating vale rotating shaft 410, to make flow divider 404 and seperating vale respectively around corresponding axis of rotation.
In this embodiment, the segmented mode of said method one can be applied, article before and after sampling apparatus between double sampling are temporarily stored in buffer memory cabin as one section, if found after weighing device is measured, the front and back double sampling article that this section of temporary article are corresponding have at least one sample sets defective, then this section keeps in article is defective products, if front and back double sampling article i.e. two sample sets corresponding to this section of temporary article are all qualified, then this section keeps in article is non-defective unit.
Embodiment two
In the embodiment of the present invention two, it send title device from different being of embodiment one, Fig. 3 emphasis shows in the present embodiment the concrete structure sending and claim device, as shown in Figure 3, this send and claims device to comprise sample hopper 309 for accepting the sample exported from the outlet of sample channel 203, for discharging the discharge door 311 of clout, lower probe tube 303, import to plug in sample hopper and the upper probe tube 301 that can move along its length direction (above-below direction shown in Fig. 3), import to be plugged in probe tube 301 and to export the elastic telescopic pipe 302 be plugged in lower probe tube 303, be located at the sampling block 3031 in lower probe tube 303 exit, be located at the import of sampling block 3031 respectively, the upper sampling plate 3071 in exit, lower sampling plate 3072 and for detect sampling block 3031 in whether have sample to fall into the second detecting sensor 306.
Wherein, upper sampling plate 3071 and described lower sampling plate 3072 coordinate, and for intercepting one by one in described sample to described sampling block 3031, and discharge described sample one by one to described weighing device.
Fig. 4 shows the concrete structure of sampling block 3031, upper sampling plate 3071 and lower sampling plate 3072.Wherein, when upper sampling plate 3071 removes the import of sampling block 3031, sample falls in sampling block, and upper sampling block 3071 moves to the import of sampling block 3031, and sample is intercepted in lower probe tube 303.Instantly when sampling plate 3072 removes the outlet of sampling block 3031, sample falls in weighing device, and lower sampling block 3072 moves to the outlet of sampling block 3031, and sample is intercepted in sampling block 3031.Upper and lower sampling block 3071,3071 coordinates and is used for intercepting sample one by one in sampling block 3031.
Embodiment three
In the embodiment of the present invention three, it is weighing device from the different of embodiment one, two, Fig. 5 emphasis shows the concrete structure of weighing device, as shown in Figure 5, this weighing device comprise for accept from send the buffering charging tray 508 claiming the sample that transports of device, charging tray 502 of weighing, for described sample of weighing in charging tray 502 is weighed weighing unit 501, for by the feeding groove 504 of sample delivery to the first non-defective unit container 505 or the first defective products container 506, the push unit being used for sample to push to from described charging tray 502 of weighing feeding groove 504.
Feeding groove 504 and container 505,506 can be movable relatively, and weighing unit 501 is also for being sent to described controller by weighing results, and described controller is used for controlling described feeding groove 504 according to analysis result or described container 505,506 moves.The structure controlling container 505,506 movement has been shown in Fig. 5.
Push unit is charging ram 507, for weighing charging tray 502 be used for described sample of weighing in charging tray 502 to push to described feeding groove 504 described in being delivered to one by one by the sample in described buffering charging tray 508.
In addition, weighing device also can comprise verification counterweight 509, for verifying weighing unit 501 under the control of the controller.Verification condition and parameter all input by above-mentioned human-computer interaction device.
Embodiment four
Embodiment four and embodiment one, two, the difference of three is to send title device, Fig. 6 shows the sectional view of the weighing device in the present embodiment, Fig. 7 is the top view of this weighing device, please simultaneously see Fig. 6 and Fig. 7, this send and claims device to comprise: for keeping in the sample cell 607 of the sample transported from described sample channel, to be located at below described sample cell 607 and to be provided with the stock layout plate 601 in multiple stock layout hole 602, for holding the 3rd supporting plate 603 of the sample in described stock layout plate 601, better enter stock layout hole 602 for auxiliary sample and the hairbrush 608 of the dust on the sample in described sample cell 607 can be removed, described stock layout plate 601 can rotate relative to its central axis, and described 3rd supporting plate 603 is provided with fall sample hole 604 and a dust fall hole 605 that dust is fallen for making the sample in described stock layout hole 602 be released into described weighing device.
When stock layout plate 601 rotates around its central axis, the sample in sample cell 607 can fall in stock layout hole 602 gradually, each stock layout hole 602 content sample.At a time, have a stock layout hole 602 corresponding with the sample hole 604 that falls, thus make the sample in this stock layout hole 602 fall into weighing device from the sample hole 604 that falls.
In addition, when stock layout plate 601 rotates around its central axis, hairbrush 608 can accelerate sample and enter stock layout hole 602, removes the dust on the sample in described sample cell 607 simultaneously, and is discharged by dust fall hole 605.Obvious, dust fall hole 605 is less than to fall sample hole 604, is not enough to sample is dropped out.
For avoiding once having multiple sample to drop out from the sample hole 604 that falls, the screening orifice plate 606 be positioned at above sample hole 604 also can be set, block other samples in sample cell 607, make once only have a sample to drop out from the sample hole 604 that falls.
It should be noted that, sample directly can fall into weighing device from the sample hole 604 that falls, and the sample delivery also exported in the sample hole 604 that falls by defeated sample groove 609 is to weighing device.
As shown in Figure 8, in this embodiment four, also realize redundant sample to discharge by mobile 3rd supporting plate 603.
It should be noted that, each apparatus structure in above-described embodiment can carry out suitable combination and distortion as required.If Fig. 9 is that sending of embodiment four claims the structure chart that is combined with the weighing device of embodiment three of device.
Embodiment five
Embodiment five shows the device structure that the article produced for multiple production unit sample respectively.In this embodiment, be described for the equipment of production capsule shape article.
As shown in Figure 10 A, this equipment has production equipment capsule filler, and this capsule filler comprises filling machine upper module 103, filling machine lower module 104, be located at the nib 105 on filling machine upper module 103 and filling machine lower module 104 and be located at and go out capsule bar 106 below filling machine lower module 104.Nib 105 one_to_one corresponding on filling machine upper module 103 and filling machine lower module 104, goes out capsule bar 106 for being ejected by the capsule shape article in nib 105.
Sampling apparatus comprises: adopt capsule pipe 109 for what carry the article that exported by corresponding nib 105, the only bag hole 112 of capsule pipe 109 side is adopted described in being located at, can along the only capsule bar (as spring) 113 of described only bag hole 112 inwall movement, can relative to described in adopt capsule pipe 109 move and be provided with described adopt capsule pipe 109 corresponding get capsule nib 115 get capsule block 116, get described in being located at capsule block 116 exit can relative to described in get the second supporting plate 117 of capsule block 116 movement, for accepting from the first defeated capsule pipe 123 getting the sample that capsule nib 115 discharges of correspondence and being located at the 3rd detecting sensor 119 detecting and whether have sample to fall in the first corresponding defeated capsule pipe 123.
Adopting capsule pipe 109 has multiple, nib 105 one_to_one corresponding on itself and capsule filler, and described first defeated capsule pipe 123 is with described to get capsule nib 115 corresponding.Described only bag hole 112 and only capsule bar 113 coordinate, making to get in capsule nib 115 has a sample to be that length by making the thickness getting capsule block 116 equal a capsules realizes at the most, and only the effect of capsule bar 113 be when get capsule block 116 be about to move to above the first defeated capsule pipe 123 adopt capsule pipe 109 export below time, only capsule bar temporarily stops the sample adopted in capsule pipe 109 and prevents it from continuing to fall, and is sheared crowded broken to avoid the sample just in time exported through adopting capsule pipe 109 at that time by the capsule block 116 of getting of in-migration; Described capsule block 116 of getting is when moving to primary importance, described in adopt capsule pipe 109, corresponding get capsule nib 115 for being released into by sample; When described get capsule block 116 move to the second place time, described in adopt capsule pipe 109, for sample is released into non-sample channel.
In the present invention, getting capsule block 116 can move along the X-direction shown in Figure 11 A.Moving to the second place when getting capsule block 116 along the X-direction shown in Figure 11 A, namely departing from and adopting capsule pipe 109 when exporting corresponding position, adopting capsule pipe 109, for sample is released into non-sample channel, the concrete non-sample channel 118 that can be released into shown in Figure 11 A.When get capsule block 116 along with Figure 11 A arrow illustrate rightabout move to the primary importance shown in Figure 11 A namely with adopt capsule pipe 109 export corresponding position time, adopting capsule pipe 109, corresponding getting capsule nib 115 for being released into by sample.It should be noted that, get capsule block 116 move to primary importance namely with adopt capsule pipe 109 and export corresponding position eve, only the sample adopted in capsule pipe 109 is temporarily stopped preventing the sample exported through adopting capsule pipe 109 from being got capsule block 116 and shears crowded broken by capsule bar 113, it should be noted that simultaneously, when getting capsule block 116 and moving along the X direction, the second supporting plate 117 with get capsule block 116 and be synchronized with the movement.
When the number of getting capsule nib 115 of getting capsule block 116 is corresponding with the number of the first defeated capsule pipe 123, namely one when getting the corresponding first defeated capsule pipe 123 of capsule nib 115, get capsule block 116 when moving to the second place, the sample got in capsule nib 115 can be released into the first corresponding defeated capsule pipe 123.
It should be noted that, in most cases, first defeated capsule pipe 123 is often corresponding multiplely gets capsule nib 115, as shown in Figure 11 B, the corresponding left side one row of first defeated capsule pipe 123 on the left side gets capsule nib (A1-A5), and first defeated capsule pipe 123 corresponding the right one row on the right gets capsule nib (B1-B5).For the sample making a row get in capsule nib falls into the first corresponding defeated capsule pipe 123 successively according to certain order, in the present invention, getting capsule block 116 can move along the Y-direction shown in Figure 11 B, and now, it is static that capsule block 116 got relatively by the second supporting plate 117.Now, getting capsule nib such as A1-A5 and just can departing from the second supporting plate 117 successively along Y-direction and corresponding with the import of the first defeated capsule pipe 123, sample to be released into the first corresponding defeated capsule pipe 123 of capsule block 116 is got.
For making the 3rd detecting sensor 119 when a row gets capsule nib 115 correspondence one first defeated capsule pipe 123, accurately can identify the corresponding relation of nib and sample, in the present invention, sampling apparatus also comprises being located to be got on capsule block 116, gets capsule nib stake 124 as corresponding in A1, B1 and the 4th detecting sensor 125 for stake 124 as described in detecting with often arranging.
Its concrete operations are as follows:
When the second supporting plate 117 is motionless, and get capsule block 116 along Y-direction slower move time (such as slowly being driven by cylinder), when the stake 124 of foremost from the 4th detecting sensor 125 through out-of-date, two samples getting capsule nib from A1 and B1 respectively just should be had to fall in the first respective defeated capsule pipe 123 through the 3rd detecting sensor 119 immediately, if now the 3rd detecting sensor 119 detects the sample from A1 and B1, then to controller transmission signal inform enter now the first defeated capsule pipe 123 be respectively A1 and B1 sample; When second stake 124 from the 4th detecting sensor 125 through out-of-date, just should have and fall in the first respective defeated capsule pipe 123 through the 3rd detecting sensor 119 immediately from two samples of A2 and B2 nib respectively, this Time Controller just knows that coming in the first defeated capsule pipe 123 after A1 is A2 sample, come B1 below be B2 sample.If but now the 3rd detecting sensor 119 only detects A2, and B2 do not detected, then the 3rd detecting sensor 119 to controller transmission signal inform enter now the first defeated capsule pipe 123 only have A2; When the 3rd stake from the 4th detecting sensor 125 through out-of-date, just should have and fall in the first respective defeated capsule pipe 123 through the 3rd detecting sensor 119 immediately from two samples of A3 and B3 nib respectively, 3rd detecting sensor 119 to controller transmission signal inform enter now the first defeated capsule pipe 123 be respectively A3 and B3 sample, and controller just know now come A1 below for A2, come A2 below be A3; And come B1 below for B3 sample.The data of the sample that such controller has just detected after weighing device has detected B1 again directly will be recorded as the sample of B3 nib.
Relate to the recording mode of controller, controller can record sample in each defeated capsule pipe 123 corresponding get capsule nib, capsule nib of getting as corresponding in the sample in the record the left side first defeated capsule pipe 123 is followed successively by A1, A2, A3, and capsule nib of getting corresponding to sample in first of the right the defeated capsule pipe 123 is followed successively by B1, B3.Afterwards, the weighing data that weighing device is obtained according to the first defeated capsule pipe 123 and record sequence, under weighing data is recorded in counter sample.
Certainly, in these cases, controller can correspond respectively to two row's nibs and arrange two groups of memory cell, foregoing is recorded as by controller afterwards, the data of the memory cell of corresponding A 1, A2, A3 are followed successively by 1,1,1, and the data of the memory cell of corresponding B1, B2, B3 are followed successively by 1,0,1.So the weight data that records by grain of weighing device just by controller by number order successively only assigned value be the memory cell of " 1 ".Such as, B1 nib has sample, then its memory cell is just by set, and first sample data that B group weighing device records also is stored into memory cell corresponding to B1 nib; When having capsule in B3 nib when sample disappearance in B2 nib, then second sample data recorded when B group weighing device will by the direct memory cell corresponding stored in B3 nib.Because the numbering of memory cell is numbered corresponding with nib, so by data in the numbering of memory cell and its, controller can judge that each tuple is according to corresponding to which nib.
In addition, the present invention other structure controls can also be adopted to only have one at every turn to get capsule nib 115 corresponding with the first defeated capsule pipe 123.As, arrange and get capsule block 116 and move by step motor control along Y-direction, only walk the distance that is got capsule nib 115 at every turn, only allow A row and B row only to fall respectively a capsules extremely each self-corresponding first defeated capsule pipe 123.Sample all should be had to fall into the first corresponding defeated capsule pipe 123 by the 3rd detecting sensor when stepper motor stops at every turn, this utilizes the start stop signal of stepper motor to come stake 124 in alternative said method and the 4th detecting sensor 125.And controller judges all with above-mentioned to arrange stake 124 identical with the method for the 4th detecting sensor 125 sample actual arrangement order and the corresponding relation that nib is numbered in the first defeated capsule pipe 123.
In addition, also can allow in the present invention get and often walk a distance of getting capsule nib 115 when capsule block 116 moves along Y-direction and just stop certain hour, carry out alternative above-mentioned stepper motor signal by time start-stop signal.
Above-mentioned sampling apparatus can also Cai Nangguan 109 import department arrange adopt capsule upper module 107, adopt capsule pipe 109 export near setting adopt capsule lower module 110.Adopt capsule upper module 107 to be provided with and to adopt nib 108 on capsule, adopt capsule lower module 110 and be provided with and adopt nib 111 under capsule.Adopt nib 108 and nib 105 one_to_one corresponding on capsule, for accepting from nib 105 sample out, and with adopt capsule pipe 109 one_to_one corresponding, the sample delivery of undertaking is adopted capsule pipe 109 to corresponding, to adopt under capsule nib 111 and adopt capsule pipe 109 one_to_one corresponding, accepting the sample adopted in capsule pipe 109 and be delivered to and corresponding get capsule nib 115.This degree of depth of getting capsule nib can hold a sample.
For making the action simultaneously of multiple only capsule bar 113, sampling apparatus is also provided with the only capsule pole socket 114 that connection respectively stops capsule bar 113.
As shown in Figure 11 C, above-mentioned sampling apparatus also can comprise Jia Nang mechanism 1071, be installed on the Jia Nang mechanism of adopting in capsule upper module 107 to glide for preventing sample, being installed on the Jia Nang mechanism of adopting in capsule pipe 109 is then the same module all coming from capsule filler to ensure to get once the got capsule of capsule module 116, especially when the nib of filling machine row two rows and above time, now by causing inner side to adopt capsule pipe and outside, to adopt capsule pipe different at the radius in knee, thus it is different to cause automatically being trapped in the capsule quantity of adopting in capsule pipe inner side and outer side, and then cause synchronization to adopt capsule pipe and outside from inner side adopting the capsule of the automatic landing of capsule pipe not from the same module of filling machine.And this problem can adopt the position of capsule pipe 109 inner clip capsule mechanism 1071 by adjustment inner side and outer side, make inner side and outer side adopt capsule pipe and can press from both sides and deposit the capsule being detained equal number and solve.When getting advantage when once the got capsule of capsule module 116 all comes from the same module of capsule filler be: the A that weighing device measures at synchronization arranges nib weight data and B, and to arrange nib weight data be originate from the synchronization in capsule filler, what this made the detection data of same group react is that in producing, each nib is in the situation of synchronization, and Jia Nang mechanism 1071 can for being directly slightly less than elastic ring or several elasticity salient point, the jump ring etc. of sample diameter.
First defeated capsule pipe 123 directly can accept the sample got capsule nib 115 and discharge.Also also can arrange defeated capsule module 122 in the first Shu Nangguan 123 import department in the present invention, defeated capsule module 122 is provided with defeated capsule nib 120, is released into the first corresponding defeated capsule pipe 123 for accepting after getting sample that capsule nib 115 discharges.
Run for accelerating sample, in addition, as shown in Figure 10 B, run for accelerating sample, realize the sample basic synchronization of sample and the production gathered, capsule gas hole 1073 can be adopted adopting setting on capsule upper module 107, defeated capsule module 122 arranges defeated capsule gas hole 121, to blow respectively to adopting in capsule pipe 109 and in defeated capsule module 122 by adopting capsule gas hole 1073 and defeated capsule gas hole 121, accelerate sample motion, certainly, similar also can by adopting capsule pipe 109 exit and defeated capsule pipe 123 exit adopts the mode of vacuum draw to accelerate sample motion.
Send that to claim in device and embodiment four similar, its difference is, it utilizes the second defeated capsule pipe 312 to replace sampling hopper 309 to accept the sample of output in the described first defeated capsule pipe 123 of correspondence.
It should be noted that, in the present invention, send and claim the quantity of device corresponding with the quantity of the first defeated capsule pipe 123, be i.e. a first defeated capsule pipe 123 correspondence second defeated capsule pipe 312, the sample in same row's nib is released into and samely send title device.Weighing device claims device quantity corresponding with sending, same weighing device is only to the samples weighing in same row's nib, certainly, if in order to improve detection efficiency of weighing, the quantity of the quantity that also can make the first defeated capsule pipe 123 and the quantity of getting capsule nib 115, the second defeated capsule pipe 312, send and claim the quantity of the quantity of device, weighing device all identical and make its one_to_one corresponding, in this case, the capsule in each nib of capsule filler correspond to oneself special weighing device and special from module nib until the whole piece passage of the charging tray 502 of weighing of weighing device.
Weighing device, sectioning can adopt structure same with the above-mentioned embodiment.
In view of controller have recorded the corresponding relation of sample and production unit and nib, thus testing result per sample can judge that fault has appearred in which nib.
It should be noted that, above-mentioned different structure can adapt to different article.The present invention can select as required.
It should be noted that, apparatus and method embodiment of the present invention is corresponding, and relevant portion can reference mutually.
Above specific embodiment, object of the present invention, technical scheme and beneficial effect are further described, it should be noted, these are only a specific embodiment of the present invention, those skilled in the art can carry out various change and modification to the present invention and not depart from the spirit and scope of the present invention.Like this, if these amendments of the present invention and modification belong within the scope of the claims in the present invention and equivalent technologies thereof, then the present invention is also intended to comprise these change and modification.

Claims (11)

1. an article quality indicator difference automatic checkout equipment, is characterized in that, this equipment comprises:
Controller, sampling apparatus, feeding device for inspection and quality index measurement mechanism;
Described controller, for sending sampling control signal to described sampling apparatus, sends censorship and controls signal to described feeding device for inspection and for sending measuring control signal to described quality index measurement mechanism;
Described sampling apparatus is for automatically sampling to the article on production line according to described sampling control signal;
Described feeding device for inspection be used for according to described censorship control signal by sampling arrangement samples to the sample often organized be transported to described quality index measurement mechanism one by one;
Described quality index measurement mechanism is used for measuring one by one the quality index of the sample often organized transported and is back to described controller by measuring the sample quality desired value obtained;
Described controller, also for judging that whether the described sample often organized is qualified according to the quality indicator value of article quality indicators standard value, article quality qualified condition and the described sample preset.
2. article quality indicator difference automatic checkout equipment as claimed in claim 1, it is characterized in that, described article quality index automatic checkout equipment also comprises sectioning;
Described controller, also for sending, segmentation is temporary controls signal to described sectioning;
Article on production line to be carried out segmentation and temporary for keeping in control signal according to described segmentation by described sectioning;
Described controller, also for sending corresponding group sample passes signal when counter sample combines lattice to described sectioning, and for the transmission corresponding group failed sample signal when counter sample group is defective to described sectioning;
Described sectioning, also for organizing sample passes signal by segmentation article delivery to the second non-defective unit container of correspondence according to described correspondence, and for working as corresponding segmentation article delivery to the second defective products container according to described correspondence group failed sample signal.
3. article quality indicator difference automatic checkout equipment as claimed in claim 1, it is characterized in that, described article quality indicator difference automatic checkout equipment also comprises: human-computer interaction device, printing equipment, warning device and/or long-distance monitorng device;
Described controller, for when determining certain sample or certain sample sets is defective, output alarm information is reported to the police to warning device;
And/or;
Described controller, for receiving article essential information, article production information, sampling parameter, mode of operation, default article quality indicators standard value and article quality qualified condition that user inputs, described sampling control signal comprises described sampling parameter; Described sampling parameter comprises sampling time interval and/or often organizes the number of sample.
4. article quality indicator difference automatic checkout equipment as claimed in claim 1, is characterized in that,
Described quality index measurement mechanism is weighing device, and described weighing device comprises: for accept from send claim the sample that transports of device charging tray of weighing, for described sample of weighing in charging tray is weighed weighing unit, for by the feeding groove of sample delivery to the first non-defective unit container or the first defective products container, the push unit being used for described sample to push to from described charging tray of weighing described feeding groove;
Described feeding groove and described container can be movable relatively, and described weighing unit is also for being sent to described controller by weighing results, and described controller is used for controlling described feeding groove according to analysis result or described container moves.
5. article quality indicator difference automatic checkout equipment as claimed in claim 4, is characterized in that,
Described weighing device also comprises buffering charging tray and charging ram;
Described buffering charging tray, send from described the sample claiming device to transport for directly accepting;
Described charging ram, for weighing charging tray be used for described sample of weighing in charging tray to push to described feeding groove described in being delivered to one by one by the sample in described buffering charging tray.
6. article quality indicator difference automatic checkout equipment as claimed in claim 4, it is characterized in that, described push unit is the second valve.
7. article quality indicator difference automatic checkout equipment as claimed in claim 4, is characterized in that,
Described sampling apparatus comprises: import and production unit export be connected sampling overall channel, for detecting sample channel that the first detecting sensor, the import that whether have article to export out from production unit be connected with described sampling overall channel, for article to be switched to the sampling valve of described sample channel or non-sample channel from described sampling overall channel; Described first detecting sensor is used for testing result to transfer to described controller, and the control signal that described sampling valve is used for sending according to described controller performs corresponding operating;
Described sending claims device to comprise: for accepting the sample hopper of the sample exported from the outlet of described sample channel, for discharging the discharge door of clout, lower probe tube, import is plugged in the upper probe tube that can move along its length direction in described sample hopper, import to be plugged in described upper probe tube and to export the elastic telescopic pipe be plugged in described lower probe tube, be located at the sampling block in described lower probe tube exit, for detecting the second detecting sensor whether having sample to fall in described sampling block, described second detecting sensor is used for testing result to transfer to described controller, and described sampling block is used for described sample to be released into weighing device one by one,
Or;
Described sending claims device to comprise: for the temporary sample transported from described sample channel sample cell, to be located at below described sample cell and be located at multiple stock layout hole stock layout plate, for hold the sample in described stock layout plate the 3rd supporting plate, better enter stock layout hole for auxiliary sample and the hairbrush of the dust the sample in described sample cell can be removed; Described stock layout plate can rotate relative to its central axis, and described 3rd supporting plate is provided with the fall sample hole of dust fall hole and for making the sample in described stock layout hole be released into described weighing device.
8. article quality indicator difference automatic checkout equipment as claimed in claim 7, it is characterized in that, described sampling apparatus also comprises import and exports with described sample channel the sample conveying tube and the first valve that are connected;
Described first valve is used for the sample in described sample conveying tube to blow to described sample hopper.
9. article quality indicator difference automatic checkout equipment as claimed in claim 4, it is characterized in that, described article are capsule shape;
Production unit is the nib on capsule filler;
Described sampling apparatus comprises: adopt capsule pipe for what carry the article that exported by corresponding nib, the only bag hole of capsule pipe side is adopted described in being located at, can along the only capsule bar of described only bag hole inwall movement, can relative to described in adopt capsule pipe move and be provided with described adopt capsule pipe corresponding get capsule nib get capsule block, get described in being located at capsule block exit can relative to described in get the second supporting plate of capsule block movement, for accepting from the first defeated capsule pipe getting the sample of capsule nib release of correspondence and being located at the 3rd detecting sensor detecting and whether have sample to fall in the first corresponding defeated capsule pipe,
The described nib one_to_one corresponding adopted on capsule pipe and described capsule filler, described first defeated capsule pipe and describedly get capsule nib one_to_one corresponding, described only bag hole and only capsule bar coordinate, for when get capsule block be about to move to above the first defeated capsule pipe adopt capsule pipe outlet below time, only capsule bar temporarily stops the sample adopted in capsule pipe and prevents it from continuing to fall; Described capsule block of getting is when moving to primary importance, described in adopt capsule pipe, corresponding get capsule nib for being released into by sample; When described get capsule block move to the second place time, described in adopt capsule pipe, for sample is released into non-sample channel;
Described 3rd detecting sensor is connected with described controller, and the corresponding relation of the nib in the result oneself detected and the sample detected and capsule filler transfers to described controller;
Described controller, the corresponding relation between the nib in the sample loading amount value and capsule filler of sample, described sample described in the outcome record that returns according to described 3rd detecting sensor and weighing device;
Described sending claims device to comprise: for accepting the second defeated capsule pipe of the sample exported in the described first defeated capsule pipe of correspondence, lower probe tube, the upper probe tube that can move along its length direction, import are plugged in described upper probe tube and outlet being plugged in elastic telescopic pipe in described lower probe tube, being located at the sampling block in described lower probe tube exit, for detecting the second detecting sensor whether having sample to fall in described sampling block; The outlet of described second defeated capsule pipe is plugged in described upper probe tube import department, and the result that described second detecting sensor is used for oneself to detect transfers to described controller, and described sampling block is used for described sample to be released into corresponding weighing device one by one.
10. the article quality indicator difference automatic checkout equipment as described in any one in claim 7-9, is characterized in that,
Described send claim device also to comprise to be located at the only sample hole of described lower probe tube side, can along the only sample bar of described only sample hole inwall movement be located at described probe tube exit can relative to the first supporting plate of described lower probe tube movement, described only sample bar and only sample hole coordinate, for intercepting described sample one by one, described first supporting plate is provided with junk hole, when described first supporting plate moves to the described lower probe tube outlet position corresponding with described junk hole, the sample in described lower probe tube is released into described weighing device through described junk hole;
Or;
Described send claim device also to comprise to be located at the upper only sample hole of described lower probe tube side, down only sample hole, can along the upper only sample bar of described only sample hole inwall movement and lower only sample bar, described upper only sample bar and lower only sample bar coordinate, for intercepting described sample one by one, and discharge described sample one by one to described weighing device;
Or;
Described send claim device also to comprise to be located at described sampling block import department can relative to the upper sampling plate of described sampling block movement, be located at described sampling block exit can relative to the lower sampling plate of described sampling block movement, described upper sampling plate and described lower sampling plate coordinate, for intercepting one by one in described sample to described sampling block, and discharge described sample one by one to described weighing device.
11. article quality indicator difference automatic checkout equipments as claimed in claim 10, is characterized in that, described article quality indicator difference automatic checkout equipment also comprises sectioning;
Described sectioning comprises: for accept total material pipe of the sample exported from described non-sample channel, at least two isocons being located at described total material pipe exit, export for controlling flow divider that synchronization only has an isocon import to open, with described isocon one_to_one corresponding and for temporary described isocon article buffer memory cabin, be located in each described buffer memory cabin and seperating vale for article being separated to the second non-defective unit container or the second defective products container.
CN201520010687.7U 2015-01-01 2015-01-01 Article quality index difference automated inspection equipment Active CN204953359U (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104772285A (en) * 2015-01-01 2015-07-15 韩杰 Article content different automatic detection method and apparatus thereof
CN112700168A (en) * 2021-01-14 2021-04-23 北京赛而生物药业有限公司 Method and device for quality inspection of capsule medicines

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104772285A (en) * 2015-01-01 2015-07-15 韩杰 Article content different automatic detection method and apparatus thereof
CN112700168A (en) * 2021-01-14 2021-04-23 北京赛而生物药业有限公司 Method and device for quality inspection of capsule medicines
CN112700168B (en) * 2021-01-14 2021-12-07 北京赛而生物药业有限公司 Method and device for quality inspection of capsule medicines

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