CN204839624U - Percutaneous left auricle of heart shutoff apparatus - Google Patents
Percutaneous left auricle of heart shutoff apparatus Download PDFInfo
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- CN204839624U CN204839624U CN201520411011.9U CN201520411011U CN204839624U CN 204839624 U CN204839624 U CN 204839624U CN 201520411011 U CN201520411011 U CN 201520411011U CN 204839624 U CN204839624 U CN 204839624U
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- shutoff
- atrial appendage
- occluding body
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Abstract
The utility model relates to a percutaneous left auricle of heart shutoff apparatus, the shutoff was physically outside and for the shutoff body, connecting rod, orientation regulator in it was equipped with by the inner to outer end in proper order, the interior shutoff body be equipped with basket support and first shutoff membrane, the basket support constitute by the basket silk, be equipped with on the basket silk to rivet and collude and protect the ball, but the connecting rod be axial length extending structure, the direction regulator direction that is used for adjusting the connecting rod, the outer shutoff body for netted hollow structure, be the pillar form, the cross section be circular, vertically the tangent plane is isosceles trapezoid, inside is equipped with second shutoff membrane, first shutoff membrane and the second shutoff membrane permeable water film that is the micropore. The utility model discloses a percutaneous left auricle of heart shutoff apparatus adopts the design theory of " nei sainei is stifled ", can realize complete shutoff, does not leave over remaining cavity, it is applicable in the left auricle of heart of the different shapes and the different degree of depth, the endothelium area is little, it is firm to implant the back position, and the security is good.
Description
Technical field
This utility model relates to technical field of medical instruments, specifically, is a kind of percutaneous left atrial appendage occlusion apparatus.
Background technology
Atrial fibrillation is a kind of common cardiac arrhythmia.The sickness rate of adult's atrial fibrillation is about 0.4%-2%.Conservative estimation, domestic at present have patients with atrial fibrillation 800-1000 ten thousand.The risk of patients with atrial fibrillation generation apoplexy adds more than 5 times.Oral warfarin anticoagulant is the foundation stone of atrial fibrillation anticoagulant therapy always.But many defects of warfarin application and inconvenience, significantly limit it in clinical application.The patient of long-term therapeutic Warfarin anticoagulation is needed, in China especially less than 10% according to guide.Research confirm, patients with atrial fibrillation have an appointment 91% thrombosis derive from left auricle, therefore shutoff left auricle will be the plan that prevention and therapy atrial fibrillation apoplexy " is effected a permanent cure ".Percutaneous/through conduit left atrial appendage occlusion art (left atrial appendage occlusion art, Percutaneour/TranscatheterLeftAtrialAppendageclosure/occ lusion, LAAC/O) be development in recent years by Wicresoft's catheterization shutoff left auricle, to reach the new technique of prevention patients with atrial fibrillation thromboembolism.Postoperative Long-term confirms that left atrial appendage occlusion art is better than warfarin on effectiveness, and is not inferior to warfarin in safety.Left atrial appendage occlusion art becomes one of revolutionary treatment technology of recent cardiac field.
The domestic and international exploitation for left atrial appendage occlusion art related equipment is like a raging fire at present.In general, can dropping into commercial market, accepting clinical trial or the apparatus researched and developed two classes respectively: (1) " interior plunger type ", be included in first Application in human body but PLAATO (the ApprivaMedical company quit listing at present, the U.S.), at present world wide use the widest WATCHMAN (BostonScientific company, the U.S.) and carrying out domestic imitated stopper LEFORT (the Shanghai shape memory company of clinical trial, happy general medical treatment, China).The feature of this kind of stopper is filled in left auricle as stopper.(2) " inside beyond the Great Wall cap-type ": be included in European widely used AmplatzerCardiacPlug series stopper (St.JudeMedical company, the U.S.) and carrying out the domestic independent development stopper LAmbre (the first Rehabilitation in Shenzhen skill, China) etc. of clinical trial.The feature of this kind of stopper has two disk-like structure, and inner disc is used for fixing, and outer disk then covers left auricle opening in left atrium face as " lid ".
Although there are many stoppers to drop into commercial market, accepted clinical trial or researching and developing at present, present inventor thinks and all there is very many design defect or potential risk.Existing stopper is nearly all exposed to rivet beyond atrial surface, is delayed the endothelialization time after apparatus implantation greatly.In addition, " interior plunger type " stopper also exists following shortcoming: the design of 1. filling in monomer structure, be more applicable to the left auricle form of single leaf, and this kind of left auricle only accounts for a part; 2. in operation technique, harder conduit needs the bottommost being deep into left auricle, is very easy to poke poor wall, therefore, there is potential operation hidden danger; 3. the design of interior plunger type inevitably also exists remaining chamber, may become the potential position in thrombosis source; 4. wayward when stopper reclaims, often occur that grapnel misplaces, cause a hidden trouble to follow-up successful procedure.And " inside beyond the Great Wall cap-type " stopper also also exists several shortcoming: 1. larger outer disk " covers " design concept of left auricle opening at atrial surface, requirement " lid " diameter is needed to be greater than the maximum gauge of various left auricle opening, therefore larger " lid " may have influence on peripheral structure, as Bicuspid valve, left superior pulmonary vein etc.; 2. larger outer disk is larger endothelialization area, will postpone endothelialization degree greatly, become potential apparatus be correlated with mural thrombus source; 3. larger endothelialization area, needs the service time extending warfarin and duplex antiplatelet drug, increases the generation of hemorrhage adverse events such as grade and causes more medical expense etc.; 4. because left auricle also also exists contraction and diastole activity, the method for lid is pasted on " blocking up outward " i.e. surface, also exists and pastes the infull problem of lid.
In sum, inventor think be necessary design one can be applicable to all kinds left auricle, plugging effect significantly, little, the better stopper of safety of endothelialization area, but have not been reported about this kind of stopper at present.
Summary of the invention
The purpose of this utility model is for deficiency of the prior art, provide one can be applicable to all kinds left auricle, plugging effect significantly, little, the safety better percutaneous left atrial appendage occlusion apparatus of endothelialization area.
For achieving the above object, the technical scheme that this utility model is taked is:
A kind of percutaneous left atrial appendage occlusion apparatus, interior occluding body and outer occluding body is provided with by the inner to outer end, described interior occluding body is provided with and struts skeleton and the first plugging film, the described skeleton that struts is provided with riveting hook, described outer occluding body is netted hollow structure, is also provided with connecting rod and direction regulator between described interior occluding body and outer occluding body; Described connecting rod is axial length Collapsible structure; Described direction regulator is used for the direction of regulating connecting rod.
Preferably, described connecting rod is selected from the one in following state: a) be metal threaded pipe compensator, or b) be provided with first connecting rod and second connecting rod, described first connecting rod and second connecting rod are threaded.
Preferably, the implementation in described direction regulator regulating connecting rod direction is selected from the one in following state: the outer end of the connecting rod a) is provided with rotates pearl, the inner of described direction regulator is provided with mating groove, described rotation pearl is positioned at mating groove, the two adjustment making described connecting rod can realize on direction that matches; B) direction regulator described in is metal hose; Or c) described in direction regulator be metal knitted pipe.
Preferably, described outer occluding body entirety is in important actor shape, and cross section is circular, and longitudinal tangent plane is isosceles trapezoid.
More preferably, the maximum gauge of described outer occluding body is 36-40mm.
Preferably, be provided with the second plugging film in described outer occluding body, the edge of the second described plugging film is fixed on the wall of outer occluding body, and the plane at the second plugging film place is parallel with two end faces of outer occluding body.
Preferably, the first described plugging film and the second plugging film are the porous film of 140-180 μm of hole.
Preferably, described struts skeleton in working order down in umbrella, and be made up of basket silk, described basket silk is arc; Described riveting hook and the inclination angle of basket silk are 30-60 degree; The first described plugging film is coated on the outer surface strutting skeleton the inner.
Preferably, described riveting hook be located at basket silk and left auricle wall under duty point of contact on.
Preferably, the free end of described basket silk is provided with Protective ball.
This utility model advantage is:
1, percutaneous left atrial appendage occlusion apparatus of the present utility model adopts the design concept of " Nei Sainei blocks up ", be provided with interior occluding body and outer occluding body, there is dual-plugging film, outer occluding body is consistent with left auricle physiology shape, and specifications design is reasonable, left auricle wall energy enough externally occluding body forms the compression of 8%-20%, therefore can realize complete shutoff, do not leave over remaining chamber, and endothelialization area is little;
2, percutaneous left atrial appendage occlusion apparatus of the present utility model is provided with telescopic connecting rod and rotating direction regulator, is therefore applicable to the left auricle of difformity and different depth;
3, the dual-plugging film of percutaneous left atrial appendage occlusion apparatus of the present utility model is the PTFE porous membrane material of micropore, can promote the endothelialization process after implanting;
4, percutaneous left atrial appendage occlusion apparatus of the present utility model, left auricle wall energy enough externally occluding body produces the compression of 8%-20%, and the position that hooks of the riveting in interior occluding body and number reasonable in design, therefore after implanting, position is firm, not easily be shifted, plugging effect is lasting, and safety is good.
Accompanying drawing explanation
Accompanying drawing 1 is the structural representation of the percutaneous left atrial appendage occlusion apparatus of embodiment 1.
Accompanying drawing 2 is the connecting rod of embodiment 1 and the connection diagram of direction regulator.
Accompanying drawing 3 is structural representations of the percutaneous left atrial appendage occlusion apparatus of embodiment 2.
Accompanying drawing 4 is structural representations of the percutaneous left atrial appendage occlusion apparatus of embodiment 3.
Accompanying drawing 5 is bar linkage structure schematic diagrams of the percutaneous left atrial appendage occlusion apparatus of embodiment 4.
Accompanying drawing 6 is structural representations of the percutaneous left atrial appendage occlusion apparatus of embodiment 5.
Detailed description of the invention
Below in conjunction with accompanying drawing, detailed description of the invention provided by the invention is elaborated.
The Reference numeral related in accompanying drawing and ingredient as follows:
1. in, occluding body 11. struts skeleton
111. basket silk 12. first plugging films
13. Protective ball 14. rivetings hook
2. connecting rod 21. rotates pearl
22. first connecting rod 23. second connecting rods
3. direction regulator 31. mating groove
4. the inner end face of the outer occluding body of outer occluding body 41.
42. outer shutoff external end end face 43. second plugging film
5. action bars link
Embodiment 1 percutaneous left atrial appendage occlusion of the present utility model apparatus (one)
Refer to Fig. 1, Fig. 1 is the structural representation of the percutaneous left atrial appendage occlusion apparatus of embodiment 1.Described percutaneous left atrial appendage occlusion apparatus is provided with interior occluding body 1, connecting rod 2, direction regulator 3 and outer occluding body 4 successively by the inner to outer end.Described interior occluding body 1 comprises and struts skeleton 11 and the first plugging film 12.The described skeleton 11 that struts is made up of eight basket silks 111; Described basket silk 111 descends curved in working order and has point of contact with left auricle wall; One end of eight basket silks 111 accumulates a branch of and is fixed on the inner end face of connecting rod 2, and each basket silk 111 around the axis of connecting rod 2 in circumferentially dispersed arrangement, make described to strut skeleton 11 in umbrella; The other end (i.e. free end) of eight basket silks 111 is equipped with Protective ball 13, and the position of the nearly free end of basket silk 111 is provided with riveting hook 14, particularly, under described riveting hook 14 is positioned at duty, basket silk 111 is with on the point of contact of left auricle wall, and it is 30-60 degree that described riveting hooks 14 with the inclination angle of basket silk 111.The first described plugging film 12 is the PTFE porous film of micropore, is coated on the outer surface strutting skeleton 11 the inner, and the edge of the first plugging film 12 is positioned at the point of contact place of basket silk 11 and left auricle wall under duty.Described connecting rod 2 is axial length Collapsible structure, and particularly, described connecting rod 2 is metal threaded pipe compensator, its inner with strut skeleton 11 and be connected, outer end is flexibly connected with direction regulator 3.
Refer to Fig. 2, Fig. 2 is the connecting rod of embodiment 1 and the connection diagram of direction regulator.The outer end of described connecting rod 2 is provided with rotates pearl 21, and described rotation pearl 21 is spherical for what expand.The inner of described direction regulator 3 is provided with mating groove 31, and the inwall of described mating groove 31 is dome shape.Described rotation pearl 21 is positioned at mating groove 31, the two adjustment making described connecting rod 2 can realize on direction relative to direction regulator 3 that matches.
Refer to Fig. 1 again.The outer end of described direction regulator 3 is fixed on the inner end face central authorities of outer occluding body 4.Described outer occluding body 4 is netted hollow structure, overall in important actor shape, and cross section is circular, and longitudinal tangent plane is isosceles trapezoid, and the diameter of the inner end face 41 of outer occluding body is less than the diameter of the external end end face 42 of outer shutoff.The inside of outer occluding body 4 is provided with the second plugging film 43, and the second described plugging film 43 is the PTFE porous film of micropore, and its edge is fixed on the wall of outer occluding body 4, and the plane at the second plugging film 43 place is parallel with two end faces of outer occluding body 4.The central authorities of described outer shutoff external end end face 42 are provided with the action bars link 5 of outside occluding body 4 inner recess, and described action bars link 5 is screwed hole, is provided with the screw thread matched with action bars.
The maximum gauge of described outer occluding body 4 is 36-40mm, the maximum gauge 2-6mm longer than the maximum gauge of interior occluding body 1 of described outer occluding body 4.
It should be noted that: herein, described " outer end " refers to one end that this member distance left atrium is nearer under duty, and one end on the other side is then " the inner ".Described basket silk 111 is curved, can ensure that strutting skeleton 11 fully launches in umbrella down in working order, described herein " arc " to refer on circumference or curve arbitrary one section, preferably, it should ensure that lower described basket silk 111 has point of contact with left auricle wall in working order, with the grappling guaranteeing that riveting hook 14 can reach and left auricle wall is also firm with it, ensure that the edge of the first plugging film 12 fully contacts with left auricle wall, realizes gapless shutoff on the other hand.The number of described basket silk 111 is not limited only to the present embodiment, can also be the numbers such as six, seven, nine, ten, but 8 is the situation having choosing most, this number can ensure to form to strut skeleton 11 the most firm, well can support the first plugging film 12, and the riveting of this number hooks fixed effect the best of 14, less to the damage of left auricle wall.Described Protective ball 13 can reduce the pressure of basket silk 111 pairs of left auricle walls, reduces damage.Described connecting rod 2 is designed to telescopic structure, is therefore applicable to the left auricle of different depth, all can play best plugging effect by the length of regulating connecting rod 2.The structure of described connecting rod 2 is not limited only to the present embodiment, and can also be cover rod-type Collapsible structure, ball incarceration formula Collapsible structure etc., but be preferably the embodiment of the present embodiment, length adjustment be easier, meets the trend of current medical apparatus and instruments easy and simple to handleization.Described direction regulator 3 is for the direction of regulating connecting rod 2, and this makes percutaneous left atrial appendage occlusion apparatus of the present utility model not only be applicable to the left auricle of conventional single leaf, can also be applicable to the left auricle that curvature is larger, as " chicken wing type ".Realize direction regulate mode be also not limited only to the present embodiment, can also be other structure types, as described in direction regulator can also be metal knitted pipe etc.Described outer occluding body 4 for concordant shutoff at left auricle opening part, and the specification of the outer occluding body 4 of the present embodiment can ensure that the external occluding body 4 of left auricle wall forms the compression factor of 8%-20%, realize " interior stifled ", ensure complete shutoff left auricle, do not stay remaining chamber, and the mode of " interior stifled " is different from and directly overlays left atrium opening part, it does not increase the area needing endothelialization; Described outer occluding body 4 is designed to important actor shape, cross section is circle, longitudinal tangent plane is the shape of isosceles trapezoid, matches, can reach best plugging effect with the physiology shape of left auricle.The second described plugging film 43 realizes the second heavily shutoff for the thrombosis in left auricle; and the second plugging film 43 is located at the inside of outer occluding body 4; by retaining and cushioning effect of netted outer occluding body 4; the shape of the second plugging film 43 can well be protected; ensure that it uses rear deformation little for a long time, plugging effect is still better.Described action bars link 5 is for fixing with action bars, and to be implanted in left auricle by percutaneous left atrial appendage occlusion apparatus of the present utility model, it not only can arrange screw thread and be connected with action bars, can also be fixed by buckle-type and the action bars matched.The first described plugging film 12 and the second plugging film 43 are all preferably the porous membrane material of micropore, the endothelialization process after implanting can be promoted, described micropore is preferably 140-180 μm, and described porous membrane material can be PTFE, also can be other materials.
Embodiment 2 percutaneous left atrial appendage occlusion of the present utility model apparatus (two)
Refer to Fig. 3, Fig. 3 is the structural representation of the percutaneous left atrial appendage occlusion apparatus of embodiment 2.Described percutaneous left atrial appendage occlusion apparatus is substantially identical with embodiment 1, and difference is only: the diameter of the inner end face 41 of described outer occluding body is greater than the diameter of the external end end face 42 of outer shutoff.
The percutaneous left atrial appendage occlusion apparatus of the present embodiment is suitable for the left auricle that shutoff outer diameter is greater than inner diameter profile.
Embodiment 3 percutaneous left atrial appendage occlusion of the present utility model apparatus (three)
Refer to Fig. 4, Fig. 4 is the structural representation of the percutaneous left atrial appendage occlusion apparatus of embodiment 3.Described percutaneous left atrial appendage occlusion apparatus is substantially identical with embodiment 1, and difference is only: the maximum gauge 10-25mm longer than the maximum gauge of interior occluding body 1 of described outer occluding body 4.
The percutaneous left atrial appendage occlusion apparatus of the present embodiment is suitable for shutoff outer diameter and inner diameter difference apart from larger left auricle.
Embodiment 4 percutaneous left atrial appendage occlusion of the present utility model apparatus (four)
Described percutaneous left atrial appendage occlusion apparatus is substantially identical with embodiment 1, and difference is only that the structure of described connecting rod 2 is different.
Refer to Fig. 5, Fig. 5 is the bar linkage structure schematic diagram of the percutaneous left atrial appendage occlusion apparatus of embodiment 4.Described connecting rod 2 is axial length Collapsible structure, particularly, described connecting rod 2 is not metal threaded pipe compensator structure, but is provided with first connecting rod 22 and second connecting rod 23, described first connecting rod 22 and second connecting rod 23 are threaded, thus make the adjustable length of connecting rod 2.
Embodiment 5 percutaneous left atrial appendage occlusion of the present utility model apparatus (five)
Refer to Fig. 6, Fig. 6 is the structural representation of the percutaneous left atrial appendage occlusion apparatus of embodiment 5.Described percutaneous left atrial appendage occlusion apparatus is substantially identical with embodiment 1, it is different that difference is only to realize the adjustable mode in connecting rod 2 direction, particularly, the outer end of described connecting rod 2 is not provided with rotates pearl, but the inner that is direct and direction regulator 3 is fixed, described direction regulator 3 is metal hose.
The implantation process of percutaneous left atrial appendage occlusion apparatus of the present utility model is: be positioned in conduit by percutaneous left atrial appendage occlusion apparatus of the present utility model, fixing operation bar and action bars link 5, then after delivering to target location, return conduit, described basket silk 111 discharges, first plugging film 12 and the second plugging film 43 expand all naturally, pullback operation bar slightly again, the external end end face 42 of outer shutoff is flushed with left auricle opening part, rivet 14 is anchored on left auricle inwall, in this process, described connecting rod 2 can issue the rotation of the male character types in Chinese operas, usu. referring tov the bearded character degree in the squeezing action of left auricle physiology shape, final trend is consistent with the physiology shape of left auricle, after having operated, retraction operation bar.Percutaneous left atrial appendage occlusion apparatus of the present utility model is the structure of " two film one bar of binary ", be applicable to the left auricle of difformity (as single leaf, leafy, " waist " more shallow) and different depth, and be interior shutoff and dual-plugging, effectively can isolate the blood UNICOM of left auricle and left atrium, plugging effect is remarkable, and endothelialization area is little, safety is better.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the inventive method; can also make some improvement and supplement, these improve and supplement and also should be considered as protection scope of the present invention.
Claims (10)
1. a percutaneous left atrial appendage occlusion apparatus, interior occluding body and outer occluding body is provided with by the inner to outer end, described interior occluding body is provided with and struts skeleton and the first plugging film, the described skeleton that struts is provided with riveting hook, described outer occluding body is netted hollow structure, it is characterized in that, between described interior occluding body and outer occluding body, be also provided with connecting rod and direction regulator; Described connecting rod is axial length Collapsible structure; Described direction regulator is used for the direction of regulating connecting rod.
2. percutaneous left atrial appendage occlusion apparatus according to claim 1, it is characterized in that, described connecting rod is selected from the one in following state: a) be metal threaded pipe compensator, or b) be provided with first connecting rod and second connecting rod, described first connecting rod and second connecting rod are threaded.
3. percutaneous left atrial appendage occlusion apparatus according to claim 1, it is characterized in that, the implementation in described direction regulator regulating connecting rod direction is selected from the one in following state: the outer end of the connecting rod a) is provided with rotates pearl, the inner of described direction regulator is provided with mating groove, described rotation pearl is positioned at mating groove, the two adjustment making described connecting rod can realize on direction that matches; B) direction regulator described in is metal hose; Or c) described in direction regulator be metal knitted pipe.
4. percutaneous left atrial appendage occlusion apparatus according to claim 1, is characterized in that, described outer occluding body entirety is in important actor shape, and cross section is circular, and longitudinal tangent plane is isosceles trapezoid.
5. percutaneous left atrial appendage occlusion apparatus according to claim 4, is characterized in that, the maximum gauge of described outer occluding body is 36-40mm.
6. percutaneous left atrial appendage occlusion apparatus according to claim 4, it is characterized in that, be provided with the second plugging film in described outer occluding body, the edge of the second described plugging film is fixed on the wall of outer occluding body, and the plane at the second plugging film place is parallel with two end faces of outer occluding body.
7. percutaneous left atrial appendage occlusion apparatus according to claim 6, is characterized in that, the first described plugging film and the second plugging film are the porous film of 140-180 μm of hole.
8. percutaneous left atrial appendage occlusion apparatus according to claim 1, is characterized in that, described struts skeleton in working order down in umbrella, and be made up of basket silk, described basket silk is arc; Described riveting hook and the inclination angle of basket silk are 30-60 degree; The first described plugging film is coated on the outer surface strutting skeleton the inner.
9. percutaneous left atrial appendage occlusion apparatus according to claim 8, is characterized in that, described riveting hook be located at basket silk and left auricle wall under duty point of contact on.
10. percutaneous left atrial appendage occlusion apparatus according to claim 8, is characterized in that, the free end of described basket silk is provided with Protective ball.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520411011.9U CN204839624U (en) | 2015-06-15 | 2015-06-15 | Percutaneous left auricle of heart shutoff apparatus |
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| CN201520411011.9U CN204839624U (en) | 2015-06-15 | 2015-06-15 | Percutaneous left auricle of heart shutoff apparatus |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106466196A (en) * | 2016-09-22 | 2017-03-01 | 杭州诺茂医疗科技有限公司 | A kind of split type occluder for left auricle |
| CN106473791A (en) * | 2016-09-22 | 2017-03-08 | 杭州诺茂医疗科技有限公司 | A kind of occluder for left auricle of adjustable distance |
| CN106955135A (en) * | 2017-04-07 | 2017-07-18 | 上海申淇医疗科技有限公司 | A kind of plugging device choked flow film and its manufacture method |
| CN107233114A (en) * | 2016-03-28 | 2017-10-10 | 上海微创医疗器械（集团）有限公司 | Occluder for left auricle |
| CN107233116A (en) * | 2016-03-28 | 2017-10-10 | 上海微创医疗器械（集团）有限公司 | Occluder for left auricle |
| CN107233117A (en) * | 2016-03-28 | 2017-10-10 | 上海微创医疗器械（集团）有限公司 | Occluder for left auricle |
| CN107233115A (en) * | 2016-03-28 | 2017-10-10 | 上海微创医疗器械（集团）有限公司 | Occluder for left auricle |
| CN107303191A (en) * | 2016-04-25 | 2017-10-31 | 上海微创医疗器械（集团）有限公司 | Occluder for left auricle and its manufacture method |
| CN109464173A (en) * | 2018-12-20 | 2019-03-15 | 先健科技(深圳)有限公司 | Plugging device |
| WO2019165966A1 (en) * | 2018-03-02 | 2019-09-06 | 上海微创医疗器械（集团）有限公司 | Occluder, and medical device |
| WO2022042718A1 (en) * | 2020-08-31 | 2022-03-03 | 杭州德诺电生理医疗科技有限公司 | Left atrial appendage occluder |
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| CN107233115A (en) * | 2016-03-28 | 2017-10-10 | 上海微创医疗器械（集团）有限公司 | Occluder for left auricle |
| CN107233115B (en) * | 2016-03-28 | 2020-01-24 | 上海微创医疗器械（集团）有限公司 | Left auricle plugging device |
| CN107233117B (en) * | 2016-03-28 | 2019-10-25 | 上海微创医疗器械（集团）有限公司 | Occluder for left auricle |
| CN107233114A (en) * | 2016-03-28 | 2017-10-10 | 上海微创医疗器械（集团）有限公司 | Occluder for left auricle |
| CN107233116A (en) * | 2016-03-28 | 2017-10-10 | 上海微创医疗器械（集团）有限公司 | Occluder for left auricle |
| CN107233117A (en) * | 2016-03-28 | 2017-10-10 | 上海微创医疗器械（集团）有限公司 | Occluder for left auricle |
| CN107303191B (en) * | 2016-04-25 | 2020-10-27 | 上海微创医疗器械（集团）有限公司 | Left auricle occluder and manufacturing method thereof |
| CN107303191A (en) * | 2016-04-25 | 2017-10-31 | 上海微创医疗器械（集团）有限公司 | Occluder for left auricle and its manufacture method |
| CN106473791A (en) * | 2016-09-22 | 2017-03-08 | 杭州诺茂医疗科技有限公司 | A kind of occluder for left auricle of adjustable distance |
| CN106466196A (en) * | 2016-09-22 | 2017-03-01 | 杭州诺茂医疗科技有限公司 | A kind of split type occluder for left auricle |
| CN106473791B (en) * | 2016-09-22 | 2023-10-27 | 杭州德诺电生理医疗科技有限公司 | Left auricle plugging device with adjustable distance |
| CN106466196B (en) * | 2016-09-22 | 2023-11-07 | 杭州德诺电生理医疗科技有限公司 | Split type left auricle plugging device |
| CN106955135A (en) * | 2017-04-07 | 2017-07-18 | 上海申淇医疗科技有限公司 | A kind of plugging device choked flow film and its manufacture method |
| WO2019165966A1 (en) * | 2018-03-02 | 2019-09-06 | 上海微创医疗器械（集团）有限公司 | Occluder, and medical device |
| CN109464173A (en) * | 2018-12-20 | 2019-03-15 | 先健科技(深圳)有限公司 | Plugging device |
| CN109464173B (en) * | 2018-12-20 | 2024-04-02 | 先健科技(深圳)有限公司 | Plugging device |
| WO2022042718A1 (en) * | 2020-08-31 | 2022-03-03 | 杭州德诺电生理医疗科技有限公司 | Left atrial appendage occluder |
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Granted publication date: 20151209 Termination date: 20160615 |