CN204767021U - Hollow silk fibroin microneedle structure - Google Patents
Hollow silk fibroin microneedle structure Download PDFInfo
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- CN204767021U CN204767021U CN201520289323.7U CN201520289323U CN204767021U CN 204767021 U CN204767021 U CN 204767021U CN 201520289323 U CN201520289323 U CN 201520289323U CN 204767021 U CN204767021 U CN 204767021U
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Abstract
The utility model relates to a hollow silk fibroin microneedle structure, its needle body shell are by the basement and evenly plant row and forms in the hull shape needle body that this basement side surface and inside cavity formed the aciculiform cavity, and the interior cystica of aciculiform cavity has model medicine portion, has greatly increased the medicine carrying volume of micropin, it often needs in addition the area to store up defects such as drug storage, pressure control device to compare traditional hollow micropin, and this application is through with model medicine cystica in the inside cavity of hull shape needle body and the pressure of production after combining swelling intermediate layer swelling to and the swelling action behind the needle body shell contact body fluid, impel the model medicine to see through the micropore release of aquogel form needle body shell, release the medicine rate high, release that medicine speed is big, controlled release nature is excellent, hull shape needle body among this application hollow silk fibroin microneedle structure pointed end is fragile hard and soluble micro molecule silk fibroin solidfied material in addition, possesses sufficient brute force during the dry state and thrusts skin, dissolves rapidly behind the contact body fluid and forms the most advanced entity pore of needle body, has promoted greatly that the transdermal of model medicine releases.
Description
Technical field
This utility model relates to a kind of medical microneedle configuration, particularly relates to a kind of air silk fibroin microneedle configuration.
Background technology
Along with the development of micro-processing technology, a kind ofly sting expelling pathogenic factors from the exterior skin but do not injure corium and neural micropin technology was come out, for transdermal administration brings new thinking before the more than ten years.Size pierces through the skin surface (horny layer) of permeability extreme difference at micron-sized micropin dot matrix in the mode of reversible Wicresoft, causes biomacromolecule to be able to the mechanical passage passed through, and does not but produce pain and skin trauma.But still there is many technical bottlenecks in current micropin medicine-feeding technology, mainly comprise forming technique complexity, manufacturing cost is too high, the toxicity of micropin material, poor biocompatibility, easy fracture residue in skin and cause anaphylaxis, and micropin release rule etc. cannot be controlled comparatively accurately.Thrust preferably to change skin permeation sexuality though conventional metals, glass, siliceous micropin possess, but generally medicine is applied in microneedle surface, drug loading is little, is difficult to reach therapeutic effect.
Current microneedle cutaneous system more and more causes the concern of people in the Transdermal absorption field of hydrophilic small molecule drugs, polypeptide and pharmaceutical grade protein, DNA etc.Microneedle cutaneous mode avoids conventional oral administration by the low problem of the medicine bioavailability brought by effect etc. of intestines and stomach pH, digestive enzyme and liver, avoids that the acupuncture that drug administration by injection brings to patient is painful, skin lesion can maintain metastable blood drug level.Especially medicament slow release and controlled release properties preferably empty micropin there is great development and apply prospect especially.
Though conventional metals, glass, the entity micropin such as siliceous possess thrust to change skin permeation sexuality preferably, but generally medicine are applied in microneedle surface, drug loading is little, and controlled capability is poor, is difficult to reach therapeutic effect.Conventional metals, glass, silicon dioxide, siliceous and polymeric hollow micropin improve by the method for additional drug storage warehouse that entity micropin is low at carrying drug ratio, the defect of medicine controlled releasing difference, but complex structure, cost is higher, uses inconvenience, is not suitable for large batch of production.
In currently available technology, Chinese invention patent (CN10258032A) discloses the preparation method of a kind of fibroin albumen microneedle device and silk nano granular, adopt solvable fibroin albumen solidfied material parcel medicine carrying silk nano granular, then micropin is made, after this micropin thrusts skin, outer field fibroin albumen solidfied material dissolves rapidly, discharges the nano-particle of medicine carrying, reaches the object of drug release.But this fibroin microneedle device is solubility entity micropin, and base material is solubility fibroin albumen, and outer fibroin albumen runs into body fluid and can dissolve very soon, causes the quick release of medicine, is unfavorable for slow release.Solution may be under pressure and extrude, and the slow release for medicine is also unfavorable.After micropin dissolves, epidermis micropore disappears, and is unfavorable for lasting, the stability release of medicine.Chinese invention patent (CN103260693A) discloses another kind of based on fibroin albumen micropin and preparation method thereof, employing steam is annealed, be exposed to the medium method of methanol solution carries out post processing to the fibroin micropin after medicine carrying also shaping, reach the content controlling fibroin albumen β-pleated sheet structure, thus make micropin water insoluble, the speed of further Drug controlled release.But these insoluble processing procedures may make the activity of medicine lose.The fibroin albumen Stability Analysis of Structures of β-pleated sheet, not easily water absorption and swelling behavior occurs, molecular gap is too small, thus drug release is slow, and medicine realeasing rate is low, is difficult to the blood drug level reaching tool therapeutic effect.In the disclosed fibroin albumen micropin of Chinese invention patent (201410061578.8) and preparation thereof, adopt excusing from death concussion process fibroin albumen to form the solution of the pre-crystallized structure of tool, form gel-type micropin.This micropin fibroin molecular structure is fine and close, and containing a large amount of SilkII type crystallizations, water absorption, swellability are little, is unfavorable for quick, lasting, the stability release of medicine.Up to now, the relevant report of fibroin albumen empty micropin is not had.Chinese invention patent (CN102526870A) discloses a kind of different plane hollow microneedle based on surface micro fabrication technique and preparation method thereof, adopt wet-etching technology, UV-LIGA technique and pouring technology, complex process, technical requirement is high, related corresponding release auxiliary equipment is needed, as drug storage warehouse, pressure apparatus etc. in actual use procedure.
Utility model content
For entity micropin poor biocompatibility such as existing glass, silicon dioxide, siliceous and metals, carrying drug ratio is low, medicine controlled releasing is weak and the defect such as empty micropin finished product structure complexity, practical operating difficulties, and for the deficiency of existing solubility, insoluble polymer microneedle drug controlled capability aspect, the purpose of this utility model is to provide a kind of air silk fibroin microneedle configuration, and good biocompatibility, the carrying drug ratio of this microneedle configuration and skin are high, medicine realeasing rate is large, medicine controlled releasing is good.
The technical solution of the utility model is:
A kind of air silk fibroin microneedle configuration, be made up of needle body shell, model drug portion, swelling interlayer and coating, described needle body shell is by substrate and evenly plant and list in this substrate one side surface and the hull shape needle body that inner hollow forms aciculiform cavity forms, and the tip of described hull shape needle body is that to solidify hardness under dry state high but can dissolve the empty structure that tapers off to a point after absorbing body fluid; Described model drug portion is encapsulated in aciculiform cavity, and described swelling interlayer is located between model drug portion and coating, and this swelling interlayer can extrude to model drug portion after absorbing body fluid.
Its further technical scheme is:
The thickness of described hull shape needle body is 15 ~ 30 μm.
The tip of described hull shape needle body is poured into a mould formed by being solidified the high but small-molecular-weight fibroin albumen that is that can dissolve after absorbing body fluid of hardness under dry state.
The part of described hull shape needle body except tip is formed by pouring into a mould through the high but fibroin albumen that is that swellingly can form loose porous hydrogel structure after contact body fluid of solidification intensity under swelling modified dry state.
Described swelling interlayer is made up of the complex of high swelling type sodium alginate and calcium ion.
Described coating is made up of the insoluble fibroin protein film of monolayer through high humidity treatment.
By such scheme, this utility model at least has the following advantages: microneedle configuration described in the utility model compares the mode of the entity microneedle surface coated former medicines such as traditional glass, silicon dioxide, siliceous and metal, the present invention is with internal cavities encapsulated drug, and carrying drug ratio is high; Compare conventional hollow micropin often to need separately to be with the defect such as drug storage warehouse, pressure control device, the application is by being encapsulated in hull shape needle body internal cavities by model drug and in conjunction with the pressure of the swelling rear generation of swelling interlayer, and the swelling behavior after needle body housing contacts body fluid, impel model drug through the micropore release of the gluey needle body shell of water-setting, medicine realeasing rate is high, rate of releasing drug is large, controlled capability is excellent; In addition the hull shape needle body tip in the application's air silk fibroin microneedle configuration is crisp hard and solubility micromolecule fibroin albumen solidfied material, possess enough brute forces during dry state and thrust skin, dissolve rapidly after contact body fluid and form the most advanced and sophisticated entity duct of needle body, greatly facilitating the transdermal release of model drug.
Above-mentioned explanation is only the general introduction of the technical program, in order to better understand technological means of the present utility model, and can be implemented according to the content of description, coordinates accompanying drawing to be described in detail as follows below with preferred embodiment of the present utility model.
Accompanying drawing explanation
Fig. 1 is this utility model hollow fibroin microneedle configuration model schematic;
Fig. 2 is this utility model hollow fibroin microneedle configuration three-dimensional stereo model schematic diagram;
Fig. 3 is this utility model hollow fibroin micropin drug-supplying system release pharmaceutical procedures schematic diagram;
Wherein:
1-needle body shell; 11-hull shape needle body;
12-aciculiform cavity; 13-substrate;
2-model drug portion; The swelling interlayer of 3-;
4-coating.
Detailed description of the invention
Below in conjunction with accompanying drawing 1-3 and embodiment, detailed description of the invention of the present utility model is described in further detail.Following examples for illustration of this utility model, but are not used for limiting scope of the present utility model.
Air silk fibroin microneedle configuration as shown in Figure 1, is made up of needle body shell 1, model drug portion 2, swelling interlayer 3 and coating 4.
Described needle body shell 1 is by substrate 13 and evenly plant and list in this substrate one side surface and the hull shape needle body 11 that inner hollow forms aciculiform cavity 12 forms, the thickness of this hull shape needle body 11 is 15 ~ 30 μm, the volume of needle-like cavity 12 can be increased, to increase the drug loading of micropin under the prerequisite ensureing hull shape needle body intensity as far as possible.
Described substrate 13 is fibroin albumen formation, the tip of described hull shape needle body 11 is that to solidify hardness under dry state high but absorb after body fluid and can dissolve the empty structure that tapers off to a point, the tip of this hull shape needle body 11 is poured into a mould formed by being solidified the high but small-molecular-weight fibroin albumen that is that can dissolve after absorbing body fluid of hardness under dry state, because this tip portion is firmly crisp under dry state, micromolecule fibroin albumen solidfied material solvable after contact body fluid, therefore it possesses enough hardness and thrusts skin when dry state, but dissolve rapidly after absorbing body fluid and form the physical channel connecting needle-like cavity 12, i.e. most advanced and sophisticated cavity, significantly can promote the release of model drug, the part of this hull shape needle body 11 except tip is formed by pouring into a mould through the high but fibroin albumen that is that swellingly can form loose porous hydrogel structure after contact body fluid of solidification intensity under swelling modified dry state, because this part is selected through swelling modified fibroin albumen solidfied material, it is glassy state when dry state and possesses enough intensity and thrusts skin, but when being swelled into loose porous hydrogel housing after absorption body fluid, be beneficial to the peripheral wall surfaces diffusion transfer of model drug from hull shape needle body to skin, be conducive to the Co ntrolled release of model drug simultaneously.
Described model drug portion 2 is encapsulated in aciculiform cavity 12, swelling interlayer 3 is located between model drug portion 2 and coating 4, and this swelling interlayer 3 can extrude to model drug portion 2 after absorbing body fluid, the solidfied material that described swelling interlayer 3 is made up of the complex of high swelling type sodium alginate and calcium ion forms, and it micropore release of loose porous hydrogel of being swelled into from hull shape needle body peripheral wall surfaces of high level expansion thus cavity, the tip release be dissolved into from hull shape needle body tip for model drug, model drug can provide extruding force after absorbing body fluid.Described coating 4 is made up of the insoluble fibroin protein film of monolayer through high humidity treatment.
In microneedle configuration described in the utility model, the rate of release of model drug depends on the swelling rate at the tip place of the swellbility that the swellbility of swelling interlayer 3, hull shape needle body 11 divide except tip external and hull shape needle body.
Microneedle configuration described in the utility model compares the mode of the entity microneedle surface coated former medicines such as traditional glass, silicon dioxide, siliceous and metal, and the present invention is with internal cavities encapsulated drug, and carrying drug ratio is high; Compare conventional hollow micropin often to need separately to be with the defect such as drug storage warehouse, pressure control device, the application is by being encapsulated in hull shape needle body internal cavities by model drug and in conjunction with the pressure of the swelling rear generation of swelling interlayer, and the swelling behavior after needle body housing contacts body fluid, impel model drug through the micropore release of the gluey needle body shell of water-setting, medicine realeasing rate is high, rate of releasing drug is large, controlled capability is excellent; In addition the hull shape needle body tip in the application's air silk fibroin microneedle configuration is crisp hard and solubility micromolecule fibroin albumen solidfied material, possess enough brute forces during dry state and thrust skin, dissolve rapidly after contact body fluid and form the most advanced and sophisticated entity duct of needle body, greatly facilitating the transdermal release of model drug.
The above is only preferred implementation of the present utility model; be not limited to this utility model; should be understood that; for those skilled in the art; under the prerequisite not departing from know-why described in the application; can also make some improvement and modification, these improvement and modification also should be considered as the protection domain of the application.
Claims (6)
1. an air silk fibroin microneedle configuration, it is characterized in that: be made up of needle body shell (1), model drug portion (2), swelling interlayer (3) and coating (4), described needle body shell (1) is by substrate (13) and evenly plant and list in this substrate one side surface and the hull shape needle body (11) that inner hollow forms aciculiform cavity (12) forms, and the tip of described hull shape needle body (11) is that to solidify hardness under dry state high but can dissolve the empty structure that tapers off to a point after absorbing body fluid; Described model drug portion (2) is encapsulated in aciculiform cavity (12), described swelling interlayer (3) is located between model drug portion (2) and coating (4), and this swelling interlayer (3) can extrude to model drug portion (2) after absorbing body fluid.
2. air silk fibroin microneedle configuration according to claim 1, is characterized in that: the thickness of described hull shape needle body (11) is 15 ~ 30 μm.
3. air silk fibroin microneedle configuration according to claim 2, is characterized in that: cast formed by solidifying the high but small-molecular-weight fibroin albumen that is that can dissolve after absorbing body fluid of hardness under dry state in the tip of described hull shape needle body (11).
4. air silk fibroin microneedle configuration according to claim 2, is characterized in that: the part of described hull shape needle body (11) except tip is formed by casting through the high but fibroin albumen that is that swellingly can form loose porous hydrogel structure after contact body fluid of solidification intensity under swelling modified dry state.
5. air silk fibroin microneedle configuration according to claim 1, is characterized in that: described swelling interlayer (3) is made up of the complex of high swelling type sodium alginate and calcium ion.
6. air silk fibroin microneedle configuration according to claim 1, is characterized in that: described coating (4) is made up of the insoluble fibroin protein film of monolayer through high humidity treatment.
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| CN201520289323.7U CN204767021U (en) | 2015-05-07 | 2015-05-07 | Hollow silk fibroin microneedle structure |
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| CN201520289323.7U CN204767021U (en) | 2015-05-07 | 2015-05-07 | Hollow silk fibroin microneedle structure |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105771082A (en) * | 2016-04-07 | 2016-07-20 | 南通纺织丝绸产业技术研究院 | Blank pipe fibroin microneedle drug administration system and preparation method thereof |
| CN106176573A (en) * | 2016-08-24 | 2016-12-07 | 湖北大学 | A kind of solubility hollow microneedles and preparation method thereof |
| CN106362223A (en) * | 2016-08-26 | 2017-02-01 | 南通纺织丝绸产业技术研究院 | Porous silk fibroin microneedle administration device and preparation method thereof |
| CN106645336A (en) * | 2016-11-15 | 2017-05-10 | 惠州市力道电子材料有限公司 | Micro-needle electrode with porous metal modified surface and preparation method of micro-needle electrode |
| CN108079431A (en) * | 2018-02-12 | 2018-05-29 | 南通纺织丝绸产业技术研究院 | A kind of multilayer fibroin albumen compound needle wall micropin |
| CN110841116A (en) * | 2019-11-29 | 2020-02-28 | 深圳大学 | Focus in-situ drug controlled release system and preparation method thereof |
| CN110897996A (en) * | 2019-12-11 | 2020-03-24 | 北京化工大学 | Preparation method of soluble lidocaine high polymer microneedle |
| KR20200137249A (en) * | 2019-05-29 | 2020-12-09 | 서울과학기술대학교 산학협력단 | Microneedle array and the fabrication method of it |
| CN112423829A (en) * | 2018-05-18 | 2021-02-26 | 浦项工科大学校产学协力团 | Transdermal drug delivery patch and method for producing same |
| CN112996554A (en) * | 2018-10-31 | 2021-06-18 | 富士胶片株式会社 | Microneedle array device |
| CN113499307A (en) * | 2021-04-09 | 2021-10-15 | 北京中医药大学 | Storage type microneedle preparation and preparation method thereof |
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- 2015-05-07 CN CN201520289323.7U patent/CN204767021U/en active Active
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105771082A (en) * | 2016-04-07 | 2016-07-20 | 南通纺织丝绸产业技术研究院 | Blank pipe fibroin microneedle drug administration system and preparation method thereof |
| CN106176573A (en) * | 2016-08-24 | 2016-12-07 | 湖北大学 | A kind of solubility hollow microneedles and preparation method thereof |
| CN106176573B (en) * | 2016-08-24 | 2019-06-21 | 湖北大学 | A kind of solubility hollow microneedles and preparation method thereof |
| CN106362223A (en) * | 2016-08-26 | 2017-02-01 | 南通纺织丝绸产业技术研究院 | Porous silk fibroin microneedle administration device and preparation method thereof |
| CN106362223B (en) * | 2016-08-26 | 2019-05-03 | 南通纺织丝绸产业技术研究院 | Porous fibroin albumen micropin drug delivery device and preparation method thereof |
| CN106645336B (en) * | 2016-11-15 | 2020-12-29 | 惠州市力道电子材料有限公司 | Microneedle electrode with porous metal modified surface and preparation method thereof |
| CN106645336A (en) * | 2016-11-15 | 2017-05-10 | 惠州市力道电子材料有限公司 | Micro-needle electrode with porous metal modified surface and preparation method of micro-needle electrode |
| CN108079431A (en) * | 2018-02-12 | 2018-05-29 | 南通纺织丝绸产业技术研究院 | A kind of multilayer fibroin albumen compound needle wall micropin |
| CN112423829B (en) * | 2018-05-18 | 2023-03-28 | 浦项工科大学校产学协力团 | Transdermal drug delivery patch and method for producing same |
| CN112423829A (en) * | 2018-05-18 | 2021-02-26 | 浦项工科大学校产学协力团 | Transdermal drug delivery patch and method for producing same |
| CN112996554A (en) * | 2018-10-31 | 2021-06-18 | 富士胶片株式会社 | Microneedle array device |
| CN112996554B (en) * | 2018-10-31 | 2023-07-11 | 富士胶片株式会社 | Microneedle array device |
| KR20200137249A (en) * | 2019-05-29 | 2020-12-09 | 서울과학기술대학교 산학협력단 | Microneedle array and the fabrication method of it |
| KR102407520B1 (en) | 2019-05-29 | 2022-06-13 | 서울과학기술대학교 산학협력단 | Microneedle array and the fabrication method of it |
| CN110841116A (en) * | 2019-11-29 | 2020-02-28 | 深圳大学 | Focus in-situ drug controlled release system and preparation method thereof |
| CN110897996A (en) * | 2019-12-11 | 2020-03-24 | 北京化工大学 | Preparation method of soluble lidocaine high polymer microneedle |
| CN113499307A (en) * | 2021-04-09 | 2021-10-15 | 北京中医药大学 | Storage type microneedle preparation and preparation method thereof |
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| TR01 | Transfer of patent right |
Effective date of registration: 20200715 Address after: Room b1134, 9 / F, building 1, 2816 Yixian Road, Baoshan District, Shanghai 201900 Patentee after: Paraxon Pharmaceutical Biotechnology (Shanghai) Co., Ltd Address before: Suzhou City, Jiangsu province 215100 Xiangcheng District Ji Road No. 8 Patentee before: Suzhou University |
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| TR01 | Transfer of patent right |