CN108079431A - A kind of multilayer fibroin albumen compound needle wall micropin - Google Patents
A kind of multilayer fibroin albumen compound needle wall micropin Download PDFInfo
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- CN108079431A CN108079431A CN201810147574.XA CN201810147574A CN108079431A CN 108079431 A CN108079431 A CN 108079431A CN 201810147574 A CN201810147574 A CN 201810147574A CN 108079431 A CN108079431 A CN 108079431A
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- fibroin albumen
- crystalline texture
- layering
- needle body
- micropin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/07—Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Botany (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention discloses a kind of multilayer fibroin albumen compound needle wall micropins, it is made of pure silk fibroin or the fibroin albumen layering for being loaded with drug, different medicament categories or different drugloading rates are loaded with by each layer, and structural adjustment is carried out to the micropin pin wall material of different layers in the long a certain range of pin, it is superimposed with the silk fibroin multilayer of different structure, micropin outer layer is made quickly to dissolve release drug, reach blood concentration, internal layer, which slowly releases the drug, maintains the effect of blood concentration, suitable for medication cycle length, requires high treatment requirement to sustained release.Multilayer fibroin albumen compound needle wall micropin provided by the invention realizes the superposition of different layers in single needle body, can effectively adjust the drug release rate of layering.
Description
Technical field
The present invention relates to a kind of medical micropin delivery system more particularly to a kind of multilayer fibroin albumen compound needle wall are micro-
Pin.
Background technology
Transdermal drug delivery system refers to that the mode that drug is smeared or sticked is gathered in skin surface, afterwards with certain rate
Skin permeation enters human circulation, so as to be absorbed into a kind of sanguimotor delivery form of human body by capillary.Skin
Cuticula is obstacle of the drug transdermal administration into human body maximum, and micropin can penetrate the cuticula of skin and be nearly free from pain
With damage, body fluid dissolving or swelling release drug can be met through the needle body of cuticula.Current microneedle cutaneous system is still deposited
In some shortcomings, poor biocompatibility, manufacture cost such as needle body material are excessively high, the sharp frangibility of needle body, without unified technology
Standard requirement etc..Though conventional metals material micropin possesses preferable piercing performance, drug is generally applied to microneedle surface,
Drugloading rate is small to be difficult to reach therapeutic effect, and stop may be caused uncomfortable and repelled anti-metal material micropin in vivo for a long time
It should.
Soluble solid load medicine micropin infiltration is into releasing by drug and biodegradable or water-soluble polymer's mixing treatment
Almost noresidue after medicine；The infiltration of medication coat micropin is surface that drug is applied to insoluble needle body, the medicine after skin is pierced into
Object dissolving comes off；Empty micropin infiltration is that drug is coated in hollow needle body, and drug release is swollen after contacting body fluid；Blank pipe type micropin
Infiltration can wear out skin, and drug can be made to enter human body by micropin internal pipeline.
Before the present invention makes, Chinese invention patent（CN103800998A）Disclose a kind of Silk fibroin gel micropin
System and preparation method thereof, the micropin of swelling drug release is made using fibroin albumen and drug blending, which is insoluble
Gel micropin, and skin can be pierced into certain strength, swelling drug release occurs after body fluid is touched in skin.Middle promulgated by the State Council
Bright patent（CN10258032A）The preparation method of a kind of fibroin albumen microneedle device and silk nano granular is disclosed, use is solvable
Fibroin albumen solidfied material package carry medicine silk nano granular, micropin is then made, the micropin be pierced into skin after, the fibroin of outer layer
Albumen solidfied material dissolves rapidly, releases the nano particle for carrying medicine, achievees the purpose that drug release.
The drug release effect of single type micropin at this stage can only its integrally-regulated rate of releasing drug, it is impossible to Discrete control drug release speed
Rate is especially difficult to reach the requirement that largely administration, later stage is needed slowly to release the drug the state of an illness in the early stage.
The content of the invention
The present invention, in the presence of that can not realize Discrete control, the deficiency of a pin multiple medicine, is provided for the drug release of micropin in the prior art
A kind of multi-layer two-piece needle wall fibroin albumen micropin of new structure, different types of drug can be loaded in same needle body, is had
The function of one pin multiple medicine, and processing is modified by the silk fibroin protein solution to layering, every layer of release efficiency is made to improve or reach
To the effect of sustained release.
The technical scheme is that providing a kind of multilayer fibroin albumen compound needle wall micropin, micropin needle body is tied for layering
Structure, including fibroin albumen basal layer, layering needle body and soluble needle body superficial layer, they is in pure silk fibroins or fibroin albumen
Contain drug molecule；The fibroin albumen of the fibroin albumen basal layer is the II type crystalline texture of fibroin of beta sheet structure；It is described
The soluble fibroin albumen that needle body superficial layer is less than 10000 dalton by molecular weight is formed；The layering needle body is 1~5 layer
Fibroin albumen microneedle configuration, in each layer fibroin albumen microneedle configuration, the crystalline texture of fibroin albumen include random coil structure,
I type crystalline texture and II type crystalline texture, the fibroin albumen crystalline texture that each layer fibroin albumen microneedle configuration is included it is identical or
It is different.
In technical solution of the present invention, the needle body of the fibroin albumen basal layer is solid coniform, and the length of needle body is
200~700 μm, a diameter of 0.01mm~0.2mm of half-peak of needle body.
It is described layering needle body fibroin albumen microneedle configuration, fibroin albumen crystalline texture for I type crystalline texture be denoted as A and
Random coil structure, wherein, 5≤A≤10%.
It is described layering needle body fibroin albumen microneedle configuration, fibroin albumen crystalline texture for I type crystalline texture be denoted as A and
Random coil structure, wherein, 10% ＜ A≤20%.
The fibroin albumen microneedle configuration of the layering needle body, fibroin albumen crystalline texture are denoted as A including I type crystalline texture
B is denoted as with II type crystalline texture, wherein, 20% ＜ A≤25%, 5%≤B ＜ 10%.
The fibroin albumen microneedle configuration of the layering needle body, fibroin albumen crystalline texture include I type crystalline texture A and II
Type crystalline texture B, wherein, 30%≤A, 10%≤B.
The fibroin albumen microneedle configuration of the layering needle body, fibroin albumen crystalline texture are denoted as including II type crystalline texture
B, 20%≤B.
The present invention a preferred embodiment be：Layering needle body is 5 layers of fibroin albumen microneedle configuration, from inside to outside, each layer silk
The fibroin albumen crystalline texture that fibroin microneedle configuration is included respectively is：
First layer：Fibroin albumen crystalline texture is denoted as A and random coil structure for I type crystalline texture, wherein, 5≤A≤10%；
Second layering：Fibroin albumen crystalline texture is denoted as A and random coil structure for I type crystalline texture, wherein, 10% ＜ A≤
20%；
3rd layering：Fibroin albumen crystalline texture is denoted as A including I type crystalline texture and II type crystalline texture is denoted as B, wherein, 20%
＜ A≤25%, 5%≤B ＜ 10%；
4th layering：Fibroin albumen crystalline texture includes I type crystalline texture A and II type crystalline texture B, wherein, 30%≤A, 10%
≤B；
5th layering：Fibroin albumen crystalline texture is denoted as B, 20%≤B including II type crystalline texture.
Compared with prior art, the present invention has the advantage that：
1. micropin provided by the invention, main material is fibroin albumen, and the excellent in mechanical performance under dry state is easy to be pierced into skin
Skin plays drug effect, and fibroin albumen is polymeric material, good to the compatibility of organism, even if needle body breaks after piercing
It splits and leaves in vivo also without larger impact.
2. micropin provided by the invention is multi-layer compound structure, there are more medicines that carry to select, load medicine can be layered and reach one
Pin is mostly used or the effect of a pin multiple medicine, and after skin is pierced into, outer layer carries medicine fibroin albumen quick release, and internal layer carries medicine fibroin egg
White slow sustained release can make up the shortcomings that single micropin drug release is not easy to control.Microneedle configuration is multilayer, can be according to specific disease
Feelings requirement is changed, and can will also be not easy the medicine layering being blended loading in same needle body, during being once pierced into successively
Discharge different types of drug.
3. micropin needle body provided by the invention is multi-layer compound structure, place is modified to the structure of every layer of fibroin albumen
Reason can control the rate of release of every layer of load medicine fibroin albumen, and needle body carries medicine sectional point concentration and carries out, and micropin outer layer is instant soon
Solution releases the drug substance stable state of an illness, and blood concentration is stablized in micropin internal layer swelling slowly drug release whithin a period of time.
Description of the drawings
Fig. 1 is multilayer fibroin albumen compound needle wall microneedle configuration decomposition model schematic diagram provided by the invention；
Fig. 2 is the photo of multilayer fibroin albumen compound needle wall micropin provided in an embodiment of the present invention under an optical microscope；
Fig. 3 is section of the multilayer fibroin albumen compound needle wall micropin provided in an embodiment of the present invention under laser confocal microscope
Picture；
Fig. 4 is the drug release patterns figure that fibroin albumen provided in an embodiment of the present invention carries three layers of compound needle wall micropin of insulin.
In figure, 1. basal layers；2. it is layered needle body；3. needle body superficial layer.
Specific embodiment
With reference to the accompanying drawings and examples, the specific embodiment of the present invention is described in further detail.
Embodiment 1
Referring to attached drawing 1, it is the present embodiment provides a kind of multilayer fibroin albumen compound needle wall microneedle configuration decomposition model schematic diagrames；
Micropin is mainly made of fibroin albumen, and micropin needle body is layered structure, including basal layer 1 and layering needle body 2 and needle body surface
Layer 3 is formed；Needle body is layered by 5 layers of fibroin albumen containing different structure.
1 needle body of basal layer is solid coniform, and the length of needle body is 200~700 μm, a diameter of 0.01mm of half-peak of needle body
~0.2mm, fibroin albumen are the II type crystalline texture of fibroin of beta sheet structure, are made of high intensity fibroin albumen material.Micropin
Superficial layer 3 is made of soluble small-molecular-weight fibroin albumen, and molecular weight is less than 10000 dalton, dissolves in body fluid.
Micropin layering needle body 2 is made of 5 layers of fibroin albumen containing different structure.In micropin layering needle body, first layer
Fibroin albumen based on random coil structure, contain the I type crystalline texture of fibroin albumen no more than 10%；The silk of second layering
Fibroin contains the I type crystalline texture of fibroin albumen no more than 20% based on random coil structure；The fibroin egg of 3rd layering
In vain based on I type crystalline texture of fibroin albumen, contain I type crystalline texture of fibroin albumen not less than 25% and no less than 5%
II type crystalline texture of fibroin albumen；4th layering fibroin albumen based on I type crystalline texture of fibroin albumen, containing not less than
30% I type crystalline texture of fibroin albumen and no less than 10% II type crystalline texture of fibroin albumen；The fibroin egg of 5th layering
In vain based on II type crystalline texture of fibroin albumen, contain no less than 20% II type crystalline texture of fibroin albumen.
Embodiment 2
The present embodiment provides a kind of three layers of compound needle wall micropin for carrying medicine insulin, micropin is layered needle body and contains different knots by 3 layers
The fibroin albumen of structure and the drug insulin of different content are formed.Micropin needle body is layered structure, including basal layer and layering
Needle body and needle body superficial layer are formed.
Basal layer needle body is solid coniform, and the length of needle body is 200~700 μm, a diameter of 0.01mm of half-peak of needle body
~0.2mm, fibroin albumen are the II type crystalline texture of fibroin of beta sheet structure, are made of high intensity fibroin albumen material, also contain
There is the insulin of 1wt%.
Micropin is layered needle body based on I type crystalline texture of fibroin albumen, contains I type of the fibroin albumen crystallization not less than 25%
Structure and no less than 5% II type crystalline texture of fibroin albumen, the also insulin containing 1.5wt%.
Microneedle surface layer is made of soluble small-molecular-weight fibroin albumen, and molecular weight is less than 10000 dalton, dissolves in body
Liquid, the also insulin containing 2wt%.
It is the photo of multi-layer two-piece needle wall micropin under an optical microscope in the present embodiment, it can be seen that micro- referring to attached drawing 2
Needle set has different layered structures.
It is cross-section photograph of the multilayer micropin under laser confocal microscope in the present embodiment referring to attached drawing 3, it can be seen that
Intermediate basal layer needle body is that the lighttight fibroin albumen of black is II type crystalline texture of beta sheet structure, from the inside to the outside, micro-
Pin, which is layered needle body and soluble surface's layer, can significantly distinguish the structure of its different levels.
Referring to attached drawing 4, for the drug release of fibroin albumen provided in this embodiment load three layers of compound needle wall micropin of insulin
Graph.By Fig. 4, it can be seen that, the insulin releasing speed of different layers is different, has reached outer layer quick release, internal layer is slowly released
The effect put.
Claims (8)
1. a kind of multilayer fibroin albumen compound needle wall micropin, it is characterised in that micropin needle body is layered structure, including fibroin albumen
Basal layer（1）, layering needle body（2）And soluble needle body superficial layer（3）, the material of micropin is in pure silk fibroin or fibroin albumen
Contain drug molecule；The fibroin albumen of the fibroin albumen basal layer is the II type crystalline texture of fibroin of beta sheet structure；It is described
Needle body superficial layer（3）The soluble fibroin albumen for being less than 10000 dalton by molecular weight is formed；The layering needle body（2）For 1~
5 layers of fibroin albumen microneedle configuration, in each layer fibroin albumen microneedle configuration, the crystalline texture of fibroin albumen includes random coil
Structure, I type crystalline texture and II type crystalline texture, the fibroin albumen knot that layering each layer fibroin albumen microneedle configuration of needle body is included
Crystal structure is identical or different.
2. a kind of multilayer fibroin albumen compound needle wall micropin according to claim 1, it is characterised in that：The fibroin egg
White basal layer（1）Needle body to be solid coniform, the length of needle body is 200~700 μm, a diameter of 0.01mm of half-peak of needle body~
0.2mm。
3. a kind of multilayer fibroin albumen compound needle wall micropin according to claim 1, it is characterised in that：The layering needle body
（2）Fibroin albumen microneedle configuration, fibroin albumen crystalline texture is denoted as A and random coil structure for I type crystalline texture,
In, 5≤A≤10%.
4. a kind of multilayer fibroin albumen compound needle wall micropin according to claim 1, it is characterised in that：The layering needle body
（2）Fibroin albumen microneedle configuration, fibroin albumen crystalline texture is denoted as A and random coil structure for I type crystalline texture,
In, 10% ＜ A≤20%.
5. a kind of multilayer fibroin albumen compound needle wall micropin according to claim 1, it is characterised in that：The layering needle body
（2）Fibroin albumen microneedle configuration, fibroin albumen crystalline texture including I type crystalline texture be denoted as A and II type crystalline texture note
Make B, wherein, 20% ＜ A≤25%, 5%≤B ＜ 10%.
6. a kind of multilayer fibroin albumen compound needle wall micropin according to claim 1, it is characterised in that：The layering needle body
（2）Fibroin albumen microneedle configuration, fibroin albumen crystalline texture include I type crystalline texture A and II type crystalline texture B, wherein,
30%≤A, 10%≤B.
7. a kind of multilayer fibroin albumen compound needle wall micropin according to claim 1, it is characterised in that：The layering needle body
（2）Fibroin albumen microneedle configuration, fibroin albumen crystalline texture is denoted as B, 20%≤B including II type crystalline texture.
8. a kind of multilayer fibroin albumen compound needle wall micropin according to claim 1, it is characterised in that：The layering needle body
（2）For 5 layers of fibroin albumen microneedle configuration, from inside to outside, the fibroin albumen crystallization knot that each layer fibroin albumen microneedle configuration is included
Structure respectively is：
First layer：Fibroin albumen crystalline texture is denoted as A and random coil structure for I type crystalline texture, wherein, 5≤A≤10%；
Second layering：Fibroin albumen crystalline texture is denoted as A and random coil structure for I type crystalline texture, wherein, 10% ＜ A≤
20%；
3rd layering：Fibroin albumen crystalline texture is denoted as A including I type crystalline texture and II type crystalline texture is denoted as B, wherein, 20%
＜ A≤25%, 5%≤B ＜ 10%；
4th layering：Fibroin albumen crystalline texture includes I type crystalline texture A and II type crystalline texture B, wherein, 30%≤A, 10%
≤B；
5th layering：Fibroin albumen crystalline texture is denoted as B, 20%≤B including II type crystalline texture.
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| CN201810147574.XA CN108079431A (en) | 2018-02-12 | 2018-02-12 | A kind of multilayer fibroin albumen compound needle wall micropin |
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| CN201810147574.XA CN108079431A (en) | 2018-02-12 | 2018-02-12 | A kind of multilayer fibroin albumen compound needle wall micropin |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109045459A (en) * | 2018-06-06 | 2018-12-21 | 中山大学 | Core-shell structure micropin and preparation method thereof |
| CN114712696A (en) * | 2022-04-08 | 2022-07-08 | 北京化工大学 | Method for preparing three-section type continuous administration polymer microneedle |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109045459A (en) * | 2018-06-06 | 2018-12-21 | 中山大学 | Core-shell structure micropin and preparation method thereof |
| CN114712696A (en) * | 2022-04-08 | 2022-07-08 | 北京化工大学 | Method for preparing three-section type continuous administration polymer microneedle |
| CN114712696B (en) * | 2022-04-08 | 2023-06-23 | 北京化工大学 | Method for preparing three-section sustained-administration polymer microneedle |
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