CN204709869U - Column chromatography eluant, eluent heating system - Google Patents
Column chromatography eluant, eluent heating system Download PDFInfo
- Publication number
- CN204709869U CN204709869U CN201520374077.5U CN201520374077U CN204709869U CN 204709869 U CN204709869 U CN 204709869U CN 201520374077 U CN201520374077 U CN 201520374077U CN 204709869 U CN204709869 U CN 204709869U
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- China
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- eluant
- eluent
- pipeline
- preheater
- storage tank
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Abstract
The utility model discloses a kind of column chromatography eluant, eluent heating system, comprise first circulatory system and second circulatory system, first circulatory system is by the preheater connected by pipeline, eluant, eluent storage tank clamping sleeve, with the first circulating pump composition, circulation fluid is water, preheater has filler, second circulatory system is made up of the eluant, eluent storage tank that eluent is housed connected by pipeline and the second circulating pump, eluant, eluent storage tank has exhaust-valve and filling opening, there is in the pipeline of second circulatory system discharge opeing lateral and the tapping valve of transfer eluant, eluent, preheater connects steam pipeline steam valve and is connected with outside vapor source, the water circulation pipe of preheater is provided with thermometer, the Steam Heating pipeline of preheater is provided with vaporimeter, eluant, eluent storage tank is provided with thermometer.The utility model is that the column chromatography delay phenomenon produced when solving low temperature, meets actual production requirement by heating eluant, eluent, ensures stability and the end product quality of column chromatography wash-out.
Description
Technical field
The utility model relates to pharmaceutical technology sectors, particularly a kind of column chromatography eluent heating system.
Background technology
Along with the development of new Chinese medicine and deepening continuously of the modernization of Chinese medicine, the advantages such as column chromatography technology is high with separative efficiency, separation condition Selecting parameter is strong, operating condition is gentle, the application in being separated of Chinese medicine and biological active constituents from natural medicines and active component, purifying gets more and more.
By being permitted multifactor impact in column chromatographic isolation and purification process, as applied sample amount and flow velocity, eluant, eluent kind and flow velocity, concentration, consumption etc.; In addition, the wash-out of temperature to column chromatography also has certain influence, and particularly when temperature is lower, column chromatography wash-out often occurs delay phenomenon, causes eluent to increase, quality reduces, for postprocessing working procedures increases workload and affect end product quality.
Utility model content
Technical problem to be solved in the utility model is to provide a kind of column chromatography eluant, eluent heating system, easy control simple to operate, meet actual production requirement, the column chromatography delay phenomenon produced when effectively can solve low temperature, ensure stability and the end product quality of column chromatography wash-out.
For solving the problems of the technologies described above, the technical solution of a kind of column chromatography eluant, eluent of the utility model heating system is: comprise first circulatory system and second circulatory system; First circulatory system is made up of the preheater 1 connected by pipeline, eluant, eluent storage tank clamping sleeve 11 and the first circulating pump 8, the circulation fluid of first circulatory system is water, preheater 1 has filler, second circulatory system is made up of the eluant, eluent storage tank 10 that eluent is housed connected by pipeline and the second circulating pump 8a, eluant, eluent storage tank 10 has filling opening, has discharge opeing lateral and the tapping valve 17 of transfer eluant, eluent in the pipeline of second circulatory system.
Preferably, column chromatography eluant, eluent heating system of the present utility model, described preheater 1 connects steam pipeline, and pipeline is provided with steam valve 3, and steam valve 3 is connected with outside vapor source.
Further, column chromatography eluant, eluent heating system of the present utility model, the water circulation pipe of described preheater 1 is provided with thermometer 4, and in described preheater 1, the temperature of water is 40 ~ 70 DEG C.
Further, column chromatography eluant, eluent heating system of the present utility model, the Steam Heating pipeline of described preheater 1 is provided with vaporimeter 5, and the force value of described preheater 1 inner vapor is 0 ~ 0.2MPa.
Preferably, column chromatography eluant, eluent heating system of the present utility model, described eluant, eluent storage tank 10 is provided with thermometer 4a, and in eluant, eluent storage tank 10, Eluant temperature is 20 ~ 35 DEG C.
The technique effect that the utility model can reach is:
The utility model is that the column chromatography delay phenomenon produced when solving low temperature, meets actual production requirement by heating eluant, eluent, ensures stability and the end product quality of column chromatography wash-out.
Accompanying drawing explanation
Below in conjunction with the drawings and specific embodiments, the utility model is described in further detail:
Fig. 1 is column chromatography eluant, eluent heating system schematic diagram of the present utility model.
Description of reference numerals in figure:
1 is preheater, and 2 is water supply pipe valve,
3 is steam valve, and 4 is preheater temperature table,
4a is eluant, eluent tank temperature table, and 5 is vaporimeter,
6 is flowing water Valve, and 8 is the first circulating pump,
8a is the second circulating pump, and 9 is the first circulating pump valve
10 is eluant, eluent storage tank, and 11 is eluant, eluent storage tank clamping sleeve,
12 is eluant, eluent storage tank clamping sleeve water inlet valve, and 13 is eluant, eluent storage tank clamping sleeve outlet valve,
14 is eluant, eluent storage tank exhaust-valve, and 15 is eluant, eluent tank bottom valve,
16 is pipeline valve, and 17 is tapping valve.
Detailed description of the invention
As shown in Figure 1, column chromatography eluant, eluent heating system of the present utility model, comprise first circulatory system and second circulatory system, first circulatory system is made up of the preheater 1 connected by pipeline, eluant, eluent storage tank clamping sleeve 11 and the first circulating pump 8, the circulation fluid of first circulatory system is water, preheater 1 has filler, and eluant, eluent storage tank clamping sleeve 11 has discharge outlet; Second circulatory system is made up of the eluant, eluent storage tank 10 that eluent is housed connected by pipeline and the second circulating pump 8a, and eluant, eluent storage tank 10 has filling opening, has discharge opeing lateral and the tapping valve 17 of transfer eluant, eluent in the pipeline of second circulatory system;
Preheater 1 has filler, and connect water supply pipe, filler place is provided with water supply pipe valve 2;
Preheater 1 connects steam pipeline, and pipeline is provided with steam valve 3, and steam valve is connected with outside vapor source;
Preheater 1 is provided with delivery port and water inlet, and preheater 1 delivery port connects eluant, eluent storage tank clamping sleeve 11 water inlet by pipeline, and preheater water inlet connects eluant, eluent storage tank clamping sleeve 11 delivery port by pipeline;
Preheater 1 outlet conduit is provided with flowing water Valve 6, and preheater 1 inlet channel is provided with inlet valve 7;
The first circulating pump 8 is provided with between preheater 1 and eluant, eluent storage tank 10;
The first circulating pump valve 9 is provided with between first circulating pump 8 and eluant, eluent storage tank 10;
Liquid outlet bottom eluant, eluent storage tank 10 and the liquid inlet at top, connect the second circulating pump 8a two ends by pipeline;
Pipeline between the liquid inlet of eluant, eluent storage tank 10 and the second circulating pump 8a liquid outlet is provided with pipeline valve 16, has the discharge opeing lateral and tapping valve 17 that shift eluant, eluent;
Open water supply pipe valve 2, in preheater 1, add suitable quantity of water, open steam valve 3, keep pressure gauge reading to be less than 0.2MPa, being heated to thermometer reading is 60 DEG C, steam off valve 3, stops heating;
Open flowing water Valve 6, inlet valve 7, water inlet valve 12, outlet valve 13; Open the first circulating pump 6 and the first circulating pump valve 9, eluant, eluent in eluant, eluent storage tank 10 is heated, when temperature reaches 25 DEG C, close flowing water Valve 6, inlet valve 7, first circulating pump valve 9, water inlet valve 12, outlet valve 13 and the first circulating pump 8, utilize hot water in eluant, eluent storage tank clamping sleeve 11 to continue to heat eluant, eluent; Open eluant, eluent tank bottom valve 15, pipeline valve 16 and the second circulating pump 8a, make eluant, eluent homogeneous temperature by eluant, eluent inner loop;
After eluant, eluent temperature arrives predetermined temperature, closing duct valve 16, opening tapping valve 17 can shift eluant, eluent, and operation completes.
Claims (5)
1. a column chromatography eluant, eluent heating system, is characterized in that: comprise first circulatory system and second circulatory system;
The first described circulatory system is made up of the preheater connected by pipeline, eluant, eluent storage tank clamping sleeve and the first circulating pump, and the circulation fluid of described first circulatory system is water, and described preheater has filler;
The second described circulatory system is made up of the eluant, eluent storage tank that eluent is housed connected by pipeline and the second circulating pump, described eluant, eluent storage tank has filling opening, has discharge opeing lateral and the tapping valve of transfer eluant, eluent in the pipeline of described second circulatory system.
2. column chromatography eluant, eluent heating system according to claim 1, is characterized in that: described preheater connects steam pipeline, and pipeline is provided with steam valve, and described steam valve is connected with outside vapor source.
3. column chromatography eluant, eluent heating system according to claim 2, is characterized in that: the water circulation pipe of described preheater is provided with thermometer, and in described preheater, the temperature of water is 40 ~ 70 DEG C.
4. column chromatography eluant, eluent heating system according to claim 2, is characterized in that: the Steam Heating pipeline of described preheater is provided with vaporimeter, the force value of described preheater inner vapor is 0 ~ 0.2MPa.
5. column chromatography eluant, eluent heating system according to claim 1, is characterized in that: described eluant, eluent storage tank is provided with exhaust-valve, and keeps often opening; Described eluant, eluent storage tank is provided with thermometer, and in described eluant, eluent storage tank, Eluant temperature is 20 ~ 35 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520374077.5U CN204709869U (en) | 2015-06-03 | 2015-06-03 | Column chromatography eluant, eluent heating system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520374077.5U CN204709869U (en) | 2015-06-03 | 2015-06-03 | Column chromatography eluant, eluent heating system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204709869U true CN204709869U (en) | 2015-10-21 |
Family
ID=54308902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520374077.5U Expired - Fee Related CN204709869U (en) | 2015-06-03 | 2015-06-03 | Column chromatography eluant, eluent heating system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN204709869U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10648749B2 (en) | 2017-03-03 | 2020-05-12 | Swagelok Company | Fluid system components with thermal conditioning passages |
| USD886237S1 (en) | 2018-09-04 | 2020-06-02 | Swagelok Company | Thermal trace valve body |
-
2015
- 2015-06-03 CN CN201520374077.5U patent/CN204709869U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10648749B2 (en) | 2017-03-03 | 2020-05-12 | Swagelok Company | Fluid system components with thermal conditioning passages |
| US10976118B2 (en) | 2017-03-03 | 2021-04-13 | Swagelok Company | Fluid system components with thermal conditioning passages |
| USD886237S1 (en) | 2018-09-04 | 2020-06-02 | Swagelok Company | Thermal trace valve body |
| USD895772S1 (en) | 2018-09-04 | 2020-09-08 | Swagelok Company | Thermal trace valve body |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151021 Termination date: 20170603 |