CN204671925U - A kind of methanol recovery device for fluorouracil synthesis - Google Patents
A kind of methanol recovery device for fluorouracil synthesis Download PDFInfo
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- CN204671925U CN204671925U CN201520282521.0U CN201520282521U CN204671925U CN 204671925 U CN204671925 U CN 204671925U CN 201520282521 U CN201520282521 U CN 201520282521U CN 204671925 U CN204671925 U CN 204671925U
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Abstract
The utility model is about a kind of methanol recovery device for fluorouracil synthesis, comprise a Norfloxacin Reaction still, first stainless steel pipe bundle condenser, second stainless steel pipe bundle condenser, receiving slit, surge tank, high vacuum lobe pump and liquid rotary pump, described Norfloxacin Reaction still is provided with offgas outlet and steam (vapor) outlet, steam (vapor) outlet is connected with the steam inlet of the first stainless steel pipe bundle condenser, the cooling liquid outlet of the first stainless steel pipe bundle condenser is connected with the steam inlet of the second stainless steel pipe bundle condenser, the cooling liquid outlet of the second stainless steel pipe bundle condenser is connected with receiving slit, receiving slit is connected with surge tank, surge tank is connected with high vacuum lobe pump, high vacuum lobe pump is connected with liquid rotary pump, described receiving slit is provided with Pressure gauge.After adopting said structure, its beneficial effect is that organic efficiency methanol quality that is high, that reclaim is good, can be used further to the synthesis of fluorouracil.
Description
Technical field
The utility model relates to pharmaceutical chemistry technical field, refers more particularly to a kind of methanol recovery device for fluorouracil synthesis.
Background technology
Fluorouracil is anti-miazines medicine, must being that the acid of 5-fluorodeoxyuridine has antitumor activity through enzymatic conversion, suppressing the synthesis of DNA by suppressing thymidylate synthase.Fluorouracil has the effect of good clinical treatment tumour, enjoys attracting attention of Ge great drugmaker at present, and wherein, the quality of fluorouracil crude product is the key of producing fluorouracil bulk drug.But the method that disclosed fluorouracil condensation is reclaimed at present adopts conventional vacuum pump recovered under reduced pressure, cannot reach high vacuum state, cause recovery not thorough, impurity is many, not only affects yield, also have impact on the quality of fluorouracil crude product to a certain extent.
Therefore, need to design a kind of new separate mode, guaranteeing that methyl alcohol is separated when reclaiming thoroughly, improve the quality of fluorouracil crude product on the one hand, reducing the production cost of fluorouracil crude product on the other hand.
Utility model content
The purpose of this utility model is to provide a kind of methanol recovery device for fluorouracil synthesis, to make Methanol Recovery abundant, thus improves the quality of fluorouracil crude product.
For achieving the above object, the utility model is by the following technical solutions:
A kind of methanol recovery device for fluorouracil synthesis, comprise a Norfloxacin Reaction still, first stainless steel pipe bundle condenser, second stainless steel pipe bundle condenser, receiving slit, surge tank, high vacuum lobe pump and liquid rotary pump, described Norfloxacin Reaction still is provided with offgas outlet and steam (vapor) outlet, steam (vapor) outlet is connected with the steam inlet of the first stainless steel pipe bundle condenser, the cooling liquid outlet of the first stainless steel pipe bundle condenser is connected with the steam inlet of the second stainless steel pipe bundle condenser, the cooling liquid outlet of the second stainless steel pipe bundle condenser is connected with receiving slit, receiving slit is connected with surge tank, surge tank is connected with high vacuum lobe pump, high vacuum lobe pump is connected with liquid rotary pump, the final vacuum of described retracting device can be increased, to make recovery thorough, described receiving slit is provided with Pressure gauge.
According to the utility model, described Norfloxacin Reaction still is provided with thermometer, for showing the temperature of Norfloxacin Reaction still, guarantees that the steam that the steam (vapor) outlet of Norfloxacin Reaction still is discharged is methanol steam.
According to the utility model, the offgas outlet of Norfloxacin Reaction still is provided with exhaust-valve, and steam (vapor) outlet is provided with steam valve, and the below of Norfloxacin Reaction still is provided with Steam Heating valve.
According to the utility model, the cooling medium inlet of the first stainless steel pipe bundle condenser and the second stainless steel pipe bundle condenser and cooling medium outlet are respectively equipped with the first liquid feed valve, the first liquid valve, the second liquid feed valve and the second liquid valve.
According to the utility model, be provided with the first safety valve between receiving slit and surge tank, the outlet of surge tank is provided with the second safety valve.
Methanol recovery device for fluorouracil synthesis of the present utility model, its beneficial effect is:
1, the setting of high vacuum lobe pump, make this methanol recovery device to reach vacuum state, be convenient to fully reclaim the methanol steam produced in fluorouracil crude product building-up process, avoid methyl alcohol to remain in fluorouracil crude product, thus improve the quality of fluorouracil crude product, reduce production cost.
2, high vacuum lobe pump and liquid rotary pump mating reaction, increase the final vacuum of described methanol recovery device, and make Methanol Recovery more thorough, the methanol quality of recovery is high, and impurity is few, can be used further to the synthesis of fluorouracil.
3, the setting of surge tank, can reduce the vacuum of methanol recovery device on the one hand, be convenient to methanol steam and enter stainless steel pipe bundle condenser, prevents high vacuum lobe pump from sucking other media and damaging high vacuum lobe pump on the other hand.
4, two stainless steel pipe bundle condensers are arranged in series, and guarantee that steam fully cools, thus improve the quality and efficiency that reclaim methyl alcohol.
Accompanying drawing explanation
Fig. 1 is the structural representation of the methanol recovery device for fluorouracil synthesis of the present utility model.
Detailed description of the invention
Below in conjunction with accompanying drawing, the methanol recovery device for fluorouracil synthesis of the present utility model is described in further detail.
As shown in Figure 1, for of the present utility model for the methanol recovery device of fluorouracil synthesis, comprise a Norfloxacin Reaction still 1, first stainless steel pipe bundle condenser 2, second stainless steel pipe bundle condenser 3, receiving slit 4, surge tank 5, high vacuum lobe pump 6 and liquid rotary pump 7, described Norfloxacin Reaction still 1 is provided with offgas outlet 11 and steam (vapor) outlet 12, steam (vapor) outlet 12 is connected with the steam inlet 21 of the first stainless steel pipe bundle condenser 2, the cooling liquid outlet 22 of the first stainless steel tubulation condensation 2 device is connected with the steam inlet 31 of the second stainless steel pipe bundle condenser 3, the cooling liquid outlet 32 of the second stainless steel pipe bundle condenser 3 is connected with receiving slit 4, receiving slit 4 is connected with surge tank 5, surge tank 5 is connected with high vacuum lobe pump 6, high vacuum lobe pump 6 is connected with liquid rotary pump 7, the final vacuum of described retracting device can be increased, to make Methanol Recovery thorough, described receiving slit 4 is provided with Pressure gauge 8.
Described Norfloxacin Reaction still 1 is provided with thermometer 9, for showing the temperature of Norfloxacin Reaction still 1, to make to keep low-temperature heat in Norfloxacin Reaction still 1 always, guarantees that the steam that the steam (vapor) outlet 12 of Norfloxacin Reaction still 1 is discharged is methanol steam.
The offgas outlet 11 of described Norfloxacin Reaction still 1 is provided with exhaust-valve 13, and steam (vapor) outlet 12 is provided with steam valve 14, and the below of Norfloxacin Reaction still 1 is provided with Steam Heating valve 15.
The cooling medium inlet of the first stainless steel pipe bundle condenser 2 and the second stainless steel pipe bundle condenser 3 and cooling medium outlet are respectively equipped with the first liquid feed valve 23, first liquid valve 24, second liquid feed valve 33 and the second liquid valve 34.
Be provided with the first safety valve 41 between described receiving slit 4 and surge tank 5, the outlet of surge tank 5 is provided with the second safety valve 51.
Use procedure of the present utility model is as follows:
First open the exhaust-valve 13 of Norfloxacin Reaction still 1, after the gas emptying in Norfloxacin Reaction still 1, open high vacuum lobe pump 6, liquid rotary pump 7 and the first safety valve 41, second safety valve 51, first liquid feed valve 23, first liquid valve 24, second liquid feed valve 33 and the second liquid valve 34; Then the exhaust-valve 13 of Norfloxacin Reaction still 1 is closed, open the steam valve 14 of Norfloxacin Reaction still 1, by the time when Pressure gauge 8 shows-0.095Mpa, open the Steam Heating valve 15 of Norfloxacin Reaction still 1, distillate to methyl alcohol, the methanol steam distillated through the first stainless steel pipe bundle condenser 2 and the second stainless pipe bundle condenser 3, after being cooled to methanol liquid, enters in accumulator tank 4 successively.
After recovery terminates, first open the exhaust-valve 13 of Norfloxacin Reaction still 1, then close all the other valves.
In sum, the methanol recovery device for fluorouracil synthesis of the present utility model, its organic efficiency methanol quality that is high, that reclaim is good, can be used further to the synthesis of fluorouracil.
Claims (5)
1. the methanol recovery device for fluorouracil synthesis, it is characterized in that, comprise a Norfloxacin Reaction still, first stainless steel pipe bundle condenser, second stainless steel pipe bundle condenser, receiving slit, surge tank, high vacuum lobe pump and liquid rotary pump, described Norfloxacin Reaction still is provided with offgas outlet and steam (vapor) outlet, steam (vapor) outlet is connected with the steam inlet of the first stainless steel pipe bundle condenser, the cooling liquid outlet of the first stainless steel pipe bundle condenser is connected with the steam inlet of the second stainless steel pipe bundle condenser, the cooling liquid outlet of the second stainless steel pipe bundle condenser is connected with receiving slit, receiving slit is connected with surge tank, surge tank is connected with high vacuum lobe pump, high vacuum lobe pump is connected with liquid rotary pump, described receiving slit is provided with Pressure gauge.
2., as claimed in claim 1 for the methanol recovery device of fluorouracil synthesis, it is characterized in that, described Norfloxacin Reaction still is provided with thermometer.
3., as claimed in claim 1 for the methanol recovery device of fluorouracil synthesis, it is characterized in that, the offgas outlet of described Norfloxacin Reaction still is provided with exhaust-valve, and steam (vapor) outlet is provided with steam valve, and the below of Norfloxacin Reaction still is provided with Steam Heating valve.
4. as claimed in claim 1 for the methanol recovery device of fluorouracil synthesis, it is characterized in that, the cooling medium inlet of the first stainless steel pipe bundle condenser and the second stainless steel pipe bundle condenser and cooling medium outlet are respectively equipped with the first liquid feed valve, the first liquid valve, the second liquid feed valve and the second liquid valve.
5., as claimed in claim 1 for the methanol recovery device of fluorouracil synthesis, it is characterized in that, be provided with the first safety valve between described receiving slit and surge tank, the outlet of surge tank is provided with the second safety valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520282521.0U CN204671925U (en) | 2015-05-04 | 2015-05-04 | A kind of methanol recovery device for fluorouracil synthesis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520282521.0U CN204671925U (en) | 2015-05-04 | 2015-05-04 | A kind of methanol recovery device for fluorouracil synthesis |
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| CN204671925U true CN204671925U (en) | 2015-09-30 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106179123A (en) * | 2016-08-30 | 2016-12-07 | 无锡东恒新能源科技有限公司 | A kind of organic solvent extraction mechanism with vacuum extractor |
| CN106215449A (en) * | 2016-08-29 | 2016-12-14 | 石家庄杰克化工有限公司 | A kind of 4,6 dihydroxy-pyrimidine response system tail gas treatment process |
| CN108744570A (en) * | 2018-06-20 | 2018-11-06 | 无棣县格桑花技术服务中心 | A kind of distillation equipment for Chemical Manufacture of environmental protection |
| CN109731363A (en) * | 2019-04-02 | 2019-05-10 | 烟台爵巧食品有限公司 | The distillation equipment of methanol fuel in a kind of Chemical Manufacture |
| CN114470849A (en) * | 2022-02-09 | 2022-05-13 | 安徽碳鑫科技有限公司 | High-efficient recovery unit of methyl alcohol vapour |
-
2015
- 2015-05-04 CN CN201520282521.0U patent/CN204671925U/en active Active
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106215449A (en) * | 2016-08-29 | 2016-12-14 | 石家庄杰克化工有限公司 | A kind of 4,6 dihydroxy-pyrimidine response system tail gas treatment process |
| CN106215449B (en) * | 2016-08-29 | 2018-11-16 | 石家庄杰克化工有限公司 | A kind of 4,6- dihydroxy-pyrimidine reaction system tail gas treatment process |
| CN106179123A (en) * | 2016-08-30 | 2016-12-07 | 无锡东恒新能源科技有限公司 | A kind of organic solvent extraction mechanism with vacuum extractor |
| CN108744570A (en) * | 2018-06-20 | 2018-11-06 | 无棣县格桑花技术服务中心 | A kind of distillation equipment for Chemical Manufacture of environmental protection |
| CN109731363A (en) * | 2019-04-02 | 2019-05-10 | 烟台爵巧食品有限公司 | The distillation equipment of methanol fuel in a kind of Chemical Manufacture |
| CN109731363B (en) * | 2019-04-02 | 2019-07-12 | 烟台爵巧食品有限公司 | The distillation equipment of methanol fuel in a kind of Chemical Manufacture |
| CN114470849A (en) * | 2022-02-09 | 2022-05-13 | 安徽碳鑫科技有限公司 | High-efficient recovery unit of methyl alcohol vapour |
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