CN204536264U - Electrochemical chip detection system - Google Patents
Electrochemical chip detection system Download PDFInfo
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- CN204536264U CN204536264U CN201520083806.1U CN201520083806U CN204536264U CN 204536264 U CN204536264 U CN 204536264U CN 201520083806 U CN201520083806 U CN 201520083806U CN 204536264 U CN204536264 U CN 204536264U
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Abstract
The utility model discloses: electrochemical chip detection system, comprise chip reader and detector, described chip reader comprise place successively from top to bottom renovate, test board and end box, processor, AD converter, storer, Bluetooth data transfer module, touch-screen and USB data transmission interface that described detector comprises housing and arranges in the housing.The beneficial effects of the utility model are: be provided with a well heater below reaction compartment, heat reaction compartment, chip biological molecular activity is strengthened, reacts completely; The side plate of groove is made up of glass fibre, has heat insulation effect, prevents temperature to be sent in reader, impacts the control chip of reader inside; Push pedal is set at the place of windowing, fixation reaction groove, makes the reflecting point one_to_one corresponding of cylindrical hole on reactive tank and chip, ensure that the reactive tank that in motion in the wild can not be moves, avoid cross pollution.
Description
Technical field
The utility model relates to biochemical reaction field, particularly relates to a kind of electrochemical chip detection system.
Background technology
Biochemical anti-terrorism in medical diagnosis now, food industry (analysis of food composition, food additives, harmful poisonous substance etc. detects), military medicine (detection of biotoxin), the demand that environmental monitoring (water analysis) detects immediately for scene is more and more higher, and therefore tool is of great significance by a kind of instrument system that can meet on-the-spot instant detection.At present existing many detection techniques and equipment (as Gene Chip system, Biochemical Analyzer, microorganism detector etc.) are for the detection of multiple biology or abiotic mark, but due to the limitation of self-technique, as long in complex operation, analysis time and need professional technique background personnel or because of factors such as instrument cost are too high, bulky, the on-the-spot instant demand detected cannot be met.
It is that development with Cutting-edge science technology is closely related that bioelectrochemical learns a skill, and it can carry out to material the examination and analysb forming form and component content, in the development of life science, energy science, information science and environmental science, have important effect.Microelectromechanical systems (MEMS) is the emerging application foundation technology grown up on the basis of microelectric technique in the later stage the 80's of 20th century, and MEMS has the advantages such as microminiaturization, integrated, applied range.Form the new cutting edge technology of biological microelectromechanical systems (Bio-MEMS) with the use in conjunction of biology techniques in recent years, be widely applied to multiple research field, especially in medical diagnosis.Have that volume is little, lightweight, cost is low due to MEMS and the advantage such as stable performance, consistance be good, based on the Portable electrochemistry biochip detector system that this technical foundation is developed, there is the advantages such as volume is little, selectivity is strong, analysis speed is fast, accuracy is high, detection limit is large, testing cost is low; After the wireless information transfer Technology Integration of Present Attitude maturation, this electrochemica biological chip detector system availability strengthens greatly, can meet the on-the-spot instant demand detecting and analyze data wireless transmission, this portable inspectiont instrument system is applicable to hospital, family or individual soldier's testing equipment.
The reader mostly being single channel line-connection type structure of current employing, this structure cannot provide a kind of testing environment of closed for electrochemica biological chip, easily causes that to detect sample contaminated, does not have the function of multi-channel synchronous Signal transmissions; Especially reduce because chip surface biomolecule (enzyme, nucleic acid, antigen, antibody) is active in low temperature environment, cause detecting the situation that cannot carry out.
Utility model content
The purpose of this utility model is the shortcoming and defect overcoming above-mentioned prior art, electrochemical chip detection system is provided, solve in existing electrochemical chip detection system, reader for the testing environment that electrochemica biological chip provides be open, cause detecting sample easily contaminated, and when the temperature of the surroundings is low, chip surface biomolecule activity reduces, cause the defect detecting error.
The purpose of this utility model is achieved through the following technical solutions: electrochemical chip detection system, comprises chip reader and detector;
Described chip reader comprises renovating of placing successively from top to bottom, test board and end box, described end box is provided with groove, the position of renovating respective slot is provided with windowing of cooperation, test board is fixed on the bottom surface of renovating, the contact pilotage of test board extends to the top of groove, the below of described groove is provided with a well heater, the bottom surface of groove is close to by well heater, the end face renovated is embedded with a display, a Temperature Controlling Chip is provided with in end box, Temperature Controlling Chip electrical connection well heater and display, described Temperature Controlling Chip and test board are connected to detector by USB interface, described window in be positioned at contact pilotage top be provided with a push pedal, push pedal is connected to through push rod windows on the madial wall of contact pilotage, push rod is through the madial wall of windowing, its top away from one end of push pedal is provided with a projection, protruding through renovating, be exposed on the end face renovated,
Processor, AD converter, storer, Bluetooth data transfer module, touch-screen and USB data transmission interface that described detector comprises housing and arranges in the housing, described processor is connected to chip reader through AD converter, USB data transmission interface, and storer, Bluetooth data transfer module and touch-screen are all connected on processor.
In this device, renovate with end box hinged, making to renovate to stir is connected on end box, groove and window in the same size, cover after renovating, window with groove is that upper and lower relation settles relation, electrochemica biological chip is positioned in groove, chip (i.e. electrochemica biological chip) and groove agree with, cover after renovating, namely the contact pilotage of test board touches the electrode contact point of chip, then a reactive tank is put into from windowing, reactive tank coordinates with chip, the reflecting point place of chip is provided with cylindrical hole one by one, allow well staff from this cylindrical hole instillation reaction liquid on the reflecting point of chip, and reactant liquor is confined at reflecting point place by reactive tank, it is not allowed to spread, prevent cross pollution, but the size of reactive tank is less than chip, need the electrode contact point of exposed chip, so need a push pedal driving a reaction groove, make the cylindrical hole of reactive tank and the reflecting point one_to_one corresponding of chip, and the vibration of reactive tank is also forbidden in push pedal, when preventing staff's mobile device, because not steady, reactive tank is caused to move, make reactant liquor cross pollution, push pedal promotes to move by push rod, push pedal is parallel to the long direction of window, push rod is vertical and that window is long direction, its other end has a projection, projection is positioned on the end face renovated, staff stirs projection, namely push rod can be operated, push pedal is moved, push rod can be packed up before using, can placing response groove, in using, namely projection is stirred, fixation reaction groove.The bottom portion of groove of this device arranges a well heater, because the temperature of reaction has a lot of change, so be generally first regulate temperature, when making temperature reach temperature of reaction, putting into chip etc., the biomolecule activity of such chip surface is best, react also more complete, temperature is also sent on display and shows by chip temperature, facilitate operated by personnel, and the reaction condition of test board test and the temperature data of chip temperature, also can be sent in outside host computer, carry out data storage, facilitate staff to check course of reaction.Test board can not stop groove and window, so can be provided with the opening of cooperation.
Further, the interior bottom of described groove is provided with a shock-absorbing buffer pad, causes external force to the impact of electrochemica biological chip under reducing field environment because moving.
Further, described groove has corresponding both sides to be respectively arranged with a breach, these two breach symmetries.Symmetrically arranged breach coordinates with human finger size, facilitates staff to take out chip.
Further, described test board is fixed on the bottom surface of renovating by baffle plate, and the position that baffle plate correspondence is windowed should be provided with the opening of cooperation.
Further, described window on be provided with a window lid, reaction environment is sealed, stops the extraneous pollution to inner reactant liquor.
Further, described groove comprises base plate and side plate, and base plate is connected to end box through side plate, and described side plate adopts glass fibre to make, and such well heater is only to groove base plate heating, and side plate can carry out heat insulation, can not cause temperatures involved to device.
Further, described housing is provided with anti-slip veins.
The beneficial effects of the utility model are:
(1) be provided with a well heater below the reaction compartment of reader, reaction compartment heated, chip biological molecular activity is strengthened, reacts completely;
(2) side plate of the groove of reader is made up of glass fibre, has heat insulation effect, prevents temperature to be sent in reader, impacts the control chip of reader inside.
(3) place of windowing of reader arranges push pedal, fixation reaction groove, makes the reflecting point one_to_one corresponding of cylindrical hole on reactive tank and chip, ensures that the reactive tank that in motion in the wild can not be moves, avoids cross pollution.
Accompanying drawing explanation
Fig. 1 is the structural representation of embodiment 1 chips reader;
Fig. 2 is the detector structural representation of embodiment 1;
Fig. 3 is the fractionation schematic diagram renovated in embodiment 1;
Fig. 4 is fractionation schematic diagram when end box arranges chip and reactive tank in embodiment 1;
Fig. 5 is the structural representation of windowing in embodiment 1;
Fig. 6 is the structural representation of embodiment 1 further groove;
Fig. 7 is embodiment 1 further groove structure schematic diagram;
Fig. 8 is the electrical block diagram of test board in embodiment 1;
Fig. 9 is the electrical block diagram of chip temperature in embodiment 1;
Figure 10 is the circuit structure block diagram of detector inside in embodiment 1;
Figure 11 is fractionation schematic diagram when end box arranges chip and reactive tank in embodiment 2;
Figure 12 is fractionation schematic diagram when end box arranges chip and reactive tank in embodiment 3;
Figure 13 is the structural representation of embodiment 3.
Name in accompanying drawing corresponding to Reference numeral is called: 1, renovate, 2, test board, 3, end box, 4, well heater, 5, display, 6, Temperature Controlling Chip, 7, baffle plate, 8, chip, 9, reactive tank, 10, chip reader, 11, detector, 12, housing, 13, anti-slip veins, 101, window, 102, window lid, 103, push pedal, 104, push rod, 105, protruding, 201, contact pilotage, 301, groove, 302, shock-absorbing buffer pad, 303, base plate, 304, side plate, 305, breach.
Embodiment
Below in conjunction with embodiment, the utility model is described in further detail, but structure of the present utility model is not limited only to following examples:
Embodiment 1
As shown in Figures 1 to 10, electrochemical chip detection system, comprises chip reader 10 and detector 11;
Described chip reader 10 comprise place successively from top to bottom renovate 1, test board 2 and end box 3, described end box 3 is provided with groove 301, what the position of renovating respective slot 301 on 1 was provided with cooperation windows 101, test board 2 is fixed on the bottom surface of renovating 1, the contact pilotage 201 of test board 2 extends to the top of groove 301, the below of described groove 301 is provided with a well heater 4, the bottom surface of groove 301 is close to by well heater 4, the end face renovating 1 is embedded with a display 5, a Temperature Controlling Chip 6 is provided with in end box 3, Temperature Controlling Chip 6 is electrically connected well heater 4 and display 5, described Temperature Controlling Chip 6 and test board 2 are connected to detector 11 by USB interface, the described top being positioned at contact pilotage 201 in 101 of windowing is provided with a push pedal 103, push pedal 103 is connected to through push rod 104 and windows 101 on the madial wall of contact pilotage 201, push rod 104 through window 101 madial wall, its top away from one end of push pedal 103 is provided with a projection 105, protruding 105 through renovating 1, be exposed at and renovate on the end face of 1.
Described detector 11 comprises housing 12 and is arranged on processor, AD converter, storer, Bluetooth data transfer module, touch-screen and the USB data transmission interface in housing 12, described processor is connected to chip reader 10 through AD converter, USB data transmission interface, and storer, Bluetooth data transfer module and touch-screen are all connected on processor.
In this device, renovate 1 with end box 3 hinged, make to renovate 1 can stir and be connected on end box 3, groove 301 and window 101 in the same size, cover after renovating 1, window 101 and groove 301 settle relation in upper and lower relation, electrochemica biological chip is positioned in groove, chip 8(and electrochemica biological chip) agree with groove 301, cover after renovating 1, namely the contact pilotage 201 of test board 2 touches the electrode contact point of chip 8, then 101 a reactive tank 9 is put into from windowing, reactive tank 9 coordinates with chip 8, the reflecting point place of chip 8 is provided with cylindrical hole one by one, allow well staff from this cylindrical hole instillation reaction liquid on the reflecting point of chip 8, and reactant liquor is confined at reflecting point place by reactive tank 9, it is not allowed to spread, prevent cross pollution, but the size of reactive tank 9 is less than chip, need the electrode contact point of exposed chip 8, so need a push pedal 103 driving a reaction groove 9, make the cylindrical hole of reactive tank 9 and the reflecting point one_to_one corresponding of chip 8, and the vibration of reactive tank 9 is also forbidden in push pedal 103, when preventing staff's mobile device, because not steady, reactive tank 9 is caused to move, make reactant liquor cross pollution, push pedal 103 promotes to move by push rod 104, push pedal 103 is parallel to the long direction of window, push rod 104 is vertical and that window is long direction, its other end has a projection 105, projection 105 is positioned at renovates on the end face of 1, staff stirs protruding 105, namely push rod 104 can be operated, push pedal 103 is moved, push rod 103 can be packed up before using, can placing response groove 9, in using, namely protruding 105 are stirred, fixation reaction groove 9.A well heater 4 is set bottom the groove 301 of this device, because the temperature of reaction has a lot of change, so be generally first regulate temperature, when making temperature reach temperature of reaction, putting into chip 8 etc., the biomolecule activity on such chip 8 surface is best, react also more complete, temperature is also sent on display 5 and shows by chip temperature 6, facilitate operated by personnel, and test board 2 reaction condition of testing and the temperature data of chip temperature 6, also can be sent in outside host computer, carry out data storage, facilitate staff to check course of reaction.Test board 2 can not stop groove and window, so can be provided with the opening of cooperation.The data that chip reader 10 reads are transported to detector 11 through USB interface, and data can store by detector, and show on the touchscreen, check for staff.
In the present embodiment, renovate in 1 though display 5 embeds, but display 5 is mounted on test board 2, chip temperature 6 and the public USB interface of test board 2, USB interface is fixed on chip temperature 6, Fig. 7 is the electrical block diagram of test board 2, and Fig. 8 is the electrical block diagram of chip temperature 6.
Housing 12 is provided with anti-slip veins 13, when staff is hand-held, when the palm of the hand is perspired, device easily skids off from hand, arranges anti-slip veins 13, and namely anti-locking apparatus skids off from hand.
In the present embodiment, test board 2 is fixed on the bottom surface of renovating 1 by baffle plate 7, baffle plate 7 correspondence window 101 position should be provided with the opening of cooperation.
Window in the present embodiment on 101 and be provided with a window lid 102, reaction environment is sealed, stop the extraneous pollution to inner reactant liquor.
The present embodiment further groove 301 comprises base plate 303 and side plate 304, base plate 303 is connected to end box 3 through side plate 304, and described side plate 304 adopts glass fibre to make, and such well heater 4 is only to groove 101 bottom plate heating, side plate 304 can carry out heat insulation, can not cause temperatures involved to device.
In the present embodiment, the processor of detector 11 adopts 32 microprocessors of ARM company Cortex-M3 kernel, using STM32F103VCT6 as key control unit, has high-performance, low price, low-power consumption and multiple high precision, peripheral hardware at a high speed.
Wherein electrochemica biological chip detector inside is integrated with AD and DA of 12 bit resolutions of multichannel band DMA function, can when microprocessor seldom participates in, automatically, at a high speed carry out AD and DA conversion, the sweep signal for constant voltage and continuous current mode exports and micro voltage, electric current input collection provide high speed, high-resolution support.
USB data transmission interface and Bluetooth data transfer module, detector can be realized with computing machine or PDA(palm PC, mobile phone) between high speed communication, also wireless information transfer can be carried out by USB port in data batchmove to USB flash disk or by bluetooth, for follow-up data process is provided convenience, reduce local system volume, weight thus, improve portability.
Touch-screen adopts the very color LCDs of TFT of 8.7 inch band touch functions, software systems adopt UCGUI embedded GUI supporting system, coordinate UCOS2 multiple task real-time operation system, provide the alternating interface between man and computer of a convenience, succinct similar windows system in the mode of character, figure, image, the data simultaneously realizing 16 tunnel systems control in real time and gather.
The high precision that detector 11 also adopts ADI company to produce, Low dark curient, low drifting, the track rail amplifier AD8544 of low imbalance and high cmrr, basic hardware condition is provided for prime micro-signal amplifies, the OPA551 big current amplifier that have employed BB company provides the output current being greater than 100mA for testing circuit, constant voltage and continuous current working method is switched by CMOS multi-way switch 4051, for ensureing the mode that have employed quick No-contact switch of life-span and science, adopt multi-disc multi-way switch 4051, form the multi pass acquisition system on 16 tunnels, each detecting unit front end adopts separately a set of discharge circuit, after the multi pass acquisition on 16 tunnels is comprehensive, the gain-programmed amplifier INA110 of BB company is adopted to coordinate the low internal resistance multi-way switch ADG1611 of ADI, can realize × 1, × 10, × 100, × 200, the selection of several enlargement factors such as × 500, for micro-signal, wide range, high-precision collection provides reliable foundation.
Power module in detector 11 adopts ASM1117 low pressure difference linear voltage regulator, 34063 switching regulator integrated circuit and LT1964 low pressure difference linearity negative voltage voltage stabilizer produce-5V voltage, for testing circuit provide 200mA ± 5V power supply, LM385-2.5 is adopted to provide the accurate reference voltage of 2.5V, for AD, DA conversion, the circuit such as electrical level transfer provide reliable reference voltage.Internal system adopts 2A lithium battery power supply, and external 5V/2A D.C. regulated power supply also can be adopted to power.
Embodiment 2
As Figure 11, structure and the embodiment 1 of the present embodiment are basically identical, and difference is that the interior bottom of groove 301 is provided with a shock-absorbing buffer pad 302, cause external force to the impact of chip 8 under reducing field environment because moving.
Embodiment 3
As Figure 12, Figure 13, structure and the embodiment 2 of the present embodiment are basically identical, and difference is that groove 301 has corresponding both sides to be respectively arranged with a breach 305, and these two breach 305 are symmetrical.Symmetrically arranged breach 305 coordinates with human finger size, facilitates staff to take out chip 8.
Above content is the further description done the utility model in conjunction with concrete preferred implementation, can not assert that embodiment of the present utility model is confined to these explanations.For the utility model person of an ordinary skill in the technical field, not departing from other embodiments drawn under the technical solution of the utility model, all should be included in protection domain of the present utility model.
Claims (7)
1. electrochemical chip detection system, is characterized in that, comprises chip reader (10) and detector (11), described chip reader (10) comprises renovating (1) of placing successively from top to bottom, test board (2) and end box (3), described end box (3) is provided with groove (301), the position of renovating (1) upper respective slot (301) is provided with window (101) of cooperation, test board (2) is fixed on the bottom surface of renovating (1), the contact pilotage (201) of test board (2) extends to the top of groove (301), the below of described groove (301) is provided with a well heater (4), the bottom surface of groove (301) is close to by well heater (4), the end face renovating (1) is embedded with a display (5), a Temperature Controlling Chip (6) is provided with in end box (3), Temperature Controlling Chip (6) electrical connection well heater (4) and display (5), described Temperature Controlling Chip (6) and test board (2) are connected to detector (11) by USB interface, the top being positioned at contact pilotage (201) in described window (101) is provided with a push pedal (103), push pedal (103) is connected to through push rod (104) and windows (101) on the madial wall of contact pilotage (201), push rod (104) is through the madial wall of window (101), its top away from one end of push pedal (103) is provided with a projection (105), protruding (105) are through renovating (1), be exposed at renovate (1) end face on, described detector (11) comprises housing (12) and is arranged on processor, AD converter, storer, Bluetooth data transfer module, touch-screen and the USB data transmission interface in housing (12), described processor is connected to chip reader (10) through AD converter, USB data transmission interface, and storer, Bluetooth data transfer module and touch-screen are all connected on processor.
2. electrochemical chip detection system according to claim 1, is characterized in that, the interior bottom of described groove (301) is provided with a shock-absorbing buffer pad (302).
3. electrochemical chip detection system according to claim 1 and 2, is characterized in that, described groove (301) has corresponding both sides to be respectively arranged with a breach (305), and these two breach (305) are symmetrical.
4. electrochemical chip detection system according to claim 1, is characterized in that, described test board (2) is fixed on the bottom surface of renovating (1) by baffle plate (7).
5. electrochemical chip detection system according to claim 1, is characterized in that, described window (101) is provided with a window lid (102).
6. electrochemical chip detection system according to claim 1, it is characterized in that, described groove (301) comprises base plate (303) and side plate (304), and base plate (303) is connected to end box (3) through side plate (304), and described side plate (304) adopts glass fibre to make.
7. electrochemical chip detection system according to claim 1, is characterized in that, described housing (12) is provided with anti-slip veins (13).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520083806.1U CN204536264U (en) | 2015-02-06 | 2015-02-06 | Electrochemical chip detection system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520083806.1U CN204536264U (en) | 2015-02-06 | 2015-02-06 | Electrochemical chip detection system |
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| CN204536264U true CN204536264U (en) | 2015-08-05 |
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| CN201520083806.1U Expired - Fee Related CN204536264U (en) | 2015-02-06 | 2015-02-06 | Electrochemical chip detection system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114252481A (en) * | 2020-09-24 | 2022-03-29 | 禅谱科技股份有限公司 | Multi-channel potentiostat device |
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2015
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114252481A (en) * | 2020-09-24 | 2022-03-29 | 禅谱科技股份有限公司 | Multi-channel potentiostat device |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150805 Termination date: 20160206 |