CN204503113U - Multistage microballoon screening chip - Google Patents
Multistage microballoon screening chip Download PDFInfo
- Publication number
- CN204503113U CN204503113U CN201520035008.1U CN201520035008U CN204503113U CN 204503113 U CN204503113 U CN 204503113U CN 201520035008 U CN201520035008 U CN 201520035008U CN 204503113 U CN204503113 U CN 204503113U
- Authority
- CN
- China
- Prior art keywords
- microballoon
- screening
- width
- sample
- passage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
The utility model provides a kind of multistage microballoon screening chip, it is primarily of screening unit composition, and one-level screening unit mainly comprises sample holes, 3 sample introduction branched bottoms are respectively communicated with a microballoon screening passage, sample outlet hole, 6 microballoon transport channels, collecting pit, collecting pit outlet vertical cut valves.The utility model beneficial effect is that the particle diameter uniformity of screening is better, and a slice chip side by side can organize multistage screening unit more, screens simultaneously, or screen different samples simultaneously, improve screening operation efficiency, simply easy to make, use cost is cheap, can batch use of large-scale production.
Description
Technical field
The utility model relates to a kind of novel microballoon screening chip, from use, is a kind of multistage microballoon screening chip used in fields such as material, medical science, bioengineering.
Background technology
At present, along with the development of bioengineering, the treatment of medical science targeted drug, apply microparticle material more and more, simultaneously in material science development, the research and apply of other microparticle material of microstage received is also increasingly extensive.At present, the size selection of microparticle material, mostly also be filter or dry small package method, the method is for the microballoon prepared with use liquid, and it is not very convenient to screen, and particularly easily makes filtration inefficiencies for micron-level particle size, or filtration time is very long; Adopt method for sieving again as microballoon is dried, there are the problems referred to above equally, but also add the oven dry cost of manufacture because of the particulate that exceeds standard.Micro-fluidic chip is the new technology grown up in recent years, for micro droplets particulate, has speed fast, the feature that screening size distribution is low.
Therefore, the micro-fluidic microballoon screening chip of a kind of more professional one is needed, for the screening of micron order particulate in solution.
Summary of the invention
The technical solution of the utility model is: a kind of multistage microballoon screening chip, it is primarily of screening unit composition, it is characterized in that: first order screening unit is included in a sample holes on chip body one end, sample holes connecting length is the sample introduction main channel of 10mm ~ 15mm, ensures the pipeline pressure of sample introduction liquid.Sample introduction main channel end furcations, separates 3 sample introduction branched bottoms, and every bar sample introduction branched bottom is communicated with the long microballoon screening passage of a 20mm ~ 30mm, and design ensures the carrying out of screening like this.The end of microballoon screening passage is communicated with the sample outlet hole of the long sample output passage of 10mm and sample output passage bottom, and this also for ease of and ensures fully carrying out of screening, required duct length.Be connected with a microballoon transport channel in the both sides of every bar microballoon screening passage, 3 microballoon screening passages totally 6 microballoon transport channels are all parallel to sample output passage, in order to pipeline arrangement and the sample flow direction consistent.Article 6, microballoon transport channel jointly enters an oval collecting pit after the sample outlet hole exceeding sample output passage bottom, is convenient to store microballoon and follow-up pressurized flow.A collecting pit passing away is had to be connected to collecting pit outlet vertical cut valve at the other end of collecting pit.The sample that the design of outlet and stop valve is convenient to screen can be derived from any one-level, is convenient to the flow velocity of sample, the regulation and control of the flow direction simultaneously.More than constitute first order screening unit.
The collecting pit outlet vertical cut valve of first order screening unit is communicated with by interface channel with the injection port vertical cut valve that next stage screens unit, the collecting pit outlet vertical cut valve of the screening unit of next stage is communicated with by interface channel with the injection port vertical cut valve of the screening unit of lower next stage again, by that analogy; Period import and export are all designed with stop valve, and effect is also pressurization in process easy to use or negative pressure, flow velocity, the flow direction of regulation and control sample.
Middle every one-level screening unit is except injection port vertical cut valve is different from the first order screening sample holes of unit, the outlet of collecting pit is different from the screening unit of afterbody microballoon transport is portalled, and it is identical that all the other all screen cellular construction with the first order; The import and export of the screening unit of afterbody are that injection port vertical cut valve and microballoon transport are portalled, and it is identical that all the other structures also screen unit with the first order.The degree of depth of all passages is equal with the width of sample introduction branched bottom.The batch machining that micro-fluidic chip is convenient in such design is produced.In technique scheme, described collecting pit outlet vertical cut valve and injection port vertical cut valve are all threeways, and design is the control manipulation for the ease of screening, and the facility of combination operation that each inter-stage is bypassed the immediate leadership.
In technique scheme, described microballoon screening passage, symmetrical chiasma distribution barricade and opposite side barricade on two sidewalls in its microballoon screening chamber, barricade and opposite side barricade are 60 ° ~ 80 ° towards going out sample prescription to the opening angle screening chamber wall with microballoon, and height and microballoon screen the deep equality of passage.Purpose of design is under certain flow rate, by the laminar fluid of the microballoon of micro-fluidic chip screening passage, can after barricade turbulization, microballoon is pooled to the open bottom of each barricade and opposite side barricade, collects microtubule screening by microballoon.Barricade and the distribution of opposite side barricade transpostion interval, and length all exceedes the pipe centerline of microballoon screening passage, microballoon is screened chamber segmentation, overlook and see that microballoon screening chamber is snakelike, its object is also the formation in order to increase turbulent flow, and fluid will screen at microballoon that left and right, chamber is snakelike to be flow through.Microballoon screening each barricade in chamber and the open bottom of opposite side barricade have microballoon collect microtubule, microballoon collect microtubule be connected with the microballoon transport channel that microballoon screens passage both sides, this has designed the screening of microballoon, principle and cross-flow filtration similar.
In technique scheme, the microballoon of described screening unit collects the width of microtubule between 5 μm ~ 500 μm, the width dimensions of the microballoon collection microtubule of 3 microballoon screening passages of every one-level screening unit is consistent, the width dimensions of the microballoon collection microtubule of screening unit at different levels is descending to successively decrease step by step, or the width dimensions of the microballoon collection microtubule of screening unit at different levels is consistent except first order screening unit.The width of microtubule collected by the microballoon of screening unit 2 ~ 8 specifications, such as: the first order 500 μm, 300 μm, the second level, the third level 100 μm, the fourth stage 80 μm, level V 50 μm, the 6th grade 30 μm, the 7th grade 20 μm, the 8th grade 10 μm; Or the first order 80 μm, 50 μm, the second level, the third level 30 μm, the fourth stage 20 μm, level V 10 μm, the 6th grade 5 μm; Or the first order 10 μm, the second level are 5 μm to the 8th grade.Screening operation is convenient in this design, and the combined sorting of bypassing the immediate leadership between screening unit at different levels, the facility of particle diameter section screening.The width of the microballoon screening passage of described screening unit at different levels is 2 times of the width of sample introduction main channel, the width of sample introduction branched bottom is 4/5 of the width of sample introduction main channel, sample introduction main channel is identical with the width of sample output passage, and the width of microballoon transport channel is that microballoon collects the 2-4 of microtubule width doubly.Design is the flow differential pressure in order to meet each pipeline fluid, screens the modularized design of unit simultaneously, is convenient to the template construct of chip and the batch production of chip.
The utility model technical characterstic is easy to make, professional stronger.
Compared with screening microballoon with existing conventional filtration or sieve method, the utility model has following beneficial effect: (1) is professional stronger, can directly and automatic liquid adding device be used in conjunction, the particle diameter uniformity of screening is better; (2) a slice chip side by side can organize multistage screening unit more, screens simultaneously, or the sample that colleague's screening is different, improves screening operation efficiency; (3) simply easy to make, use cost is cheap, can batch use of large-scale production.
Accompanying drawing explanation
Fig. 1 is the microballoon screening chip schematic diagram of a kind of three level screen unit of the present utility model.
Fig. 2 is the enlarged diagram of microballoon of the present utility model screening passage.
Fig. 3 is the microballoon screening chip schematic diagram of a kind of eight grades of screening unit of the present utility model, is followed successively by the first order from top to bottom to the 8th grade.
In figure: 1. chip body; 2. sample holes; 3. sample introduction main channel; 4. sample introduction branched bottom; 5. microballoon screening passage; 6. microballoon transport channel; 7. sample output passage; 8. sample outlet hole; 9. collecting pit; 10. collecting pit passing away; 11. collecting pit outlet vertical cut valves; 12. interface channels; 13. injection port vertical cut valves; 14. microballoon transports are portalled; 15. microballoon screening chambeies; Microtubule collected by 16. microballoons; 17. barricades; 18. opposite side barricades.
Detailed description of the invention
Further the utility model is illustrated below in conjunction with drawings and Examples.
Embodiment one
With reference to Fig. 1, Fig. 2, an a kind of microballoon screening chip having a three level screen unit, the long 10mm in sample introduction main channel 3, wide 1.00mm, dark 1.00mm; Screening unit microballoon screening passage 5 long 20mm, wide be 2.50mm, dark 0.80mm; Barricade 17 and opposite side barricade 18 highly screen passage 5 deep equality with microballoon is 0.80mm; The width of sample introduction branched bottom 4 is 0.80mm, dark 0.80mm; The long 10mm of sample output passage 7, wide 1.00mm, dark 0.80mm; Interface channel 12 width 1.00mm, dark 0.80mm.
The width of the microballoon collection microtubule 16 of first order screening unit is 500 μm, and the width of microballoon transport channel 6 is 1.00mm; The opening angle that barricade 17 and opposite side barricade 18 and microballoon screen chamber 15 wall is 80 °.
The width of the microballoon collection microtubule 16 of second level screening unit is 100 μm, and the width of microballoon transport channel 6 is 0.20mm; The opening angle that barricade 17 and opposite side barricade 18 and microballoon screen chamber 15 wall is 75 °.
The width of the microballoon collection microtubule 16 of third level screening unit is 50 μm, and the width of microballoon transport channel 6 is 0.15mm.The opening angle that barricade 17 and opposite side barricade 18 and microballoon screen chamber 15 wall is 65 °.
Embodiment two
With reference to Fig. 2, Fig. 3, one has eight grades of a kind of microballoon screening chips screening unit, the long 15mm in sample introduction main channel 3, wide 1.00mm; Screening unit microballoon screening passage 5 long 30mm, wide be 2.00mm; The width of sample introduction branched bottom 4 is 0.80mm, the long 10mm of sample output passage 7, wide 1.00mm; Interface channel 12 width 1.00mm.
The width of the microballoon collection microtubule 16 of first order screening unit is 500 μm, and the width of microballoon transport channel 6 is 1.00mm; The opening angle that barricade 17 and opposite side barricade 18 and microballoon screen chamber 15 wall is 80 °.
The width of the microballoon collection microtubule 16 of second level screening unit is 200 μm, and the width of microballoon transport channel 6 is 0.40mm; The opening angle that barricade 17 and opposite side barricade 18 and microballoon screen chamber 15 wall is 70 °.
The width of the microballoon collection microtubule 16 of third level screening unit is 90 μm, and the width of microballoon transport channel 6 is 0.18mm; The opening angle that barricade 17 and opposite side barricade 18 and microballoon screen chamber 15 wall is 60 °.
The width of the microballoon collection microtubule 16 of fourth stage screening unit is 40 μm, and the width of microballoon transport channel 6 is 0.12mm; The opening angle that barricade 17 and opposite side barricade 18 and microballoon screen chamber 15 wall is 60 °.
The width of the microballoon collection microtubule 16 of level V screening unit is 30 μm, and the width of microballoon transport channel 6 is 90 μm; The opening angle that barricade 17 and opposite side barricade 18 and microballoon screen chamber 15 wall is 60 °.
The width of the microballoon collection microtubule 16 of the 6th grade of screening unit is 20 μm, and the width of microballoon transport channel 6 is 80 μm; The opening angle that barricade 17 and opposite side barricade 18 and microballoon screen chamber 15 wall is 75 °.
The width of the microballoon collection microtubule 16 of the 7th grade of screening unit is 10 μm, and the width of microballoon transport channel 6 is 40 μm; The opening angle that barricade 17 and opposite side barricade 18 and microballoon screen chamber 15 wall is 80 °.
The width of the microballoon collection microtubule 16 of the 8th grade of screening unit is 5 μm, and the width of microballoon transport channel 6 is 20 μm; The opening angle that barricade 17 and opposite side barricade 18 and microballoon screen chamber 15 wall is 80 °.
Embodiment three
With reference to Fig. 2, Fig. 3, one has eight grades of a kind of microballoon screening chips screening unit, the long 15mm in sample introduction main channel 3, wide 1.00mm; Screening unit microballoon screening passage 5 long 30mm, wide be 2.00mm; The width of sample introduction branched bottom 4 is 0.80mm, the long 10mm of sample output passage 7, wide 1.00mm; Interface channel 12 width 1.00mm.
The width of the microballoon collection microtubule 16 of first order screening unit is 20 μm, and the width of microballoon transport channel 6 is 0.18mm; The opening angle that barricade 17 and opposite side barricade 18 and microballoon screen chamber 15 wall is 80 °.
The width of the microballoon collection microtubule 16 of second level screening unit is 10 μm, and the width of microballoon transport channel 6 is 0.12mm; The opening angle that barricade 17 and opposite side barricade 18 and microballoon screen chamber 15 wall is 60 °.
The width of the microballoon collection microtubule 16 of third level screening unit is 10 μm, and the width of microballoon transport channel 6 is 90 μm; The opening angle that barricade 17 and opposite side barricade 18 and microballoon screen chamber 15 wall is 65 °.
The width of the microballoon collection microtubule 16 of fourth stage screening unit is 10 μm, and the width of microballoon transport channel 6 is 80 μm; The opening angle that barricade 17 and opposite side barricade 18 and microballoon screen chamber 15 wall is 70 °.
The width of the microballoon collection microtubule 16 of level V screening unit is 10 μm, and the width of microballoon transport channel 6 is 40 μm; The opening angle that barricade 17 and opposite side barricade 18 and microballoon screen chamber 15 wall is 70 °.
The width of the microballoon collection microtubule 16 of the 6th grade of screening unit is 10 μm, and the width of microballoon transport channel 6 is 20 μm; The opening angle that barricade 17 and opposite side barricade 18 and microballoon screen chamber 15 wall is 75 °.
The width of the microballoon collection microtubule 16 of the 7th grade of screening unit is 10 μm, and the width of microballoon transport channel 6 is 20 μm; The opening angle that barricade 17 and opposite side barricade 18 and microballoon screen chamber 15 wall is 80 °.
The width of the microballoon collection microtubule 16 of the 8th grade of screening unit is 10 μm, and the width of microballoon transport channel 6 is 20 μm; The opening angle that barricade 17 and opposite side barricade 18 and microballoon screen chamber 15 wall is 80 °.
Claims (3)
1. a multistage microballoon screening chip, it is primarily of screening unit composition, it is characterized in that: first order screening unit is included in a sample holes (2) on chip body (1) one end, sample holes (2) connecting length is the sample introduction main channel (3) of 10mm ~ 15mm, sample introduction main channel (3) end furcations, separate 3 sample introduction branched bottoms (4), every bar sample introduction branched bottom (4) is communicated with long microballoon screening passage (5) of a 20mm ~ 30mm, the end of microballoon screening passage (5) is communicated with the sample outlet hole (8) of the long sample output passage (7) of 10mm and sample output passage (7) bottom, a microballoon transport channel (6) is connected with in the both sides of every bar microballoon screening passage (5), article 3, microballoon screening passage (5) totally 6 microballoon transport channels (6) be all parallel to sample output passage (7), after exceeding the sample outlet hole (8) of sample output passage (7) bottom, jointly enter an oval collecting pit (9), have a collecting pit passing away (10) to be connected to collecting pit outlet vertical cut valve (11) at the other end of collecting pit (9), more than constitute first order screening unit, collecting pit outlet vertical cut valve (11) of first order screening unit is communicated with by interface channel (12) with the injection port vertical cut valve (13) that next stage screens unit, collecting pit outlet vertical cut valve (11) of the screening unit of next stage is communicated with by interface channel (12) with the injection port vertical cut valve (13) of the screening unit of lower next stage again, by that analogy, middle every one-level screening unit transports except portal (14) except injection port vertical cut valve (13) is different from the microballoon that the first order screens the sample holes (2) of unit, the outlet of collecting pit (9) is different from the screening unit of afterbody, and all the other screening cellular constructions all screening unit with the first order are identical, the import and export of the screening unit of afterbody are that injection port vertical cut valve (13) and microballoon transport are portalled (14), and it is identical that all the other structures also screen unit with the first order, and the degree of depth of all passages is equal with the width of sample introduction branched bottom (4).
2. multistage microballoon screening chip according to claim 1, it is characterized in that: described microballoon screening passage (5), symmetrical chiasma distribution barricade (17) and opposite side barricade (18) on two sidewalls of its microballoon screening chamber (15), barricade (17) and opposite side barricade (18) are 60 ° ~ 80 ° towards going out sample prescription to the opening angle screening chamber (15) wall with microballoon, and height and microballoon screen the deep equality of passage (5); Barricade (17) and the distribution of opposite side barricade (18) transpostion interval, and length all exceedes the pipe centerline of microballoon screening passage (5), microballoon is screened chamber (15) segmentation, overlooks and sees that microballoon screening chamber (15) is in snakelike; Have microballoon to collect microtubule (16) at each barricade (17) of microballoon screening chamber (15) and the open bottom of opposite side barricade (18), microballoon is collected microtubule (16) and is connected with the microballoon transport channel (6) that microballoon screens passage (5) both sides.
3. multistage microballoon screening chip according to claim 1, it is characterized in that: the microballoon of described screening unit collects the width of microtubule (16) between 5 μm ~ 500 μm, the width dimensions that microtubule (16) collected by microballoon in 3 microballoons screening passage (5) of every one-level screening unit is consistent, the width dimensions of microballoon collection microtubule (16) of screening unit at different levels is descending to successively decrease step by step, or the width dimensions of microballoon collection microtubule (16) of screening unit at different levels is consistent except first order screening unit; The width of microballoon collection microtubule (16) of screening unit has 2 ~ 8 specifications; The width of microballoon screening passage (5) of screening unit at different levels is 2 times of the width of sample introduction main channel (3), the width of sample introduction branched bottom (4) is 4/5 of the width of sample introduction main channel (3), sample introduction main channel (3) is identical with the width of sample output passage (7), and the width of microballoon transport channel (6) is 2 ~ 4 times that microtubule (16) width collected by microballoon.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520035008.1U CN204503113U (en) | 2015-01-20 | 2015-01-20 | Multistage microballoon screening chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520035008.1U CN204503113U (en) | 2015-01-20 | 2015-01-20 | Multistage microballoon screening chip |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204503113U true CN204503113U (en) | 2015-07-29 |
Family
ID=53701116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520035008.1U Expired - Fee Related CN204503113U (en) | 2015-01-20 | 2015-01-20 | Multistage microballoon screening chip |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN204503113U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117607223A (en) * | 2024-01-22 | 2024-02-27 | 南昌航空大学 | Self-driven micro-fluidic system based on monolithic column enrichment and separation |
-
2015
- 2015-01-20 CN CN201520035008.1U patent/CN204503113U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117607223A (en) * | 2024-01-22 | 2024-02-27 | 南昌航空大学 | Self-driven micro-fluidic system based on monolithic column enrichment and separation |
| CN117607223B (en) * | 2024-01-22 | 2024-04-09 | 南昌航空大学 | Self-driven micro-fluidic system based on monolithic column enrichment and separation |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2016354119B2 (en) | Inertial droplet generation and particle encapsulation | |
| Shen et al. | High-throughput rare cell separation from blood samples using steric hindrance and inertial microfluidics | |
| US9333510B2 (en) | Devices and methods for shape-based particle separation | |
| US9662602B2 (en) | Method of sorting particles or particle clusters in a fluid flowing in a channel | |
| CN106434302B (en) | A kind of micro-current controlled cell separating chips in Portable no-power source | |
| WO2014145152A3 (en) | On-chip microfluidic processing of particles | |
| KR101662808B1 (en) | Apparatus and method for microfluidic chip filtration using spiral branch channel | |
| WO2019047498A1 (en) | Whole blood plasma separation system and method | |
| CN107377024B (en) | Micro-fluidic syringe filter and its application method | |
| CN104549587B (en) | A kind of triple channel microballoon screening chip and using method | |
| CN104549588B (en) | A kind of multistage microballoon screening chip and using method | |
| CN105664538B (en) | A kind of multi-stage reducing spiral oil water separator | |
| CN111778159B (en) | Multi-stage sorting micro-fluidic chip for cells | |
| CN204503113U (en) | Multistage microballoon screening chip | |
| CN102703300A (en) | Multi-sorting-area structure for cell sorting and use method of multi-sorting-area structure | |
| CN108160126A (en) | Micro particles high throughput is enriched with micro-fluidic chip | |
| Inglis et al. | A scalable approach for high throughput branch flow filtration | |
| CN114260037B (en) | 3D stacked multistage inertia micro-fluidic separation chip and preparation method thereof | |
| CN104607258B (en) | A kind of notch cuttype microballoon screening chip and using method | |
| CN204503111U (en) | Triple channel microballoon screening chip | |
| CN104388299B (en) | A kind of micro-fluidic chip for cell capture | |
| CN208894250U (en) | General inertia focuses micro-fluidic chip | |
| CN209210783U (en) | Micro-fluidic chip | |
| CN213943181U (en) | S-shaped micro-channel multistage separation device | |
| CN207981404U (en) | A kind of silicon carbide overflow tank |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150729 Termination date: 20160120 |
|
| EXPY | Termination of patent right or utility model |