CN204454956U - A kind of Purification of Taxol system - Google Patents
A kind of Purification of Taxol system Download PDFInfo
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- CN204454956U CN204454956U CN201520056226.3U CN201520056226U CN204454956U CN 204454956 U CN204454956 U CN 204454956U CN 201520056226 U CN201520056226 U CN 201520056226U CN 204454956 U CN204454956 U CN 204454956U
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- previous cleaning
- fine purifiation
- elutriant
- purification
- taxol
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Abstract
The utility model discloses a kind of Purification of Taxol system, comprise previous cleaning solvent tank (1), fine purifiation solvent tank (2), previous cleaning chromatography tower (3), splitter (4), fine purifiation chromatography tower (5), previous cleaning elutriant storage tank (6), fine purifiation elutriant storage tank (7), previous cleaning elutriant concentrating unit (8), fine purifiation elutriant concentrating unit (9), crystallizer (10) and pipeline.Application the utility model carries out the purification of taxol crude product, and its purification process is very simple, and purification solvent can recycle, and material loss is low, and purification efficiency is high, and cost for purification is low.
Description
Technical field
The utility model relates to the technical field of Purification of Taxol, is specifically related to a kind of Purification of Taxol system.
Background technology
Taxol is the secondary metabolite of a kind of complexity in Chinese yew genus plants, is universally acknowledged wide spectrum, strong active cancer therapy drug.At present, taxol mainly extracts and obtains from Chinese yew raw material.The existing common method extracting taxol from Chinese yew raw material first obtains taxol crude product through steps such as raw material pulverizing, soak extraction, concentrated, extractions, more obtained high-purity taxol after taxol crude product being carried out purifications.
Preparing in the process of taxol with in Ramulus et folium taxi cuspidatae raw material, the purification of taxol crude product is an important step.At present, the purification of taxol mainly adopts column chromatography to purify, in commercial process, the weak point of existing Purification of Taxol device is used to be: structure is reasonable not, and purification process is complicated, and purification efficiency is low, solvent usage quantity is large, and production cost is higher.
Utility model content
The technical problem that the utility model solves is for above-mentioned deficiency, provides a kind of rational in infrastructure, effectively can improve Purification of Taxol efficiency, reduces the Purification of Taxol system of Purification of Taxol cost.
The technical scheme that the utility model adopts is: a kind of Purification of Taxol system, comprises previous cleaning solvent tank (1), fine purifiation solvent tank (2), previous cleaning chromatography tower (3), splitter (4), fine purifiation chromatography tower (5), previous cleaning elutriant storage tank (6), fine purifiation elutriant storage tank (7), previous cleaning elutriant concentrating unit (8), fine purifiation elutriant concentrating unit (9), crystallizer (10) and pipeline, described previous cleaning solvent tank (1), fine purifiation solvent tank (2) is connected with previous cleaning chromatography tower (3) by pipeline, previous cleaning chromatography tower (3) is connected with splitter (4) by pipeline, splitter (4) is by pipeline and previous cleaning elutriant storage tank (6), fine purifiation chromatography tower (5) is connected, previous cleaning elutriant storage tank (6) is connected with previous cleaning elutriant concentrating unit (8) by pipeline, previous cleaning elutriant concentrating unit (8) is also connected with previous cleaning solvent tank (1) by pipeline, fine purifiation chromatography tower (5) is connected with fine purifiation elutriant storage tank (7) by pipeline, fine purifiation elutriant storage tank (7) is connected with fine purifiation elutriant concentrating unit (9) by pipeline, fine purifiation elutriant concentrating unit (9) is also by pipeline and fine purifiation solvent tank (2), crystallizer (10) is connected.
The beneficial effects of the utility model are: 1, apply the utility model, when taxol crude product is purified, first with the previous cleaning solvent in previous cleaning solvent tank, preliminary wash-out is carried out to the taxol crude product in previous cleaning chromatography tower, wash out partial impurities, previous cleaning eluent stream containing impurity flows in previous cleaning elutriant storage tank after splitter, flow into previous cleaning elutriant concentrating unit again and carry out concentration and recovery, the previous cleaning solvent of concentration and recovery is transferred back in previous cleaning solvent tank; And then with the fine purifiation solvent of fine purifiation solvent tank, fine purifiation wash-out is carried out to the taxol crude product in previous cleaning chromatography tower, fine purifiation solvent streams flows into fine purifiation chromatography tower and carries out fine purifiation wash-out after previous cleaning chromatography tower, splitter, fine purifiation elutriant flows into fine purifiation elutriant concentrating unit again and carries out concentration and recovery, obtain the enriched material containing taxol section, the fine purifiation solvent of concentration and recovery is transferred back in fine purifiation solvent tank, enriched material containing taxol section flows in crystallizer and carries out crystallization, thus obtains the higher taxol of purity; 2, apply the utility model and carry out the purification of taxol crude product, its purification process is very simple, and purification solvent can recycle, and material loss is low, and purification efficiency is high, and cost for purification is low.
Accompanying drawing explanation
Fig. 1 is the structural representation of a kind of Purification of Taxol system of the utility model.
Nomenclature: 1-previous cleaning solvent tank; 2-fine purifiation solvent tank; 3-previous cleaning chromatography tower; 4-splitter; 5-fine purifiation chromatography tower; 6-previous cleaning elutriant storage tank; 7-fine purifiation elutriant storage tank; 8-previous cleaning elutriant concentrating unit; 9-fine purifiation elutriant concentrating unit; 10-crystallizer; 11-transferpump A; 12-transferpump B; 13-transferpump C; 14-transferpump D.
Embodiment
Below in conjunction with accompanying drawing with specifically implement to be described further the utility model.
A kind of Purification of Taxol system, as shown in Figure 1, previous cleaning solvent tank 1, fine purifiation solvent tank 2, previous cleaning chromatography tower 3, splitter 4, fine purifiation chromatography tower 5, previous cleaning elutriant storage tank 6, fine purifiation elutriant storage tank 7, previous cleaning elutriant concentrating unit 8, fine purifiation elutriant concentrating unit 9, crystallizer 10 and pipeline is comprised.Described previous cleaning solvent tank 1, fine purifiation solvent tank 2 are connected with previous cleaning chromatography tower 3 by pipeline, and previous cleaning chromatography tower 3 is connected with splitter 4 by pipeline, and splitter 4 is also connected with previous cleaning elutriant storage tank 6, fine purifiation chromatography tower 5 respectively by pipeline.Described previous cleaning elutriant storage tank 6 is connected with previous cleaning elutriant concentrating unit 8 by pipeline, and previous cleaning elutriant concentrating unit 8 is also connected with previous cleaning solvent tank 1 by pipeline.Described fine purifiation chromatography tower 5 is connected with fine purifiation elutriant storage tank 7 by pipeline, fine purifiation elutriant storage tank 7 is also connected with fine purifiation elutriant concentrating unit 9 by pipeline, and fine purifiation elutriant concentrating unit 9 is also connected with fine purifiation solvent tank 2, crystallizer 10 respectively by pipeline.
When taxol crude product is purified, taxol crude product is loaded the upper strata of previous cleaning chromatography tower 3, first by transferpump A11, the previous cleaning solvent in previous cleaning solvent tank 1 is inputted in previous cleaning chromatography tower 3, preliminary wash-out is carried out to the taxol crude product in previous cleaning chromatography tower 3, wash out partial impurities, previous cleaning elutriant containing impurity is shunted through splitter 4 and is flowed in previous cleaning elutriant storage tank 6, flow into previous cleaning elutriant concentrating unit 8 again and carry out concentration and recovery, the previous cleaning solvent of concentration and recovery is transmitted back in previous cleaning solvent tank 1 by transferpump C13, then by transferpump B12, the fine purifiation solvent of fine purifiation solvent tank 2 is inputted in previous cleaning chromatography tower 3, fine purifiation wash-out is carried out to the taxol crude product in previous cleaning chromatography tower, fine purifiation solvent streams is through previous cleaning chromatography tower 3, splitter 4 flows into fine purifiation chromatography tower 5 again and carries out fine purifiation wash-out, fine purifiation elutriant flows into fine purifiation elutriant concentrating unit 9 again and carries out concentration and recovery, obtain the enriched material containing taxol section, the fine purifiation solvent of concentration and recovery is transmitted back in fine purifiation solvent tank 2 by transferpump D14, enriched material containing taxol section flows in crystallizer 10 and carries out crystallization, obtain the taxol that purity is higher.Application the utility model carries out the purification of taxol crude product, and its purification process is simple, and purification solvent can recycle, and material loss is low, and purification efficiency is high, and cost for purification is low.
Claims (1)
1. a Purification of Taxol system, is characterized in that: comprise previous cleaning solvent tank (1), fine purifiation solvent tank (2), previous cleaning chromatography tower (3), splitter (4), fine purifiation chromatography tower (5), previous cleaning elutriant storage tank (6), fine purifiation elutriant storage tank (7), previous cleaning elutriant concentrating unit (8), fine purifiation elutriant concentrating unit (9), crystallizer (10) and pipeline, described previous cleaning solvent tank (1), fine purifiation solvent tank (2) is connected with previous cleaning chromatography tower (3) by pipeline, previous cleaning chromatography tower (3) is connected with splitter (4) by pipeline, splitter (4) is by pipeline and previous cleaning elutriant storage tank (6), fine purifiation chromatography tower (5) is connected, previous cleaning elutriant storage tank (6) is connected with previous cleaning elutriant concentrating unit (8) by pipeline, previous cleaning elutriant concentrating unit (8) is also connected with previous cleaning solvent tank (1) by pipeline, fine purifiation chromatography tower (5) is connected with fine purifiation elutriant storage tank (7) by pipeline, fine purifiation elutriant storage tank (7) is connected with fine purifiation elutriant concentrating unit (9) by pipeline, fine purifiation elutriant concentrating unit (9) is also by pipeline and fine purifiation solvent tank (2), crystallizer (10) is connected.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520056226.3U CN204454956U (en) | 2015-01-27 | 2015-01-27 | A kind of Purification of Taxol system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520056226.3U CN204454956U (en) | 2015-01-27 | 2015-01-27 | A kind of Purification of Taxol system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204454956U true CN204454956U (en) | 2015-07-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201520056226.3U Active CN204454956U (en) | 2015-01-27 | 2015-01-27 | A kind of Purification of Taxol system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN204454956U (en) |
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2015
- 2015-01-27 CN CN201520056226.3U patent/CN204454956U/en active Active
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