CN204446847U - A kind of disposable per nasal brain-targeted drug delivery device - Google Patents
A kind of disposable per nasal brain-targeted drug delivery device Download PDFInfo
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- CN204446847U CN204446847U CN201520123590.7U CN201520123590U CN204446847U CN 204446847 U CN204446847 U CN 204446847U CN 201520123590 U CN201520123590 U CN 201520123590U CN 204446847 U CN204446847 U CN 204446847U
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
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- Biomedical Technology (AREA)
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
This utility model relates to a kind of disposable per nasal brain-targeted drug delivery device, comprise administrator, administrator comprises conduit and is arranged on the fog-spray nozzle of one end of described conduit, administrator also comprise there is inner chamber and syringe for depositing preparation, described one end of described conduit can extend into the nasal cavity regio olfactoria of more than horizontal level corresponding to middle nasal concha through the meatus nasi communis of human body, administrator also comprise be arranged in described syringe the inner chamber of described syringe is separated into multiple chamber independent of each other and the pressure sensitive film broken under pressure, the other end of described conduit is connected and the tube chamber of described conduit and connected chamber with in described multiple chamber, administrator also comprises for being separated with connected chamber by the tube chamber of described conduit and the dissolvable film that can partly or entirely dissolve after contacting preparation.This doser by preparation high-efficiency delivery to nasal cavity regio olfactoria, and then can absorb directly into brain, plays therapeutical effect central nervous system.
Description
Technical field
This utility model relates to a kind of disposable per nasal brain-targeted drug delivery device.
Background technology
Treat brain diseases as multiple sclerosis, parkinson disease, epilepsy, A Zihai silent disease, brain tumor, acquired immune deficiency syndrome (AIDS) and other infectious disease and acute poisoning time, medically there is a difficult problem always, that is: how blood brain barrier is overcome, medicine is entered rapidly in central nervous system (central nervous system, CNS) to play drug action.Applying more method clinically is at present open blood brain barrier by reversibility, and intrathecal injection and carotid injection administration, make agent permeates therethrough and enter central nervous system.But these methods require that in operating technology high, security risk is large, and application is subject to certain restriction.Based on the special construction of nasal cavity, by nasal-cavity administration treatment brain diseases have Noninvasive, brain bioavailability high, first passage metabolism and the advantage such as body circulation and blood brain barrier can be walked around, and handled easily.
In recent years, as long as much research all demonstrates by appropriate means, it is feasible that medicine directly enters brain by nasal cavity.Nasal cavity regio olfactoria is the position that in human body, unique place's neurocyte directly contacts with surrounding, by neurocyte (nervi olfactory, nervi trigeminus) path, intercellular substance path or all can realize the transmission of medicine per nasal Brain targeting with the blood capillary path that brain venous sinus is directly connected.But how medicine is sent as central nervous system by the approach of nasal cavity-brain effectively, and avoid too much directly absorption by nasal membrane to enter peripheral circulation and be one and have a difficult problem to be solved.
Existing large quantifier elimination focuses on the absorption efficiency being improved medicine per nasal-brain approach by the change of preparation, comprise methods such as increasing the particle diameter of medicine at the holdup time of nasal cavity, the permeability improving nasal membrane, drug molecule modification, change medicine, the permeability with liposome increase medicine, also form many patents.Patent CN101600417A discloses a kind of dopamine lid human relations gel preparation of nasal administration, the bioavailability that the per nasal Brain targeting improving medicine by lipotropy system absorbs.Patent CN102370623A discloses a kind of preparation method of liquid fatty substance microgranule for per nasal brain-targeted drug delivery.Patent CN102174080A discloses the polypeptide obtained by display technique of bacteriophage, for modified medicaments carrier to realize per nasal brain-targeted drug delivery effect.Patent CN1839799A discloses a kind of by Phytoagglutinin modified pharmaceutical carrier, to increase medicine holdup time in nasal cavity, thus realizes the method for per nasal brain-targeted drug delivery effect.Also patent is had to be conceived to be realized by doser the object of per nasal Brain targeting delivering drugs, patent CN201280021497 discloses a kind of nose medicine delivery apparatus, this device is intranasal form aerosolization by HFA Hydrofluoroalkane propellant, and by nozzle, medicine plume is delivered to nasal cavity regio olfactoria, thus being absorbed into brain, the ratio that its medicine enters regio olfactoria is more than 64.2%.
But nasal cavity regio olfactoria of the prior art doser also has following shortcoming: 1) although medicine can be delivered to nasal cavity regio olfactoria by the nozzle of doser, but nozzle can not extend into nasal cavity regio olfactoria, so medicine all can not be delivered to nasal cavity regio olfactoria, as in prior art, the medicine of about 64% can only be delivered to nasal cavity regio olfactoria, cause the waste of medicine, also can cause unnecessary economic loss to sufferer.2) doser is not pre-packaged design, each administration all needs powder charge again, makes up a prescription, operate more loaded down with trivial details, also lose time, particularly hospital's first aid, battlefield nerve gas removing toxic substances etc. are needed to the occasion of Quick medicine, probably can not can process in time sufferer because of the waste of powder charge, time of compounding.3) because each administration all needs the container again made up a prescription, administration makes storage of pharmaceutical to need often to open, easily make medicine occur rotten and can not use, particularly easily waste is caused for the medicine that some storage stabilities are low.4) each administration all will carry out the tedious steps that cleans, sterilize, if cleaning, sterilization thoroughly easily do not cause cross-contamination.
Summary of the invention
Technical problem to be solved in the utility model overcomes the deficiencies in the prior art, provides a kind of disposable per nasal brain-targeted drug delivery device.
For solving above technical problem, this utility model adopts following technical scheme:
A kind of disposable per nasal brain-targeted drug delivery device, comprise administrator, described administrator comprises conduit and is arranged on the fog-spray nozzle of one end of described conduit, described administrator also comprise there is inner chamber and syringe for depositing preparation, described one end of described conduit can extend into the nasal cavity regio olfactoria of more than horizontal level corresponding to middle nasal concha through the meatus nasi communis of human body, described administrator also comprise be arranged in described syringe the inner chamber of described syringe is separated into multiple chamber independent of each other and the pressure sensitive film broken under pressure, the other end of described conduit is connected and the tube chamber of described conduit and connected chamber with in described multiple chamber, described administrator also comprises for being separated with connected chamber by the tube chamber of described conduit and the dissolvable film that can partly or entirely dissolve after contacting preparation.
Further, described dissolvable film is arranged on the junction of described syringe and described conduit.
Further, described administrator also comprise be arranged on described conduit described one end, for cushioning the nasal cavity adapter of described conduit for the direct stimulation of nasal membrane.
The substantially tapered periphery being wrapped in described conduit of described nasal cavity adapter, the material of described nasal cavity adapter is selected from the one in medical silica-gel, neoprene, butadiene rubber, natural rubber, nitrile rubber, ethylene propylene diene rubber.
Further, described conduit is flexible pipe, and its external diameter is 0.1 ~ 50 millimeter.
The material of described conduit is selected from the one in medical silica-gel, latex, plastics, thermoplastic elastomer (TPE) (TPE).
Further, described fog-spray nozzle has the hole that the diameter of more than 1 or 1 is 0.1 ~ 1000 micron.
Preferably, the diameter in described hole is 1 ~ 100 micron.
Further, described syringe comprises the injection tube with described inner chamber and the piston be arranged in described injection tube, and described injection tube is provided with opening, and the described other end of described conduit connects over said opening.
Further, described doser also comprises pre-packaged several formulations composition in described multiple chamber respectively, the formulation ingredients being wherein connected with the chamber indoor storage of described conduit is the formulation ingredients that can not dissolve described dissolvable film, containing the formulation ingredients dissolving described dissolvable film in the formulation ingredients of at least one the chamber indoor storage in other chambers.
Further, described chamber is 2 ~ 3.
In above-mentioned, the formulation ingredients dissolving described dissolvable film can be solvent, other formulation ingredients can be bioactive substance, described bioactive substance be selected from micromolecule non-peptide nonprotein medicine, peptide class/pharmaceutical grade protein, natural animal-plant and extract thereof, diagnostic agent one or more.
Described micromolecule non-peptide nonprotein medicine is selected from atropine and derivant thereof, pralidoxime, trimedoxime, obidoxime chloride, two pyridine monoxime, the two oxime of two pyridine, temozolomide (temozolomide), nitrosourea medicament, etoposide (etoposide), platinum medicine, irinotecan (irinotecan), capecitabine (capecitabine), methotrexate (methotrexate), gemcitabine (gemcitabine), topotecan (topotecan), cytosine arabinoside (cytarabine), thio-tepa (thiotepa), vincristine (vincristine), procarbazine (procarbazine), morphine, fentanyl, oxycodone, butorphanol, tramadol, granisetron, ondansetron, tropisetron, palonosetron, indisetron, sumatriptan, Zolmitriptan, rizatriptan, naratriptan, Ergotamine, triazolam, melatonin, carbamazepine, midazolam, donepezil, tiapride, cefaclor, enoxacin, acyclovir, zidovudine, didanosine, that Wei Laping, indinavir, dantrolene, digoxin, benzhexol, Biperiden, dextromethorphan, naloxone, betahistine, naphazoline, diltiazem, tranilast, loperamide, diclofenac, Beclomethasone, chlorpheniramine, sldenafil, Vardenafil, cobalamin, finasteride, epinephrine, 5-FU, low molecular weight heparin, one or more combination in tacrolimus.
Described peptide class/pharmaceutical grade protein is selected from insulin, growth hormone, somatostatin, growth hormone-releasing peptide, vasopressin, Desmopressin, vassopressin in spy, glucagon, calcitonin, interferon, erythropoietin, interleukin, parathyroid hormone (PTH1-34), parathyroid hormone (PTH1-84), parathyroid hormone PTH related peptides, GLP-1, vassopressin, leuprorelin, granulocyte colony-stimulating factor, prolactin antagonist, human menopausal gonadotropin, chorionic-gonadotropin hormone, follicle stimulating hormone, interstitialcellstimulating hormone (ICSH), leptin, Avastin (bevacizumab), Rituximab (rituximab), nerve growth factor, stem cell factor, keratinocyte growth factor, thioredoxin, one or more combination in cyclosporin and their analog.
Described natural animal-plant and extract thereof are selected from one or more the combination in Herba Asari, Borneolum Syntheticum, Radix Saposhnikoviae, Herba Schizonepetae, Radix Puerariae, Herba Hedyotidis Diffusae, Fructus Schisandrae Chinensis, Fructus Lycii, Rhododendron simsii Planch., Radix Sophorae Flavescentis, blue or green Semen Juglandis, rutin, Semen Ginkgo, Rhizoma Acori Graminei, Radix Ginseng, saponin, Cornu Cervi Pantotrichum, Herba Hyperici perforati, Radix Morindae Officinalis, Flos Albiziae, Radix Bupleuri, Radix Angelicae Sinensis, Herba Cistanches, Radix Scutellariae.
Described diagnostic agent is contrast agent.
Described solvent is selected from water, physiological buffer, benzoic acid Bian ester, Oleum Gossypii semen, N, N-dimethyl acetylamide, ethanol, glycerol, Oleum Arachidis hypogaeae semen, Polyethylene Glycol, seed of Papaver somniferum L. powder, propylene glycol, safflower oil, Oleum sesami, soybean oil, Oleum Brassicae campestris, arabic gum, aluminum monostearate, carboxymethyl cellulose, sodium carboxymethyl cellulose, CREMOPHORE EL, NaTDC, EPC, gelatin hydrolysate, lecithin, polyoxyethylene fatty acid, Tween 80, polysorbas20, polyvinylpyrrolidone, dodecyl sodium sulfate, sorbitol, cyclodextrin, benzoic acid, sodium benzoate, salicylic acid, sodium salicylate, para-amino benzoic acid, urethane, carbamide, amide, acetamide, Borax, one or more combination in potassium iodide.
Due to the enforcement of technique scheme, this utility model compared with prior art tool has the following advantages:
This utility model doser adopts disposable apparatus design, eliminates the repeated washing of doser, the tedious steps of sterilization, more reduces the potential risk of cross-contamination.
The conduit of this utility model doser can be deep into nasal cavity regio olfactoria, realizes brain-targeted drug delivery.
The conduit of this utility model doser is provided with fog-spray nozzle, and fog-spray nozzle makes it fogging fully and nasal cavity regio olfactoria nerve contact, improves the bioavailability of brain-targeted drug delivery.
Accompanying drawing explanation
Fig. 1 is the structural representation of this utility model doser;
Name in figure represented by numeral is called:
1. syringe; 101, injection tube; 102, piston; 2, conduit; 3, pressure sensitive film; 4, fog-spray nozzle; 5, hole; 6, nasal cavity adapter; 7, the first chamber; 8, the second chamber; 9, dissolvable film.
Detailed description of the invention
Below in conjunction with Figure of description, this utility model is further described.
As shown in Figure 1, a kind of disposable per nasal brain-targeted drug delivery device, comprise administrator, administrator comprises conduit 2 and is arranged on the fog-spray nozzle 4 of one end of conduit 2, administrator also comprise there is inner chamber and syringe 1 for depositing preparation, one end being provided with fog-spray nozzle 4 of conduit 2 can extend into the nasal cavity regio olfactoria of more than horizontal level corresponding to middle nasal concha through the meatus nasi communis of human body, administrator also comprises being arranged in syringe 1 inner chamber of syringe 1 is separated into multiple chamber independent of each other and the pressure sensitive film 3 broken under pressure, the other end of conduit 2 is connected with in multiple chamber and the tube chamber of conduit 2 and connected chamber, administrator also comprises for being separated with connected chamber by the tube chamber of conduit 2 and the dissolvable film 9 that can partly or entirely dissolve after contacting preparation.
In this example, dissolvable film 9 is arranged on the junction of syringe 1 and conduit 2.
Administrator of the present utility model also comprise be arranged on conduit 2 the one end being provided with fog-spray nozzle 4, for cushioning the nasal cavity adapter 6 of conduit 2 for the direct stimulation of nasal membrane.Particularly, the tapered periphery being wrapped in conduit 2 of nasal cavity adapter 6, the material of nasal cavity adapter 6 is selected from the one in medical silica-gel, neoprene, butadiene rubber, natural rubber, nitrile rubber, ethylene propylene diene rubber.
Conduit 2 of the present utility model is flexible pipe, and its external diameter is 0.1 ~ 50 millimeter, and its material is selected from the one in medical silica-gel, latex, plastics, thermoplastic elastomer (TPE) (TPE).
The diameter that fog-spray nozzle 4 of the present utility model has more than 1 or 1 is the hole 5 of 0.1 ~ 1000 micron.Be preferably 1 ~ 100 micron.
In this example, syringe 1 comprises the injection tube 101 with inner chamber and the piston 102 be arranged in injection tube 101, and injection tube 101 is provided with opening, and one end of conduit 2 is connected on opening.
Doser of the present utility model also comprises pre-packaged several formulations composition in multiple chamber respectively, the formulation ingredients being wherein connected with the chamber indoor storage of conduit 2 is the formulation ingredients that can not dissolve dissolvable film 9, and the formulation ingredients of at least one the chamber indoor storage in other chambers is the formulation ingredients that can dissolve dissolvable film 9.
In above-mentioned, the formulation ingredients dissolving dissolvable film 9 can be solvent, other formulation ingredients can be bioactive substance, described bioactive substance be selected from micromolecule non-peptide nonprotein medicine, peptide class/pharmaceutical grade protein, natural animal-plant and extract thereof, diagnostic agent one or more.
In this example, the inner chamber of injection tube 101 is separated into two chambers by pressure sensitive film 3, and be respectively the first chamber 7 and the second chamber 8, conduit 2 is connected with the second chamber 8.Wherein, solvent is deposited in the first chamber 7, and the formulation ingredients deposited in the second chamber 8 can not dissolve dissolvable film 9.
The operation principle of doser of the present utility model:
First chamber 7 and the second chamber 8 have all deposited formulation ingredients, and the solvent of solubilized dissolvable film 9 is deposited in the first chamber 7, when needing administration, one end with fog-spray nozzle 4 of conduit 2 is extend into the nasal cavity regio olfactoria of more than horizontal level corresponding to middle nasal concha through the meatus nasi communis of human body, then the formulation ingredients in the first chamber 7 is extruded with the piston 102 of manual injection device 1, pressure sensitive film 3 is stressed to break, formulation ingredients mixing in first chamber 7 and in the second chamber 8, simultaneously dissolvable film 9 is met dissolution with solvents and is communicated with the tube chamber of conduit 2 by the second chamber 8, mixed mixture is delivered in conduit 2 by further push piston 102, then after fog-spray nozzle 4 is atomized, nasal cavity regio olfactoria is delivered to, and then directly suck brain, therapeutical effect is played central nervous system.
Doser tool of the present utility model has the following advantages:
1) once daily device: doser adopts succinct design, and be easy to get and the material preparation of safety with relatively inexpensive, eliminate the repeated washing of doser, the tedious steps of sterilization, more reduce the potential risk of cross-contamination.
2) multiple chamber design: by multiple independently chamber design, achieves not solvent-laden preparation and solvent system is independently preserved, and ensures that medicine has good stable effect duration in doser.
3) pre-packaged design: before use, make presser sensor film rupture by inside push piston thus be communicated with the chamber of the storage of solvent originally separated and store the chamber of not solvent-laden preparation, make the not solvent-laden preparation of accurately pre-subpackage and solvent can within very short time mix homogeneously, be directly used in administration, the process avoiding convenient administration device suction medicine to make up a prescription, is particularly useful for the occasion that hospital's first aid, battlefield nerve gas removing toxic substances etc. need Quick medicine.
4) conduit is used for nasal-cavity administration: due to human body rhinostenosis, general doser cannot probe into nasal meatus deep and carry out administration.Overwhelming majority medicine all cannot enter nasal cavity regio olfactoria, more cannot realize the administration object of nasal cavity Brain targeting.This utility model doser mixes the nasal cavity adapter of good biocompatibility, quality softness by conduit, make administering position can be deep into the horizontal level of meatus nasi communis close to nasal cavity regio olfactoria, substantially increase the targeting dosage that medicine enters regio olfactoria, local, avoid medicine enters peripheral circulation waste through Nasal Mucosa Absorption, also at utmost reduce the periphery side effect of medicine simultaneously.
5) the porous design of fog-spray nozzle: connect a fog-spray nozzle containing a large amount of micropore in catheter tip, necessarily injecting under pressure, by medicine aerosolization as much as possible, can make it fully and nasal cavity regio olfactoria nerve contact, improves the bioavailability of brain-targeted drug delivery.
Above this utility model is described in detail; its object is to allow the personage being familiar with this art can understand content of the present utility model and be implemented; protection domain of the present utility model can not be limited with this; all equivalences done according to spirit of the present utility model change or modify, and all should be encompassed in protection domain of the present utility model.
Claims (10)
1. a disposable per nasal brain-targeted drug delivery device, comprise administrator, described administrator comprises conduit and is arranged on the fog-spray nozzle of one end of described conduit, it is characterized in that: described administrator also comprise there is inner chamber and syringe for depositing preparation, described one end of described conduit can extend into the nasal cavity regio olfactoria of more than horizontal level corresponding to middle nasal concha through the meatus nasi communis of human body, described administrator also comprise be arranged in described syringe the inner chamber of described syringe is separated into multiple chamber independent of each other and the pressure sensitive film broken under pressure, the other end of described conduit is connected and the tube chamber of described conduit and connected chamber with in described multiple chamber, described administrator also comprises for being separated with connected chamber by the tube chamber of described conduit and the dissolvable film that can partly or entirely dissolve after contacting preparation.
2. disposable per nasal brain-targeted drug delivery device according to claim 1, is characterized in that: described dissolvable film is arranged on the junction of described syringe and described conduit.
3. disposable per nasal brain-targeted drug delivery device according to claim 1, is characterized in that: described administrator also comprise be arranged on described conduit described one end, for cushioning the nasal cavity adapter of described conduit for the direct stimulation of nasal membrane.
4. disposable per nasal brain-targeted drug delivery device according to claim 1, it is characterized in that: described conduit is flexible pipe, its external diameter is 0.1 ~ 50 millimeter.
5. disposable per nasal brain-targeted drug delivery device according to claim 1, is characterized in that: the diameter that described fog-spray nozzle has more than 1 or 1 is the hole of 0.1 ~ 1000 micron.
6. disposable per nasal brain-targeted drug delivery device according to claim 5, is characterized in that: the diameter in described hole is 1 ~ 100 micron.
7. disposable per nasal brain-targeted drug delivery device according to claim 1, it is characterized in that: described doser also comprises pre-packaged several formulations composition in described multiple chamber respectively, the formulation ingredients being wherein connected with the chamber indoor storage of described conduit is the formulation ingredients that can not dissolve described dissolvable film, containing the formulation ingredients dissolving described dissolvable film in the formulation ingredients of at least one the chamber indoor storage in other chambers.
8. disposable per nasal brain-targeted drug delivery device according to claim 7, it is characterized in that: the formulation ingredients of the described dissolvable film of described dissolving is solvent, the described formulation ingredients that can not dissolve described dissolvable film is the one in micromolecule non-peptide nonprotein medicine, peptide class/pharmaceutical grade protein, natural animal-plant and extract thereof, diagnostic agent.
9. the disposable per nasal brain-targeted drug delivery device according to claim 1 or 7, is characterized in that: described chamber is 2 ~ 3.
10. disposable per nasal brain-targeted drug delivery device according to claim 1, it is characterized in that: described syringe comprises the injection tube with described inner chamber and the piston be arranged in described injection tube, described injection tube is provided with opening, and the described other end of described conduit connects over said opening.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520123590.7U CN204446847U (en) | 2015-03-03 | 2015-03-03 | A kind of disposable per nasal brain-targeted drug delivery device |
| PCT/CN2015/100089 WO2016138793A1 (en) | 2015-03-03 | 2015-12-31 | Disposable intranasal brain-targeting drug delivery apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520123590.7U CN204446847U (en) | 2015-03-03 | 2015-03-03 | A kind of disposable per nasal brain-targeted drug delivery device |
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| Publication Number | Publication Date |
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| CN204446847U true CN204446847U (en) | 2015-07-08 |
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| CN201520123590.7U Active CN204446847U (en) | 2015-03-03 | 2015-03-03 | A kind of disposable per nasal brain-targeted drug delivery device |
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| Country | Link |
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| CN (1) | CN204446847U (en) |
| WO (1) | WO2016138793A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016138795A1 (en) * | 2015-03-03 | 2016-09-09 | 苏州同力生物医药有限公司 | Disposable intranasal brain-targeting drug delivery apparatus |
| WO2016138793A1 (en) * | 2015-03-03 | 2016-09-09 | 苏州同力生物医药有限公司 | Disposable intranasal brain-targeting drug delivery apparatus |
| CN115068795A (en) * | 2022-07-28 | 2022-09-20 | 纳索菲德(上海)制药技术有限公司 | Spray head for spraying liquid medicine into nose and device thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4016126A1 (en) * | 1990-04-17 | 1991-10-24 | Coster Tecnologie Speciali Spa | DEVICE FOR TRANSNASAL OR ORAL ADMINISTRATION OF MEDICATIONS OR THE LIKE |
| MXPA04004162A (en) * | 2001-11-02 | 2005-01-25 | Meridian Medical Technologies | A medicament container, a medicament dispensing kit for administering medication and a method for packaging the same. |
| CN201105005Y (en) * | 2007-11-25 | 2008-08-27 | 任美娥 | Disposable irrigator for care |
| JP2012515121A (en) * | 2009-01-12 | 2012-07-05 | アクティヴパック， インコーポレイテッド | Packaged products, inserts and compartments for aseptic mixing of substances and methods for use therewith |
| EP2629820B1 (en) * | 2010-10-20 | 2019-08-07 | Teleflex Medical Incorporated | Miniature fluid atomizer |
| DK2790758T3 (en) * | 2011-12-16 | 2017-11-20 | Indosys Ltd | Cartridge for a drug dose and delivery device |
| CN104902954B (en) * | 2012-08-14 | 2018-01-23 | Chd生物科学公司 | Wound care products with superacid composite |
| CN204446847U (en) * | 2015-03-03 | 2015-07-08 | 苏州同力生物医药有限公司 | A kind of disposable per nasal brain-targeted drug delivery device |
| CN204446845U (en) * | 2015-03-03 | 2015-07-08 | 苏州同力生物医药有限公司 | A kind of disposable per nasal brain-targeted drug delivery device |
| CN104667391B (en) * | 2015-03-03 | 2017-08-25 | 苏州同力生物医药有限公司 | A kind of disposable intranasal brain-targeted drug delivery device |
-
2015
- 2015-03-03 CN CN201520123590.7U patent/CN204446847U/en active Active
- 2015-12-31 WO PCT/CN2015/100089 patent/WO2016138793A1/en active Application Filing
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016138795A1 (en) * | 2015-03-03 | 2016-09-09 | 苏州同力生物医药有限公司 | Disposable intranasal brain-targeting drug delivery apparatus |
| WO2016138793A1 (en) * | 2015-03-03 | 2016-09-09 | 苏州同力生物医药有限公司 | Disposable intranasal brain-targeting drug delivery apparatus |
| CN115068795A (en) * | 2022-07-28 | 2022-09-20 | 纳索菲德(上海)制药技术有限公司 | Spray head for spraying liquid medicine into nose and device thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016138793A1 (en) | 2016-09-09 |
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